scholarly journals Prescription Patterns of Anti-dementia and Psychotropic Drugs in People Living With Dementia in China

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 649-650
Author(s):  
Zhang Yingyang ◽  
Hao Luo ◽  
Gloria H Y Wong ◽  
Terry Y S Lum ◽  
Celine Chui ◽  
...  
Keyword(s):  
Psychotropic Drugs ◽  
Clinical Symptoms ◽  
Anatomical Therapeutic Chemical ◽  
Drug Prescription ◽  
Prescribing Patterns ◽  
Prescription Patterns ◽  
Factors Associated ◽  
Tertiary Hospitals ◽  
Functioning Level ◽  
Critical Intervention

Abstract Pharmacotherapy of dementia is a critical intervention for managing symptoms of and slowing progression of dementia. However, evidence on prescribing patterns of dementia medications and their associated factors in China is lacking. This study aimed to examine prescribing rates of anti-dementia and psychotropic drugs, and investigate factors associated with prescription of anti-dementia drugs and its co-prescription with psychotropic drugs in China. We used data from the Clinical Pathway for Alzheimer’s Disease in China study, an eight-week multi-center registry study that was conducted in tertiary hospitals between Nov 12, 2012, and Jan 31, 2013. Anti-dementia and psychotropic drugs were coded according to the Anatomical Therapeutic Chemical codes. Logistic regressions were performed to examine factors associated with prescription patterns after controlling for demographic and clinical characteristics of people living with dementia and caregivers’ characteristics. A total of 746 participants were included in this study, of which almost 80% of participants were prescribed anti-dementia drugs, and one-third were prescribed at least one psychotropic drug. The concomitant prescription rate of anti-dementia and psychotropic drugs was 24·3%. Logistic regression results showed that first consultation, dementia subtypes, dementia severity, functioning level, and having symptoms of psychosis and apathy were significantly associated with anti-dementia drug prescription. Frontotemporal dementia, worse functioning level, psychosis, agitation, and depression were significantly associated with co-prescription of anti-dementia and psychotropic agents. Practices of dementia prescriptions generally concurred with clinical guidelines in tertiary hospitals in China, while prescription of anti-dementia and psychotropic medications mainly depended on clinical symptoms of patients with dementia.

scholarly journals Drug Prescription Profiles in Patients with Polypharmacy in Spain: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data

2021 ◽  
Vol 18 (9) ◽  
pp. 4754
Author(s):  
Miguel Ángel Hernández-Rodríguez ◽  
Ermengol Sempere-Verdú ◽  
Caterina Vicens-Caldentey ◽  
Francisca González-Rubio ◽  
Félix Miguel-García ◽  
...  
Keyword(s):  
Psychotropic Drugs ◽  
Large Scale ◽  
Anatomical Therapeutic Chemical ◽  
Drug Prescription ◽  
Age Groups ◽  
System Level ◽  
Real World Data ◽  
Converting Enzyme Inhibitors ◽  
Cross Sectional ◽  
Β Blockers

We aimed to identify and compare medication profiles in populations with polypharmacy between 2005 and 2015. We conducted a cross-sectional study using information from the Computerized Database for Pharmacoepidemiologic Studies in Primary Care (BIFAP, Spain). We estimated the prevalence of therapeutic subgroups in all individuals 15 years of age and older with polypharmacy (≥5 drugs during ≥6 months) using the Anatomical Therapeutic Chemical classification system level 4, by sex and age group, for both calendar years. The most prescribed drugs were proton-pump inhibitors (PPIs), statins, antiplatelet agents, benzodiazepine derivatives, and angiotensin-converting enzyme inhibitors. The greatest increases between 2005 and 2015 were observed in PPIs, statins, other antidepressants, and β-blockers, while the prevalence of antiepileptics was almost tripled. We observed increases in psychotropic drugs in women and cardiovascular medications in men. By patient´s age groups, there were notable increases in antipsychotics, antidepressants, and antiepileptics (15–44 years); antidepressants, PPIs, and selective β-blockers (45–64 years); selective β-blockers, biguanides, PPIs, and statins (65–79 years); and in statins, selective β-blockers, and PPIs (80 years and older). Our results revealed important increases in the use of specific therapeutic subgroups, like PPIs, statins, and psychotropic drugs, highlighting opportunities to design and implement strategies to analyze such prescriptions’ appropriateness.

scholarly journals Drug prescription patterns and factors associated with polypharmacy in >1 million older adults in Tokyo

2020 ◽  
Vol 20 (4) ◽  
pp. 304-311 ◽  
Author(s):  
Tatsuro Ishizaki ◽  
Seigo Mitsutake ◽  
Shota Hamada ◽  
Chie Teramoto ◽  
Sayuri Shimizu ◽  
...  
Keyword(s):  
Older Adults ◽  
Drug Prescription ◽  
Prescription Patterns ◽  
Factors Associated

scholarly journals Risk and Environmental Factors Associated with the Presence of Canine Parvovirus Type 2 in Diarrheic Dogs from Thessaly, Central Greece

Pathogens ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 590
Author(s):  
Maria Kantere ◽  
Labrini V. Athanasiou ◽  
Alexios Giannakopoulos ◽  
Vassilis Skampardonis ◽  
Marina Sofia ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Clinical Symptoms ◽  
Gastrointestinal Disease ◽  
Environmental Parameters ◽  
Canine Parvovirus ◽  
Geographical Information ◽  
Factors Associated ◽  
Working Dogs ◽  
Canine Parvovirus Type 2

Canine parvovirus type 2 (CPV-2) primarily infects dogs, which are the main host reservoir, causing severe gastrointestinal disease associated with immunosuppression. The present study was conducted in Thessaly, Greece and aimed to identify risk and environmental factors associated with CPV-2 infection in diarrheic dogs. Fecal samples were collected from 116 dogs presenting diarrhea and were tested by polymerase chain reaction (PCR) for the presence of CPV-2 DNA. Supplementary data regarding clinical symptoms, individual features, management factors and medical history were also gathered for each animal during clinical evaluation. Sixty-eight diarrheic dogs were found to be positive for the virus DNA in their feces. Statistical analysis revealed that CPV-2 DNA was less likely to be detected in senior dogs, while working dogs, namely hounds and shepherds, had higher odds to be positive for the virus. Livestock density and land uses, specifically the categories of discontinuous urban fabric and of human population density, were identified as significant environmental parameters associated with CPV-2 infection by using Geographical Information System (GIS) together with the Ecological Niche Model (ENM). This is the first description of the environmental variables associated with the presence of CPV-2 DNA in dogs’ feces in Greece.

Anticancer Drug Prescription Patterns in Japan: Future Directions in Cancer Therapy

2018 ◽  
Vol 52 (6) ◽  
pp. 718-723 ◽  
Author(s):  
Shoyo Shibata ◽  
Maiko Matsushita ◽  
Yoshimasa Saito ◽  
Takeshi Suzuki
Keyword(s):  
Cancer Therapy ◽  
Anticancer Drug ◽  
Drug Prescription ◽  
Future Directions ◽  
Prescription Patterns

Drug Prescription Patterns in Schizophrenia Outpatients: Analysis of Data from a German Health Insurance Fund

2009 ◽  
Vol 42 (02) ◽  
pp. 66-71 ◽  
Author(s):  
S. Weinbrenner ◽  
H.-J. Assion ◽  
T. Stargardt ◽  
R. Busse ◽  
G. Juckel ◽  
...  
Keyword(s):  
Health Insurance ◽  
Drug Prescription ◽  
Insurance Fund ◽  
Health Insurance Fund ◽  
Prescription Patterns ◽  
German Health

scholarly journals A Network Approach for the Study of Drug Prescriptions: Analysis of Administrative Records from a Local Health Unit (ASL TO4, Regione Piemonte, Italy)

2021 ◽  
Vol 18 (9) ◽  
pp. 4859
Author(s):  
Gianluca Miglio ◽  
Lara Basso ◽  
Lucrezia G. Armando ◽  
Sara Traina ◽  
Elisa Benetti ◽  
...  
Keyword(s):  
Administrative Data ◽  
Anatomical Therapeutic Chemical ◽  
Drug Prescription ◽  
Local Health ◽  
Prescription Data ◽  
Health Unit ◽  
Local Health Unit ◽  
Administrative Records ◽  
Edge Linking ◽  
Novel Approach

In a Drug Prescription Network (DPN), each drug is represented as a node and two drugs co-prescribed to the same patient are represented as an edge linking the nodes. The use of DPNs is a novel approach that has been proposed as a means to study the complexity of drug prescription. The aim of this study is to demonstrate the analytical power of the DPN-based approach when it is applied to the analysis of administrative data. Drug prescription data that were collected at a local health unit (ASL TO4, Regione Piemonte, Italy), over a 12-month period (July 2018–June 2019), were used to create several DPNs that correspond to the five levels of the Anatomical Therapeutic Chemical classification system. A total of 5,431,335 drugs prescribed to 361,574 patients (age 0–100 years; 54.7% females) were analysed. As indicated by our results, the DPNs were dense networks, with giant components that contain all nodes. The disassortative mixing of node degrees was observed, which implies that non-random connectivity exists in the networks. Network-based methods have proven to be a flexible and efficient approach to the analysis of administrative data on drug prescription.

scholarly journals Effectiveness and safety of infliximab dose escalation in patients with refractory Takayasu arteritis: A real-life experience from a monocentric cohort

2021 ◽  
Author(s):  
Alessandro Tomelleri ◽  
Corrado Campochiaro ◽  
Silvia Sartorelli ◽  
Francesco Baldassi ◽  
Federico Fallanca ◽  
...  
Keyword(s):  
Takayasu Arteritis ◽  
Dose Escalation ◽  
Dose Group ◽  
Life Experience ◽  
Clinical Symptoms ◽  
Standard Dose ◽  
Univariate Analysis ◽  
Real Life ◽  
Factors Associated ◽  
Observational Cohort

ABSTRACT Objectives To evaluate effectiveness and safety of infliximab dose escalation in Takayasu arteritis (TAK) patients. To identify factors associated with refractoriness to standard-dose infliximab. Methods Medical records of infliximab-treated TAK patients from a large single-centre observational cohort were reviewed. Infliximab therapy duration, concomitant therapies, and reasons for dose escalation and therapy suspension were evaluated. Occurrence of adverse events was recorded. A comparison between patients who maintained infliximab standard-dose and those who needed dose-escalation was performed. Factors associated with refractoriness to standard dose were analysed. Results Forty-one patients were included. Starting infliximab dose was 5 mg/kg 6-weekly and 28 patients (68%) needed dose escalation. Persistence/recurrence of clinical symptoms was the most frequent reason for escalation. Median therapy duration was 39 (IQR, 26–61) months in the standard-dose group and 68 (38–87) months in the intensified-dose group. In the intensified-dose-group, infliximab was suspended in eight patients (29%) after a median of 38 (31–71) months, due to loss of response (n = 7) or patient’s request (n = 1). Patients in the intensified-dose group had a higher number of relapses (3.4 vs 0.8 events/patient) and received a higher cumulative steroid dose (1.7 [1.6–2.3] vs 1.3 [1–1.6] g/month of prednisone). Three patients from the intensified-dose group had serious infections; one patient from the standard-dose group developed paradoxical psoriasis. At univariate analysis, age at diagnosis and age at infliximab start were associated with infliximab escalation. Conclusion In TAK, dose escalation is safe and allows to optimise infliximab durability in refractory patients. Younger patients seem to be more refractory to standard dosages.

scholarly journals Trend and Factors Associated with Repeat Computed Tomography Examinations in Tertiary Hospitals: Linked Health Administrative Data in Western Australia

2020 ◽  
Vol 5 (5) ◽  
Author(s):  
Ninh Ha
Keyword(s):  
Ct Scan ◽  
Western Australia ◽  
Age Groups ◽  
Ct Scanning ◽  
Major Surgery ◽  
Factors Associated ◽  
Inappropriate Use ◽  
Tertiary Hospitals ◽  
Picture Archiving And Communication ◽  
Hospital Morbidity

IntroductionComputed tomography (CT) has become an essential part of clinical practice. However, repeat CT scans has raised a concern about unnecessary exposure to ionising radiation and waste of health care resource. While substantial effort is underway to reduce inappropriate use of diagnostic imaging tests including CT, little evidence of any change in repeat CT use and its associated factors. Objectives and ApproachThis study aimed to measure trend in repeat CT use and identify factors associated with repeat CT use in tertiary hospitals in Western Australia (WA). This study used WA linked administrative records from hospital morbidity, emergency department presentations, and picture archiving and communication system datasets to capture all tertiary hospitalisations and number of CT use during the admission from 2003 to 2015. Multivariate logistic regression was used to examine trend and determine characteristics associated with repeat CT, for admissions with and without major surgery during hospitalisation. ResultsAmong 303,439 admissions with CT scan 11.9% had repeat CT scan in the same anatomic areas. While the probability of repeat CT among admission with surgery remained unchanged over the study period, its counterpart significantly reduced about 4% per year. Regardless of surgical status, repeat CT scanning was significantly lower among females, Indigenous and older age groups but higher among people living in rural and remote areas. We found that admissions for circulatory conditions, injuries, cancer or multimorbidity had significantly higher probability of having repeat CT. Conclusion / ImplicationsThis study indicates that clinical factors such as cancer, injury and multimorbidity are factors contributing to repeat CT. A reduction of repeat CT over the study period among admissions without surgical procedure suggests a potential reduction of unnecessary CT scan, although further study is needed to fully capture whether this is an actual change in practice.

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