P5317Prevalence of cardiovascular diseases in the Middle-East: systemic review and meta-analysis

Background Cardiovascular diseases are the leading cause of mortality in the world and CVDs are responsible for 34% of all deaths in the middle east population. To better understanding of the current CVD prevalence in the middle east population we conducted this systematic review and meta-analysis. Aim To assess the prevalence and risk factors of CVD among middle east adult population from the published literature. Methods Electronic data basis such as PubMed, Sciencedirect, Embase and Google scholar were searched, from the year 2011 to December 2018. All the original articles published in English and have investigated the prevalence of CVD and risk factors. Study characteristics, participants demographics and risk factors of CVD were recorded. To pull the CVD prevalence, we used random effect meta-analysis. we assess heterogeneity using both the formal tests and subgroup analysis. We also assessed the quality of the studies and examined the publication bias. Results We retrieved 2931 potentially relevant papers through searches of electronic and gray literatures, of which 44 articles met inclusion criteria after the screening and were included in systematic review and meta-analysis (N=191,979). The weighted pooled prevalence of CVD was 13.7% (95% CI: 11.1%-16.3%) in the Middle-East. The prevalence of cardiovascular disease risk factors such as dyslipidemia accounts 43.1% (95% CI: 17%-69.3%), diabetes mellitus 32.3%, 95% CI: 23.8%-40.8%), hypertension 30.7% (95% CI: 25.2%-36.3%). Other traditional CVD risk factors, smoking 16.3% (95% CI: 12.9%-19.7%), and family history of CVDs 18.7% (95% CI: 15.2%-22.2%). Conclusion A high CVD prevalence of 13.7% was identified and dyslipidemia remain to be a significant independent risk factor for CVD in the Middle-East. Interventional strategies are urgently required for primary prevention of CVD and its associated risk factors in Middle East population.