930Development and feasibility of a mHealth supported Comprehensive Intervention Model (“CIMmH”) for esophageal cancer patients

Abstract Background Esophageal cancer patients often experience a clinically relevant deterioration of quality of life (QoL) after esophagectomy due to malnutrition, lack of physical exercise, and psychological problems. This study aims to evaluate the feasibility and efficacy of a comprehensive intervention model using the mHealth system (CIMmH) on the mobile platform that offers accessible nutritional, exercise, and psychosocial support to esophageal cancer patients after esophagectomy. Methods Twenty esophageal cancer patients were invited to join the CIMmH for 12 weeks. The CIMmH included an online component and an offline consultation component. The participants were assessed before surgery and at 1-month and 3-month intervals after esophagectomy. QoL, depressive symptoms, anxiety, stress, nutrition, and physical fitness were measured. Results Sixteen out of 20 (80%) completed the program. One month after esophagectomy, the global health scale significantly decreased while fatigue, pain, and dyspnea increased. At the 3-month follow-up, only pain, difficulty with eating, dry mouth and trouble with talking were significantly worse than the baseline. All other dimensions in the QoL returned to the preoperative level. Weight and BMI were reduced throughout the study and no significant changes were observed in physical fitness. Depressive symptoms significantly increased one month after surgery. Conclusions The CIMmH had good feasibility and demonstrated encouraging preliminary efficacy for enhancing recovery after surgery among esophageal cancer patients in China. Key messages Esophageal cancer, Quality of life, Nutrition, Physical exercise, Psychological support, Mobile Health (mHealth)

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Development and Feasibility of a Mobile Health–Supported Comprehensive Intervention Model (CIMmH) for Improving the Quality of Life of Patients With Esophageal Cancer After Esophagectomy: Prospective, Single-Arm, Nonrandomized Pilot Study (Preprint)

10.2196/preprints.18946 ◽

2020 ◽

Author(s):

Chao Cheng ◽

Rainbow Tin Hung Ho ◽

Yan Guo ◽

Mengting Zhu ◽

Weixiong Yang ◽

...

Keyword(s):

Quality Of Life ◽

Esophageal Cancer ◽

Depressive Symptoms ◽

Physical Fitness ◽

Mobile Health ◽

Control Group ◽

Intervention Model ◽

Comprehensive Intervention

BACKGROUND Patients with esophageal cancer often experience clinically relevant deterioration of quality of life (QOL) after esophagectomy owing to malnutrition, lack of physical exercise, and psychological symptoms. OBJECTIVE This study aimed to evaluate the feasibility, safety, and efficacy of a comprehensive intervention model using a mobile health system (CIMmH) in patients with esophageal cancer after esophagectomy. METHODS Twenty patients with esophageal cancer undergoing the modified McKeown surgical procedure were invited to join the CIMmH program with both online and offline components for 12 weeks. The participants were assessed before surgery and again at 1 and 3 months after esophagectomy. QOL, depressive symptoms, anxiety, stress, nutrition, and physical fitness were measured. RESULTS Of the 20 patients, 16 (80%) completed the program. One month after esophagectomy, patients showed significant deterioration in overall QOL (P=.02), eating (P=.005), reflux (P=.04), and trouble with talking (P<.001). At the 3-month follow-up, except for pain (P=.02), difficulty with eating (P=.03), dry mouth (P=.04), and trouble with talking (P=.003), all other QOL dimensions returned to the preoperative level. There were significant reductions in weight (P<.001) and BMI (P=.02) throughout the study, and no significant changes were observed for physical fitness measured by change in the 6-minute walk distance between baseline and the 1-month follow-up (P=.22) or between baseline and the 3-month follow-up (P=.52). Depressive symptoms significantly increased 1 month after surgery (P<.001), while other psychological measures did not show relevant changes. Although there were declines in many measures 1 month after surgery, these were much improved at the 3-month follow-up, and the recovery was more profound and faster than with traditional rehabilitation programs. CONCLUSIONS The CIMmH was feasible and safe and demonstrated encouraging efficacy testing with a control group for enhancing recovery after surgery among patients with esophageal cancer in China. CLINICALTRIAL Chinese Clinical Trial Registry (ChiCTR-IPR-1800019900); http://www.chictr.org.cn/showprojen.aspx?proj=32811.

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Development and Feasibility of a Mobile Health–Supported Comprehensive Intervention Model (CIMmH) for Improving the Quality of Life of Patients With Esophageal Cancer After Esophagectomy: Prospective, Single-Arm, Nonrandomized Pilot Study

Journal of Medical Internet Research ◽

10.2196/18946 ◽

2020 ◽

Vol 22 (8) ◽

pp. e18946

Author(s):

Chao Cheng ◽

Rainbow Tin Hung Ho ◽

Yan Guo ◽

Mengting Zhu ◽

Weixiong Yang ◽

...

Keyword(s):

Quality Of Life ◽

Esophageal Cancer ◽

Depressive Symptoms ◽

Physical Fitness ◽

Mobile Health ◽

Control Group ◽

Intervention Model ◽

Comprehensive Intervention

Background Patients with esophageal cancer often experience clinically relevant deterioration of quality of life (QOL) after esophagectomy owing to malnutrition, lack of physical exercise, and psychological symptoms. Objective This study aimed to evaluate the feasibility, safety, and efficacy of a comprehensive intervention model using a mobile health system (CIMmH) in patients with esophageal cancer after esophagectomy. Methods Twenty patients with esophageal cancer undergoing the modified McKeown surgical procedure were invited to join the CIMmH program with both online and offline components for 12 weeks. The participants were assessed before surgery and again at 1 and 3 months after esophagectomy. QOL, depressive symptoms, anxiety, stress, nutrition, and physical fitness were measured. Results Of the 20 patients, 16 (80%) completed the program. One month after esophagectomy, patients showed significant deterioration in overall QOL (P=.02), eating (P=.005), reflux (P=.04), and trouble with talking (P<.001). At the 3-month follow-up, except for pain (P=.02), difficulty with eating (P=.03), dry mouth (P=.04), and trouble with talking (P=.003), all other QOL dimensions returned to the preoperative level. There were significant reductions in weight (P<.001) and BMI (P=.02) throughout the study, and no significant changes were observed for physical fitness measured by change in the 6-minute walk distance between baseline and the 1-month follow-up (P=.22) or between baseline and the 3-month follow-up (P=.52). Depressive symptoms significantly increased 1 month after surgery (P<.001), while other psychological measures did not show relevant changes. Although there were declines in many measures 1 month after surgery, these were much improved at the 3-month follow-up, and the recovery was more profound and faster than with traditional rehabilitation programs. Conclusions The CIMmH was feasible and safe and demonstrated encouraging efficacy testing with a control group for enhancing recovery after surgery among patients with esophageal cancer in China. Trial Registration Chinese Clinical Trial Registry (ChiCTR-IPR-1800019900); http://www.chictr.org.cn/showprojen.aspx?proj=32811.

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1511CIMmH, an mHealth Comprehensive Intervention Model for esophageal cancer patients: A Multi-center RCT Protocol

International Journal of Epidemiology ◽

10.1093/ije/dyab168.724 ◽

2021 ◽

Vol 50 (Supplement_1) ◽

Author(s):

He Xu ◽

Yan Guo ◽

Yu Zeng ◽

Yiran Li ◽

Mengting Zhu

Keyword(s):

Esophageal Cancer ◽

Physical Exercise ◽

Cancer Patients ◽

Intervention Group ◽

Psychological Support ◽

Walking Distance ◽

Control Group ◽

Intervention Model ◽

Potential Cost ◽

Comprehensive Intervention

Abstract Background Post-esophagectomy patients often experience a clinically relevant deterioration of quality of life after esophagectomy due to malnutrition, impaired exercise capacity, and psychological problems. The widespread use of mobile health (mHealth) has been increasingly promising for interdisciplinary healthcare givers to deliver efficient and potential cost-effective interventions in cancer patients. However, comprehensive interventions delivered by mHealth with a rigorous design of randomized controlled trial in post-esophagectomy patients were scarce. Methods This study developed the first comprehensive intervention model by mHealth with a parallel RCT design, providing nutrition, physical exercise, and psychological support for post-esophagectomy patients. A total of 120 patients will be randomized into the intervention group or the control group receiving treatment as usual. Participants in the intervention group will receive the 3-month intervention of the CIMmH program via the enhanced WeChat platform and by specialists (offline). The online program includes nutrition guidelines, physical exercise instructions, and psychological courses. All participants will be assessed at baseline, 1, and 3 months after esophagectomy. The primary outcomes are health-related QOL, weight, and physical fitness measured by 6-minute walking distance. Secondary outcomes include nutritional biomarkers, body composition, strength, interleukin-6, depressive symptoms, anxiety, and coping. Discussion This study is among the first efforts to innovatively develop a comprehensive intervention program to prompt rehabilitation in post-esophagectomy patients. Once proven effective, CIMmH could be integrated into the management of post-esophagectomy patients. Key messages Esophageal cancer, QOL, Nutrition, Physical exercise, Psychological support, mHealth

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QUALITY OF LIFE IN ESOPHAGEAL CANCER PATIENTS

Pearson's Thoracic and Esophageal Surgery ◽

10.1016/b978-0-443-06861-4.50214-8 ◽

2008 ◽

pp. 663-674

Author(s):

Mark I. van Berge Henegouwen ◽

Mirjam Locadia ◽

Mirjam A.G. Sprangers ◽

Jan J.B. van Lanschot

Keyword(s):

Quality Of Life ◽

Esophageal Cancer ◽

Cancer Patients

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Depressive Symptoms among Cancer Patients in a Philippine Tertiary Hospital: Prevalence, Factors, and Influence on Health-Related Quality of Life

Journal of Palliative Medicine ◽

10.1089/jpm.2013.0022 ◽

2013 ◽

Vol 16 (10) ◽

pp. 1280-1284 ◽

Cited By ~ 6

Author(s):

Jocelyn C. Que ◽

Teresa T. Sy Ortin ◽

Karen O. Anderson ◽

Consuelo B. Gonzalez-Suarez ◽

Thomas W. Feeley ◽

...

Keyword(s):

Quality Of Life ◽

Depressive Symptoms ◽

Cancer Patients ◽

Tertiary Hospital ◽

Health Related Quality ◽

Related Quality ◽

Health Related

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Characteristics of infertility specific quality of life in Hungarian couples

Orvosi Hetilap ◽

10.1556/oh.2014.29867 ◽

2014 ◽

Vol 155 (20) ◽

pp. 783-788 ◽

Cited By ~ 12

Author(s):

Réka Eszter Cserepes ◽

Tamás Kőrösi ◽

Antal Bugán

Keyword(s):

Quality Of Life ◽

Depressive Symptoms ◽

Couple Therapy ◽

Psychosocial Support ◽

Affective Responses ◽

Couple Relationship ◽

Men And Women ◽

Gender Comparison ◽

Depression Level

Introduction: Experiencing involuntary childlessness has a great impact on couples’ quality of life. Aim: The aim of the authors was to examine the intercorrelations among infertility specific quality of life and depression on the levels of individuals and couples. Method: 126 couples in five fertility centers in Hungary filled out the FertiQoL and Beck Depression Inventory and answered some sociodemographic questions. Results: In gender comparison, women reported about more depressive symptoms and poorer quality of life than men. Both in men and women, the higher depression level correlated with lower level of quality of life. Moreover, the presence of more depressive symptoms in women was related to men’s poorer quality of life. Conclusions: The results show that differences may exist in affective responses to infertility between women and men and that female affective problems take effects on the level of the couple relationship. These findings may be useful in psychosocial support of the couples facing infertility, especially in couple counselling or couple therapy. Orv. Hetil., 2014, 155(20), 783–788.

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Feasibility and efficacy of a supervised home-based physical exercise program for metastatic cancer patients receiving oral targeted therapy: study protocol for the phase II/III - UNICANCER SdS 01 QUALIOR trial

BMC Cancer ◽

10.1186/s12885-020-07381-4 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Florence Joly ◽

Claudia Lefeuvre-Plesse ◽

Claire Garnier-Tixidre ◽

Carole Helissey ◽

Nathalie Menneveau ◽

...

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Targeted Therapy ◽

Physical Exercise ◽

Cancer Patients ◽

Phase Ii ◽

Metastatic Cancer ◽

Activity Program ◽

Home Based

Abstract Background Currently, oral targeted therapies are known to be effective and are frequently used to treat metastatic cancer patients, but fatigue is a frequently reported early side effect of these treatments. This fatigue may impact the patient’s treatment adherence and result in a negative impact on quality of life. Physical exercise significantly improved the general well-being and quality of life of advanced cancer patients. However, there is no specific physical activity program adapted for patients with advanced disease. Methods QUALIOR is a two-part, randomized, open-label, and multicenter with two arms phase II/III trial. Patients (phase II: n = 120; phase III: n = 312) with metastatic cancer (breast cancer, kidney cancer, lung cancer, and other cancers [including but not limited to colon cancer, melanoma, sarcoma, or hepatocarcinoma]) treated with a first- or second-line oral targeted therapy without chemotherapy will be included. Patients will be randomized (2:1) to a 3-month supervised home-based standardized physical activity program or to a recommended adapted physical activity (via a booklet). The primary objective of the phase II is to evaluate the feasibility of the supervised program. The primary objective of the phase III is the evaluation of the benefit of the supervised home-based program compare to the recommended program in terms of fatigue and quality of life at 3 months. The secondary objectives aim to evaluate the impact of the supervised program on fatigue over time, pain, physical capacities, psychosocial and cognitive functions, general quality of life, frequency of dose reduction and patients’ adherence to the targeted therapy, overall survival, and progression-free survival. This study will also evaluate the medico-economic impact of supervised program compared to the recommended adapted physical activity program. Discussion The aim of this study is to evaluate home-based physical exercise program for metastatic cancer patients treated with oral targeted therapies to help patients to cope with fatigue and improve quality of life. Trial registration This trial was registered in ClinicalTrials.gov since May 2017 (NCT03169075).

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