scholarly journals EVALUATING THE ASSOCIATION BETWEEN SLEEP AND MEMORY IN OLDER VETERANS WITH PTSD

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S269-S269
Author(s):  
Katherine S Hall ◽  
Miriam C Morey ◽  
Hayden Bosworth ◽  
Jean Beckham ◽  
Michelle Pebole
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Sleep Quality ◽  
Cognitive Abilities ◽  
Sleep Disturbances ◽  
Quality Parameters ◽  
Poor Sleep ◽  
Subjective Memory ◽  
Memory Complaints ◽  
Sleep Parameters

Abstract Sleep disturbances are core symptoms of posttraumatic stress disorder (PTSD), and recent studies also suggest a link between PTSD and cognitive impairment. There is some evidence of an association between sleep disturbances and cognitive abilities, such as memory, though few studies have focused on older adults and fewer still among those with mental health conditions. This study examined the association between subjective memory complaints and sleep (quality and quantity) in older veterans with PTSD. Fifty-four veterans with PTSD (M age=67.4, 85.2% African American, 90.7% men) participated in the study. Sleep was assessed using the Pittsburgh Sleep Quality Inventory (PSQI) and the PSQI Addendum for PTSD (PSQI-A). Memory was assessed using the Frequency of Forgetting Scale (FOF) derived from the Memory Functioning Questionnaire. The relationship between sleep quality parameters and FOF were examined using bivariate correlations and independent samples t test. Over 60% of participants met military-specific criteria for poor sleep (PSQI≥10; PSQI-A>5). Overall sleep quality on the PSQI-A was significantly associated with worse memory (r=-0.38, p<.01). Among specific sleep parameters (e.g., sleep latency, sleep duration), greater daytime dysfunction due to sleepiness was significantly associated with worse memory (r=-0.44, p<.01). Between-group analyses comparing memory complaints across participants classified as ‘poor’ versus ‘good’ sleepers on the PSQI-A approached significance (t(52)=1.93, p=.06). This study suggests that poor sleep may be a correlate of memory complaints among older adults with PTSD. Future studies are needed to determine whether poor sleep is an underlying factor in the link between PTSD and cognitive impairment.

601 Comparison of Sleep Parameters in Children with Achondroplasia and Trisomy 21

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A236-A237
Author(s):  
Jodi Gustave ◽  
Kaelyn Gaza ◽  
Jennifer Marriner ◽  
Seema Rani ◽  
Abigail Strang ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Rem Sleep ◽  
Trisomy 21 ◽  
Sleep Disturbances ◽  
Sleep Latency ◽  
Sleep Efficiency ◽  
Sleep Architecture ◽  
Poor Sleep ◽  
Arousal Index ◽  
Sleep Parameters

Abstract Introduction Children with achondroplasia and Trisomy 21 (T21) have increased incidence of sleep disturbances including sleep disordered breathing. Abnormal sleep architecture has been documented in children with T21. It is important to continue to analyze sleep parameters in both groups since poor sleep quality is associated with neurocognitive impairment. Methods Following IRB approval, we performed a retrospective chart review of patients at Nemours/A.I. duPont Hospital for Children in Wilmington, DE with achondroplasia and T21 who underwent an initial polysomnogram (PSG) between 2015 and 2020. We compared sleep architecture parameters between the groups including sleep efficiency, total sleep time (TST), sleep latency, arousal index and concentration of N3 and REM sleep. Results In patients with achondroplasia (n=49, mean age 5.8 months and 63.3% male), 12% reported restless sleep. PSG data revealed TST of 392 minutes, mean sleep efficiency of 82%, mean sleep latency of 9.4 min, mean arousal index of 40, 22% REM sleep and 32% N3 sleep. In the patients with T21 (n=32, mean age 17.8 months and 50% male), 59% reported restless sleep. PSG data revealed TST of 393 minutes, mean sleep efficiency of 82%, mean sleep latency of 14 minutes, arousal index of 35, 15% REM sleep and 40% N3 sleep. The differences in REM and N3 sleep between the two groups were statistically significant (p-values of 0.001 and 0.04, respectively), but the differences in arousal index, TST and sleep efficiency were not. Conclusion Our study showed that children with T21 subjectively noted more restless sleep compared to patients with achondroplasia although TST and sleep efficiency were similar. Patients with achondroplasia had a higher arousal index that was not statistically significant. Children with achondroplasia had a shorter sleep latency and more robust REM concentration, likely due to their younger age. There was a higher concentration of N3 sleep in patients with T21. This is likely due to the decrease in REM concentration. In conclusion, it is important to establish expected sleep parameters in patients with achondroplasia and T21 to maximize sleep quality and mitigate negative neurocognitive effects of poor sleep. Support (if any):

Sleep patterns and physical function in older adults attending primary health care

2020 ◽  
Author(s):  
Lucía Arias-Fernández ◽  
Andrea M Smith-Plaza ◽  
María Barrera-Castillo ◽  
Jessica Prado-Suárez ◽  
Esther Lopez-Garcia ◽  
...  
Keyword(s):  
Older Adults ◽  
Health Care ◽  
Sleep Quality ◽  
Physical Function ◽  
Muscle Weakness ◽  
Sleep Disturbances ◽  
Poor Sleep ◽  
Poor Sleep Quality ◽  
Physical Frailty ◽  
Primary Health

Abstract Background Sleep disturbances may contribute to physical function impairment among older adults. Objective To examine the associations between sleep quality and duration and impaired physical function among older adults. Methods Cross-sectional study involving 392 non-institutionalized adults aged ≥65 years, who were recruited from primary health care centres in Spain. Sleep quality and duration were assessed with the Pittsburgh Sleep Quality Index (PSQI). The FRAIL scale was used to identify physical frailty, the short physical performance battery to assess lower extremity functional impairment (LEFI) and grip strength was measured using a hand-held dynamometer to assess muscle weakness. Statistical analyses were performed with logistic regression models adjusted for potential confounders. Results Participants with poor sleep quality (PSQI global score ≥10) were more likely to have functional limitations; the odds ratio (95% confidence interval) was 2.90 (1.10–7.64) for physical frailty, 2.73 (1.34–5.58) for LEFI and 2.32 (1.14–4.75) for muscle weakness. Sleep quality components associated with frailty were sleep disturbances, use of sleeping medication and daytime dysfunction. The only quality component associated with LEFI was poor sleep efficiency, while subjective poor sleep quality and daytime dysfunction were linked to muscle weakness. No associations were observed between night-time sleep duration and physical function indicators. Conclusions Poor self-reported sleep quality, but not sleep duration, was associated with an increased frequency of physical frailty, LEFI and muscle weakness. Interventions to improve sleep quality could contribute to healthy ageing.

scholarly journals Association of depressive symptoms and subjective memory complaints with the incidence of cognitive impairment in older adults with high blood pressure

2019 ◽  
Vol 10 (3) ◽  
pp. 413-420 ◽  
Author(s):  
Miguel Germán Borda ◽  
José Manuel Santacruz ◽  
Dag Aarsland ◽  
Sandy Camargo-Casas ◽  
Carlos Alberto Cano-Gutierrez ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
Cognitive Impairment ◽  
Depressive Symptoms ◽  
High Blood Pressure ◽  
Subjective Memory Complaints ◽  
Subjective Memory ◽  
Memory Complaints

scholarly journals 0866 A Comparison Of Resting Cerebral Blood Flow And Sleep Quality In Older Adults

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A330-A330
Author(s):  
C C Hays ◽  
E A Almklov ◽  
H J Orff ◽  
C E Wierenga
Keyword(s):  
Older Adults ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Sleep Quality ◽  
Sleep Disturbances ◽  
Future Research ◽  
Aging Brain ◽  
Time Interval ◽  
Poor Sleep ◽  
Increased Risk

Abstract Introduction Sleep disturbances have been linked to a variety of health-related consequences, including clinically significant cognitive alterations. Older adults represent a particularly vulnerable population given that advanced age is associated with an increased risk for both sleep disorders, such as insomnia, and cognitive decline. Examining the relationship between resting cerebral blood flow (rCBF) and sleep quality in older adults will better our understanding of the neurophysiologic implications of poor sleep in aging adults. Methods Thirty-three cognitively normal older adults (15 males) between the ages of 65-85 (mean age=73) were administered the Pittsburg Sleep Quality Index (PSQI) and underwent assessment of rCBF using arterial spin labeling (ASL). Those who scored above 5 on the PSQI were defined as poor sleepers (n=17) and those who scored 5 or below were defined as good sleepers (n=16). Groups were then compared on voxel-wise whole-brain rCBF using independent samples t-tests statistically adjusting for age, sex, and the time interval between neuroimaging and sleep assessment. Results Compared to good sleepers, poor sleepers exhibited higher rCBF within bilateral thalamus and the left precuneus and lower rCBF within the left putamen (all ps<.01, uncorrected). Conclusion In this preliminary investigation, poor sleepers exhibited a differential pattern of rCBF in several brain regions, including those involved in consciousness and other important cognitive abilities such as attention. Future research is needed to determine the short- and long-term implications of poor sleep on the aging brain. Support U.S. Department of Veterans Affairs Clinical Sciences Research and Development Service Merit Award 5I01CX000565 (CEW) & VA Rehabilitation Research & Development - Career Development Award - RX001512-01A2 (HJO)

Memory Compensation Strategies in Older People with Mild Cognitive Impairment

2020 ◽  
Vol 26 (1) ◽  
pp. 86-96
Author(s):  
Pinghsiu Lin ◽  
Haley M. LaMonica ◽  
Sharon L. Naismith ◽  
Loren Mowszowski
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Daily Life ◽  
Well Being ◽  
Strategy Use ◽  
Subjective Memory Complaints ◽  
Subjective Memory ◽  
Memory Complaints ◽  
Memory Strategy

AbstractObjectives:With the rapid growth of the older population worldwide, understanding how older adults with mild cognitive impairment (MCI) use memory strategies to mitigate cognitive decline is important. This study investigates differences between amnestic and nonamnestic MCI subtypes in memory strategy use in daily life, and how factors associated with cognition, general health, and psychological well-being might relate to strategy use.Methods:One hundred forty-eight participants with MCI (mean age = 67.9 years, SD = 8.9) completed comprehensive neuropsychological, medical, and psychological assessments, and the self-report ‘Memory Compensation Questionnaire’. Correlational and linear regression analyses were used to explore relationships between memory strategy use and cognition, general health, and psychological well-being.Results:Memory strategy use does not differ between MCI subtypes (p > .007) despite higher subjective everyday memory complaints in those with amnestic MCI (p = .03). The most marked finding showed that increased reliance-type strategy use was significantly correlated with more subjective memory complaints and poorer verbal learning and memory (p < .01) in individuals with MCI. Moreover, fewer subjective memory complaints and better working memory significantly predicted (p < .05) less reliance strategy use, respectively, accounting for 10.6% and 5.3% of the variance in the model.Conclusions:In general, the type of strategy use in older adults with MCI is related to cognitive functioning. By examining an individual’s profile of cognitive dysfunction, a clinician can provide more personalized clinical recommendations regarding strategy use to individuals with MCI, with the aim of maintaining their day-to-day functioning and self-efficacy in daily life.

scholarly journals Prospective and Retrospective Memory Complaints in Mild Cognitive Impairment and Mild Alzheimer's Disease

2009 ◽  
Vol 10 (1) ◽  
pp. 59-75 ◽  
Author(s):  
Anne Eschen ◽  
Mike Martin ◽  
Ursula Schreiter Gasser ◽  
Matthias Kliegel
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Executive Functions ◽  
Prospective Memory ◽  
Cognitive Abilities ◽  
Retrospective Memory ◽  
Healthy Older Adults ◽  
Memory Complaints

AbstractCurrent management attempts for Alzheimer's disease (AD) focus on the identification of individuals in the preclinical stage. This has led to the development of the diagnostic concept of Mild Cognitive Impairment (MCI), which applies to individuals with declining cognitive abilities but largely preserved everyday functioning. Previous findings indicate that prospective memory deficits are a sensitive marker of preclinical AD and that awareness of prospective memory failures is particularly high, based on its dependence on executive functions. Thus, the goal of this study was to evaluate the usefulness of subjective prospective versus retrospective memory complaints for an initial screening for MCI and their respective associations with executive functions. 71 healthy older adults, 27 MCI patients, and 9 patients with mild AD completed the Prospective and Retrospective Memory Questionnaire (PRMQ) and three executive functions tests. The healthy and the MCI group could not be distinguished by their level of subjective prospective or retrospective memory complaints, but the mild AD patients differed from the other groups by complaining more about retrospective than prospective memory failures. For the healthy older adults, the prospective memory complaints were correlated to an inhibition test, whereas they did not correlate with any of the executive function tests in the MCI patients. In contrast, in both groups the retrospective memory complaints were related to a task switching test. The findings are discussed with respect to differences between the three groups in cognitive abilities, attention to failures of, use of mnemonic aids for, and everyday demands of prospective and retrospective memory.

Subjective memory complaints in an elderly population with poor sleep quality

2015 ◽  
Vol 21 (5) ◽  
pp. 532-536 ◽  
Author(s):  
Suk-Hoon Kang ◽  
In-Young Yoon ◽  
Sang Don Lee ◽  
Tae Kim ◽  
Chung Suk Lee ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Elderly Population ◽  
Poor Sleep ◽  
Subjective Memory Complaints ◽  
Poor Sleep Quality ◽  
Subjective Memory ◽  
Memory Complaints

scholarly journals Sleep disturbances and frailty status in older adults in Vietnam

2021 ◽  
Vol 141 (5) ◽  
pp. 69-74
Author(s):  
Nguyen Trung Anh ◽  
Nguyen Thi Ngoc Anh ◽  
Dang Thi Xuan ◽  
Nguyen Xuan Thanh
Keyword(s):  
Older Adults ◽  
Sleep Quality ◽  
Sleep Disturbance ◽  
Sleep Disturbances ◽  
Early Morning ◽  
Cross Sectional Study ◽  
Poor Sleep ◽  
Cross Sectional ◽  
Frailty Status ◽  
Geriatric Hospital

This cross-sectional study aimed to describe sleep disturbance and its association with frailty syndrome among 903 older adults at the National Geriatric Hospital in Vietnam. Frailty was diagnosed according to the Fried criteria. Sleep disturbances was assessed based on the Pittsburgh Sleep Quality Index (PSQI). Of 903 patients, the mean age was 71.8 (SD = 8.5), and 537 (59.5%) were female. Most (96.7%) of the patients diagnosed with frailty had poor sleep; 95.3% had to get up at midnight or early morning; 93.3% could not sleep within 30 minutes; 86% had sleep efficiency less than 85%; 53.3% coughed at night; 50.7% had nightmares; and 27.3% and 22.7% of patients felt hot and cold, respectively. The majority (80.0%) of patients must get up to use the bathroom. In conclusion, most older adult diagnosed with frailty experienced at least one form of of sleep disturbance. Medical staffs should attend to the patient’s sleep quality, especially in patients with frailty.

scholarly journals Psychiatric Disorders and Mild Cognitive Impairment in Older Veterans With Subjective Memory Complaints

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 295-295
Author(s):  
Mia Delgadillo ◽  
Megan Frank ◽  
Aidan Boese ◽  
Tilman Schulte ◽  
J Kaci Fairchild
Keyword(s):  
Older Adults ◽  
Substance Use ◽  
Cognitive Impairment ◽  
Anxiety Disorder ◽  
Psychiatric Disorder ◽  
Psychiatric Disorders ◽  
Substance Use Disorders ◽  
Subjective Memory Complaints ◽  
Subjective Memory ◽  
Memory Complaints

Abstract Psychiatric disorders pose a unique risk for Alzheimer’s disease (AD). Prior research indicates psychiatric disorders in MCI increase AD vulnerability. Less research has been done to understand how psychiatric disorders may affect the development of MCI. Understanding these potentially modifiable risk factors is important as they may represent a potential target of intervention for secondary prevention of AD. The present study examines the relationship between psychiatric disorders and amnestic MCI (aMCI) in a sample of Veterans with subjective memory complaints. The sample included 150 older adults with subjective memory complaints (90% male, age = 70.6±8.2). aMCI diagnosis was based upon performance on the delayed recall trials of the Rey Auditory Verbal Learning Test and Logical Memory II of the Wechsler Memory Scale-4th edition. Psychiatric disorders (e.g., Mood Disorders, Anxiety Disorders, and Substance Use Disorders) were assessed using the Mini Neuropsychiatric Interview for DSM-IV. Logistic regression modeling demonstrated that diagnosis of anxiety disorders, but not mood or substance use disorders, was significantly associated with aMCI status. Specifically, older adults with an anxiety disorder were less likely to have aMCI than those older adults without an anxiety disorder. Additional analyses revealed that within those with aMCI (n=107), persons with a psychiatric disorder were significantly younger than those without a psychiatric disorder by an average of 6 years. These findings support prior research on the complex relationship of anxiety and cognitive impairment as well as suggest that those with psychiatric disorders may be at risk for developing aMCI at younger ages.

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