The Pharmacotherapy of Target Symptoms Associated with Autistic Disorder and Other Pervasive Developmental Disorders

2000 ◽  
Vol 8 (2) ◽  
pp. 45-63 ◽  
Author(s):  
D. J. Posey
Keyword(s):  
Autistic Disorder ◽  
Pervasive Developmental Disorders ◽  
Developmental Disorders

Autistic disorder versus other pervasive developmental disorders in young children: same or different?

2001 ◽  
Vol 10 (1) ◽  
pp. 67-78 ◽  
Author(s):  
D. A. Allen ◽  
M. Steinberg ◽  
M. Dunn ◽  
D. Fein ◽  
C. Feinstein ◽  
...  
Keyword(s):  
Young Children ◽  
Autistic Disorder ◽  
Pervasive Developmental Disorders ◽  
Developmental Disorders

Pervasive Developmental Disorders Rating Scale: Development and Construct Validity

2005 ◽  
Vol 97 (1) ◽  
pp. 245-257
Author(s):  
Thomas O. Williams ◽  
Ronald C. Eaves
Keyword(s):  
Factor Analysis ◽  
Confirmatory Factor Analysis ◽  
Construct Validity ◽  
Autistic Disorder ◽  
Pervasive Developmental Disorders ◽  
Developmental Disorders ◽  
Rating Scale ◽  
Factor Model ◽  
Confirmatory Factor ◽  
Competing Models

The Pervasive Developmental Disorders Rating Scale was designed for use in screening of pervasive developmental disorders. This paper describes the rationale and development of the scale and assesses its construct validity with ratings from a sample of 362 children ranging in age from 1 to 12 years and diagnosed with autistic disorder. The hypothesized heirarchical factor model and two competing models were examined through confirmatory factor analysis. The analysis supported the factor structure of the hypothesized model in this particular sample of children with autistic disorder. Limitations and areas for research are discussed.

Study of the Relationship Between Tuberous Sclerosis Complex and Autistic Disorder

2006 ◽  
Vol 21 (3) ◽  
pp. 199-204 ◽  
Author(s):  
Virginia Wong
Keyword(s):  
Hong Kong ◽  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Autistic Disorder ◽  
Pervasive Developmental Disorders ◽  
Developmental Disorders ◽  
Eastern Region ◽  
Behavioral Phenotypes ◽  
Female Ratio ◽  
Male To Female

There has been increasing awareness that there are behavioral phenotypes in tuberous sclerosis complex with neuropsychiatric symptom complex such as autistic disorder and attention-deficit hyperactivity disorder (ADHD). However, the neurobiologic basis of autistic disorder in tuberous sclerosis complex is still unknown. We studied two cohorts of children followed up since 1986 until 2003, one cohort with tuberous sclerosis complex and another cohort with autistic disorder, to determine the incidence of autistic disorder in tuberous sclerosis complex and the incidence of tuberous sclerosis complex in autistic disorder respectively. We established a Tuberous Sclerosis Complex Registry in 1985 at the University of Hong Kong. In 2004, 44 index cases (the male to female ratio was 0.75:1) were registered. Three had a positive family history of tuberous sclerosis complex. Thus, the total number of tuberous sclerosis complex cases was 47. We adopted the diagnostic criteria of tuberous sclerosis complex for case ascertainment. The period prevalence rate of tuberous sclerosis complex for children and adolescents aged < 20 years is 3.5 per 10,000 (on Hong Kong island, excluding the eastern region with 125,100 aged < 20 years in 2003). Of 44 cases with tuberous sclerosis complex, 7 had autistic disorder. Thus, the incidence of autistic disorder in tuberous sclerosis complex is 16%. During the 17-year period (1986—2003), we collected a database of 753 children (668 boys and 84 girls; male to female ratio 8:1) with autistic disorder and pervasive developmental disorders. For all children with autistic disorder or pervasive developmental disorders, we routinely examined for any features of tuberous sclerosis complex by looking for neurocutaneous markers such as depigmented spots, which appear in 50% of children with tuberous sclerosis complex by the age of 2 years. For those with infantile spasm or epilepsy, the clinical features of tuberous sclerosis complex were monitored regularly during follow-up. Of these, seven had tuberous sclerosis complex. Thus, the incidence of tuberous sclerosis complex in autistic disorder is 0.9%. All of these children are mentally retarded, with moderate to severe grades in an intellectual assessment conducted by a clinical psychologist. Future studies should be directed toward looking at the various behavioral phenotypes in tuberous sclerosis complex and defining these with standardized criteria to look for any real association with the underlying genetic mutation of TSC1 or TSC2 gene or even the site of tubers in the brain. ( J Child Neurol 2006;21:199—204; DOI 10.2310/7010.2006.00046).

scholarly journals Psychosocial Care Centers and the profile of pervasive developmental disorder cases in Brazil, 2014-2017

2021 ◽  
Vol 31 (2) ◽  
Author(s):  
Jeane Tomazelli ◽  
Conceição Fernandes
Keyword(s):  
Information System ◽  
Pervasive Developmental Disorder ◽  
Autistic Disorder ◽  
Pervasive Developmental Disorders ◽  
Developmental Disorders ◽  
Developmental Disorder ◽  
Psychosocial Care ◽  
Age Group ◽  
Communicative Practices ◽  
Unified Health System

Abstract The study describes the profile of children and adolescents with pervasive developmental disorders (PDD) attended at the Psychosocial Care Centers (CAPS) and professionals from these establishments in Brazil and regions. It uses data from the Outpatient Information System of the Unified Health System (SIA/SUS) and the National System of Health Establishments System (SCNES) in 2014-2017. The SIA/SUS was deterministically linked with the SCNES, based on the establishment number. PDD cases were individualized using a variable coded SUS card; 18,852 diagnoses of PDD were recorded in CAPS, most of them by spontaneous demand, 73.2% performed in CAPSi, 50.3% in the age group of 1-6 years old, 80% male and highest proportions of females over 13 years (p <0.001). PDD was not specified in 54.3% of the diagnoses; autistic disorder was the most common PDD (27.2%). Professional teams vary by CAPS type; Procedures of communicative practices and psychosocial rehabilitation were not expressive (10.3%). It was concluded that studies are necessary to clarify a high spontaneous demand, to understand treatment outside CAPSi and to define parameters to evaluate if the procedures used are appropriated for the therapeutic project and possibilities monitoring and evaluate the care of people with PDD.

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