scholarly journals PREVALENCE AND HERITABILITY OF PERCEIVED MENTAL FATIGABILITY IN THE LONG LIFE FAMILY STUDY

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S233-S233
Author(s):  
Alexa J Meinhardt ◽  
Theresa Gmelin ◽  
Allison L Kuipers ◽  
Stacy L Andersen ◽  
Stephanie Cosentino ◽  
...  
Keyword(s):  
Older Adults ◽  
Family Structure ◽  
Family Study ◽  
Female Self ◽  
Field Center ◽  
Genetic Heritability ◽  
Long Life ◽  
Study Participants

Abstract We examined the prevalence and heritability of perceived mental fatigability among older adults enrolled in the Long Life Family Study. Participants (N=2342; 55% female) self-administered the Pittsburgh Fatigability Scale (PFS; scores range 0-50; higher score=greater fatigability). Using the PFS mental subscale, we evaluated differences across age strata (adjusted for family structure and field center) and estimated genetic heritability using the variance covariance methods implemented in SOLAR to determine genetic heritability (adjusted for age, sex, and field center). PFS mental score (mean±SD) and prevalence of higher mental fatigability (PFS ≥13) was greater across age strata: 60-69 (N=996, 5.9± 6.5, 14.5%), 70-79 (N=830, 6.8 ±7.6, 18.7%), 80-89 (N=251, 11.7±10.8, 41.8%), and ≥90 (N=265, 20.2±13.6, 67.2%), p<0.0001. Only among those ≥90, females (21.7±13.5) had greater mental fatigability than males (18.0±13.5), p=0.03. Residual heritability of mental fatigability was 0.17, p<0.0001. Future analyses will evaluate correlates of mental fatigability to identify potential avenues for intervention.

scholarly journals Epidemiology of Perceived Physical Fatigability in Older Adults: The Long Life Family Study

2019 ◽  
Vol 75 (9) ◽  
pp. e81-e88 ◽  
Author(s):  
Kelsea R LaSorda ◽  
Theresa Gmelin ◽  
Allison L Kuipers ◽  
Robert M Boudreau ◽  
Adam J Santanasto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Family Study ◽  
Whole Body ◽  
Physically Active ◽  
Targeted Interventions ◽  
Field Center ◽  
Cognitive Risk ◽  
Genetic Heritability ◽  
Long Life

Abstract Background Fatigability is a construct that measures whole-body tiredness anchored to activities of a fixed intensity and duration; little is known about its epidemiology and heritability. Methods Two generations of family members enriched for exceptional longevity and their spouses were enrolled (2006–2009) in the Long Life Family Study (LLFS). At Visit 2 (2014–2017, N = 2,355) perceived physical fatigability was measured using the 10-item self-administered Pittsburgh Fatigability Scale (PFS), along with demographic, medical, behavioral, physical, and cognitive risk factors. Results Residual genetic heritability of fatigability was 0.263 (p = 6.6 × 10–9) after adjustment for age, sex, and field center. PFS physical scores (mean ± SD) and higher physical fatigability prevalence (% PFS ≥ 15) were greater with each age strata: 60–69 (n = 1,009, 11.0 ± 7.6, 28%), 70–79 (n = 847, 12.5 ± 8.1, 37%), 80–89 (n = 253, 19.3 ± 9.9, 65.2%), and 90–108 (n = 266, 28.6 ± 9.8, 89.5%), p < .0001, adjusted for sex, field center, and family relatedness. Women had a higher prevalence of perceived physical fatigability compared to men, with the largest difference in the 80–89 age strata, 74.8% versus 53.5%, p < .0001. Those with greater body mass index, worse physical and cognitive function, and lower physical activity had significantly higher perceived physical fatigability. Conclusions Perceived physical fatigability is highly prevalent in older adults and strongly associated with age. The family design of LLFS allowed us to estimate the genetic heritability of perceived physical fatigability. Identifying risk factors associated with higher perceived physical fatigability can inform the development of targeted interventions for those most at risk, including older women, older adults with depression, and those who are less physically active.

scholarly journals INTEGRATIVE ANALYSIS OF LONGITUDINAL CHANGES OF NEUROPSYCHOLOGICAL TESTS IN LONG LIFE FAMILY STUDY PARTICIPANTS

2018 ◽  
Vol 2 (suppl_1) ◽  
pp. 404-405
Author(s):  
P Sebastiani ◽  
S L Andersen ◽  
B Sweigart ◽  
S Cosentino ◽  
B Thyragajan ◽  
...  
Keyword(s):  
Neuropsychological Tests ◽  
Family Study ◽  
Integrative Analysis ◽  
Longitudinal Changes ◽  
Long Life ◽  
Study Participants

scholarly journals Leukocyte Telomere Length Is Unrelated to Cognitive Performance Among Non-Demented and Demented Persons: An Examination of Long Life Family Study Participants

2020 ◽  
Vol 26 (9) ◽  
pp. 906-917
Author(s):  
Adiba Ashrafi ◽  
Stephanie Cosentino ◽  
Min S. Kang ◽  
Joseph H. Lee ◽  
Nicole Schupf ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Telomere Length ◽  
Semantic Processing ◽  
Family Study ◽  
Clinical Information ◽  
Biological Aging ◽  
Leukocyte Telomere Length ◽  
Information Processing Speed ◽  
Long Life ◽  
Study Participants

AbstractObjective:Leukocyte telomere length (LTL) is a widely hypothesized biomarker of biological aging. Persons with shorter LTL may have a greater likelihood of developing dementia. We investigate whether LTL is associated with cognitive function, differently for individuals without cognitive impairment versus individuals with dementia or incipient dementia.Method:Enrolled subjects belong to the Long Life Family Study (LLFS), a multi-generational cohort study, where enrollment was predicated upon exceptional family longevity. Included subjects had valid cognitive and telomere data at baseline. Exclusion criteria were age ≤ 60 years, outlying LTL, and missing sociodemographic/clinical information. Analyses were performed using linear regression with generalized estimating equations, adjusting for sex, age, education, country, generation, and lymphocyte percentage.Results:Older age and male gender were associated with shorter LTL, and LTL was significantly longer in family members than spouse controls (p < 0.005). LTL was not associated with working or episodic memory, semantic processing, and information processing speed for 1613 cognitively unimpaired individuals as well as 597 individuals with dementia or incipient dementia (p < 0.005), who scored significantly lower on all cognitive domains (p < 0.005).Conclusions:Within this unique LLFS cohort, a group of families assembled on the basis of exceptional survival, LTL is unrelated to cognitive ability for individuals with and without cognitive impairment. LTL does not change in the context of degenerative disease for these individuals who are biologically younger than the general population.

P4-073: IN ABSENCE OF DEMENTIA, COGNITIVE PERFORMANCE DOES NOT RELATE TO THE BIOMARKER OF LEUKOCYTE TELOMERE LENGTH: AN EXAMINATION OF LONG LIFE FAMILY STUDY PARTICIPANTS

2006 ◽  
Vol 14 (7S_Part_27) ◽  
pp. P1462-P1462
Author(s):  
Adiba Ashrafi ◽  
Stephanie Cosentino ◽  
Min Suk Kang ◽  
Joseph H. Lee ◽  
Nicole Schupf ◽  
...  
Keyword(s):  
Telomere Length ◽  
Cognitive Performance ◽  
Family Study ◽  
Leukocyte Telomere Length ◽  
Long Life ◽  
Study Participants

scholarly journals Age and Sex Distributions of Age-Related Biomarker Values in Healthy Older Adults from the Long Life Family Study

2016 ◽  
Vol 64 (11) ◽  
pp. e189-e194 ◽  
Author(s):  
Paola Sebastiani ◽  
Bharat Thyagarajan ◽  
Fangui Sun ◽  
Lawrence S. Honig ◽  
Nicole Schupf ◽  
...  
Keyword(s):  
Older Adults ◽  
Family Study ◽  
Healthy Older Adults ◽  
Age Related ◽  
Long Life ◽  
Age And Sex

scholarly journals Association Between APOE Alleles and Change of Neuropsychological Tests in the Long Life Family Study

2021 ◽  
Vol 79 (1) ◽  
pp. 117-125
Author(s):  
Mengtian Du ◽  
Stacy L. Andersen ◽  
Nicole Schupf ◽  
Mary F. Feitosa ◽  
Megan S. Barker ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Test Scores ◽  
Healthy Aging ◽  
Family Study ◽  
Apoe Genotype ◽  
Cognitive Test ◽  
Cross Sectional ◽  
Long Life ◽  
E4 Allele

Background: The Long Life Family Study (LLFS) is a family based, prospective study of healthy aging and familial longevity. The study includes two assessments of cognitive function that were administered approximately 8 years apart. Objective: To test whether APOE genotype is associated with change of cognitive function in older adults. Methods: We used Bayesian hierarchical models to test the association between APOE alleles and change of cognitive function. Six longitudinally collected neuropsychological test scores were modelled as a function of age at enrollment, follow-up time, gender, education, field center, birth cohort indicator (≤1935, or >1935), and the number of copies of ɛ2 or ɛ4 alleles. Results: Out of 4,587 eligible participants, 2,064 were male (45.0%), and age at enrollment ranged from 25 to 110 years, with mean of 70.85 years (SD: 15.75). We detected a significant cross-sectional effect of the APOE ɛ4 allele on Logical Memory. Participants carrying at least one copy of the ɛ4 allele had lower scores in both immediate (–0.31 points, 95% CI: –0.57, –0.05) and delayed (–0.37 points, 95% CI: –0.64, –0.10) recall comparing to non-ɛ4 allele carriers. We did not detect any significant longitudinal effect of the ɛ4 allele. There was no cross-sectional or longitudinal effect of the ɛ2 allele. Conclusion: The APOE ɛ4 allele was identified as a risk factor for poorer episodic memory in older adults, while the APOE ɛ2 allele was not significantly associated with any of the cognitive test scores.

scholarly journals Prevalence and severity of perceived mental fatigability in older adults: The Long Life Family Study

2021 ◽  
Author(s):  
Rebecca W. Cohen ◽  
Alexa J. Meinhardt ◽  
Theresa Gmelin ◽  
Yujia (Susanna) Qiao ◽  
Kyle D. Moored ◽  
...  
Keyword(s):  
Older Adults ◽  
Family Study ◽  
Long Life

scholarly journals Bidirectional Relationship Between Subjective Age and Frailty: Findings From the NHATS

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 271-271
Author(s):  
Yuxiao Li ◽  
Minhui Liu ◽  
Christina Miyawaki ◽  
Xiaocao Sun ◽  
Tianxue Hou ◽  
...  
Keyword(s):  
Older Adults ◽  
Clinical Syndrome ◽  
Community Dwelling ◽  
Chronological Age ◽  
Subjective Age ◽  
Bidirectional Relationship ◽  
Study Participants ◽  
Community Dwelling Older Adults ◽  
The Relationship ◽  
Hispanic White

Abstract Frailty is a clinical syndrome that becomes increasingly common as people age. Subjective age refers to how young or old individuals experience themselves to be. It is associated with many risk factors of frailty, such as increased depression, worse cognitive function, and poorer psychological wellbeing. In this study, we examined the relationship between subjective age and frailty using the 2011-2015 waves of the National Health and Aging Trends Study. Participants were community-dwelling older adults without frailty in the initial wave (N=1,165). Subjective age was measured by asking participants, “What age do you feel most of the time?” Based on the Fried five phenotypic criteria: exhaustion, unintentional weight loss, low physical activity, slow gait, and weak grip strength, frailty was categorized into robust=0, pre-frail=1 or 2; frail=3 or more criteria met. Participants were, on average, 74.1±6.5 years old, female (52%), and non-Hispanic White (81%). Eighty-five percent of the participants felt younger, and 3% felt older than their chronological age, but 41% of them were pre-frail/frail. Generalized estimating equations revealed that an “older” subjective age predicted a higher likelihood of pre-frailty and frailty (OR, 95%CI= 1.01, 1.01-1.02). In contrast, frailty predicted an “older” subjective age (OR, 95%CI= 2.97, 1.65-5.35) adjusting for demographics and health conditions. These findings suggest a bidirectional relationship between subjective age and frailty. Older people who feel younger than their chronological age are at reduced risk of becoming pre-frail/frail. Intervention programs to delay frailty progression should include strategies that may help older adults perceive a younger subjective age.

scholarly journals The Association of Sensory Impairment With Incident Disability-Related Cessation of Employment in Older Adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 216-216
Author(s):  
Ahmed Shakarchi ◽  
Emmanuel Garcia Morales ◽  
Nicholas Reed ◽  
Bonnielin Swenor
Keyword(s):  
Older Adults ◽  
Hearing Aids ◽  
Population Based ◽  
Sensory Impairment ◽  
Loss To Follow Up ◽  
Increased Risk ◽  
Cox Proportional Hazard Regression ◽  
Study Participants ◽  
Adjusted Model

Abstract Sensory impairment (SI) is common among older adults, and it is an increasingly important public health challenge as the population ages. We evaluated the association between SI and incident disability-related cessation of employment in older adults using the population-based Health and Retirement Study. Participants employed in 2006 completed biennial interviews until self-reported incident disability-related cessation of employment. Participants were censored at loss to follow-up, retirement, or 2018. Participants rated their vision and hearing, using eyeglasses or hearing aids if applicable, on a Likert scale (poor, fair, good, very good, excellent). SI was defined as poor or fair ability, and SI was categorized as neither SI (NSI), vision impairment alone (VI), hearing impairment alone (HI), and dual SI (DSI). Cox proportional hazard regression assessed the association between SI and incident disability-related cessation of employment, adjusting for demographic and health covariates. Overall, 4726 participants were included: 421 (8.9%) were with VI, 487 (10.3) with HI, and 203 (4.3%) with DSI. Mean age was 61.0 ± 6.8 years, 2488 (52.6%) were women, and 918 (19.4) were non-White. In the fully adjusted model, incident disability-related cessation of employment over the 12-year follow-up period was higher in VI (Hazard Ratio (HR)=1.30, 95% confidence interval (CI)=0.92, 1.85), HI (HR=1.60, CI=1.16, 2.22), and DSI (HR=2.02, CI=1.38, 2.96). These findings indicate that employed older adults with SI are at increased risk of incident disability-related cessation of employment, and that older adults with DSI are particularly vulnerable. Addressing SI in older adults may lengthen their contribution to the workforce.

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