O-077 Cancer risk in a nationwide cohort of children and young adults conceived by assisted reproductive technology in 1983-2012

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
M Spaan ◽  
M Goddijn ◽  
T Roseboom ◽  
C Lambalk ◽  
F Van Leeuwen
Keyword(s):  
General Population ◽  
Cancer Risk ◽  
The Netherlands ◽  
Assisted Reproductive Technology ◽  
Health Risks ◽  
Reproductive Technology ◽  
Cancer Risks ◽  
Maternal Risk ◽  
Specific Cancer

Abstract Study question Are children conceived by assisted reproductive technology (ART) at increased cancer risk, compared with the general population and with non-ART conceived offspring from subfertile women? Summary answer Overall cancer risk was not increased in ART-conceived offspring compared with non-ART conceived offspring from subfertile women (median follow-up, 17 years). What is known already There is growing evidence that ART procedures could perturb epigenetic processes during the pre-implantation period. Although the results of most studies are reassuring for children born after in vitro fertilization (IVF), recent studies showed (non-)significantly increased cancer risks after intracytoplasmic sperm injection (ICSI) and frozen embryo transfer (FET). Since the proportion of children born after these techniques increased dramatically over the past decades, it is important from a public health perspective to investigate cancer risk after ICSI and FET in larger studies. Study design, size, duration Data were used from the OMEGA-cohort, a historical nationwide cohort with prospective follow-up in the Netherlands. Offspring of women who were treated in one of the 13 IVF clinics or 2 regional fertility centers between 1983-2012 were included. Of 98,165 live-born children, 53,154 were ART-conceived and 45,211 were non-ART conceived (conceived naturally with or without ovarian hyperstimulation) by subfertile women. Participants/materials, setting, methods Data on type of fertility treatment and maternal risk factors were available from medical records from the mothers and the Dutch Perinatal registry. Cancer incidence was ascertained through linkage with the Netherlands Cancer Registry. Cancer risk in ART-conceived children was compared with risk in children not conceived by ART from subfertile women (hazard ratios [HRs]) and with children from the general population (standardized incidence ratios [SIRs]). Main results and the role of chance The median age at end of follow-up was 17 years and was shorter in ART-conceived children (16.1 years) compared with non-ART children (19.1 years). In total, 382 cancers were observed, 166 in the ART group and 222 in the non-ART group. In preliminary analyses, overall cancer risk was not increased in ART-conceived children, neither compared with children not conceived by ART from subfertile women (HR:0.98, 95% confidence interval (CI) = 0.79-1.22) nor compared with the general population (SIR:0.98, 95% CI = 0.81-1.11). Risks were also not significantly increased in children conceived by ICSI or FET (HR:1.20, 95%CI = 0.85-1.70; 1.25, 95%CI = 0.68-2.43, respectively). From 18 years of age onwards, the HR of cancer in ART-conceived versus non-ART individuals was 1.22 (95%CI = 0.86-1.74). There were no significantly increased site-specific cancer risks in ART-conceived children compared with non-ART children and the general population. Risk of lymphoblastic leukaemia was not increased in the ART group compared with the non-ART group (HR: 1.03, 95% CI = 0.58-1.82). Limitations, reasons for caution Despite the large cohort and long-term follow-up the number of cancer cases was limited which hampered some subgroup analyses, especially for analyses according to specific cancer types and children born after FET. Wider implications of the findings The results from this study importantly contribute to the current knowledge about health risks in ART-offspring. Physicians may inform parents who consider ART about potential health risks for ART-conceived children. Furthermore, pediatric oncologists caring for ART-conceived children/adolescents with cancer need evidence-based information about the association between ART and cancer risk. Trial registration number n.a.

scholarly journals Albuminuria, Kidney Function, and Cancer Risk in the Community

2020 ◽  
Vol 189 (9) ◽  
pp. 942-950
Author(s):  
Yejin Mok ◽  
Shoshana H Ballew ◽  
Yingying Sang ◽  
Josef Coresh ◽  
Corinne E Joshu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Kidney Disease ◽  
Cancer Risk ◽  
Cancer Incidence ◽  
Prostate Cancer Screening ◽  
Sensitivity Analyses ◽  
Site Specific ◽  
Specific Cancer ◽  
Shared Risk

Abstract Few studies have comprehensively investigated the association of 2 key kidney disease measures, estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (ACR), with cancer incidence. In 8,935 participants at the baseline (1996–1998) from the Atherosclerosis Risk in Communities study, we quantified the associations of eGFR (based on creatinine and cystatin C) and ACR with cancer risk using Cox regression models adjusted for potential confounders. Due to changing guidelines for prostate cancer screening during the follow-up period, we investigated overall cancer, overall nonprostate cancer, and site-specific cancer. During a median follow-up of 14.7 years, 2,030 incident cancer cases occurred. In demographically adjusted models, low eGFR and high ACR were associated with cancer incidence (both overall and overall nonprostate cancer). These associations were attenuated after adjusting for other shared risk factors, with a significant association remaining only for ACR (≥103 compared with 5 mg/g) and overall nonprostate cancer. For site-specific cancer, only high ACR showed a significant association with lung and urinary tract cancers. Of these, the association between ACR and lung cancer appeared most robust in several sensitivity analyses. Kidney disease measures, particularly high ACR, were independently associated with cancer risk. The association between ACR and lung cancer was uniquely robust, warranting future studies to explore potential mechanisms.

scholarly journals Cancer risk among parous women following assisted reproductive technology

2015 ◽  
Vol 30 (8) ◽  
pp. 1952-1963 ◽  
Author(s):  
M.M. Reigstad ◽  
I.K. Larsen ◽  
T.Å. Myklebust ◽  
T.E. Robsahm ◽  
N.B. Oldereid ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Assisted Reproductive Technology ◽  
Reproductive Technology

scholarly journals Cancer potencies and margin of exposure used for comparative risk assessment of heated tobacco products and electronic cigarettes aerosols with cigarette smoke

2020 ◽  
Author(s):  
Gregory Rodrigo ◽  
Guy Jaccard ◽  
Donatien Tafin Djoko ◽  
Alexandra Korneliou ◽  
Marco Esposito ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Health Risks ◽  
Electronic Cigarettes ◽  
Epidemiological Data ◽  
Cancer Risks ◽  
Predictive Tool ◽  
Potential Health ◽  
Tobacco Products ◽  
Margin Of Exposure

Abstract Health risk associated with the use of combustible cigarettes is well characterized and numerous epidemiological studies have been published for many years. Since more than a decade, innovative non-combusted tobacco products have emerged like heated tobacco products (HTP) or electronic cigarettes (EC). Long-term effects of these new products on health remain, however, unknown and there is a need to characterize associated potential health risks. The time dedicated to epidemiological data generation (at least 20 to 40 years for cancer endpoint), though, is not compatible with innovative development. Surrogates need, therefore, to be developed. In this work, non-cancer and cancer risks were estimated in a range of HTP and commercial combustible cigarettes based upon their harmful and potentially harmful constituent yields in aerosols and smoke, respectively. It appears that mean lifetime cancer risk values were decreased by more than one order of magnitude when comparing HTPs and commercial cigarettes, and significantly higher margin of exposure for non-cancer risk was observed for HTPs when compared to commercial cigarettes. The same approach was applied to two commercial ECs. Similar results were also found for this category of products. Despite uncertainties related to the factors used for the calculations and methodological limitations, this approach is valuable to estimate health risks associated to the use of innovative products. Moreover, it acts as predictive tool in absence of long-term epidemiological data. Furthermore, both cancer and non-cancer risks estimated for HTPs and ECs highlight the potential of reduced risk for non-combusted products when compared to cigarette smoking.

Night work and breast cancer risk in a general population prospective cohort study in The Netherlands

2014 ◽  
Vol 29 (8) ◽  
pp. 577-584 ◽  
Author(s):  
Lando L. J. Koppes ◽  
Goedele A. Geuskens ◽  
Anjoeka Pronk ◽  
Roel C. H. Vermeulen ◽  
Ernest M. M. de Vroome
Keyword(s):  
Breast Cancer ◽  
Cohort Study ◽  
Breast Cancer Risk ◽  
General Population ◽  
Cancer Risk ◽  
The Netherlands ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Night Work

scholarly journals Cancer risk after total hip replacements. A prospective study of 41,402 patients in the Norwegian Arthroplasty Register linked to the Cancer Registry of Norway

2020 ◽  
Author(s):  
Eva Dybvik ◽  
Ove Furnes ◽  
Leif I. Havelin ◽  
Sophie D. Fosså ◽  
Clement Trovik ◽  
...  
Keyword(s):  
General Population ◽  
Cancer Risk ◽  
Cancer Registry ◽  
Arthroplasty Register ◽  
Total Hip ◽  
Total Hip Replacements ◽  
Hip Replacements ◽  
Risk Of Cancer ◽  
Norwegian Arthroplasty Register

Abstract Background Concerns have been raised that implants used in total hip replacements (THR) could lead to a future increased cancer risk. Several different materials and metals are used in joint prosthesis, as well as different fixation techniques and types of articulation for the surface of the joint can lead to an increased escape of particles or ions into the human body. Methods Patients with THR registered in the Norwegian Arthroplasty Register during 1987-2009 were linked to the Cancer registry of Norway. Patients with THR due to osteoarthritis, under the age of 75 at time of surgery, were included. Standardized incidence ratios (SIR) were applied to compare cancer risk for THR patients to the general population. Types of THR were divided into cemented (both components), uncemented (both components), and hybrid (cemented femoral and uncemented acetabular component). To account for selection mechanisms, time dependent covariates were applied in Cox-regression, adjusting for cancer risk the first 10 years after surgery. The analyses were adjusted for age, gender, and if the patient had additional THR-surgery in the same or the opposite hip. The study is according to the STROBE guidelines.Results When comparing patients with THR to the general population in Norway we found no differences in the risk. The overall SIR for the THR-patients after 10 years of follow-up was 1.02 (95% CI: 0.97-1.07). For cemented THR, the SIR after 10 years of follow-up was 0.99 (95% CI: 0.94-1.05), while it was 1.16 (95% CI: 1.02-1.30) for uncemented THRs, and 1.12 (95% CI: 0.91-1.33) for hybrid THRs. Adjusted Cox analyses showed that patients with uncemented THRs had an elevated risk of cancer (hazard ratio: HR=1.24, 95% CI: 1.05-1.46, p=0.009) when compared to patients with cemented THRs after 10 years of follow-up. The risk for patients with hybrid THRs was not significantly increased (HR=1.07, 95% CI: 0.85-1.35, p=0.55) compared to patients with cemented THRs. Conclusions We found that receiving an uncemented THR was associated with a small increased risk of cancer, in particular prostate cancer for younger men.

scholarly journals MicroSort® sperm sorting causes no increase in major malformation rate

2016 ◽  
Vol 28 (10) ◽  
pp. 1580
Author(s):  
Donald P. Marazzo ◽  
David Karabinus ◽  
Lawrence A. Johnson ◽  
Joseph D. Schulman
Keyword(s):  
General Population ◽  
Assisted Reproductive Technology ◽  
Intracytoplasmic Sperm Injection ◽  
Pregnancy Outcomes ◽  
Intrauterine Insemination ◽  
Reproductive Technology ◽  
Major Malformation ◽  
Sperm Sorting ◽  
Technology Control ◽  
Record Review

The purpose of the present study was to evaluate the safety of MicroSort (MicroSort Division, GIVF, Fairfax, VA, USA) sperm sorting by monitoring major malformations in infants and fetuses conceived using sorted spermatozoa. Data were collected in a prospective protocol with monitoring that began from conception through birth until 1 year of life. Comprehensive ascertainment identified fetuses and stillbirths with malformations after 16 weeks gestation, pregnancies terminated for malformations and babies with major malformations. Outcomes in MicroSort pregnancies were compared with outcomes in published studies that used active and comprehensive ascertainment of malformations in the general population and in pregnancies established after assisted reproduction. Using comprehensive outcomes from all pregnancies, the rate of major malformations in MicroSort pregnancies conceived after IVF with or without intracytoplasmic sperm injection was 7.8%; this did not differ significantly from the rates reported in the three assisted reproductive technology control studies not associated with MicroSort (8.6%, 9.2% and 8.3%). Similarly, the rate of major malformations in MicroSort pregnancies initiated with intrauterine insemination was 6.0%, not significantly different from that reported in non-assisted reproductive technology pregnancies not associated with MicroSort (6.9%, 4.6% and 5.7%). Prospective record review of pregnancy outcomes and paediatric evaluation to 1 year indicate no association between MicroSort sperm sorting and major malformations.

scholarly journals Cancer risk after total hip replacements. A prospective study of 41,402 patients in the Norwegian Arthroplasty Register linked to the Cancer Registry of Norway

2020 ◽  
Author(s):  
Eva Dybvik ◽  
Ove Furnes ◽  
Leif I. Havelin ◽  
Sophie D. Fosså ◽  
Clement Trovik ◽  
...  
Keyword(s):  
General Population ◽  
Cancer Risk ◽  
Cancer Registry ◽  
Arthroplasty Register ◽  
Total Hip ◽  
Total Hip Replacements ◽  
Increased Risk ◽  
Hip Replacements ◽  
Norwegian Arthroplasty Register

Abstract Background: Concerns have been raised that implants used in total hip replacements (THR) could lead to increased cancer risk. Several different materials, metals and fixation techniques are used in joint prostheses and different types of articulation can cause an increased invasion of particles or ions into the human body. Methods: Patients with THR registered in the Norwegian Arthroplasty Register during 1987-2009 were linked to the Cancer registry of Norway. Patients with THR due to osteoarthritis, under the age of 75 at time of surgery, were included. Standardized incidence ratios (SIR) were applied to compare cancer risk for THR patients to the general population. Types of THR were divided into cemented (both components), uncemented (both components), and hybrid (cemented femoral and uncemented acetabular components). To account for selection mechanisms, time dependent covariates were applied in Cox-regression, adjusting for cancer risk the first 10 years after surgery. The analyses were adjusted for age, gender and if the patient had additional THR-surgery in the same or the opposite hip. The study follows the STROBE guidelines.Results: Comparing patients with THR to the general population in Norway we found no differences in cancer risk. The overall SIR for the THR-patients after 10 years follow-up was 1.02 (95% CI: 0.97-1.07). For cemented THR, the SIR after 10 years follow-up was 0.99 (95% CI: 0.94-1.05), for uncemented, 1.16 (95% CI: 1.02-1.30), and for hybrid 1.12 (95% CI: 0.91-1.33). Adjusted Cox analyses showed that patients with uncemented THRs had an elevated risk for cancer (hazard ratio: HR=1.24, 95% CI: 1.05-1.46, p=0.009) when compared to patients with cemented THRs after 10 years follow-up. Stratified by gender the increased risk was only present for men. The risk for patients with hybrid THRs was not significantly increased (HR=1.07, 95% CI: 0.85-1.35, p=0.55) compared to patients with cemented THRs.Conclusions: THR patients had no increased risk for cancer compared to the general population. We found, however, that receiving an uncemented THR was associated with a small increased risk for cancer compared to cemented THR in males, but that this may be prone to unmeasured confounding.

scholarly journals A prospective study on cancer risk after total hip replacements for 41,402 patients linked to the Cancer registry of Norway

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Eva Dybvik ◽  
Ove Furnes ◽  
Leif I. Havelin ◽  
Sophie D. Fosså ◽  
Clement Trovik ◽  
...  
Keyword(s):  
General Population ◽  
Cancer Risk ◽  
Cancer Registry ◽  
Cox Regression ◽  
Total Hip ◽  
Total Hip Replacements ◽  
Increased Risk ◽  
Hip Replacements ◽  
Joint Prostheses

Abstract Background Concerns have been raised that implants used in total hip replacements (THR) could lead to increased cancer risk. Several different materials, metals and fixation techniques are used in joint prostheses and different types of articulation can cause an increased invasion of particles or ions into the human body. Methods Patients with THR registered in the Norwegian Arthroplasty Register during 1987–2009 were linked to the Cancer registry of Norway. Patients with THR due to osteoarthritis, under the age of 75 at time of surgery, were included. Standardized incidence ratios (SIR) were applied to compare cancer risk for THR patients to the general population. Types of THR were divided into cemented (both components), uncemented (both components), and hybrid (cemented femoral and uncemented acetabular components). To account for selection mechanisms, time dependent covariates were applied in Cox-regression, adjusting for cancer risk the first 10 years after surgery. The analyses were adjusted for age, gender and if the patient had additional THR-surgery in the same or the opposite hip. The study follows the STROBE guidelines. Results Comparing patients with THR to the general population in Norway we found no differences in cancer risk. The overall SIR for the THR-patients after 10 years follow-up was 1.02 (95% CI: 0.97–1.07). For cemented THR, the SIR after 10 years follow-up was 0.99 (95% CI: 0.94–1.05), for uncemented, 1.16 (95% CI: 1.02–1.30), and for hybrid 1.12 (95% CI: 0.91–1.33). Adjusted Cox analyses showed that patients with uncemented THRs had an elevated risk for cancer (hazard ratio: HR = 1.24, 95% CI: 1.05–1.46, p = 0.009) when compared to patients with cemented THRs after 10 years follow-up. Stratified by gender the increased risk was only present for men. The risk for patients with hybrid THRs was not significantly increased (HR = 1.07, 95% CI: 0.85–1.35, p = 0.55) compared to patients with cemented THRs. Conclusions THR patients had no increased risk for cancer compared to the general population. We found, however, that receiving an uncemented THR was associated with a small increased risk for cancer compared to cemented THR in males, but that this may be prone to unmeasured confounding.

Sign in / Sign up

Export Citation Format

Share Document