scholarly journals Closing the Capacity-Ability Gap: Using Technology to Support Aging With Disability

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Tracy L Mitzner ◽  
Jon A Sanford ◽  
Wendy A Rogers
Keyword(s):  
Great Promise ◽  
User Requirements ◽  
Intervention Model ◽  
Current State ◽  
Age Related ◽  
Wide Range ◽  
Technology Intervention ◽  
Bridge Models ◽  
Age Related Changes

Abstract There is a critical need to develop supports for older adults who have a wide range of abilities, including those aging with long-term impairments. Without appropriate support, many individuals will be functioning below optimal levels and will face participation barriers. Technology holds great promise to provide individualized support for a wide range of abilities and for a variety of domains. To ensure technology interventions are designed well and meet research-documented user requirements, we need more specific, actionable models to provide guidance for those developing and designing interventions. In this paper, we present the TechSAge Aging and Disability Model to bridge models from the aging and disability literatures and to disambiguate the population of individuals aging into disability from those aging with disability (i.e., pre-existing impairments). We also present the TechSAge Technology Intervention Model to support aging with pre-existing impairments, which provides direction and touch points for technology interventions. These models reflect the complex and dynamic interaction between age-related changes and an individual’s prior capabilities and limitations. We describe the need for these models with respect to filling a gap in the disability and aging literature by highlighting the importance of differentiating between age-related changes and long-term impairments when designing interventions. We also show the need for quantitative and qualitative data to refine the models given complexities of the current state of the literature and survey data. The TechSAge Technology Intervention Model can be used to drive and inform technology redesign and development.

scholarly journals Activation of the receptor tyrosine kinase RET improves long-term hematopoietic stem cell outgrowth and potency

Blood ◽  
2020 ◽  
Vol 136 (22) ◽  
pp. 2535-2547 ◽  
Author(s):  
W. Grey ◽  
R. Chauhan ◽  
M. Piganeau ◽  
H. Huerga Encabo ◽  
M. Garcia-Albornoz ◽  
...  
Keyword(s):  
Intracellular Signaling ◽  
Culture Conditions ◽  
Cellular Growth ◽  
Great Promise ◽  
Bone Marrow Niche ◽  
Hematopoietic Stem ◽  
Intracellular Signaling Pathway ◽  
Wide Range

Abstract Expansion of human hematopoietic stem cells (HSCs) is a rapidly advancing field showing great promise for clinical applications. Recent evidence has implicated the nervous system and glial family ligands (GFLs) as potential drivers of hematopoietic survival and self-renewal in the bone marrow niche; how to apply this process to HSC maintenance and expansion has yet to be explored. We show a role for the GFL receptor, RET, at the cell surface of HSCs in mediating sustained cellular growth, resistance to stress, and improved cell survival throughout in vitro expansion. HSCs treated with the key RET ligand/coreceptor complex, glial-derived neurotrophic factor and its coreceptor, exhibit improved progenitor function at primary transplantation and improved long-term HSC function at secondary transplantation. Finally, we show that RET drives a multifaceted intracellular signaling pathway, including key signaling intermediates protein kinase B, extracellular signal-regulated kinase 1/2, NF-κB, and p53, responsible for a wide range of cellular and genetic responses that improve cell growth and survival under culture conditions.

scholarly journals The Impact of Long‐Term Physical Activity on Age‐Related Changes in Protein and Gene Expression

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Ian R Lanza ◽  
Daniel K Short ◽  
Kevin R Short ◽  
Yan W Asmann ◽  
Sreekumar Raghavakaimal ◽  
...  
Keyword(s):  
Gene Expression ◽  
Physical Activity ◽  
Age Related ◽  
The Impact ◽  
Age Related Changes

Effect Of Age-Related Changes In Long-Term Facilitation In Humans During NREM Sleep

2011 ◽  
Author(s):  
Rene Franco-Elizondo ◽  
Sukanya Pranathiageswaran ◽  
M. Safwan Badr ◽  
Susmita Chowdhuri
Keyword(s):  
Nrem Sleep ◽  
Age Related ◽  
Long Term Facilitation ◽  
Effect Of Age ◽  
Age Related Changes

scholarly journals Age-related changes in emotional behavior: Evidence from a 13-year longitudinal study of long-term married couples.

Emotion ◽  
2020 ◽  
Vol 20 (2) ◽  
pp. 149-163 ◽  
Author(s):  
Alice Verstaen ◽  
Claudia M. Haase ◽  
Sandy J. Lwi ◽  
Robert W. Levenson
Keyword(s):  
Longitudinal Study ◽  
Married Couples ◽  
Emotional Behavior ◽  
Age Related ◽  
Age Related Changes

scholarly journals Global challenges and the formation of the digital economy: current state, security problems, development trends

2020 ◽  
pp. 52-60
Author(s):  
Natalya Lytnyeva ◽  
Sergey Voronov ◽  
Natalia Kidanova
Keyword(s):  
Rapid Development ◽  
Information Age ◽  
Economic Security ◽  
The State ◽  
Economic Agents ◽  
State Security ◽  
Current State ◽  
Wide Range ◽  
Main Basis

At present, the issues of economic security seem to be relevant both for the economic development of the state and for complex scientific research. A wide range of the vital activities of society includes indicators that reflect the potential threats that can be encountered by economic agents. The problem of economic security is now becoming increasingly important, and this in turn is caused by the rapid development of a diversified alternative economy that uses the latest achievements of scientific and technological progress. It is quite difficult to predict the development of the country’s economy in the long term when the current challenges and threats are not taken into account. That is why in the information age, where information technology is the main basis for conducting economic activity, and information security is one of the main directions of state development, while the state itself acts as an economic institution. Therefore, the development of the digital economy in Russia poses both opportunities and significant threats.

Providing dignified continence care to older people at end of life

2019 ◽  
Vol 25 (10) ◽  
pp. 504-512 ◽  
Author(s):  
Linda Nazarko
Keyword(s):  
Quality Of Life ◽  
Older People ◽  
End Of Life ◽  
Older Person ◽  
Entire Family ◽  
Long Term Conditions ◽  
Age Related ◽  
Age Related Changes

The prevalence of urinary incontinence increases as a person ages, as age-related changes make it more difficult to maintain continence. Long-term conditions and treatments prescribed to treat conditions, such as heart failure, can lead to an urgency to void the bladder. Frailty can make it difficult for an older person to respond this need. At end of life, mobility is often compromised and people can experience extreme fatigue. Caregivers can obtain support to manage an individual's incontinence during the day but often struggle alone at night. Caregivers can become exhausted and a situation can reach breaking point. Working with the older person and caregivers to determine the goals of care and how to meet them can make a huge difference. It can take the pressure off the entire family, meet a person's needs and enable the person to stay at home. This article aims to enable nurses to understand the problems older people may experience and how to work with the older person and caregivers to develop solutions that maintain dignity and enhance quality of life.

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