scholarly journals Elevated plasma free fatty acids predict sudden cardiac death: a 6.85-year follow-up of 3315 patients after coronary angiography

2007 ◽  
Vol 28 (22) ◽  
pp. 2763-2769 ◽  
Author(s):  
S. Pilz ◽  
H. Scharnagl ◽  
B. Tiran ◽  
B. Wellnitz ◽  
U. Seelhorst ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Sudden Cardiac Death ◽  
Coronary Angiography ◽  
Free Fatty Acids ◽  
Cardiac Death ◽  
Elevated Plasma ◽  
Plasma Free Fatty Acids

scholarly journals Elevated plasma free fatty acids are associated with sudden death: A prospective community-based evaluation at the time of cardiac arrest

Heart Rhythm ◽  
2014 ◽  
Vol 11 (4) ◽  
pp. 691-696 ◽  
Author(s):  
Rasmus Havmoeller ◽  
Kyndaron Reinier ◽  
Carmen Teodorescu ◽  
Naser Ahmadi ◽  
Dorothy Kwok ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cardiac Arrest ◽  
Sudden Death ◽  
Free Fatty Acids ◽  
Elevated Plasma ◽  
Community Based ◽  
Plasma Free Fatty Acids

PPAR-α activation required for decreased glucose uptake and increased susceptibility to injury during ischemia

2005 ◽  
Vol 288 (6) ◽  
pp. H2677-H2683 ◽  
Author(s):  
Marcello Panagia ◽  
Geoffrey F. Gibbons ◽  
George K. Radda ◽  
Kieran Clarke
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Glucose Uptake ◽  
Null Mouse ◽  
Elevated Plasma ◽  
Wild Type ◽  
Plasma Free Fatty Acids ◽  
Protein Levels ◽  
Glut 4 ◽  
Metabolic States

The transcription of key metabolic regulatory enzymes in the heart is altered in the diabetic state, yet little is known of the underlying mechanisms. The aim of this study was to investigate the role of peroxisome proliferator-activated receptor-α (PPAR-α) in modulating cardiac insulin-sensitive glucose transporter (GLUT-4) protein levels in altered metabolic states and to determine the functional consequences by assessing cardiac ischemic tolerance. Wild-type and PPAR-α-null mouse hearts were isolated and perfused 6 wk after streptozotocin administration or after 14 mo on a high-fat diet or after a 24-h fast. Myocardial d-[2-3H]glucose uptake was measured during low-flow ischemia, and differences in GLUT-4 protein levels were quantified using Western blotting. In wild-type mice in all three metabolic states, elevated plasma free fatty acids were associated with lower total cardiac GLUT-4 protein levels and decreased glucose uptake during ischemia, resulting in poor postischemic functional recovery. Although PPAR-α-null mice also had elevated plasma free fatty acids, they had neither decreased cardiac GLUT-4 levels nor decreased glucose uptake during ischemia and, consequently, did not have poor recovery during reperfusion. We conclude that elevated plasma free fatty acids are associated with increased injury during ischemia due to decreased cardiac glucose uptake resulting from lower cardiac GLUT-4 protein levels, the levels of GLUT-4 being regulated, probably indirectly, through PPAR-α activation.

RESEARCH THE VALUE OF THE COMBINATION OF T WAVE ALTERNANS AND NT-PROBNT IN PREDICTING SUDDEN CARDIAC DEATH

2012 ◽  
pp. 74-83
Author(s):  
Anh Tien Hoang ◽  
Nhat Quang Nguyen
Keyword(s):  
Myocardial Infarction ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Ventricular Arrhythmias ◽  
Healthy Person ◽  
Treadmill Test ◽  
T Wave ◽  
T Wave Alternans

Background: Decades of research now link TWA with inducible and spontaneous clinical ventricular arrhythmias. This bench-to-bedside foundation makes TWA, NT-ProBNP a very plausible index of susceptibility to ventricular arrythmia, and motivates the need to define optimal combination of TWA and NT-ProBNP in predicting ventricular arrythmia in myocardial infarction patients. We research this study with 2 targets: 1. To evaluate the role of TWA in predicting sudden cardiac death in myocardial infarction patients. 2. To evaluate the role of NT-ProBNP in predicting sudden cardiac death in myocardial infarction patients 3. Evaluate the role of the combined NT-ProBNP and TWA in predicting sudden cardiac death in myocardial infarction patients. Methods: Prospective study with follow up the mortality in 2 years: 71 chronic myocardial infarction patients admitted to hospital from 5/2009 to 5/20011 and 50 healthy person was done treadmill test to caculate TWA; ECG, echocardiography, NT-ProBNP. Results: Cut-off point of NT-ProBNP in predicting sudden cardiac death is 3168 pg/ml; AUC = 0,86 (95% CI: 0,72 - 0,91); Cut-off point of TWA in predicting sudden cardiac death is 107 µV; AUC = 0,81 (95% CI: 0,69 - 0,87); NT-ProBNP can predict sudden cardiac death with OR= 7,26 (p<0,01); TWA can predict sudden cardiac death with OR= 8,45 (p<0,01). The combined NT-ProBNP and TWA in predicting ventricular arrythmia in heart failure patients: OR= 17,91 (p<0,001). Conclusions: The combined NT-ProBNP and TWA have the best predict value of sudden cardiac death in myocardial infarction patients, compare to NT-ProBNP or TWA alone

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