scholarly journals VITAMIN D INSUFFICIENCY AND COGNITIVE TRAJECTORIES IN OLDER ADULTS: THE RANCHO BERNARDO STUDY

2017 ◽  
Vol 1 (suppl_1) ◽  
pp. 469-469
Author(s):  
G.A. Laughlin ◽  
D. Kritz-Silverstein ◽  
J. Bergstrom ◽  
E. Reas ◽  
S. Jassal ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Vitamin D Insufficiency

Bone geometry is correlated with arterial stiffness in overweight older adults with vitamin D insufficiency

2018 ◽  
Author(s):  
Alexander Rodriguez ◽  
Cecilia Xu ◽  
Lachlan McMillan ◽  
Velandai Srikanth ◽  
David Scott ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Arterial Stiffness ◽  
Bone Geometry ◽  
Vitamin D Insufficiency

Serum Vitamin D and Cingulate Cortex Thickness in Older Adults: Quantitative MRI of the Brain

2019 ◽  
Vol 16 (11) ◽  
pp. 1063-1071 ◽  
Author(s):  
Gonzague Foucault ◽  
Guillaume T Duval ◽  
Romain Simon ◽  
Olivier Beauchet ◽  
Mickael Dinomais ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Brain Mri ◽  
Serum Vitamin ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Vitamin D Insufficiency ◽  
Anterior Cingulate ◽  
Posterior Cingulate ◽  
Significant Difference

Background: Vitamin D insufficiency is associated with brain changes, and cognitive and mobility declines in older adults. Method: Two hundred and fifteen Caucasian older community-dwellers (mean±SD, 72.1±5.5years; 40% female) received a blood test and brain MRI. The thickness of perigenual anterior cingulate cortex, midcingulate cortex and posterior cingulate cortex was measured using FreeSurfer from T1-weighted MR images. Age, gender, education, BMI, mean arterial pressure, comorbidities, use of vitamin D supplements or anti-vascular drugs, MMSE, GDS, IADL, serum calcium and vitamin B9 concentrations, creatinine clearance were used as covariables. Results: Participants with vitamin D insufficiency (n=80) had thinner total cingulate thickness than the others (24.6±1.9mm versus 25.3±1.4mm, P=0.001); a significant difference found for all 3 regions. Vitamin D insufficiency was cross-sectionally associated with a decreased total cingulate thickness (β=- 0.49, P=0.028). Serum 25OHD concentration correlated positively with the thickness of perigenual anterior (P=0.011), midcingulate (P=0.013) and posterior cingulate cortex (P=0.021). Conclusion: Vitamin D insufficiency was associated with thinner cingulate cortex in the studied sample of older adults. These findings provide insight into the pathophysiology of cognitive and mobility declines in older adults with vitamin D insufficiency.

scholarly journals Vitamin D Insufficiency and Cognitive Function Trajectories in Older Adults: The Rancho Bernardo Study

2017 ◽  
Vol 58 (3) ◽  
pp. 871-883 ◽  
Author(s):  
Gail A. Laughlin ◽  
Donna Kritz-Silverstein ◽  
Jaclyn Bergstrom ◽  
Emilie T. Reas ◽  
Simerjot K. Jassal ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Cognitive Function ◽  
Vitamin D Insufficiency

Ethnic Differences in Vitamin D Insufficiency in South Florida Community-Dwelling Older Adults

2012 ◽  
Vol 60 (10) ◽  
pp. 1990-1991
Author(s):  
David E. Smolar ◽  
Gabriella A. Engstrom ◽  
Sanya Diaz ◽  
Ruth Tappen ◽  
Joseph G. Ouslander
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Ethnic Differences ◽  
Vitamin D Insufficiency ◽  
South Florida ◽  
Community Dwelling ◽  
Community Dwelling Older Adults

scholarly journals Interaction Between Vitamin D and Interleukin 6 on Slow Gait Speed: 6-Year Follow-up Data of Older Adults From InCHIANTI

2019 ◽  
Vol 75 (6) ◽  
pp. 1161-1166
Author(s):  
Jatupol Kositsawat ◽  
Chia-Ling Kuo ◽  
Lisa C Barry ◽  
David Melzer ◽  
Stefania Bandinelli ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Interleukin 6 ◽  
Gait Speed ◽  
Estimating Equation ◽  
Population Based ◽  
Vitamin D Insufficiency ◽  
Reactive Protein ◽  
25 Hydroxy Vitamin D ◽  
Independent Effects

Abstract Background Whereas the independent effects of biomarkers, including 25-hydroxy vitamin D (25(OH)D), insulin-like growth factor 1, C-reactive protein, and interleukin 6 (IL-6), on gait speed in older adults have been evaluated, their joint effects on gait speed are not well understood. Methods Study subjects aged at least 65 at baseline (N = 970) were enrolled in the population-based Invecchiare in Chianti (InCHIANTI) study from 1998 to 2000 and were followed up at 3 and 6 years. All above biomarkers and gait speed data were measured at each of the three time points. Using a generalized estimating equation approach, we determined if slow gait speed (<0.8 m/s) was associated with the biomarkers. Further investigation was conducted for interactions between high IL-6 (≥.87 pg/mL) and other biomarkers focusing on low 25(OH)D (<20 ng/mL). Results After controlling for other biomarkers and potential confounders, IL-6 emerged as the only biomarker independently associated with gait speed. The association between high IL-6 and slow gait speed was enhanced by low 25(OH)D, with significant interaction between high IL-6 and low 25(OH)D (p = .038). The odds ratio of slow gait speed for low 25(OH)D and high IL-6 was 1.63 (95% confidence interval [CI]: 1.15, 2.32) compared with the reference groups with both biomarker levels at the other ends. Conclusion The association of low vitamin D with slow gait speed statistically interacts with high IL-6. Coexisting vitamin D insufficiency and inflammation may provide a better biomarker for identifying those at risk of developing impairments in gait speed than either factor alone.

scholarly journals Vitamin D status and obesity markers in older adults: results from West China Health and Aging Trends study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yunli Zhao ◽  
Wanyu Zhao ◽  
Qiukui Hao ◽  
Meiling Ge ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Laboratory Data ◽  
Bioelectrical Impedance ◽  
Vitamin D Insufficiency ◽  
Vitamin D Status ◽  
Clinical Trial Registry ◽  
Visceral Fat Area ◽  
West China

Abstract Backgrounds Vitamin D deficiency and insufficiency in older adults seems to be common, but the prevalence estimates are lacking in West China. Previous studies suggested that low vitamin D status was associated with obesity. However, most of them evaluated obesity based on body mass index (BMI) and there are no studies at present exploring the association between vitamin D status and different obesity markers. The present study aims to investigate the prevalence of low vitamin D status and evaluate the association between the vitamin D status and different obesity markers among older adults in West China. Methods Data was based on the baseline of West China Health and Aging Trends study (WCHAT). All of the participants were older than 60 years old in the present study. Vitamin D status was based on laboratory data, and obesity markers were assessed by bioelectrical impedance analysis (BIA) using the InBody 770 analyzer. Multiple linear regression was performed to find the association between the vitamin D status and various obesity markers. Results The study included 2661 individuals (mean age: 67.7 ± 6.0 years; males: 41 %). The mean vitamin D level was 18.8 ± 6.3 ng/ml (range: 5 to 59 ng/ml); 5.2 % of participants had a sufficient level of vitamin D, 31.8 % had vitamin D insufficiency, and 63.0 % had vitamin D deficiency. Our results showed that vitamin D status was negatively associated with fat mass index (FMI), visceral fat area (VFA), and waist-hip ratio (WHR) in both sexes. Comparing to other obesity markers, WHR had the strongest correlation with vitamin D status in both sexes (β = -6.090, P = 0.046 in males; β = -11.253, P < 0.001 in females). No significant association was found between vitamin D status and BMI in males. Conclusion The prevalence of vitamin D insufficiency and deficiency among older adults in West China was high. Among the older adults in west China, WHR showed stronger association with vitamin D status and was better for the prediction of vitamin D insufficiency or deficiency in both sexes, compared to BMI. Trial registration Chinese Clinical Trial Registry: ChiCTR1800018895.

scholarly journals Vitamin D insufficiency and deficiency and mortality from respiratory diseases in a cohort of older adults: potential for limiting the death toll during and beyond the COVID-19 pandemic

2020 ◽  
Author(s):  
Hermann Brenner ◽  
Bernd Holleczek ◽  
Ben Schöttker
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Respiratory Disease ◽  
Respiratory Diseases ◽  
Vitamin D Insufficiency ◽  
Blood Levels ◽  
P Value ◽  
Disease Mortality ◽  
Increased Risk

AbstractBackgroundThe COVID-19 pandemic goes along with increased mortality from acute respiratory disease, and measures to limit the spread of the infection go along with increased risk of vitamin D deficiency, especially among high risk groups. It has been suggested that vitamin D3 supplementation might help to reduce respiratory disease mortality.MethodsWe assessed the prevalence of vitamin D insufficiency and deficiency, defined by 25(OH)D blood levels of 30-50 and <30 nmol/L, respectively, and their association with mortality from respiratory diseases during 15 years of follow-up in a cohort of 9,548 adults aged 50-75 years from Saarland, Germany.ResultsVitamin D insufficiency and deficiency were common (44% and 15%, respectively). Compared to sufficient vitamin D status, respiratory disease mortality was 2.1 (95%-CI 1.3-3.2)- and 3.0 (95%-CI 1.8-5.2)-fold increased, respectively. Although significant increases were seen in both women and men, they were much stronger among women, with 8.5 (95% CI 2.4-30.1) and 2.3 (95% CI 1.1-4.4)-fold increase of respiratory disease mortality in case of vitamin D deficiency among women and men, respectively (p-value for interaction =0.041). Overall, 41% (95% CI 20%-58%) of respiratory disease mortality was statistically attributable to vitamin D insufficiency or deficiency.ConclusionVitamin D insufficiency and deficiency are common and account for a large proportion of respiratory disease mortality in older adults, supporting suggestions that vitamin D3 supplementation might make a major contribution to limit the burden of the COVID-19 pandemic, particularly among women.

THE EFFECT OF HIGH DOSE VITAMIN D3 ON PHYSICAL PERFORMANCE IN FRAIL OLDER ADULTS. A FEASIBILITY STUDY

2018 ◽  
pp. 1-7
Author(s):  
N.W. BRAY ◽  
T.J. DOHERTY ◽  
M. MONTERO-ODASSO
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Physical Performance ◽  
Feasibility Study ◽  
Vitamin D3 ◽  
Gait Speed ◽  
Vitamin D Insufficiency ◽  
Vitamin D Supplementation ◽  
Short Physical Performance Battery ◽  
Vitamin D Levels

Background: Vitamin D deficiency is ubiquitous in frailty but the effectiveness of vitamin D supplementation to improve outcomes in frail individuals is unclear. It has been postulated that higher than the current recommended doses (800 IU/day) may be needed to achieve a neuromuscular effect in frail individuals. Objectives: 1) determine if 4000 IU per day of vitamin D3 is safe for frail older adults; and 2) establish the efficacy of this dose to improve physical performance outcomes in this population. Design: Open-label, feasibility study. Setting: Community retirement centre. Participants: 40 older adults with frail or pre-frail characteristics. Intervention: 4000 IU of vitamin D3 and 1200 mcg of calcium carbonate daily for four months. Measurements: Physical performance (grip strength, gait speed and short physical performance battery score), cognitive health and vitamin D and iPTH serum levels before and after the intervention. Results: Frail individuals improved short physical performance battery score (1.19, p = 0.005), fast gait speed (4.65, p = 0.066) and vitamin D levels (7.81, p = 0.011). Only frail females made a significant improvement in grip strength (1.92, p = 0.003). Stratifying the sample by baseline vitamin D levels revealed that participants with vitamin D insufficiency (≤ 75 nmol/L) significantly improved short physical performance battery score (1.06, p = 0.04), fast gait speed (6.28, p = 0.004) and vitamin D levels (25.73, p = <0.0001). Pre-frail individuals, as well as those with sufficient vitamin D levels (> 75 nmol/L) made no significant improvement in any outcome. Conclusions: Vitamin D supplementation using 4000 IU/daily is safe and has a modest beneficial effect on physical performance for frail individuals and those with insufficient vitamin D levels. Participants with vitamin D insufficiency (≤ 75 nmol/L) showed greater benefits. Our feasibility study provides results to help calculate effect size for a future RCT.

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