scholarly journals Vitamin D status and obesity markers in older adults: results from West China Health and Aging Trends study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yunli Zhao ◽  
Wanyu Zhao ◽  
Qiukui Hao ◽  
Meiling Ge ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Laboratory Data ◽  
Bioelectrical Impedance ◽  
Vitamin D Insufficiency ◽  
Vitamin D Status ◽  
Clinical Trial Registry ◽  
Visceral Fat Area ◽  
West China

Abstract Backgrounds Vitamin D deficiency and insufficiency in older adults seems to be common, but the prevalence estimates are lacking in West China. Previous studies suggested that low vitamin D status was associated with obesity. However, most of them evaluated obesity based on body mass index (BMI) and there are no studies at present exploring the association between vitamin D status and different obesity markers. The present study aims to investigate the prevalence of low vitamin D status and evaluate the association between the vitamin D status and different obesity markers among older adults in West China. Methods Data was based on the baseline of West China Health and Aging Trends study (WCHAT). All of the participants were older than 60 years old in the present study. Vitamin D status was based on laboratory data, and obesity markers were assessed by bioelectrical impedance analysis (BIA) using the InBody 770 analyzer. Multiple linear regression was performed to find the association between the vitamin D status and various obesity markers. Results The study included 2661 individuals (mean age: 67.7 ± 6.0 years; males: 41 %). The mean vitamin D level was 18.8 ± 6.3 ng/ml (range: 5 to 59 ng/ml); 5.2 % of participants had a sufficient level of vitamin D, 31.8 % had vitamin D insufficiency, and 63.0 % had vitamin D deficiency. Our results showed that vitamin D status was negatively associated with fat mass index (FMI), visceral fat area (VFA), and waist-hip ratio (WHR) in both sexes. Comparing to other obesity markers, WHR had the strongest correlation with vitamin D status in both sexes (β = -6.090, P = 0.046 in males; β = -11.253, P < 0.001 in females). No significant association was found between vitamin D status and BMI in males. Conclusion The prevalence of vitamin D insufficiency and deficiency among older adults in West China was high. Among the older adults in west China, WHR showed stronger association with vitamin D status and was better for the prediction of vitamin D insufficiency or deficiency in both sexes, compared to BMI. Trial registration Chinese Clinical Trial Registry: ChiCTR1800018895.

scholarly journals Nutrihealth Study: Seasonal Variation in Vitamin D Status Among the Slovenian Adult and Elderly Population

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1838 ◽  
Author(s):  
Maša Hribar ◽  
Hristo Hristov ◽  
Matej Gregorič ◽  
Urška Blaznik ◽  
Katja Zaletel ◽  
...  
Keyword(s):  
Vitamin D ◽  
Seasonal Variation ◽  
Vitamin D Deficiency ◽  
Elderly Population ◽  
Sun Exposure ◽  
Epidemiological Data ◽  
The Elderly ◽  
Vitamin D Insufficiency ◽  
Ultraviolet B ◽  
Vitamin D Status

Several studies conducted around the world showed substantial vitamin D insufficiency and deficiency among different population groups. Sources of vitamin D in the human body include ultraviolet B (UVB)-light-induced biosynthesis and dietary intake, but people’s diets are often poor in vitamin D. Furthermore, in many regions, sun exposure and the intensity of UVB irradiation during wintertime are not sufficient for vitamin D biosynthesis. In Slovenia, epidemiological data about vitamin D status in the population were investigated through a national Nutrihealth study—an extension to the national dietary survey SI.Menu (2017/18). The study was conducted on a representative sample of 125 adult (18–64 years) and 155 elderly (65–74 years old) subjects, enrolled in the study in different seasons. Their vitamin D status was determined by measuring the serum 25-hydroxy-vitamin D (25(OH)D) concentration. Thresholds for vitamin D deficiency and insufficiency were 25(OH)D levels below 30 and 50 nmol/L, respectively. Altogether, 24.9% of the adults and 23.5% of the elderly were found to be vitamin D deficient, while an insufficient status was found in 58.2% and 62.9%, respectively. A particularly concerning situation was observed during extended wintertime (November–April); vitamin D deficiency was found in 40.8% and 34.6%, and insufficient serum 25(OH)D levels were observed in 81.6% and 78.8%, respectively. The results of the study showed high seasonal variation in serum 25(OH)D levels in both the adult and elderly population, with deficiency being especially pronounced during wintertime. The prevalence of this deficiency in Slovenia is among the highest in Europe and poses a possible public health risk that needs to be addressed with appropriate recommendations and/or policy interventions.

Vitamin D deficiency in patients with pancreatic cancer.

2012 ◽  
Vol 30 (4_suppl) ◽  
pp. 353-353
Author(s):  
Andrea Wang-Gillam ◽  
Kevin Ding ◽  
May Cho ◽  
Albert C. Lockhart ◽  
Ling Chen ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Cancer Patients ◽  
Metastatic Disease ◽  
Vitamin D Insufficiency ◽  
Clinical Staging ◽  
Vitamin D Status ◽  
Local Disease ◽  
Caucasian Patients

353 Background: Vitamin D deficiency is common in many cancer patients but little is known about the vitamin D status in patients with pancreatic cancer. Frequently, patients with pancreatic cancer have malabsorption syndrome, and since vitamin D is fat soluble, it is likely to be deficient in this population. Methods: We conducted a retrospective review on patients with pancreatic cancer who were treated at Siteman Cancer Center (SCC). Patients’ demographic information, clinical staging at the time of vitamin D assessment, vitamin D status and survival data were collected. Vitamin D deficiency was defined as serum 25-hydroxyvitamin D [(25(OH)D] <20 ng/mL; vitamin D insufficiency was defined as 25(OH)D <30 but >20. Results: Between Dec 2007 and June 2011, 184 out of 625 pancreatic cancer patients had their vitamin D level checked at least once. Median age was 64 (range 34-86); 87 patients were female and 97 were male. The majority (159) were Caucasian. Sixty-four (34.8%) patients were post resection, while 34 (18.5%) and 86 (46.7%) had local disease and metastatic disease, respectively. Out of 184, 43 (23.3%) patients had normal vitamin D levels, while 53 (28.8%) and 88 (47.85%) were found to be vitamin D insufficient and deficient, respectively. All 28 non-Caucasian patients had either vitamin D deficiency or insufficiency, and their median 25(OH)D level was 11 ng/mL, compared to 21 ng/mL for Caucasian patients. The median 25(OH)D level was 17.5 ng/mL in patients with resected cancer, 22 ng/mL in patients with local disease, and 23 ng/mL in patients with metastatic disease. After adjusting age and stage, 25(OH)D <20 ng/mL was found to be an independent prognostic factor (p= 0.071). Conclusions: Vitamin D insufficiency and deficiency is prevalent amongst our patients with all stages of pancreatic cancer. Vitamin D appears to be prognostic and should routinely be assessed in patients with pancreatic cancer.

scholarly journals A Clinical Analysis of Vitamin D Status in Patients Before Spinal Surgery

2016 ◽  
Vol 101 (7-8) ◽  
pp. 367-374
Author(s):  
Qingqing Li ◽  
Jianwei Zhang ◽  
Jian Chen ◽  
Jin Fan ◽  
Tao Jiang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Spinal Surgery ◽  
Smoking Habit ◽  
High Body Mass Index ◽  
Clinical Analysis ◽  
Vitamin D Insufficiency ◽  
Vitamin D Status ◽  
Factors Associated

The goal of this paper was to study preoperative concentrations of vitamin D in patients undergoing spinal surgery and analyze relevant risk factors associated with vitamin D deficiency. Vitamin D plays an important role in maintaining normal functions of skeletal muscles, and vitamin D insufficiency or deficiency may affect outcomes of spinal surgery patients. A retrospective analysis was conducted on 503 patients undergoing spinal surgery in the First Affiliated Hospital with Nanjing Medical University from September 2012 to October 2013. Preoperative concentrations of serum 25-hydroxyvitamin D [25(OH)D] were measured. Normal vitamin D was defined as a serum 25(OH)D level ≥ 32 ng/mL, vitamin D insufficiency as ≥20 and &lt;32 ng/mL, and vitamin D deficiency as &lt;20 ng/mL. Relevant risk factors associated with vitamin D insufficiency and deficiency were analyzed. In 503 spinal surgery patients, rate of vitamin D deficiency and insufficiency was 71.4% and 23.9%. Rate of vitamin D deficiency in female patients was significantly higher than that in male (P &lt; 0.001). Rate of vitamin D deficiency in patients with high body mass index (P = 0.009) or patients with smoking habit (P &lt; 0.001) was much higher than other patients. Multivariate analysis demonstrated that female (P &lt; 0.001), smoking (P = 0.005), and winter (P = 0.001) were potential risk factors for vitamin D deficiency. Screening preoperative vitamin D status and relevant treatment should be reinforced in spine surgery patients.

scholarly journals Vitamin D Deficiency Among Patients with COVID-19 : Case Series and Recent Literature Review 

2020 ◽  
Author(s):  
Rizaldy Taslim Pinzon ◽  
Angela Angela ◽  
Andryawan Wahyu Pradana
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Case Series ◽  
Hypovitaminosis D ◽  
Vitamin D Insufficiency ◽  
Laboratory Method ◽  
Vitamin D Status ◽  
Vitamin D Supplements

Abstract Background The world is now challenging the pandemic of COVID-19 infection. Previous studies showed the plausibility of Vitamin D prophylaxis and therapy for COVID-19, particularly in settings where hypovitaminosis D is frequent. Recent study from Indonesian showed that prevalence of vitamin D deficiency were 23.0%. The examination of Vitamin D status is not a routine in Indonesian clinical setting. Methods This study is a Case Series from confirmed cases of COVID-19 in Bethesda hospital Yogyakarta Indonesia. The data of clinical symptoms, clinical signs, and laboratory examination were obtained from electronic medical record. The vitamin D status was measured by standardized laboratory method. We searched PubMed and Google Scholar for studies that included terms for Vitamin D and COVID-19. Results The data was obtained from 10 participants consist of 50% male and 50% female. The mean of age was 49.6 years. The prevalence of vitamin D deficiency in this case was 90% and 10% of insufficiency. Patients in this case had various symptom and also had various chronic disease as comorbidity. Conclusions The prevalence of vitamin D deficiency in this case series in Bethesda hospital Yogyakarta, Indonesia is 90% and 10% vitamin D insufficiency. We found no clinical evidence that vitamin D supplements are beneficial in preventing or treating COVID-19. Randomized controlled trials need to determine and evaluated this recommendation.

scholarly journals Vitamin D status and outcomes for hospitalised older patients with COVID-19

2020 ◽  
pp. postgradmedj-2020-138712
Author(s):  
Vadir Baktash ◽  
Tom Hosack ◽  
Nishil Patel ◽  
Shital Shah ◽  
Pirabakaran Kandiah ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Older Patients ◽  
P Value ◽  
Vitamin D Status ◽  
Clinical Markers ◽  
Thoracic Imaging ◽  
Hydroxyvitamin D ◽  
High Dependency

PurposeOlder adults are more likely to be vitamin D deficient. The aim of the study was to determine whether these patients have worse outcomes with COVID-19.MethodsWe conducted a prospective cohort study between 1 March and 30 April 2020 to assess the importance of vitamin D deficiency in older patients with COVID-19. The cohort consisted of patients aged ≥65 years presenting with symptoms consistent with COVID-19 (n=105). All patients were tested for serum 25-hydroxyvitamin D (25(OH)D) levels during acute illness. Diagnosis of COVID-19 was confirmed via viral reverse transcriptase PCR swab or supporting radiological evidence. COVID-19-positive arm (n=70) was sub-divided into vitamin D-deficient (≤30 nmol/L) (n=39) and -replete groups (n=35). Subgroups were assessed for disease severity using biochemical, radiological and clinical markers. Primary outcome was in-hospital mortality. Secondary outcomes were laboratory features of cytokine storm, thoracic imaging changes and requirement of non-invasive ventilation (NIV).ResultsCOVID-19-positive arm demonstrated lower median serum 25(OH)D level of 27 nmol/L (IQR=20–47 nmol/L) compared with COVID-19-negative arm, with median level of 52 nmol/L (IQR=31.5–71.5 nmol/L) (p value=0.0008). Among patients with vitamin D deficiency, there was higher peak D-dimer level (1914.00 μgFEU/L vs 1268.00 μgFEU/L) (p=0.034) and higher incidence of NIV support and high dependency unit admission (30.77% vs 9.68%) (p=0.042). No increased mortality was observed between groups.ConclusionOlder adults with vitamin D deficiency and COVID-19 may demonstrate worse morbidity outcomes. Vitamin D status may be a useful prognosticator.

scholarly journals Vitamin D deficiency among patients with COVID-19: case series and recent literature review

2020 ◽  
Vol 48 (1) ◽  
Author(s):  
Rizaldy Taslim Pinzon ◽  
Angela ◽  
Andryawan Wahyu Pradana
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Clinical Symptoms ◽  
Case Series ◽  
Hypovitaminosis D ◽  
Vitamin D Insufficiency ◽  
Vitamin D Status ◽  
Vitamin D Levels ◽  
Laboratory Examinations ◽  
The Mean

Abstract Background The world is now challenging the pandemic of COVID-19 infection. This is the third and most extensive pandemic. Previous studies showed the plausibility of vitamin D prophylaxis and therapy for COVID-19, particularly in settings where hypovitaminosis D is frequent. Recent study from Indonesian showed that the prevalence of vitamin D deficiency was 23.0%. The examination of vitamin D status is not a routine in the Indonesian clinical setting. Methods This study is a case series from confirmed cases of COVID-19 in Bethesda Hospital Yogyakarta Indonesia. The data of clinical symptoms, signs and laboratory examinations were obtained from the electronic medical records. The vitamin D status was measured by Enzyme-Linked Fluorescent Assay (ELFA) method. We searched PubMed and Google Scholar for studies that included terms for Vitamin D and COVID-19. Results The data were obtained from 10 participants consisting of 50% male and 50% female. The mean age was 49.6 years. The prevalence of vitamin D deficiency in this study was 90% (vitamin D levels < 20 ng/mL) and 10% of insufficiency (vitamin D levels < 30 ng/mL). Patients in this study had various symptoms such as fatigue (60%), fever (50%), dry cough (40%), non-specific headache (10%), and diarrhea (10%); have no symptoms (20%); and also had the various chronic diseases as comorbidity such as hypertension (40%), diabetes (10%), COPD (10%), and post stroke (10%). Conclusions All of the COVID-19 patients in this study had hypovitaminosis D. The prevalence of vitamin D deficiency in this case series is 90% and only 1 patient (10%) had vitamin D insufficiency. There are many health benefits of vitamin D and very few adverse effects. Randomized controlled trials need to determine and evaluate this recommendation in preventing or treating COVID-19. Clinicians should continue to treat people with vitamin D deficiency especially in managing COVID-19 patients.

Vitamin D deficiency in pregnancy at term: risk factors and pregnancy outcomes

2017 ◽  
Vol 31 (3) ◽  
Author(s):  
Chui Ling Lee ◽  
Beng Kwang Ng ◽  
Loo Ling Wu ◽  
Fook Choe Cheah ◽  
Hanita Othman ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Pregnancy Outcomes ◽  
Neonatal Intensive Care ◽  
Final Analysis ◽  
Vitamin D Insufficiency ◽  
Neonatal Outcomes ◽  
Significant Finding ◽  
Vitamin D Status ◽  
Tertiary Teaching

AbstractBackgroundVitamin D deficiency during pregnancy is a worldwide epidemic. The aim of this study was to determine the prevalence of vitamin D deficiency, its predictive factors and the association with pregnancy outcomes.Materials and methodsThis was a prospective observational study in a tertiary teaching hospital over 2-years’ duration from August 2013 to August 2015. A total of 680 women who completed 37 weeks of pregnancy were recruited.ResultsFive hundred and seventy-five patients were enrolled in the final analysis for pregnancy outcomes (response rate of 84.6%). There were 71.7% patients who exhibited vitamin D deficiency, 21.0% vitamin D insufficiency and only 7.3% who had adequate levels of 25-hydroxyvitamin D (25-OH-vit D) of more than 30 ng/mL. There was no statistically significant association between vitamin D status with maternal (parity, gestational diabetes mellitus, hypertension, preeclampsia, intrauterine growth restriction, preterm labor, antenatal infection, bacterial vaginosis and anemia) and neonatal outcomes (low birth weight baby and neonatal intensive care unit admission) among the three groups.ConclusionA high prevalence of low vitamin D level among pregnant women at term was seen in this study, however, there was no significant finding observed between vitamin D status and both maternal and neonatal outcomes.

scholarly journals Prevalence of 25-hydroxyvitamin D deficiency in Korean adolescents: association with age, season and parental vitamin D status

2012 ◽  
Vol 17 (1) ◽  
pp. 122-130 ◽  
Author(s):  
Shin Hye Kim ◽  
Min Kyung Oh ◽  
Ran Namgung ◽  
Mi Jung Park
Keyword(s):  
Vitamin D ◽  
High School Students ◽  
Vitamin D Deficiency ◽  
Vitamin D Insufficiency ◽  
Vitamin D Status ◽  
School Students ◽  
Cross Sectional ◽  
Korean Adolescents ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

AbstractObjectiveWe aimed to assess the prevalence and associated factors of vitamin D deficiency in healthy adolescents and to determine parent–adolescent association in vitamin D status.DesignA cross-sectional study.SettingData from the Korean National Health and Nutrition Examination Survey (KNHANES) 2008–2009. Serum 25-hydroxyvitamin D (25(OH)D) levels were measured using 125I-labelled RIA kits. Vitamin D deficiency in adolescents was defined as 25(OH)D level <27·5 nmol/l, and 25(OH)D levels between 27·5 and <50 nmol/l were considered insufficient. For the parents, vitamin D deficiency was defined as 25(OH)D level <50 nmol/l.SubjectsThe study population consisted of 2062 adolescents (1095 boys, 967 girls; aged 10–18 years) and their parents (1005 fathers, 1341 mothers).ResultsOverall, 13·4 % of adolescents (boys 11·7 %, girls 15·4 %) were 25(OH)D deficient, 54·7 % were 25(OH)D insufficient. Prevalence of vitamin D deficiency increased with age (P < 0·0001). Parental vitamin D deficiency was more prevalent in vitamin D-deficient adolescents than in non-deficient adolescents (all P < 0·0001). In multivariate logistic regression analyses, predictors for vitamin D deficiency were senior high school students (OR = 3·45–4·33), winter/spring season (OR = 3·18–5·11/5·35–7·36) and parental vitamin D deficiency (OR = 1·78–4·88; all P < 0·05).ConclusionsVitamin D insufficiency is prevalent among healthy Korean adolescents and the parent–offspring association warrants vitamin D screening for family members of deficient individuals.

scholarly journals Sun exposure, dressing habits, and vitamin D status in Morocco

2021 ◽  
Vol 319 ◽  
pp. 01097
Author(s):  
Sakhr Dadda ◽  
Karima Azekour ◽  
Fouzia Sebbari ◽  
Brahim El Houate ◽  
Bachir El Bouhali
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Sun Exposure ◽  
Vitamin D Insufficiency ◽  
Activity Level ◽  
Vitamin D Status ◽  
Vitamin D Levels ◽  
High Prevalence ◽  
Daily Sunshine ◽  
Local Healthcare

Sunlight is the main source of vitamin D. Almost 80% of vitamin D3 is produced in the skin. The region of Draa Tafilalet benefits from long daily sunshine time. As such, vitamin D deficiency should be low in this region. However, dressing habits can highly influence vitamin D status. This study aimed to evaluate sun exposure and its relation to vitamin D status among the general population in the region of Draa-Tafilalet, Morocco. Clinical, biological, and sociodemographic data were obtained from 331 adults visiting local healthcare units during the summers of 2019 and 2020. Plasma 25(OH)D2/D3 was measured by immunofluorescence. The prevalence of vitamin D deficiency was 37.5%, while Vitamin D insufficiency represented 56.5%. Most of the studied population (76.4%) had restricting dressing habits and exposed only their faces. statistic tests showed a correlation of vitamin D levels with daily sun exposure (r= 0.308, p<0.001), dressing habits (p<0.001), age (r= -0.141, p=0.01), sex (p<0.001), physical activity level (p=0.003), and BMI (r= -0.298, p<0.001). The study showed a high prevalence of vitamin D deficiency in this region. Similarly, it exposed the effects of restricting clothes and low daily sun exposure on vitamin D status.

scholarly journals Vitamin D status in children aged 0 to 3 years living in Moscow. Treatment and prevention of vitamin D deficiency

2019 ◽  
pp. 42-49
Author(s):  
M. V. Mozzhukhina ◽  
I. N. Zakharova
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Far East ◽  
Vitamin D Insufficiency ◽  
Control Group ◽  
Vitamin D Status ◽  
Treatment And Prevention ◽  
Absolute Majority ◽  
Number Of Patients ◽  
The Absolute

The aim of this paper was to assess vitamin D status in infants and young children in Moscow. 211 children aged 0 to 3 years were examined, of which 103 (48.8%) were under the age of 12 months, 64 (30.3%) children were 2 years old, 44 (20.9%) were 3 years old. The number of boys and girls was almost equal (52.6 and 47.4%). In the examined group of children, only 38.4% had the serum calcidiol level within the normal range (> 30 ng/ml). In other cases (61.6%), the children were diagnosed with one or another degree of vitamin D deficiency: severe deficiency in 2.4%; deficiency in 27.5%; insufficiency in 31.8% of patients. The frequency of registration of vitamin D insufficiency or deficiency increases significantly with the increase of years (R = -0.22, p = 0.0018). When comparing the obtained data with the results of study RODNICHOK, it was found that the vitamin D deficiency value in Moscow children was significantly lower than that in the regions located to the south (Kazan 65.0%; p <0.01; Stavropol 45 , 8%; p <0.05), and the Far East (Blagoveshchensk 42.6%; p <0.05; Khabarovsk 42.9%; p <0.05; Vladivostok 72.7%; p < 0.01). The absolute majority of the examined children (84.8%) received a prophylactic dose of vitamin D of 500 to 1500 IU/day. The 500 IU/day dose is insufficient, because 71.2% of patients in this subgroup had a low vitamin D status. A similar effect was obtained in patients taking vitamin D at a dose of 1000 and 1500 IU/day: the absolute values of cholecalciferol reliably increased by 1.8 and 1.9 times, the number of patients with normal vitamin values increased by 2.7 and 2.2 times as compared with intake of vitamin D at a dose of 500 IU; the deficiency level reduced by more than 8 times as compared to the control group and more than 2 times as compared to the patients receiving 500 IU. The seasonal factor does not have a significant effect on the serum calcidiol level (r = 0.06 at p = 0.3), which may be due to the peculiarities of the specific prevention of hypovitaminosis: a bit more than a third of children take vitamin D in summer (39.2%), whereas absolute majority (83.3%) take it in winter.

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