Outcomes in patients with cardiac masses: the underestimated burden of pseudotumours

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
P Paolisso ◽  
A Foa' ◽  
E.C D'Angelo ◽  
G Saturi ◽  
L Bergamaschi ◽  
...  
Keyword(s):  
Cardiovascular Mortality ◽  
Clinical Presentation ◽  
Malignant Tumours ◽  
Benign Lesions ◽  
Secondary Neoplasms ◽  
Small Series ◽  
Study Population ◽  
Long Term Prognosis ◽  
Benign Tumours ◽  
Cardiac Masses

Abstract Background Cardiac masses (CMs) include benign and malignant formations. So far, clinical presentation and prognosis have been reported only in small series without discriminating between subtypes. We investigated the clinical presentation and long-term prognosis of patients with cardiac masses stratifying our results according to the lesions' nature. Methods We enrolled all consecutive patients admitted to our Institution between 1999 and 2018 with imaging evidence of CMs. Definitive diagnosis was achieved by histologic examination or by radiological evidence of thrombotic resolution after anticoagulant treatment. The study population was classified as benign or malignant and subsequently into 4 subtypes: pseudo-tumours, primary benign tumours, primary malignant tumours and secondary tumours. Cardiovascular and non-cardiovascular mortality was described. Results We identified 172 patients with CMs, 125 benign and 47 malignant. Benign lesions were often incidentally diagnosed in the left heart chambers whereas malignancies were usually detected in the pericardium and right sections, resulting in more advanced symptoms. Over time – median follow-up of 48 months - survival of patients with benign formations was three-fold greater than patients with malignancies (p<0.001) with no differences in cardiovascular mortality. Patients with pseudo-tumours showed a significantly lower survival than primary benign tumours (p=0.018) while no difference was found within the malignant stratum between primary and secondary neoplasms. Conclusions CMs are a heterogeneous entity where advanced symptoms and a pericardial involvement suggest malignant forms, which exhibit a poor outcome. Among patients with benign lesions, pseudo-tumours were associated with reduced survival, supposedly as a consequence of the different underlying conditions. Funding Acknowledgement Type of funding source: None

Epidemiology and classification

2018 ◽  
pp. 463-465
Author(s):  
Cristina Basso ◽  
Peter T Buser ◽  
Stefania Rizzo ◽  
Massimo Lombardi ◽  
Gaetano Thiene
Keyword(s):  
Malignant Tumours ◽  
Cardiac Tumours ◽  
Cardiac Metastases ◽  
Benign Tumours ◽  
Cardiac Masses ◽  
Secondary Tumours

Cardiac masses include tumours, thrombi, vegetations, calcific lesions, and other very rare conditions. Cardiac tumours include benign tumours and tumour-like lesions, malignant tumours, and pericardial tumours. The estimated prevalence for primary cardiac tumours is 1:2.000 and for secondary tumours 1:100 autopsies. The incidence of cardiac metastases ranges from 2.3% to 18.3% of patients with extra-cardiac malignancies. About 10% of primary cardiac tumours are malignant and 90% benign. The majority of primary benign cardiac tumours are myxomas, followed by papillary fibroelastomas. Undifferentiated pleomorphic sarcomas are the most common primary malignant cardiac tumours, followed by angiosarcoma and leiomyosarcoma.

Positron emission mammography in the diagnosis of breast cancer

2016 ◽  
Vol 55 (01) ◽  
pp. 15-20 ◽  
Author(s):  
J. Farahati ◽  
A. G. Müller ◽  
E. Gillman ◽  
M. Hentschel ◽  
F. H. H. Müller
Keyword(s):  
Breast Cancer ◽  
High Specificity ◽  
Diagnostic Value ◽  
Glandular Tissue ◽  
Breast Cancer Patients ◽  
Malignant Tumours ◽  
Benign Lesions ◽  
Interventional Study ◽  
Positron Emission Mammography ◽  
Positron Emission

SummaryAim: To evaluate the diagnostic value (sensitivity, specificity) of positron emission mammography (PEM) in a single site non-interventional study using the maximum PEM uptake value (PUVmax). Patients, methods: In a singlesite, non-interventional study, 108 patients (107 women, 1 man) with a total of 151 suspected lesions were scanned with a PEM Flex Solo II (Naviscan) at 90 min p.i. with 3.5 MBq 18F-FDG per kg of body weight. In this ROI(region of interest)-based analysis, maximum PEM uptake value (PUV) was determined in lesions, tumours (PUVmaxtumour), benign lesions (PUVmaxnormal breast) and also in healthy tissues on the contralateral side (PUVmaxcontralateral breast). These values were compared and contrasted. In addition, the ratios of PUVmaxtumour / PUVmaxcontralateral breast and PUVmaxnormal breast / PUVmaxcontralateral breast were compared. The image data were interpreted independently by two experienced nuclear medicine physicians and compared with histology in cases of suspected carcinoma. Results: Based on a criteria of PUV>1.9, 31 out of 151 lesions in the patient cohort were found to be malignant (21%). A mean PUVmaxtumour of 3.78 ± 2.47 was identified in malignant tumours, while a mean PUVmaxnormal breast of 1.17 ± 0.37 was reported in the glandular tissue of the healthy breast, with the difference being statistically significant (p < 0.001). Similarly, the mean ratio between tumour and healthy glandular tissue in breast cancer patients (3.15 ± 1.58) was found to be significantly higher than the ratio for benign lesions (1.17 ± 0.41, p < 0.001). Conclusion: PEM is capable of differentiating breast tumours from benign lesions with 100% sensitivity along with a high specificity of 96%, when a threshold of PUVmax >1.9 is applied.

scholarly journals Enucleation of a giant symptomatic gastric lipoma, a safe surgical approach

2021 ◽  
Vol 2021 (3) ◽  
Author(s):  
Rafaela Parreira ◽  
Tiago Rama ◽  
Teresa Eloi ◽  
Vítor Carneiro ◽  
Maria Inês Leite
Keyword(s):  
Computed Tomography ◽  
Abdominal Pain ◽  
Clinical Presentation ◽  
Pyloric Obstruction ◽  
Asymptomatic Patients ◽  
Recurrent Vomiting ◽  
Low Incidence ◽  
Diagnostic Modalities ◽  
Benign Tumours ◽  
Gastric Lipoma

Abstract Gastric lipomas are rare, representing 2–3% of all benign tumours of the stomach. Most of these stomach neoplasms are small and detected incidentally during endoscopic or radiology evaluations. Computed tomography is highly specific imaging for lipoma diagnosis. Endoscopy and endoscopic ultrasound are other important diagnostic modalities to confirm the diagnosis. Identifying typical features can avoid biopsy or surgery in asymptomatic patients. In patients with larger lesions, usually more than 2 cm, clinical presentation may encompass haemorrhage, abdominal pain, pyloric obstruction and dyspepsia. As a result of its extreme low incidence, treatment is not standardized, though it is widely accepted that a symptomatic tumour mandates resection. Here, we present the case of a 60-year-old female presenting with abdominal pain and recurrent vomiting due to a giant gastric lipoma (80 × 35 × 35 mm). The patient underwent laparotomy and an enucleation was performed.

HISTOPATHOLOGICALANALYSIS OF TUMOURS AND TUMOUR-LIKE LESIONS OF COLON AND RECTUM

2021 ◽  
pp. 9-11
Author(s):  
Durga Nand Jha ◽  
Hari Shankar Mishra ◽  
Ajit Kumar Chaudhary ◽  
Debarshi Jana
Keyword(s):  
Histopathological Examination ◽  
Correct Diagnosis ◽  
Malignant Tumour ◽  
Juvenile Polyp ◽  
Tubular Adenoma ◽  
Malignant Tumours ◽  
Cross Sectional ◽  
Colorectal Biopsies ◽  
Colon And Rectum ◽  
Benign Tumours

Background:Tumours and tumour like lesions of the colon and rectum have overlapping clinical presentation and may be difcult to diagnose on clinical grounds alone. Histopathological examination although helpful to arrive at correct diagnosis, at times may be difcult and may require ancillary tests such as immunohistochemistry. Materials and Methods: A prospective cross sectional study enrolled 125 cases of colorectal biopsies after histopathological conrmation of tumours and tumour like lesions. The specimens were received at the Department of Pathology, DMCH, Laheriasarai, Bihar from December 2019 to November 2020. Results: Out of 125 cases, 32 cases were benign tumours, 36 cases were malignant tumours and 57 cases were tumour like lesions. Most common age range was 51-60 years with mean age of 38 years. Males comprised 76.74% and females 23.26% with ratio of 3:1. Juvenile polyp was the commonest lesion. Among benign tumours, tubular adenoma was the most common (19.2%), adenocarcinoma was most common malignant tumour (25.6%) and juvenile polyp was the most common tumour like lesion (27.2%). Left side was most common side (66.67%) and rectum was the most common site (48.8%). Conclusions: The commonest indications for colorectal biopsies were tumours and tumour like lesions. Juvenile polyp was the most common tumour like lesion, tubular adenoma was the most common benign tumour and adenocarcinoma was the most common malignant tumour. Histopathological examination is a gold standard for conrmation of all tumour and tumours like lesions of colon and rectum.

scholarly journals Primary Malignant Tumours of the Trigeminal Nerve

1986 ◽  
Vol 13 (2) ◽  
pp. 146-148 ◽  
Author(s):  
F.B. Maroun ◽  
M. Sadler ◽  
G.P. Murray ◽  
M. Mangan ◽  
G. Mathieson ◽  
...  
Keyword(s):  
Trigeminal Nerve ◽  
Clinical Presentation ◽  
Malignant Schwannoma ◽  
Pathological Features ◽  
Malignant Tumours

ABSTRACT:We report a case of primary malignant schwannoma of the trigeminal nerve, and review the 5 previously reported cases. Clinical presentation, along with radiological and pathological features are discussed.

scholarly journals PAROTID SWELLING IN CHILDREN

2009 ◽  
Vol 16 (01) ◽  
pp. 38-43
Author(s):  
ABID HAMEED SHEIKH ◽  
EHSAN UL HAQ ◽  
MUHAMMAD ZULFIQAR ANJUM ◽  
Gulzar Ahmad
Keyword(s):  
Treatment Options ◽  
Case Series ◽  
Cystic Hygroma ◽  
Vascular Lesions ◽  
Paediatric Surgery ◽  
Malignant Tumours ◽  
Parotid Region ◽  
Case Series Study ◽  
Parotid Swelling ◽  
Benign Tumours

Objective: To describe the clinical and pathological presentation as well as treatment options of parotid swelling inchildren. D e s i g n : Descriptive case series study. S e t t i n g : Department of Paediatric Surgery Bahawal Victoria Hospital Bahawalpur. Period:From Nov2005 to Jul2007. Material a n d m e t h o d : All patients of either sex below the age of 13 years presenting with parotid swelling wereincluded in the study. Clinical presentations, preoperative investigations, operative procedures, histopathology reports, postoperativecomplications and further management (radiotherapy &chemotherapy) were recorded. Results: Twelve patients presented with parotidswelling. Commonest presentation was a lump over the parotid region (100%) & pain (25%). Majority of tumours were benign (50%).Vascular lesions outnumbered solid tumours. 4 patients (33.33%) had haemangioma 1 patient (8.33%) had cystic hygroma, one patienteach of pleomorphic adenoma, mucoepidermoid carcinoma and Adenocarcinoma. C o n c l u s i o n : Salivary gland lesions are most likelyinflammatory in origin. Vascular tumours are common benign tumours than epithelial tumours in children. Superficial parotidectomy is theoperation for benign tumours and total conservative parotidectomy for malignant tumours.

scholarly journals Inflammatory Pseudotumour of Stomach in an old lady: a rare case report

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Azhar AH ◽  
Pasha MA ◽  
Hassan S ◽  
Zainal M ◽  
Rashidi A
Keyword(s):  
Case Report ◽  
Solid Tumor ◽  
Rare Case ◽  
Clinical Presentation ◽  
Inflammatory Pseudotumour ◽  
Secondary Neoplasms ◽  
Laboratory Techniques ◽  
Clinical Presentations ◽  
Rare Case Report ◽  
Adults And Children

Inflammatory pseudotumour (IPT) is a rare benign solid tumor in adults and children. The prevalence, etiology and pathogenesis of this condition are still uncertain. Despite the use of modern laboratory techniques and imaging, it is often difficult to make the diagnosis of IPT. Besides, occasionally the nonspecific morphological appearance and clinical presentation of the mass may mimic other more common primary or secondary neoplasms. IPT is commonly encountered in the lung and mediastinum. Other sites include abdomen (liver, pancreas, stomach, omentum), retroperitoneum, pelvis (bladder) and extremities in children. We report a rare case of gastric inflammatory pseudotumour in a 65-year-old female patient. Clinical presentations and its management along with review of literatures are presented.

scholarly journals Differential stromal reprogramming in benign and malignant naturally occurring canine mammary tumours identifies disease-promoting stromal components

2019 ◽  
Author(s):  
Parisa Amini ◽  
Sina Nassiri ◽  
Alexandra Malbon ◽  
Enni Markkanen
Keyword(s):  
Screening Method ◽  
Malignant Tumours ◽  
Differential Abundance ◽  
Naturally Occurring ◽  
Mammary Tumours ◽  
Ffpe Specimen ◽  
Summary Statement ◽  
Benign Tumours ◽  
Laser Capture ◽  
Laser Capture Microdissected

AbstractThe importance of cancer-associated stroma (CAS) for initiation and progression of cancer is well accepted. However, as stromal changes in benign forms of naturally occurring tumours are poorly understood, it remains unclear how CAS from benign and malignant tumours compare. Spontaneous canine mammary tumours are viewed as excellent models of human mammary carcinomas (mCA). We have recently reported highly conserved stromal reprogramming between canine and human mCA based on transcriptome analysis of laser-capture-microdissected FFPE specimen. To identify stromal changes between benign and malignant mammary tumours, we have analysed CAS and matched normal stroma from 13 canine mammary adenomas and compared them to 15 canine mCA. Our analyses revealed distinct stromal reprogramming even in small benign tumours. While similarities in stromal reprogramming exist, the CAS signature clearly distinguished adenomas from mCA, suggesting that it may reliably discriminate between benign and malignant tumours. We identified strongly discriminatory genes and found strong differential enrichment in several hallmark signalling pathways between benign and malignant CAS. The distinction between CAS from adenoma and mCA was further substantiated by differential abundance in cellular composition. Finally, to determine key players in CAS reprograming between adenomas and mCA, a network-based gene screening method identified modules of co-expressing genes with distinct expression profile in benign and malignant CAS, and revealed several hub genes as potential molecular drivers in CAS. Given the relevance of canine CAS as a model for the human disease, our approach identifies potential stromal drivers of tumour malignancy with implications for human mCA.Summary statementRNAsequencing-based analysis of stromal reprogramming between benign and malignant naturally occurring canine mammary tumours identifies potential molecular drivers in cancer-associated stroma that support tumour growth and malignancy.

scholarly journals Electrocardiographic characteristics of patients with coronavirus disease 2019 (COVID-2019) related pneumonia at first presentation

EP Europace ◽  
2021 ◽  
Vol 23 (Supplement_3) ◽  
Author(s):  
U Nguyen ◽  
M Strik ◽  
S Abu-Arib ◽  
A Bruekers ◽  
T Nguyen ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Negative Group ◽  
Male Mortality ◽  
Funding Sources ◽  
Atrial Enlargement ◽  
Study Population ◽  
Polymerase Chain ◽  
Repolarization Abnormalities ◽  
Funding Acknowledgements

Abstract Funding Acknowledgements Type of funding sources: None. Purpose To evaluate electrocardiographic (ECG) characteristics at first presentation in patients with possible coronavirus disease (COVID-19) pneumonia. Methods and results 356 patients presenting at the emergency room with possible COVID-19 pneumonia based on clinical presentation and computed tomography findings were included and subdivided into a COVID-19 positive group ([COVID-19-positive], n = 231, 65%) and a COVID-19 negative group ([COVID-19-negative], n = 125, 35%) based on polymerase chain reaction tests. The study population was predominantly middle aged-elderly (67 ± 14 year; n = 235, 66% male). Mortality rate was 24% after 1-month follow-up. There were no significant (NS) differences in sex, age, and mortality between the COVID-19-positive and COVID-19-negative group.  Atrial fibrillation (AF) was common (9%), though its prevalence was NS (regression analyses adjusted for age and sex) different in the COVID-19-positive vs. the COVID-19-negative group. ECG characteristics reflecting atrial enlargement and repolarization abnormalities were frequently present (&lt;38% and 14% respectively). No significant differences were found between the COVID-19-positive vs. the COVID-19-negative group for the majority of morphological ECG characteristics (Figure 1 for more detailed data).  Conclusion AF and ECG characteristics reflecting atrial enlargement and repolarization abnormalities are commonly present in COVID-19 patients. The prevalence of these ECG characteristics however do NS differ from their COVID-19-negative counterparts. Abstract Figure.

scholarly journals Cytohistopathological Study of Salivary Gland Lesions in Bundelkhand Region, Uttar Pradesh, India

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Anita Omhare ◽  
Sanjeev Kumar Singh ◽  
Jitendra Singh Nigam ◽  
Ankit Sharma
Keyword(s):  
Salivary Gland ◽  
Low Cost ◽  
Uttar Pradesh ◽  
Diagnostic Technique ◽  
High Specificity ◽  
Turnaround Time ◽  
Malignant Tumours ◽  
Female Ratio ◽  
Specificity And Sensitivity ◽  
Benign Tumours

Background. FNAC is a useful method for evaluating suspicious salivary glands lesions due to its low cost, minimum morbidity, rapid turnaround time, high specificity, and sensitivity. Aim. To know the frequency of the salivary gland lesions and cytohistological correlation in the Jhansi region, Uttar Pradesh, India. Material and Methods. In present study 124 cases were included and cytohistological correlation was made in 86 cases only. FNA was performed by using a 23/24-gauge needle without local anaesthesia. Air dried and 95% ethyl alcohol fixed wet smears were stained with Giemsa stain and Papanicolaou stain, respectively. Paraffin embedded tissue sections were stained with Haematoxylin and Eosin. Results. Parotid gland was the most commonly involved salivary gland. The commonest age group was 20 to 29 years, 30 to 39 years, and 60 to 69 years for nonneoplastic lesions, benign tumours, and malignant tumours, respectively. The overall male to female ratio was 1.17 : 1. The diagnostic accuracy of FNAC was 100%, 93.3%, and 88.2% for nonneoplastic lesions, benign tumours, and malignant tumours, respectively. Conclusion. The high accuracy, sensitivity, and specificity of FNAC confirm that preoperative cytology is a useful, quick, reliable diagnostic technique for rapid diagnosis and suitable for developing countries.

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