scholarly journals Genetic association between mannose-binding lectin polymorphisms and viral hepatitis: a meta-analysis

2019 ◽  
Vol 77 (7) ◽  
Author(s):  
Chunhua Qie ◽  
Yamin Liu ◽  
Ping Ma ◽  
Hongzhang Wu
Keyword(s):  
Viral Hepatitis ◽  
Genetic Association ◽  
Association Studies ◽  
Meta Analysis ◽  
Mannose Binding Lectin ◽  
Dominant Model ◽  
Subgroup Analyses ◽  
Mannose Binding ◽  
Exon 1 ◽  
Binding Lectin

ABSTRACT Some previous genetic association studies have tried to investigate potential associations between mannose-binding lectin (MBL) polymorphisms and viral hepatitis. However, the results of those studies were not consistent. Therefore, we performed the current meta-analysis to explore associations between MBL polymorphisms and viral hepatitis in a large pooled population. A systematic literature research of PubMed, Web of Science, Embase and CNKI was performed to identify eligible studies for pooled analyses. We used Review Manager version 5.3.3 to conduct statistical analyses. In total, 27 studies were included for analysis (4840 cases and 5729 controls). The pooled analyses showed that MBL promoter (-211C/G, dominant model: P = 0.0002, I2 = 40%; over-dominant model: P = 0.0001, I2 = 22%) and exon 1 (codon 52, 54 and 57, dominant model: P = 0.04, I2 = 49%; allele model: P = 0.01, I2 = 48%) polymorphisms were both significantly associated with viral hepatitis in the overall population. Further subgroup analyses revealed similarly significant findings for MBL promoter polymorphism in HBV and HCV, but no positive results were detected in subgroup analyses for MBL exon 1 polymorphism. These results suggested that MBL promoter and exon 1 polymorphisms could be used to identify individuals at higher susceptibility to HBV and HCV.

scholarly journals Mannose-binding lectin gene polymorphism and the susceptibility of sepsis: A meta-analysis

2021 ◽  
Author(s):  
Zhihua Hu ◽  
Shaowen Cheng ◽  
Xini Liu ◽  
Lina Xian ◽  
Xinyuan Liang ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Publication Bias ◽  
Meta Analysis ◽  
Relevant Literature ◽  
Recessive Model ◽  
Mannose Binding Lectin ◽  
Dominant Model ◽  
Mannose Binding ◽  
Binding Lectin ◽  
Allele Model

Abstract Objective To assess the association between the Mannose-binding lectin (MBL) gene polymorphism and the susceptibility to sepsis using a meta-analysis.Methods The publications were searched on PubMed, Embase, and Web of Science databases up to December 1, 2019 for relevant literature. Results A total of 32 studies (21 adult and 11 pediatric studies) were selected for analysis. Overall, in the three models of MBL +54 A/B gene polymorphisms, namely the dominant model BB + AB vs. AA (p = 0.03), the recessive model BB vs. AB + AA (p < 0.00001), and the allele model B vs. A (p = 0.04), MBL +54A/B was significantly related to the risk of sepsis. In the adult group, the MBL A/O gene polymorphism was associated with the risk of sepsis in the dominant model AO + OO vs. AA (p = 0.006) as well as in the allele model O vs. A (p = 0.04). The MBL +54A/B gene polymorphism was significantly related to the risk of sepsis in the recessive model and, therefore, may increase the risk of sepsis. In the pediatric group, no polymorphic loci were significantly associated with sepsis in any of the three models. The results of the publication bias test demonstrated no publication bias in an unadjusted estimate of the relationship between MBL A/O and -211Y/X gene polymorphism and sepsis.

scholarly journals A SNaPshot Assay for Determination of the Mannose-Binding Lectin Gene Variants and an Algorithm for Calculation of Haplogenotype Combinations

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 301
Author(s):  
Jana Mrazkova ◽  
Petr Sistek ◽  
Jan Lochman ◽  
Lydie Izakovicova Holla ◽  
Zdenek Danek ◽  
...  
Keyword(s):  
Association Studies ◽  
Genetic Association Studies ◽  
Cost Effective ◽  
European Population ◽  
Mannose Binding Lectin ◽  
Nucleotide Polymorphisms ◽  
Online Application ◽  
Czech Population ◽  
Mannose Binding ◽  
Binding Lectin

Mannose-binding lectin (MBL) deficiency caused by the variability in the MBL2 gene is responsible for the susceptibility to and severity of various infectious and autoimmune diseases. A combination of six single nucleotide polymorphisms (SNPs) has a major impact on MBL levels in circulation. The aim of this study is to design and validate a sensitive and economical method for determining MBL2 haplogenotypes. The SNaPshot assay is designed and optimized to genotype six SNPs (rs1800451, rs1800450, rs5030737, rs7095891, rs7096206, rs11003125) and is validated by comparing results with Sanger sequencing. Additionally, an algorithm for online calculation of haplogenotype combinations from the determined genotypes is developed. Three hundred and twenty-eight DNA samples from healthy individuals from the Czech population are genotyped. Minor allele frequencies (MAFs) in the Czech population are in accordance with those present in the European population. The SNaPshot assay for MBL2 genotyping is a high-throughput, cost-effective technique that can be used in further genetic-association studies or in clinical practice. Moreover, a freely available online application for the calculation of haplogenotypes from SNPs is developed within the scope of this project.

scholarly journals Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment

2021 ◽  
Vol 54 ◽  
Author(s):  
Saulo Gomes de Oliveira ◽  
Ilana Brito Ferraz de Souza ◽  
Taynan da Silva Constantino ◽  
Paula Carolina Valença Silva ◽  
Elker Lene Santos de Lima ◽  
...  
Keyword(s):  
Specific Treatment ◽  
Mannose Binding Lectin ◽  
Lectin Gene ◽  
Periportal Fibrosis ◽  
Mannose Binding ◽  
Exon 1 ◽  
Fibrosis Regression ◽  
Binding Lectin

Lack of association between Mannose Binding Lectin-2 gene polymorphisms and periodontitis: A meta-analysis

Meta Gene ◽  
2020 ◽  
Vol 26 ◽  
pp. 100757
Author(s):  
Felipe Rodolfo Pereira da Silva ◽  
Alessandro Luiz Araújo Bentes Leal ◽  
Luigi Nibali ◽  
Jae Il Shin ◽  
Marcelo Diniz Carvalho ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Association between Mannose-Binding Lectin Gene Polymorphisms and Hepatitis B Virus Infection: A Meta-Analysis

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e75371 ◽  
Author(s):  
Hang-di Xu ◽  
Ming-fei Zhao ◽  
Tian-hong Wan ◽  
Guang-zhong Song ◽  
Ji-liang He ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Mannose Binding Lectin ◽  
Hepatitis B Virus Infection ◽  
B Virus ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Associations between genetic polymorphisms of TLRs and susceptibility to tuberculosis: A meta-analysis

2019 ◽  
Vol 26 (2) ◽  
pp. 75-83 ◽  
Author(s):  
Yong Zhou ◽  
Mengtao Zhang
Keyword(s):  
Genetic Association ◽  
Fixed Effects ◽  
Web Of Science ◽  
Association Studies ◽  
Meta Analysis ◽  
Genetic Association Studies ◽  
Random Effects Models ◽  
Literature Research ◽  
Fixed Effects Models ◽  
Subgroup Analyses

Some genetic association studies have tried to investigate potential associations between TLR polymorphisms and tuberculosis. However, the results of these studies have not been consistent. Thus, we performed the present meta-analysis to explore associations between TLR polymorphisms and tuberculosis in a larger combined population. A systematic literature research of PubMed, Web of Science and Embase was performed to identify eligible studies for combined analyses. I2 statistics were employed to assess between-study heterogeneities. If I2 was >50%, random-effects models were used to combine the data. Otherwise, fixed-effects models were applied for synthetic analyses. A total of 39 genetic association studies were included in the analyses. The combined analyses showed that TLR1 rs4833095, TLR1 rs5743557, TLR1 rs5743596, TLR2 rs3804099, TLR2 rs5743704, TLR2 rs5743708, TLR6 rs5743810 and TLR8 rs3764879 polymorphisms were significantly associated with susceptibility to TB in the overall population. Further subgroup analyses revealed similar significant findings for TLR1 rs4833095, TLR1 rs5743557, TLR1 rs5743596, TLR1 rs5743618, TLR2 rs3804099, TLR2 rs5743704, TLR2 rs5743708, TLR4 rs4986790 and TLR4 rs4986791 polymorphisms in certain ethnicities. In conclusion, our findings support that these TLR polymorphisms may be used to identify individuals at high risk of developing tuberculosis.

scholarly journals Use of Mannose-Binding Lectin Gene Polymorphisms and the Serum MBL Level for the Early Detection of Neonatal Sepsis

2018 ◽  
Vol 07 (04) ◽  
pp. 150-157
Author(s):  
Magda Badawy ◽  
Doaa Saber ◽  
Hanan Madani ◽  
Dalia Mosallam
Keyword(s):  
Neonatal Sepsis ◽  
Gene Polymorphisms ◽  
Statistical Significance ◽  
Mannose Binding Lectin ◽  
Term Infants ◽  
Mbl2 Gene ◽  
Mannose Binding ◽  
Exon 1 ◽  
Binding Lectin ◽  
Septic Group

Background Mannose-binding lectin (MBL) is a component of innate immunity and is particularly important in neonates, in whom adaptive immunity has not yet completely developed. MBL deficiency and MBL2 gene polymorphisms are associated with an opsonization defect and have been associated with neonatal sepsis. Aim The aim of our study was to assess serum MBL levels and genotype MBL2 genes to determine whether they can serve as markers for predicting neonatal sepsis in neonatal intensive care units. Patients and Methods A case-control study was conducted with 114 neonates classified into two groups: the septic group included 64 neonates (41 preterm and 23 full-term infants), and the non-septic control group included 50 neonates (29 preterm and 21 full-term infants). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was used to genotype MBL2 gene exon 1 (rs1800450) and (rs1800451) SNPs. Enzyme-linked immunosorbent assay (ELISA) was used to measure MBL serum concentrations. Results The polymorphic genotypes BB and AC at codons 54 and 57, respectively, showed higher frequencies than the wild-type genotype (AA) (14.1% versus 12.9% and 28.1% versus 19.4% respectively) in both groups, and this difference was greater in the septic group than in the non-septic group; however, the differences did not reach statistical significance. The B and C allele frequencies were also higher in the septic group than in the non-septic group, but the differences did not reach statistical significance (p = 0.282 and 0.394, respectively). The serum levels of MBL were significantly lower in the septic group than in the non-septic group (p = 0.028). Conclusion This study found no association between MBL levels or MBL2 exon 1 genotypes or alleles and neonatal sepsis risk. Further studies with larger sample sizes are needed to determine the role of the MBL2 gene as a risk factor and early predictor of neonatal sepsis.

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