scholarly journals Leukocyte Telomere Length Is Unrelated to Cognitive Performance Among Non-Demented and Demented Persons: An Examination of Long Life Family Study Participants

2020 ◽  
Vol 26 (9) ◽  
pp. 906-917
Author(s):  
Adiba Ashrafi ◽  
Stephanie Cosentino ◽  
Min S. Kang ◽  
Joseph H. Lee ◽  
Nicole Schupf ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Telomere Length ◽  
Semantic Processing ◽  
Family Study ◽  
Clinical Information ◽  
Biological Aging ◽  
Leukocyte Telomere Length ◽  
Information Processing Speed ◽  
Long Life ◽  
Study Participants

AbstractObjective:Leukocyte telomere length (LTL) is a widely hypothesized biomarker of biological aging. Persons with shorter LTL may have a greater likelihood of developing dementia. We investigate whether LTL is associated with cognitive function, differently for individuals without cognitive impairment versus individuals with dementia or incipient dementia.Method:Enrolled subjects belong to the Long Life Family Study (LLFS), a multi-generational cohort study, where enrollment was predicated upon exceptional family longevity. Included subjects had valid cognitive and telomere data at baseline. Exclusion criteria were age ≤ 60 years, outlying LTL, and missing sociodemographic/clinical information. Analyses were performed using linear regression with generalized estimating equations, adjusting for sex, age, education, country, generation, and lymphocyte percentage.Results:Older age and male gender were associated with shorter LTL, and LTL was significantly longer in family members than spouse controls (p < 0.005). LTL was not associated with working or episodic memory, semantic processing, and information processing speed for 1613 cognitively unimpaired individuals as well as 597 individuals with dementia or incipient dementia (p < 0.005), who scored significantly lower on all cognitive domains (p < 0.005).Conclusions:Within this unique LLFS cohort, a group of families assembled on the basis of exceptional survival, LTL is unrelated to cognitive ability for individuals with and without cognitive impairment. LTL does not change in the context of degenerative disease for these individuals who are biologically younger than the general population.

P4-073: IN ABSENCE OF DEMENTIA, COGNITIVE PERFORMANCE DOES NOT RELATE TO THE BIOMARKER OF LEUKOCYTE TELOMERE LENGTH: AN EXAMINATION OF LONG LIFE FAMILY STUDY PARTICIPANTS

2006 ◽  
Vol 14 (7S_Part_27) ◽  
pp. P1462-P1462
Author(s):  
Adiba Ashrafi ◽  
Stephanie Cosentino ◽  
Min Suk Kang ◽  
Joseph H. Lee ◽  
Nicole Schupf ◽  
...  
Keyword(s):  
Telomere Length ◽  
Cognitive Performance ◽  
Family Study ◽  
Leukocyte Telomere Length ◽  
Long Life ◽  
Study Participants

scholarly journals Association of Leukocyte Telomere Length With Perceived Physical Fatigability

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 207-208
Author(s):  
Joseph Zmuda ◽  
Joseph Lee ◽  
Lawrence Honig ◽  
Kaare Christensen ◽  
Mary Feitosa ◽  
...  
Keyword(s):  
Telomere Length ◽  
Family Study ◽  
Functional Decline ◽  
Prognostic Indicator ◽  
Health Conditions ◽  
Biological Aging ◽  
Leukocyte Telomere Length ◽  
Potential Marker ◽  
Two Generations

Abstract Leukocyte telomere length (LTL) is a potential marker of biological aging, but its relationship to fatigability, a prognostic indicator of phenotypic aging (e.g., functional decline) is unknown. We hypothesized shorter LTL would predict greater perceived physical fatigability. Two generations of participants (N=1,997; 309 probands, 1,688 offspring) were from the Long Life Family Study (age=73.7±10.4, range 60-108, 54.4% women). LTL was assayed at baseline and 8.0±1.1 years later perceived physical fatigability was measured using the validated, self-administered 10-item Pittsburgh Fatigability Scale (PFS, 0-50, higher scores=greater fatigability). Prevalence of greater physical fatigability (PFS scores≥15) was 41.9%. Using multivariate linear regression, one kilobase pair shorter LTL predicted higher PFS Physical scores (β=0.9, p=0.025), adjusted for family relatedness, generation (indicator for age), field center, follow-up time, sex, and follow-up body mass index, physical activity, health conditions. LTL, a promising marker of future fatigability, may allow for early identification of those at-risk for deleterious aging.

Abstract P276: Metabolic Profiles of Biological Aging in American Indians: The Strong Heart Family Study

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Yun Zhu ◽  
Jiang He ◽  
Jue Lin ◽  
Tet Matsuguchi ◽  
Elizabeth Blackburn ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Telomere Length ◽  
American Indians ◽  
Multiple Testing ◽  
Family Study ◽  
Biological Aging ◽  
Metabolic Profiles ◽  
Leukocyte Telomere Length ◽  
Age Related ◽  
Strong Heart Family Study

Background: Telomere length is an emerging biomarker for cellular senescence or biological aging. Short leukocyte telomere length (LTL) has been associated with a wide range of age-related metabolic disorders such as diabetes and cardiovascular disease. Telomere attrition induces profound metabolic dysfunction in animal models, but no study has examined the metabolic profiles of biological aging assessed by telomere length in human. Objective: To identify metabolic profiles of leukocyte telomere length in American Indians participating in the Strong Heart Family Study (SHFS, 2001-2003). Methods: This study included 432 SHFS participants free of cardiovascular disease and type 2 diabetes. LTL was measured by quantitative polymerase chain reaction (qPCR). Plasma metabolites were detected using an untargeted metabolomics approach by high-resolution liquid chromatography-mass spectrometry (LC/MS). The association of leukocyte telomere length with concentration of each metabolite was examined using generalized estimating equation (GEE), adjusting for age, sex, study center, body mass index, fasting glucose and fasting insulin. Multiple testing was corrected by Bonferroni correction (significance level 2.8х10-6). Results: After adjusting for covariates and multiple testing, three metabolites including cytosine, selenophosphate and pentyl propanoate, were significantly associated with LTL. Of these, cytosine was positively associated with LTL (β=0.0476, 95% CI, 0.0474 to 0.0478, P=1.90х10-7), and selenophosphate (β =-0.1522, 95% CI, -0.1525 to -0.1519, P=2.48х10-8) and pentyl propanoate (β =-0.0644, 95% CI, -0.0683 to -0.0606, P=1.08х10-8) were negatively associated with LTL. Multivariate analysis demonstrated that participants with longer (top telomere tertile) and shorter (bottom telomere tertile) LTL can be clearly separated by partial least square discriminant analysis (PLS-DA) using these three metabolites. Multiple unknown compounds were also independently associated with LTL. Conclusions: This study, for the first time, identifies metabolites and metabolic profiles associated with interindividual variability in leukocyte telomere length, independent of potential confounders. Our findings provide novel insights into understanding of telomere biology and metabolic mechanisms underlying age-related disorders.

scholarly journals INTEGRATIVE ANALYSIS OF LONGITUDINAL CHANGES OF NEUROPSYCHOLOGICAL TESTS IN LONG LIFE FAMILY STUDY PARTICIPANTS

2018 ◽  
Vol 2 (suppl_1) ◽  
pp. 404-405
Author(s):  
P Sebastiani ◽  
S L Andersen ◽  
B Sweigart ◽  
S Cosentino ◽  
B Thyragajan ◽  
...  
Keyword(s):  
Neuropsychological Tests ◽  
Family Study ◽  
Integrative Analysis ◽  
Longitudinal Changes ◽  
Long Life ◽  
Study Participants

scholarly journals Urinary metals and leukocyte telomere length in American Indian communities: The Strong Heart and the Strong Heart Family Study

2019 ◽  
Vol 246 ◽  
pp. 311-318 ◽  
Author(s):  
Maria Grau-Perez ◽  
Jinying Zhao ◽  
Brandon Pierce ◽  
Kevin A. Francesconi ◽  
Walter Goessler ◽  
...  
Keyword(s):  
American Indian ◽  
Telomere Length ◽  
Family Study ◽  
Leukocyte Telomere Length ◽  
Strong Heart Family Study

Abstract 16704: Leukocyte Telomere Length and Risk of Stroke: The Strong Heart Family Study

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Caroline Goode ◽  
Jinying Zhao ◽  
Richard B Devereux ◽  
Santosh Murthy ◽  
Alexander E Merkler ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Atrial Fibrillation ◽  
Telomere Length ◽  
Family Study ◽  
Leukocyte Telomere Length ◽  
Potential Biomarker ◽  
Primary Model ◽  
Strong Heart Family Study

Introduction: Leukocyte telomere length (LTL) is a potential biomarker of aging and associated with several age-related diseases. Current research on an association between LTL and incident stroke has had inconclusive results. We hypothesized that LTL is associated with incident stroke among American Indians (AI) in the Strong Heart Family Study (SHFS). Methods: The SHFS is a population-based cohort study of cardiovascular disease (CVD) and its risk factors. Participants (n=2,769) recruited from regions in Arizona, Oklahoma and the Dakotas were assessed for LTL and CVD risk factors during a clinic visit between 2001 and 2003. Incident stroke events were identified through the end of 2018 (mean follow-up: 16.4 years). We assessed the association between LTL and incident stroke using frailty models based on the proportional hazards, accounting for family relatedness and established stroke risk factors that include sex, geographical location, education, smoking, atrial fibrillation, diabetes mellitus, and hypertension. Results: Among 2,769 participants, the mean age was 40.6±17.2 and 41.4% were male. During follow-up, there were 79 (2.9%) incident stroke cases. In the primary model, which adjusted for demographic variables (sex, location and education), the hazard ratios (HR) for stroke in participants in the first and second LTL quartiles were significantly higher than those in the highest (longest) LTL quartile, with HRs of 3.1 (95%CI: 1.4 - 6.6) and 3.5 (95%CI: 1.7 - 7.5), respectively. After adjusting for smoking, atrial fibrillation, diabetes mellitus, and hypertension, the association between LTL and stroke was attenuated, but remained significant when comparing the second shortest LTL quartile to the longest LTL quartile, HR: 2.3 (95% CI: 1.1 – 5.0). Conclusions: In summary, LTL was associated with incident stroke among SHFS participants. Those with shorter LTL have higher risk of stroke. Longer follow-up time may add more power to data analyses since the SHFS is relatively young, with an average baseline age of 40 years. If results are confirmed in other populations, LTL may serve as a biomarker identifying high risk individuals for the purpose of stroke prevention.

scholarly journals PREVALENCE AND HERITABILITY OF PERCEIVED MENTAL FATIGABILITY IN THE LONG LIFE FAMILY STUDY

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S233-S233
Author(s):  
Alexa J Meinhardt ◽  
Theresa Gmelin ◽  
Allison L Kuipers ◽  
Stacy L Andersen ◽  
Stephanie Cosentino ◽  
...  
Keyword(s):  
Older Adults ◽  
Family Structure ◽  
Family Study ◽  
Female Self ◽  
Field Center ◽  
Genetic Heritability ◽  
Long Life ◽  
Study Participants

Abstract We examined the prevalence and heritability of perceived mental fatigability among older adults enrolled in the Long Life Family Study. Participants (N=2342; 55% female) self-administered the Pittsburgh Fatigability Scale (PFS; scores range 0-50; higher score=greater fatigability). Using the PFS mental subscale, we evaluated differences across age strata (adjusted for family structure and field center) and estimated genetic heritability using the variance covariance methods implemented in SOLAR to determine genetic heritability (adjusted for age, sex, and field center). PFS mental score (mean±SD) and prevalence of higher mental fatigability (PFS ≥13) was greater across age strata: 60-69 (N=996, 5.9± 6.5, 14.5%), 70-79 (N=830, 6.8 ±7.6, 18.7%), 80-89 (N=251, 11.7±10.8, 41.8%), and ≥90 (N=265, 20.2±13.6, 67.2%), p&lt;0.0001. Only among those ≥90, females (21.7±13.5) had greater mental fatigability than males (18.0±13.5), p=0.03. Residual heritability of mental fatigability was 0.17, p&lt;0.0001. Future analyses will evaluate correlates of mental fatigability to identify potential avenues for intervention.

scholarly journals Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players

2021 ◽  
Vol 8 ◽  
Author(s):  
Shamma Al-Muraikhy ◽  
Maha Sellami ◽  
Alexander S Domling ◽  
Najeha Rizwana ◽  
Abdelali Agouni ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Telomere Length ◽  
Metabolic Pathways ◽  
Roc Analysis ◽  
Linear Models ◽  
Exercise Physiology ◽  
Predictive Marker ◽  
Soccer Players ◽  
Biological Aging ◽  
Leukocyte Telomere Length

Introduction: Biological aging is associated with changes in the metabolic pathways. Leukocyte telomere length (LTL) is a predictive marker of biological aging; however, the underlying metabolic pathways remain largely unknown. The aim of this study was to investigate the metabolic alterations and identify the metabolic predictors of LTL in elite male soccer players.Methods: Levels of 837 blood metabolites and LTL were measured in 126 young elite male soccer players who tested negative for doping abuse at anti-doping laboratory in Italy. Multivariate analysis using orthogonal partial least squares (OPLS), univariate linear models and enrichment analyses were conducted to identify metabolites and metabolic pathways associated with LTL. Generalized linear model followed by receiver operating characteristic (ROC) analysis were conducted to identify top metabolites predictive of LTL.Results: Sixty-seven metabolites and seven metabolic pathways showed significant associations with LTL. Among enriched pathways, lysophospholipids, benzoate metabolites, and glycine/serine/threonine metabolites were elevated with longer LTL. Conversely, monoacylglycerols, sphingolipid metabolites, long chain fatty acids and polyunsaturated fatty acids were enriched with shorter telomeres. ROC analysis revealed eight metabolites that best predict LTL, including glutamine, N-acetylglutamine, xanthine, beta-sitosterol, N2-acetyllysine, stearoyl-arachidonoyl-glycerol (18:0/20:4), N-acetylserine and 3-7-dimethylurate with AUC of 0.75 (0.64–0.87, p &lt; 0.0001).Conclusion: This study characterized the metabolic activity in relation to telomere length in elite soccer players. Investigating the functional relevance of these associations could provide a better understanding of exercise physiology and pathophysiology of elite athletes.

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