scholarly journals P817 Lung ultrasound in the evaluation of pulmonary congestion in patients with aortic stenosis

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
I Szabo ◽  
L Gargani ◽  
B Illes ◽  
A Frigy ◽  
A Varga ◽  
...  
Keyword(s):  
Aortic Stenosis ◽  
Functional Status ◽  
Lung Ultrasound ◽  
Severe Aortic Stenosis ◽  
Left Ventricular ◽  
Volume Index ◽  
Pulmonary Congestion ◽  
Interstitial Edema ◽  
Severe Aortic Regurgitation ◽  
B Lines

Abstract Background Aortic stenosis (AS) has a prolonged latent period, as AS worsens, the left ventricular adaptations become inadequate and impaired systolic and/or diastolic dysfunction, may lead to clinical heart failure (HF). The development of HF is an inflexion point in the natural history of AS. Pulmonary congestion is a nearly universal pathophysiological finding in HF, and may precede symptoms. Lung ultrasound (LUS) evaluation of B-lines has been proposed as a simple, non-invasive tool to assess pulmonary interstitial edema. Aim To assess pulmonary interstitial edema with LUS in patients with moderate and severe aortic stenosis, to define performance of LUS compared with clinical assessment and echocardiographic parameters. Methods Sixty-eight consecutive patients (36 women, mean age 74 ± 9 years) with moderate or severe aortic stenosis were enrolled. Exclusion criteria were as follows: moderate or severe aortic regurgitation, moderate or severe mitral regurgitation, cardiomyopathies and pulmonary disease. All patients underwent comprehensive echocardiography examination and LUS according to a previously validated 28 scanning-site assessment. Results we found a significant number of B-lines (≥15) in 79% of patients. B-lines were positively correlated with left atrial volume index (p < 0,05, r = 0,3) and estimated pulmonary pressure ( p < 0,0001, r= 0,62 Figure 1.) The number of B-lines didn’t correlate with the severity of AS (mean gradient vs. B-lines: p = 0,2, valve area vs. B-lines: p = 0,2.), however properly reflects different functional status of the patients (p < 0,0001, Figure 2.) Conclusion Lung ultrasound is a promising tool to detect lung congestion related to AS. The severity of congestion doesn’t correlate with the severity of AS, albeit B-lines better reflect the deteriorating functional status of the patients and the haemodynamic consequences related to AS. Abstract P817 Figure. Correlation PASP vs Blines, NYHA/B-lines

scholarly journals The prognostic value of lung ultrasound in aortic stenosis

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
G Agoston ◽  
I Szabo ◽  
L Gargani ◽  
N Nemeth ◽  
B Morvai-Illes ◽  
...  
Keyword(s):  
Heart Failure ◽  
Aortic Stenosis ◽  
Prognostic Value ◽  
Lung Ultrasound ◽  
Systolic Pressure ◽  
Pulmonary Artery Systolic Pressure ◽  
Pulmonary Congestion ◽  
Severe Aortic Regurgitation ◽  
Increased Risk ◽  
B Lines

Abstract Funding Acknowledgements Type of funding sources: None. Background Aortic stenosis (AS) is a progressive disease and once symptomatic and heart failure (HF) develops is associated with poor prognosis. The degree of the pathophysiological and structural changes in AS are associated with poor survival. Pulmonary congestion is an almost universal finding in patients with HF. Lung ultrasound (LUS) evaluation of B-lines has been proposed as a simple, non-invasive tool to assess pulmonary congestion. Aim To assess pulmonary congestion with LUS in patients with AS and to define the prognostic value of B-lines. Methods 84 consecutive patients (43 women, mean age 74 ± 9 years) with moderate or severe AS were enrolled. Exclusion criteria were as follows:  moderate or severe aortic regurgitation, moderate or severe mitral regurgitation, cardiomyopathies, pulmonary disease, renal failure. At baseline, all patients underwent comprehensive echocardiography examination and LUS according to 28 scanning-site assessment. Patients were followed-up after enrollment to establish the prognostic value of LUS. A composite endpoint was considered, including: aortic valve replacement due to deterioration of patient condition or progression of AS from moderate to severe, death (any cause), hospitalization due to acute heart failure or progression of chronic heart failure which required hospitalization. Results We found a  severe number of B-lines (total B-lines ≥30) in 31% of AS patients. The number of B-lines was correlated with estimated pulmonary artery systolic pressure (p < 0,005, r= 0,52) and increased along with NYHA class (p < 0,001) Figure 1. Patients with ≥30 B-lines had more events during the 13,4 ± 6 months follow-up  (p < 0,001, Log-rank: 10,7; Figure 2). Conclusion Assessing B-lines in AS is a simple, feasible method to detect pulmonary congestion. The number of B-lines correlates with hemodynamic changes caused by AS and with the functional status of the patients. A severe degree of sonographic pulmonary congestion is associated with an increased risk of adverse events. Abstract Figure. FC class vs. Blines and prognostic value

scholarly journals Role of Perioperative Echocardiography in Revision of Assessment: A Condition of Severe Aortic Stenosis leading to Left Ventricular Dysfunction and Apical Clot

2017 ◽  
Vol 5 (2) ◽  
pp. 77-81
Author(s):  
Imran H Bhat ◽  
Srinath Damodaran ◽  
Rupesh Kumar
Keyword(s):  
Heart Disease ◽  
Aortic Stenosis ◽  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Severe Aortic Stenosis ◽  
Open Heart Surgery ◽  
Left Ventricular ◽  
Female Ratio ◽  
Severe Aortic Regurgitation

ABSTRACT The prevalence of discrete subaortic stenosis (SAS) in adults with congenital heart disease (CHD) is 8 to 20%, with a male to female ratio of 2:1. Fixed SAS may be due to a discrete fibrous membrane, a muscular narrowing, or a combination of the two. The discrete form of fibromuscular SAS is most frequently encountered (90%), but the tunnel-type lesions are associated with a greater degree of stenosis. We report the case of a 16-year-old boy scheduled for double valve replacement (DVR) based on the preoperative echocardiographic report of rheumatic heart disease (RHD) with severe aortic stenosis (AS), severe aortic regurgitation (AR) and moderate mitral stenosis (MS), and moderate mitral regurgitation (MR) with severe left ventricular (LV) systolic dysfunction and LV apical clot. Preoperative transthoracic echocardiography (TTE) in the operation theater revealed discrete subaortic membrane (SAM) causing severe LV outflow tract obstruction (LVOTO). The patient underwent open heart surgery with resection of the discrete membrane and removal of apical clot. How to cite this article Bhat IH, Mandal B, Damodaran S, Kumar R. Role of Perioperative Echocardiography in Revision of Assessment: A Condition of Severe Aortic Stenosis leading to Left Ventricular Dysfunction and Apical Clot. J Perioper Echocardiogr 2017;5(2):77-81.

Cardiovascular System

2010 ◽  
Author(s):  
Gautam Mehta ◽  
Bilal Iqbal
Keyword(s):  
Heart Failure ◽  
Pulmonary Hypertension ◽  
Heart Disease ◽  
Left Ventricle ◽  
Aortic Stenosis ◽  
Severe Aortic Stenosis ◽  
Left Ventricular ◽  
Pulmonary Congestion ◽  
Atrial Contraction ◽  
Apex Beat

1. Always mention presence/absence of signs of endocarditis in any patient with physical signs of valvular heart disease. More than often, they are absent—but this is an important negative finding. 2. Both a low volume and a slow-rising pulse are signs of severe aortic stenosis. If the patient is in atrial fibrillation (AF), then the pulse usually has a variable volume, and some examiners believe that one cannot fully conclusively comment on pulse volume in AF. In patients with aortic stenosis and AF, the pulse exhbits a variable but diminished volume. It would be more appropriate in this setting to say, ‘the pulse is of variable but diminished volume’. 3. A narrow pulse pressure signifies a low cardiac output state, thus a sign of severe aortic stenosis. Other causes of a narrow pulse pressure include severe mitral stenosis or a hypovolaemic state. 4. If venous pressure is elevated, then look for signs of pulmonary hypertension (usually with giant systolic ‘v’ waves of tricuspid regurgitation, parasternal heave and thrill, and a loud pulmonary component to the second heart sound) or pulmonary congestion/cardiac failure (bibasal crepitations). The presence of pulmonary hypertension and pulmonary congestion are markers of severe aortic stenosis. 5. The left ventricle (LV) is hypertrophied, and is minimally displaced with a heaving character. A displaced apex beat indicates a dilated left ventricle, i.e. left ventricular failure. In the late stages of severe aortic stenosis, the left ventricle dilates and heart failure develops. However, the character of the apex beat remains the same. If the apex is displaced, in the absence of signs of severe aortic stenosis, then consider other causes of heart failure. 6. The presystolic impulse is transmission of atrial contraction just before closure of the mitral valve, as a result of forceful atrial contraction against a highly non-compliant and hypertrophied left ventricle. This is often accompanied by a fourth heart sound, and would be a marker of severe aortic stenosis. These signs would not be present in AF. A presystolic impulse is seen in other conditions with marked left ventricular hypertrophy, i.e. hypertensive heart disease or hypertrophic cardiomyopathy (giving a double apical impulse).

scholarly journals Left Ventricular Morphology and Function as a Determinant of Pulmonary Hypertension in Patients with Severe Aortic Stenosis: Cardiovascular Magnetic Resonance Imaging Study

Medicina ◽  
2019 ◽  
Vol 55 (10) ◽  
pp. 711
Author(s):  
Birute Gumauskiene ◽  
Lina Padervinskiene ◽  
Jolanta Justina Vaskelyte ◽  
Audrone Vaitiekiene ◽  
Tomas Lapinskas ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Magnetic Resonance ◽  
Aortic Valve ◽  
Aortic Stenosis ◽  
Longitudinal Strain ◽  
Severe Aortic Stenosis ◽  
Global Longitudinal Strain ◽  
Left Ventricular ◽  
Volume Index ◽  
And Function

Background and Objectives: The influence of cardiac magnetic resonance (CMR) derived left ventricular (LV) parameters on the prognosis of patients with aortic stenosis (AS) was analyzed in several studies. However, the data on the relations between the LV parameters and the development of pulmonary hypertension (PH) in severe AS is lacking. Our objectives were to evaluate the CMR-derived changes of the LV size, morphology, and function in patients with isolated severe AS and PH, and to investigate the prognostic impact of these parameters on elevated systolic pulmonary artery pressure (sPAP). Materials and Methods: Thirty patients with isolated severe AS (aortic valve area ≤1 cm2) underwent a 2D-echocardiography (2D echo) and CMR before aortic valve replacement. Indices of the LV mass and volumes and ejection fraction were analyzed by CMR. The LV global longitudinal (LV LGS) and circumferential strain (LV CS) were calculated using CMR feature tracking (CMR-FT) software (Medis Suite QStrain 2.0, Medis Medical Imaging Systems B.V., Leiden, The Netherlands). The LV fibrosis expansion was assessed using a late gadolinium enhancement sequence. PH was defined as having an estimated sPAP of ≥45 mm Hg. The statistical analysis as performed using SPSS version 23.0 (SPSS, Chicago, IL, USA) Results: 30 patients with severe AS were included in the study, 23% with severe isolated AS had PH (mean sPAP 55 ± 6.6 mm Hg). More severe LV anatomical and functional abnormalities were observed in patients with PH when compared with patients without PH—a higher LV end-diastolic volume index (EDVi) (140 [120.0–160.0] vs. 90.0 mL/m² [82.5–103.0], p = 0.04), larger LV fibrosis area (7.8 [5.6–8.0] vs. 1.3% [1.2–1.5], p = 0.005), as well as lower LV global longitudinal strain (GLS; −14.0 [−14.9–(−8.9)] vs. −21.1% [−23.4–(−17.8)], p = 0.004). By receiver–operating characteristic (ROC) curve analysis, LV EDVi > 107.7 mL/m² (Area Under the Curve (AUC) 95.7%), LV GLS < −15.5% (AUC 86.3%), and LV fibrosis area >5% (AUC 89.3) were found to be robust predictors of PH in severe AS patients. Conclusions: In patients with severe aortic stenosis, a larger end-diastolic LV volume, impaired LV global longitudinal strain, and larger LV fibrosis extent can predict the development of pulmonary hypertension.

scholarly journals 621 Anemia and its impact on clinical, echocardiographic parameters and prognosis in patients with severe aortic stenosis and normal left ventricular ejection fraction

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
C Beladan ◽  
A Calin ◽  
A D Mateescu ◽  
M Rosca ◽  
R Enache ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Stenosis ◽  
Ejection Fraction ◽  
Severe Aortic Stenosis ◽  
Nyha Class ◽  
Left Ventricular ◽  
Volume Index ◽  
All Cause Mortality ◽  
Echocardiographic Parameters ◽  
Study Population

Abstract Background Anemia is common in patients (pts) with severe aortic stenosis (AS). Untreated anemia and severe AS are individually associated with the development of heart failure, however data regarding the potential detrimental effect of anemia on left ventricular (LV) function and prognosis in pts with severe AS are controversial. Aim To investigate the impact of anemia on clinical status, echocardiographic parameters and prognosis in pts with severe AS and preserved LV ejection fraction (LVEF). Methods Consecutive patients with severe AS (aortic valve area [AVA] index ≤ 0.6 cm2/m2) and preserved LVEF (&gt;50%) referred to our echocardiography laboratory were prospectively screened. All patients underwent complete clinical examination and comprehensive echocardiography, including speckle tracking-derived measurements of LV and left atrial (LA) strain. Baseline clinical variables included NYHA class, cardiac risk factors, haemoglobin (Hb) level and glomerular filtration rates (GFR, by MDRD formula). The definition of anemia was based on gender-specific cut-off values, as recommended by the WHO (Hb &lt;13.0 g/dL for men, &lt;12.0 g/dL for women). Patients with more than mild aortic regurgitation or mitral valve disease, atrial fibrillation or cardiac pacemakers were excluded. Results The study population included 264 patients (pts) (66 ± 11 yrs, 147 men). Anemia was present in 64 pts (24%). Aortic valve replacement (AVR) was performed in 151 pts. Dividing the study population into 2 groups, according to the presence/absence of anemia, no significant differences were found between groups regarding: age (p = 0.09), body surface area (p = 0.6), LVEF (62 ± 7 vs 63 ± 6%, p = 0.2), LV Global Longitudinal Strain (-15.2 ± 4 vs -14.7 ± 3 %, p = 0.4), LV mass index (p = 0.9), mean aortic gradient (p = 0.2) and indexed AVA (0.40 ± 0.09 vs 0.39 ± 0.09 cm2/m2, p = 0.6), or presence of significant coronary artery disease (p = 0.9). Compared to pts with normal Hb level, in pts with anemia NYHA class (p = 0.03), brain natriuretic peptide values (p = 0.004), lateral E/e’(16.2 ± 6.9 vs 13.7 ± 6.3, p = 0.01) and average E/e" ratio (15.9 ± 5.9 vs 14.1 ± 5.3, p = 0.03), LA volume index (54.3 ± 16.9 vs 45.0 ± 12.1 ml/m2, p &lt; 0.001), and systolic pulmonary artery pressure (38 ± 13 vs 33 ± 8, p = 0.009) were all significantly higher. During a 3–years follow-up 47 pts died. Age, NYHA class, BNP serum level, baseline anemia, LA volume index and systolic pulmonary pressure were associated with all-cause mortality in the whole study group (p &lt; 0.03 for all). In the group of pts who underwent AVR, NYHA class was the only independent predictor of all-cause mortality. Conclusions In our study including pts with severe AS and preserved LVEF, patients with baseline anemia presented worse functional status and LV diastolic dysfunction and increased 3-year all-cause mortality compared to those with normal Hb levels. However, in pts who underwent surgical AVR, there was no impact of baseline anemia on 3-year survival.

Lung Ultrasound Predicts Well Extravascular Lung Water but Is of Limited Usefulness in the Prediction of Wedge Pressure

2014 ◽  
Vol 121 (2) ◽  
pp. 320-327 ◽  
Author(s):  
Giovanni Volpicelli ◽  
Stefano Skurzak ◽  
Enrico Boero ◽  
Giuseppe Carpinteri ◽  
Marco Tengattini ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Extravascular Lung Water ◽  
Lung Ultrasound ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Pulmonary Congestion ◽  
Lung Water ◽  
Ventricular Ejection Fraction ◽  
B Lines ◽  
Limited Usefulness

Abstract Background: Pulmonary congestion is indicated at lung ultrasound by detection of B-lines, but correlation of these ultrasound signs with pulmonary artery occlusion pressure (PAOP) and extravascular lung water (EVLW) still remains to be further explored. The aim of the study was to assess whether B-lines, and eventually a combination with left ventricular ejection fraction (LVEF) assessment, are useful to differentiate low/high PAOP and EVLW in critically ill patients. Methods: The authors enrolled 73 patients requiring invasive monitoring from the intensive care unit of four university-affiliated hospitals. Forty-one patients underwent PAOP measurement by pulmonary artery catheterization and 32 patients had EVLW measured by transpulmonary thermodilution method. Lung and cardiac ultrasound examinations focused to the evaluation of B-lines and gross estimation of LVEF were performed. The absence of diffuse B-lines (A-pattern) versus the pattern showing prevalent B-lines (B-pattern) and the combination with normal or impaired LVEF were correlated with cutoff levels of PAOP and EVLW. Results: PAOP of 18 mmHg or less was predicted by the A-pattern with 85.7% sensitivity (95% CI, 70.5 to 94.1%) and 40.0% specificity (CI, 25.4 to 56.4%), whereas EVLW 10 ml/kg or less with 81.0% sensitivity (CI, 62.6 to 91.9%) and 90.9% specificity (CI, 74.2 to 97.7%). The combination of A-pattern with normal LVEF increased sensitivity to 100% (CI, 84.5 to 100%) and specificity to 72.7% (CI, 52.0 to 87.2%) for the prediction of PAOP 18 mmHg or less. Conclusions: B-lines allow good prediction of pulmonary congestion indicated by EVLW, whereas are of limited usefulness for the prediction of hemodynamic congestion indicated by PAOP. Combining B-lines with estimation of LVEF at transthoracic ultrasound may improve the prediction of PAOP.

scholarly journals Left ventricular mechanical dispersion in flow-gradient patterns of severe aortic stenosis

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
D Lavall ◽  
L.K Kuprat ◽  
J Kandels ◽  
S Stoebe ◽  
A Hagendorff ◽  
...  
Keyword(s):  
Aortic Stenosis ◽  
Longitudinal Strain ◽  
Severe Aortic Stenosis ◽  
Left Ventricular ◽  
Low Flow ◽  
Volume Index ◽  
Aortic Valve Area ◽  
Mechanical Dispersion ◽  
Flow Gradient ◽  
Valve Area

Abstract Purpose Patients with severe aortic stenosis are classified according to flow-gradient patterns. We investigated whether left ventricular (LV) mechanical dispersion, a marker of dyssynchrony and predictor of mortality, is associated with low-flow status in aortic stenosis. Methods and results 400 consecutive patients with QRS duration &lt;120ms were included in the retrospective analysis. Patients with severe aortic stenosis (aortic valve area ≤1.0cm2) were classified as normal-flow (NF; stroke volume index &gt;35ml/m2) high-gradient (HG; mean transvalvular gradient ≥40mmHg) (n=79), NF low-gradient (LG) (n=62), low-flow (LF) LG ejection fraction (EF) ≥50% (n=57), and LF LG EF&lt;50% (n=23). Patients with moderate aortic stenosis (aortic valve area 1.5–1.0cm2; n=95) and patients with chronic systolic heart failure (n=84) without aortic stenosis served as comparison groups. Similar values of mechanical dispersion (calculated as standard deviation of time from Q/S onset on electrocardiogram to peak longitudinal strain in 17 left ventricular segments) was observed in patients with NF HG (49.4±14.7ms), NF LG (43.5±12.9ms), LF LG EF≥50% (47.2±16.3ms) and moderate aortic stenosis (44.2±15.7ms). Mechanical dispersion was increased in patients with LF LG EF&lt;50% (60.8±20.7ms) and in chronic heart failure (59.4±16.7ms) (p&lt;0.05 for both vs. NF HG‡, NF LG†, LF LG EF≥50%§ and moderate*; Figure). Mechanical dispersion correlated with LV end-systolic volume index (r=0.2530, p&lt;0.0001), LVEF (r=−0.2895, p&lt;0.0001) and global longitudinal strain (r=0.3108, p&lt;0.0001), but not with parameters of aortic stenosis. Conclusion Mechanical dispersion was similar among flow-gradient subgroups of severe aortic stenosis with preserved LVEF, but increased in patients with low-flow low-gradient and reduced LVEF. These findings indicate that mechanical dispersion is rather a marker of systolic myocardial dysfunction than of aortic stenosis. Figure 1 Funding Acknowledgement Type of funding source: None

Abstract 12459: Is Ejection Fraction <50% the Optimal Threshold for Referral for Valve Replacement in Patients With Severe Aortic Stenosis? Impact of Ejection Fraction on Post-Operative Outcome

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Jordi S Dahl ◽  
Mackram F Eleid ◽  
Hector Michelena ◽  
Christopher Scott ◽  
Rakesh Suri ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Stenosis ◽  
Ejection Fraction ◽  
Valve Replacement ◽  
Severe Aortic Stenosis ◽  
Left Ventricular ◽  
Optimal Threshold ◽  
Volume Index ◽  
Asymptomatic Patients ◽  
All Cause Mortality

Introduction: In asymptomatic patients with severe aortic stenosis (SAS), left ventricular (LV) ejection fraction (EF) <50% is generally considered to be the threshold for referral for aortic valve replacement (AVR). Hypothesis: We investigated the importance of LVEF on long-term outcome after AVR in symptomatic and asymptomatic SAS patients and studied whether LVEF < 50% is the optimal threshold for referral for AVR. Methods and Results: We retrospectively identified 2017 patients with SAS (aortic valve area (AVA)<1cm2, mean aortic valve gradient ≥40 mm Hg, or indexed AVA <0.6 cm2/m2) who underwent surgical AVR from January 1995 to June 2009 at our institution. Patients were divided into 4 groups depending on preoperative LVEF (<50% in 300 (15%) patients, 50-59% in 331 (17%), 60-69% in 908 (45%), and ≥70% in 478 (24%)). The primary end-point was all-cause mortality. During follow-up of 5.3±4.4 years, 1056 (52%) died. Five-year mortality rate increased with decreasing LVEF (41% (n=106), LVEF<50%); 35% (n=98), LVEF 50-59%; 26% (n=192), LVEF 60-69%; 22% (n=90), LVEF≥70%, p<0.0001). Compared to patients with LVEF≥60%, patients with LVEF 50-59% had increased mortality (HR 1.58, p<0.001), with a similar risk increase in both symptomatic (HR=1.56, p<0.001) and asymptomatic patients (HR 1.58, p=0.006, Figure). In a Cox regression analysis corrected for standard risk factors, LV mass index, AVA, and stroke volume index, LVEF was predictive of all-cause mortality (HR=0.89 per 10%, p<0.001). When this multivariable analysis was repeated in the subset of 1333 patients with no history of coronary artery disease, LVEF was still associated with all-cause mortality (HR=0.90 per 10%, p=0.009). Conclusion: In patients with SAS undergoing AVR, patients with LVEF 50-59% have also increased mortality compared to patients with LVEF>60%, suggesting that a different LVEF threshold should be used when referring for AVR.

scholarly journals P655 Prognostic value of the new classification of ventricular remodeling in severe aortic stenosis

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
S Gonzalez Estriegana ◽  
S Gamaza Chulian ◽  
E Diaz Retamino ◽  
B Serrano Munoz ◽  
A Giraldez Valpuesta ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Aortic Stenosis ◽  
Cardiovascular Mortality ◽  
Ventricular Remodeling ◽  
Severe Aortic Stenosis ◽  
Survival Function ◽  
Left Ventricular ◽  
Volume Index ◽  
New Classification ◽  
Concentric Hypertrophy

Abstract Introduction remodeling is defined as the changes produced in the geometry of the left ventricle after damage or overload of the myocardium. The most common classification only considers left ventricle relative wall thickness and mass index, but a new classification includes also end-diastolic volume index. Purpose to determine if the new patterns of ventricular remodeling had clinical relevance according to symptoms or cardiovacular outcomes. Methods patients with severe aortic stenosis (valve area &lt;1cm2) between 2015 and 2018 were included, excluding other concomitant at least moderate valvular diseases. The patients were classified according to the indexed ventricular mass, relative parietal thickness and left ventricular volume. Cardiovascular mortality was analyzed as the primary endpoint. Results we recruited 234 patients with severe aortic stenosis (55% women, age 77 ± 9 years) with a BMI of 29 ± 5, of which 82% were hypertensive, 47% diabetic, 47% dyslipidemic and 19% smokers. 81% were symptomatic. The average time of follow-up was 280 ± 231 days. 1% had eccentric hypertrophy, 7% mixed hypertrophy, 3% dilated hypertrophy, 73% concentric hypertrophy, 15% concentric remodeling; no patient presented normal ventricle or physiological hypertrophy. Dyspnea was the predominant symptom 100% in eccentric, mixed and dilated hypertrophy; 72% in concentric hypertrophy and 85% in concentric remodeling (p = 0.05). Most patients with mixed hypertrophy had NYHA functional class&gt; II: 0% vs 62% vs 37% vs 27% vs 37% (p = 0.008). The group with the highest cardiovascular mortality was mixed hypertrophy (0% vs 43% vs 0% vs 14% vs 11%, p = 0.04), also shown in the survival analysis (Log Rank = 0.009) (Graph 1). Conclusions in patients with severe aortic stenosis, the pattern of mixed hypertrophy was an adverse prognostic marker in our study, although prognostic role of these new remodeling patterns needs to be investigated in future prospective studies. Abstract P655 Figure. Graph 1.: Kaplan-Meier survival function

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