scholarly journals Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case-control study

2004 ◽  
Vol 19 (7) ◽  
pp. 1644-1646 ◽  
Author(s):  
H. Lashen
2013 ◽  
Vol 15 (7) ◽  
pp. 787-794 ◽  
Author(s):  
Kuan-Yi Wu ◽  
Chia-Ming Chang ◽  
Hsin-Yi Liang ◽  
Chi-Shin Wu ◽  
Erin Chia-Hsuan Wu ◽  
...  

2021 ◽  
Author(s):  
Jiayi Zhang ◽  
Gang Wu ◽  
Hailong Zhu ◽  
Fengyuan Yang ◽  
Shuman Yang ◽  
...  

Abstract Background: The existing epidemiologic studies on the association between carnitine and breast cancer development are scarce. This study examined the association between circulating carnitine levels and breast cancer in females.Methods: This 1:1 age-matched case-control study identified 991 female breast cancer cases and 991 female controls without breast cancer. All cases and controls were confirmed with a pathological test. We measured 16 types of whole blood carnitine levels, such as free carnitine (C0) and octadecanoylcarnitine (C18), using targeted metabolomic technology. Results: The average age for cases and controls were 50.0 years (SD: 8.7 years) and 49.5 years (SD: 8.7 years), respectively. After adjusting for covariates, each SD increase in malonylcarnitine (C3DC; OR 0.91; 95% CI 0.83-1.00), decenoylcarnitine (C10:1; OR 0.87; 95% CI 0.79-0.96) and decadienoylcarnitine (C10:2; OR 0.90; 95% CI 0.82-0.99) level was associated with decreased odds of breast cancer. However, higher butyrylcarnitine (C4) levels were associated with increased risk of breast cancer (OR 1.12; 95% CI 1.02-1.23). We observed no relationship between other carnitines with breast cancer. The false discovery rates for C3DC, C4, C10:1 and C10:2 were 0.172, 0.120, 0.064 and 0.139, respectively. Conclusions: Higher levels of C3DC, C10:1, and C10:2 were protective factors for breast cancer, whereas increased C4 levels were a risk factor for breast cancer.


2013 ◽  
Vol 42 (5) ◽  
pp. 585-589 ◽  
Author(s):  
Y. Sana ◽  
A. Appiah ◽  
A. Davison ◽  
K. H. Nicolaides ◽  
J. Johns ◽  
...  

2010 ◽  
Vol 36 (2) ◽  
pp. 130-134 ◽  
Author(s):  
H. E. Mccarthy ◽  
N. P. French ◽  
G. B. Edwards ◽  
K. Miller ◽  
C. J. Proudman

BMJ Open ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. e023776 ◽  
Author(s):  
Aaron Mark Drucker ◽  
Deva Thiruchelvam ◽  
Donald A Redelmeier

ObjectiveTo assess the association of eczema with a patient’s subsequent risk of death from suicide. We hypothesised that persistent eczema would be associated with an increased risk for death from suicide.DesignDouble matched case–control study.SettingGeneral population of Ontario, Canada.ParticipantsPatients 15–55 years old. We identified cases of suicide from coroners’ reports between 1 January 1994 and 31 December 2014 and matched 1:2 with alive controls based on age, sex and socioeconomic status.ExposureThe primary predictor was a history of persistent eczema, defined as five or more physician visits for the diagnosis over the preceding 5 years.Main outcome and measureLogistic regression to estimate the association between eczema and death from suicide.ResultsWe identified 18 441 cases of suicide matched to 36 882 controls over the 21-year accrual period. Persistent eczema occurred in 174 (0.94%) suicide cases and 285 (0.77%) controls yielding a 22% increased risk of suicide associated with persistent eczema (OR 1.22, 95% CI 1.01 to 1.48, p=0.037). In mediation analyses, this association was largely explained through major suicide risk factors. Two-thirds of patients with eczema who died from suicide had visited a physician in the month before their death and one in eight had visited for eczema in the month before their death. Among patients who died by suicide, jumping and poisoning were relatively more frequent mechanisms among patients with eczema.ConclusionsPatients with persistent eczema have a modestly increased subsequent risk of death from suicide, but this is not independent of overall mental health and the absolute risk is low. Physicians caring for these patients have opportunities to intervene for suicide prevention.


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