scholarly journals Evaluation of the force applied by the adductor muscles in a healthy student population performing an adduction task

2021 ◽  
Vol 31 (Supplement_2) ◽  
Author(s):  
Maria Cruz ◽  
Deolinda Rasteiro ◽  
Filipe Carvalho ◽  
Jorge Lains ◽  
Luis Roseiro
Keyword(s):  
Motor Neurons ◽  
Skeletal Muscles ◽  
Sedentary Lifestyle ◽  
Lower Limb Injuries ◽  
Performance Time ◽  
Student Community ◽  
Adductor Muscles ◽  
Limb Injuries ◽  
Resting Metabolism ◽  
The Central Nervous System

Abstract Background The adduction and abduction movement (closing and open the legs) are important tasks in daily activities. The evaluation and monitor of the force exerted by the adductor muscles can be used as a rehabilitation progress indicator, particularly in people with injuries in the central nervous system or motor neurons. The development of biomechanical devices to quantify and identify patterns in this type of force with healthy people can be a contribution in this domain. This work, approved by the Ethical Committee of IPC, aims to evaluate the force applied by the adductor muscles from a healthy group of students, performing the closing legs task. Methods The study was carried out at Applied Biomechanics Laboratory of IPC, with a group of 32 healthy volunteers from the student community (19-26 yo), half men - half women, without lower limb injuries, 59,38% with a prevalence of sedentary lifestyle. Volunteers, sitting in a comfortable position, press a biomechanical device placed between the legs. The time-force was registered for four discrete open-leg positions. Results The maximum mean forces were 199N in women and 257N in men, both in the shorter range of the open-leg position. The peak of force decreases with open leg distance for both genders and was achieved between 34%–54% of the performance time ([3, 28] seconds). Moderate correlations were identified between forces applied and skeletal muscles and resting metabolism. Conclusion The time-force applied was identified and registered with a developed biomechanical device. Obtained values are reliable and can be a support for future investigations.

scholarly journals Stac protein regulates release of neuropeptides

2020 ◽  
Vol 117 (47) ◽  
pp. 29914-29924
Author(s):  
I-Uen Hsu ◽  
Jeremy W. Linsley ◽  
Xiaoli Zhang ◽  
Jade E. Varineau ◽  
Drew A. Berkhoudt ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Motor Neurons ◽  
Skeletal Muscles ◽  
Molecular Regulation ◽  
Behavioral Analysis ◽  
Contraction Coupling ◽  
Genetic Manipulations ◽  
Neuropeptide Release ◽  
The Central Nervous System

Neuropeptides are important for regulating numerous neural functions and behaviors. Release of neuropeptides requires long-lasting, high levels of cytosolic Ca2+. However, the molecular regulation of neuropeptide release remains to be clarified. Recently, Stac3 was identified as a key regulator of L-type Ca2+channels (CaChs) and excitation–contraction coupling in vertebrate skeletal muscles. There is a small family ofstacgenes in vertebrates with other members expressed by subsets of neurons in the central nervous system. The function of neural Stac proteins, however, is poorly understood.Drosophila melanogastercontain a singlestacgene,Dstac, which is expressed by muscles and a subset of neurons, including neuropeptide-expressing motor neurons. Here, genetic manipulations, coupled with immunolabeling, Ca2+imaging, electrophysiology, and behavioral analysis, revealed that Dstac regulates L-type CaChs (Dmca1D) inDrosophilamotor neurons and this, in turn, controls the release of neuropeptides.

scholarly journals The Skeletal Muscle Emerges as a New Disease Target in Amyotrophic Lateral Sclerosis

2021 ◽  
Vol 11 (7) ◽  
pp. 671
Author(s):  
Oihane Pikatza-Menoio ◽  
Amaia Elicegui ◽  
Xabier Bengoetxea ◽  
Neia Naldaiz-Gastesi ◽  
Adolfo López de Munain ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Amyotrophic Lateral Sclerosis ◽  
Muscle Tissue ◽  
Motor Neurons ◽  
Neurodegenerative Disorder ◽  
Disease Onset ◽  
Fine Tuning ◽  
Current State ◽  
The Central Nervous System ◽  
Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that leads to progressive degeneration of motor neurons (MNs) and severe muscle atrophy without effective treatment. Most research on ALS has been focused on the study of MNs and supporting cells of the central nervous system. Strikingly, the recent observations of pathological changes in muscle occurring before disease onset and independent from MN degeneration have bolstered the interest for the study of muscle tissue as a potential target for delivery of therapies for ALS. Skeletal muscle has just been described as a tissue with an important secretory function that is toxic to MNs in the context of ALS. Moreover, a fine-tuning balance between biosynthetic and atrophic pathways is necessary to induce myogenesis for muscle tissue repair. Compromising this response due to primary metabolic abnormalities in the muscle could trigger defective muscle regeneration and neuromuscular junction restoration, with deleterious consequences for MNs and thereby hastening the development of ALS. However, it remains puzzling how backward signaling from the muscle could impinge on MN death. This review provides a comprehensive analysis on the current state-of-the-art of the role of the skeletal muscle in ALS, highlighting its contribution to the neurodegeneration in ALS through backward-signaling processes as a newly uncovered mechanism for a peripheral etiopathogenesis of the disease.

scholarly journals Anatomy and Neural Pathways Modulating Distinct Locomotor Behaviors in Drosophila Larva

Biology ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 90
Author(s):  
Swetha B. M. Gowda ◽  
Safa Salim ◽  
Farhan Mohammad
Keyword(s):  
Motor Neurons ◽  
Model Systems ◽  
Neural Pathways ◽  
Animal Movements ◽  
Drosophila Larvae ◽  
The Central Nervous System ◽  
Drosophila Larva ◽  
Locomotor Behaviors ◽  
Basic Level

The control of movements is a fundamental feature shared by all animals. At the most basic level, simple movements are generated by coordinated neural activity and muscle contraction patterns that are controlled by the central nervous system. How behavioral responses to various sensory inputs are processed and integrated by the downstream neural network to produce flexible and adaptive behaviors remains an intense area of investigation in many laboratories. Due to recent advances in experimental techniques, many fundamental neural pathways underlying animal movements have now been elucidated. For example, while the role of motor neurons in locomotion has been studied in great detail, the roles of interneurons in animal movements in both basic and noxious environments have only recently been realized. However, the genetic and transmitter identities of many of these interneurons remains unclear. In this review, we provide an overview of the underlying circuitry and neural pathways required by Drosophila larvae to produce successful movements. By improving our understanding of locomotor circuitry in model systems such as Drosophila, we will have a better understanding of how neural circuits in organisms with different bodies and brains lead to distinct locomotion types at the organism level. The understanding of genetic and physiological components of these movements types also provides directions to understand movements in higher organisms.

Prevalence of Musculoskeletal Injuries in New Zealand Army Recruits as Defined by Physical Therapy Service Presentations

2021 ◽  
Author(s):  
Narelle Hall ◽  
Maria Constantinou ◽  
Mark Brown ◽  
Belinda Beck ◽  
Suzanne Kuys
Keyword(s):  
New Zealand ◽  
Physical Therapy ◽  
Injury Prevention ◽  
Lower Limb ◽  
Injury Incidence ◽  
Basic Training ◽  
Lower Limb Injuries ◽  
Limb Injuries ◽  
Army Recruits ◽  
Therapy Service

ABSTRACT Introduction Army recruit injuries occurring during basic training can lead to high personal and organizational burdens potentially threatening deployment capability. Previous military surveillance describing recruit injury as defined by physical therapy presentations is limited to 1-year duration or includes only male infantry recruits or trained personnel. Research describing injury incidence and trends specific to New Zealand Army basic training recruits over a longer period will better inform future injury prevention programs. Aims To identify the incidence and patterns of injuries reported from physical therapy presentations for New Zealand Army recruits undertaking basic training over a 4-year period. Materials and Methods This retrospective observational study identified injuries from physical therapy service presentations in New Zealand Army recruits from 2008 to 2011. All male and female New Zealand Army recruits who presented to physical therapy, following medical triage, were included. Recruit physical therapy presentations for injury and respiratory and other conditions were collated. Injury incidence was grouped by body region (upper limbs, lower limbs, and combined spinal regions) and site (joint or segment), and cumulative and injury incidence rates were calculated. Results One thousand eight hundred and ninety-six (1,697 males and 199 females) New Zealand Army recruits commenced basic training between 2008 and 2011. One thousand six hundred and eighty-three physical therapy presentations occurred for recruit injury during New Zealand Army basic training over 4 years. Lower limb injuries accounted for over 75% (n = 1,285) of the overall demand for physical therapy service during recruit basic training. Injuries sustained at the knee and below accounted for 67% of all reported injury presentations. Conclusion Four years of injury surveillance using physical therapy presentations identified the lower limb, with the knee and below as the most commonly injured regions in New Zealand Army recruits. Injury prevention interventions for New Zealand Army recruits should aim to reduce lower limb injuries. Future research on injury surveillance would benefit from incorporating clear injury and severity definitions, established injury classification systems, and standardized incidence calculations.

scholarly journals Gait Disorders In Patients After Polytrauma

2015 ◽  
Vol 69 (1-2) ◽  
pp. 27-32
Author(s):  
Ruta Jakušonoka ◽  
Zane Pavāre ◽  
Andris Jumtiņš ◽  
Aleksejs Smolovs ◽  
Tatjana Anaņjeva
Keyword(s):  
Ground Reaction Force ◽  
Knee Flexion ◽  
Reaction Force ◽  
Three Dimensional ◽  
Step Length ◽  
Vertical Load ◽  
Lower Limb Injuries ◽  
Limb Injuries ◽  
Stance Time ◽  
Polytrauma Patients

Abstract Evaluation of the gait of patients after polytrauma is important, as it indicates the ability of patients to the previous activities and work. The aim of our study was to evaluate the gait of patients with lower limb injuries in the medium-term after polytrauma. Three-dimensional instrumental gait analysis was performed in 26 polytrauma patients (16 women and 10 men; mean age 38.6 years), 14 to 41 months after the trauma. Spatio-temporal parameters, motions in pelvis and lower extremities joints in sagittal plane and vertical load ground reaction force were analysed. Gait parameters in polytrauma patients were compared with a healthy control group. Polytrauma patients in the injured side had decreased step length, cadence, hip extension, maximum knee flexion, vertical load ground reaction force, and increased stance time and pelvic anterior tilt; in the uninjured side they had decreased step length, cadence, maximum knee flexion, vertical load ground reaction force and increased stance time (p < 0.05). The use of the three-dimensional instrumental gait analysis in the evaluation of polytrauma patients with lower limb injuries consequences makes it possible to identify the gait disorders not only in the injured, but also in the uninjured side.

scholarly journals The short musculoskeletal functional assessment (SMFA) score amongst surgical patients with reconstructive lower limb injuries in war wounded civilians

Injury ◽  
2014 ◽  
Vol 45 (12) ◽  
pp. 1996-2001 ◽  
Author(s):  
Carrie Teicher ◽  
Nancy L. Foote ◽  
Ali M.K. Al Ani ◽  
Majd S. Alras ◽  
Sufyan I. Alqassab ◽  
...  
Keyword(s):  
Functional Assessment ◽  
Lower Limb ◽  
Surgical Patients ◽  
Lower Limb Injuries ◽  
Limb Injuries
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