Matrix Metalloproteinase-9 (MMP9) and high sensitivity C - Reactive Protein (hs-CRP) in Coronary Artery Ectasia (CAE)

Matrix metalloproteinase-9 (MMP-9) has been shown to play a key role in endothelial function and perhaps pivotal in the correlation between periodontal disease and cardiovascular disease (CVD). For the study, the impact of MMP-9 of periodontitis and CVD on serum and saliva concentrations was analyzed. For the study patients with periodontitis (n = 31), CVD (n = 31), periodontitis + CVD (n = 31), and healthy patients (n = 31) were enrolled. Clinical and demographic characteristics as well as serum and salivary MMP-9 were evaluated. MMP-9 concentrations in serum and saliva were statistically elevated in patients with CVD (p < 0.01) and in patients with periodontitis plus CVD (p < 0.001) compared to patients with periodontitis and healthy subjects. Multivariate regression analysis showed that c-reactive protein (hs-CRP) was the only significant predictor for MMP-9 serum (p < 0.001), whereas hs-CRP (p < 0.001) and total cholesterol (p = 0.029) were the statistically significant salivary MMP-9 predictors. This study evidenced that patients with CVD and periodontitis + CVD presented elevated MMP-9 concentrations in serum and saliva compared to patients with periodontitis and healthy subjects. Furthermore, hs-CRP was a negative predictor of serum and salivary MMP-9.

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Analysis of Systemic Endothelin-1, Matrix Metalloproteinase-9, Macrophage Chemoattractant Protein-1, and High-Sensitivity C-Reactive Protein in Normal-Tension Glaucoma

Current Eye Research ◽

10.3109/02713683.2012.725798 ◽

2012 ◽

Vol 37 (12) ◽

pp. 1121-1126 ◽

Cited By ~ 26

Author(s):

Na Young Lee ◽

Hae-Young Lopilly Park ◽

Chan Kee Park ◽

Myung Douk Ahn

Keyword(s):

Matrix Metalloproteinase ◽

High Sensitivity ◽

Normal Tension Glaucoma ◽

Matrix Metalloproteinase 9 ◽

C Reactive Protein ◽

Endothelin 1 ◽

Reactive Protein ◽

Metalloproteinase 9

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Elevated high sensitivity C-reactive protein and uric acid levels in coronary artery ectasia.

Acta Biochimica Polonica ◽

10.18388/abp.2014_1831 ◽

2014 ◽

Vol 61 (4) ◽

Cited By ~ 6

Author(s):

Şerafettin Demir ◽

Gulhan Karakoyun ◽

Mehmet Kanadasi

Keyword(s):

Uric Acid ◽

Coronary Artery ◽

High Sensitivity ◽

Control Group ◽

Coronary Artery Ectasia ◽

C Reactive Protein ◽

Reactive Protein ◽

Group I ◽

Significant Difference ◽

Hs Crp

The aim of this study is to examine uric asid (UA) and high sensitive C-Reactive protein (Hs-CRP) levels in patients with coronary artery ectasia (CAE). Ninety-eight patients with isolated CAE (mean age 57.5±10.3), (group-I), 110 patients with CAD but without CAE (mean age 56.3±10.7), (group-II), and 105 patients with normal coronary angiographies (mean age 58.1±10.8), (group-III) were included in the study. Blood samples of all individual were taken after coronary angiography from an antecubital vein, the patients uric acid and Hs-CRP levels were assessed. The severity of ectasia was evaluated and categorized according to Markis. A significant difference was not seen in serum uric acid and Hs-CRP levels between CAE and CAD groups. However, relative to the control group, uric acid and Hs-CRP levels in CAE and CAD groups were higher to a significant degree (p=0.001, p

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P3645Prognosis in relation to high-sensitivity C-reactive protein levels in patients with non-obstructive coronary artery disease

European Heart Journal ◽

10.1093/eurheartj/ehz745.0502 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

H W Zhang ◽

Y X Cao ◽

J L Jin ◽

Y L Guo ◽

Y Gao ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Obstructive Coronary Artery Disease ◽

High Sensitivity ◽

C Reactive Protein ◽

Development Fund ◽

Reactive Protein ◽

Increased Risk ◽

Hs Crp ◽

Artery Disease

Abstract Background It has been reported that coronary artery disease (CAD) is characterized by inflammation and non-obstructive CAD (NOCAD) increases the risk of cardiovascular events (CVEs) compared with ones with normal or near-normal coronary arteries (NNCA), even is similar to obstructive CAD (OCAD). We hypothesized that elevated high-sensitivity C-reactive protein (hs-CRP) may be linked to CVEs in those patients with NOCAD. Purpose To investigate the predictive role of hs-CRP in patients with NOCAD. Methods Of 7,746 consecutive patients with angina-like chest pain admissions, 4,662 eligible patients were enrolled who received coronary artery angiography (CAG) and followed up for the CVEs comprising all-cause mortality, myocardial infarction, stroke and late revascularization. According to the results of CAG, the patients were classified as NNCA group (<20% stenosis, n=698, 15.0%), NOCAD group (20–49% stenosis, n=639, 14.3%), and OCAD group (≥50% stenosis, n=3325, 70.7%). They were further subdivided into 3 groups according to baseline hs-CRP levels (<1, 1–3 and >3 mg/L). Proportional hazards models were used to assess the risk of CVEs in all patients enrolled. Results A total of 338 patients (7.3%) experienced CVEs during an average of 13403 person-years follow-up. Patients with NOCAD and OCAD had higher rates of CVEs compared to those with NNCA (p<0.05, respectively). In Cox's models after adjustment of confounders, the risk of CVEs elevated with the increasing degrees of CAD with hazard ratio of 2.01 [95% confidence interval (95% CI): 1.07–3.79, p=0.03] for patients with NOCAD and 2.81 (95% CI: 1.60–4.93, p<0.001) for patients with OCAD compared with the NNCA group. Moreover, elevated hs-CRP levels were associated with the severity of coronary lesions and an elevated increased risk of CVEs in patients with NOCAD and OCAD compared those with NNCA (p<0.05, respectively). Conclusions Patients with NOCAD had indeed worse outcomes and hs-CRP levels were positively in relation to the CVEs in those with NOCAD, which may help to the risk assessment in ones with NOCAD. Acknowledgement/Funding This study was partly supported by Capital Health Development Fund (201614035) and CAMS Innovation Fund for Medical Sciences (2016-I2M-1-011) awarded

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Diagnostic value of serial measurement of c-reactive protein in serum and matrix metalloproteinase-9 in drainage fluid in the detection of infectious complications and anastomotic leakage in patients with colorectal resection

Vojnosanitetski pregled ◽

10.2298/vsp140723011k ◽

2015 ◽

Vol 72 (10) ◽

pp. 889-898 ◽

Cited By ~ 6

Author(s):

Zoran Kostic ◽

Marina Panisic ◽

Bosko Milev ◽

Zoran Mijuskovic ◽

Damjan Slavkovic ◽

...

Keyword(s):

Matrix Metalloproteinase ◽

Anastomotic Leakage ◽

Colorectal Resection ◽

Infectious Complications ◽

Matrix Metalloproteinase 9 ◽

C Reactive Protein ◽

Drainage Fluid ◽

Serial Measurement ◽

Reactive Protein ◽

Metalloproteinase 9

Background/Aim. Postoperative infectious complications are one of the most important problems in surgical treatment of colorectal cancer (CRC), being present in up to 40% of patients. The aim of this paper was to establish the significance of serial measurement of C-reactive protein (CRP) in serum and matrix metalloproteinase-9 (MMP-9) in drainage fluid for the detection of infectious complications and anastomotic leakage (AL) in patients with colorectal resection. Methods. CRP and MMP-9 values in serum and drainage fluid, respectively, were measured on the first, third, fifth, and seventh postoperative day (POD) in 150 patients with colorectal resection and primary anastomosis. The values obtained were compared between the patients without complications and those with surgical site and remote infections and AL. Results. Surgical site infections (SSIs) were observed in 41 (27.3%), and remote infections in 10 (6.7%) patients. Clinically evident AL was observed in 15 (10%) patients. In 82% of the patients with SSIs, serum CRP value on POD 5 exceeded 82 mg/L, with 81% specificity. AL was reported in 85% and 92% of the patients on PODs 5 and 7, respectively, with CRP values of 77 mg/L and 90 mg/L, respectively. The specificity was 77% for POD 5 and 88% for POD 7. All the patients with CRP values exceeding 139 mg/L on POD 5 had some of SSIs and/or AL. The mean values of MMP-9 were not statistically different between the group without complications (n = 99) and the group with AL (n = 15). Conclusion. Serial measurement of CRP is recommended for screening of infectious complications of colorectal resection. Patients with CRP values above 139 mg/L on POD 5 cannot be discharged from hospital, and require an intensive search for infectious complications, particularly AL. MMP-9 measurement in drainage fluid is not relevant in the detection of AL in patients with colorectal resection.

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