scholarly journals The Role of Th17 in Neuroimmune Disorders: Target for CAM Therapy. Part I

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Aristo Vojdani ◽  
Jama Lambert
Keyword(s):  
Autoimmune Diseases ◽  
Signaling Pathways ◽  
Allergic Inflammation ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 17 ◽  
Effector Cells ◽  
Pathogenic Factors ◽  
T Helper 17 Cell

CD4+effector cells, based on cytokine production, nuclear receptors and signaling pathways, have been categorized into four subsets. T-helper-1 cells produce IFN-γ, TNF-β, lymphotoxin and IL-10; T-helper-2 cells produce IL-4, IL-5, IL-10, IL-13, IL-21 and IL-31; T-helper-3, or regulatory T-cells, produce IL-10, TGF-βand IL-35; and the recently discovered T-helper-17 cell produces IL-17, IL-17A, IL-17F, IL-21, IL-26 and CCL20. By producing IL-17 and other signaling molecules, Th17 contributes to the pathogenesis of multiple autoimmune diseases including allergic inflammation, rheumatoid arthritis, autoimmune gastritis, inflammatory bowel disease, psoriasis and multiple sclerosis. In this article, we review the differential regulation of inflammation in different tissues with a major emphasis on enhancement of neuroinflammation by local production of IL-17 in the brain. By understanding the role of pathogenic factors in the induction of autoimmune diseases by Th17 cells, CAM practitioners will be able to design CAM therapies targeting Th17 and associated cytokine activities and signaling pathways to repair the intestinal and blood-brain barriers for their patients with autoimmunities, in particular, those with neuroinflammation and neurodegeneration.

scholarly journals Vitamin D and immunomodulation in the skin: a useful affirmative nexus

2021 ◽  
Author(s):  
Saptadip Samanta
Keyword(s):  
Vitamin D ◽  
Skin Diseases ◽  
Cell Formation ◽  
Interleukin 10 ◽  
The Body ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 17 ◽  
Vitamin D Receptors ◽  
T Helper 17 Cell

Skin is the largest organ of the body having multifunctional activities. It has a dynamic cellular network with unique immunologic properties to maintain defensive actions, photoprotection, immune response, inflammation, tolerogenic capacity, wound healing, etc. The immune cells of the skin exhibit distinct properties. They can synthesize active vitamin D [1,24(OH)2D3] and express vitamin D receptors. Any difficulties in the cutaneous immune system cause skin diseases (psoriasis, vitiligo, atopic dermatitis, skin carcinoma, and others). Vitamin D is an essential factor, exhibits immunomodulatory effects by regulating dendritic cells’ maturation, lymphocytes’ functions, and cytokine production. More specifically, vitamin D acts as an immune balancing agent, inhibits the exaggeration of immunostimulation. This vitamin suppresses T-helper 1 and T-helper 17 cell formation decreases inflammatory cytokines release and promotes the maturation of regulatory T cells and interleukin 10 secretion. The deficiency of this vitamin promotes the occurrence of immunoreactive disorders. Administration of vitamin D or its analogs is the therapeutic choice for the treatment of several skin diseases.

scholarly journals Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1

Immunity ◽  
2018 ◽  
Vol 48 (3) ◽  
pp. 556-569.e7 ◽  
Author(s):  
Gerd Meyer zu Horste ◽  
Dariusz Przybylski ◽  
Markus A. Schramm ◽  
Chao Wang ◽  
Alexandra Schnell ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Cell Differentiation ◽  
Cell Development ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 17 ◽  
T Helper 17 Cell

Role of T-helper 17 cell related cytokines in laryngeal cancer

2019 ◽  
Vol 133 (05) ◽  
pp. 394-398
Author(s):  
T K Muderris ◽  
F Gul ◽  
A Doblan ◽  
M Ergin ◽  
T Muderris
Keyword(s):  
Laryngeal Cancer ◽  
Lesion Group ◽  
Enzyme Linked Immunosorbent Assay ◽  
T Helper ◽  
T Helper 17 ◽  
Predictive Values ◽  
Interleukin 22 ◽  
Interleukin 17A ◽  
T Helper 17 Cell

AbstractObjectiveTo explore the role of T-helper 17 cells and their cascade in the pathogenesis of laryngeal cancer.MethodsProspectively, 110 consecutive patients with a suspicious laryngeal lesion were evaluated for serum levels of T-helper 17 cell related interleukins, including interleukins 23, 17A and 22, determined by enzyme-linked immunosorbent assay. The patients were divided into 2 groups after pathological evaluation: 49 patients with malignancy and 61 with benign pathology. Associations between interleukin levels and malignancy were determined via correlation analyses.ResultsInterleukin 17A and 22 levels were significantly higher in the malignancy group than the benign lesion group. Pearson correlation analysis showed that interleukins 17A and 22 acted in a cascade, but interleukin 23 did not. According to predictive values, interleukin 17A levels were 3.87 times and interleukin 22 levels were 1.09 times more likely to be associated with laryngeal cancer. The cut-off values for predicting laryngeal cancer were 3.55 pg/ml for interleukin 17A and 119.82 pg/ml for interleukin 22.ConclusionT-helper 17 cell related interleukins are potential biomarkers that may be helpful in diagnosing laryngeal cancer. Moreover, these data may support neutralisation of T-helper 17 cell related cytokine activity, which could be an attractive strategy for treating laryngeal cancer.

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