Ornidazole and Anaerobic Bacteria: In Vitro Sensitivity and Effects on Wound Infections after Appendectomy

1979 ◽  
Vol 139 (5) ◽  
pp. 586-589 ◽  
Author(s):  
A. Palmu ◽  
O.-V. Renkonen ◽  
U. Aromaa
Keyword(s):  
Anaerobic Bacteria ◽  
Wound Infections ◽  
In Vitro Sensitivity

scholarly journals The comparative study of the bactericidal properties of laser and photodiode radiation in the violet region of the spectrum (405 nm) on the bacteria of the mouth cavity

2016 ◽  
Vol 15 (4) ◽  
pp. 202-206
Author(s):  
Aleksandr Viktorovich Lepilin ◽  
Yu. M Raigorodsky ◽  
D. A Grigor’eva ◽  
N. L Erokina ◽  
I. A Kas’yan ◽  
...  
Keyword(s):  
Power Density ◽  
Immune Responsiveness ◽  
Wound Infections ◽  
Bacteriostatic Effect ◽  
Postoperative Wound ◽  
Mouth Cavity ◽  
In Vitro Sensitivity ◽  
Bactericidal Properties ◽  
The Comparative Study

The ever increasing number of the patients presenting with postoperative wound infections and abscess is attributed by the majority of the authors to the significant changes in microflora, the impairment of therapeutic effectiveness of broad-spectrum antibiotics, and the reduction of the immune responsiveness. The present study has demonstrated that the microorganisms present in the mouth cavity show high in vitro sensitivity to laser radiation in the violet range of the spectrum. Specifically, irradiation at a distance of 3 cm from the treated surface and the time of exposure 5 minutes (at the power density 70 mW/cm2) produced a well apparent bacteriostatic effect whereas irradiation of a surface positioned 1 cm from the emitting source at the power density of 150 mW/cm2 caused complete eradication of the microorganisms.

In-vitro susceptibility of anaerobic bacteria to gar-936, a new glycylcycline

2000 ◽  
Vol 6 (3) ◽  
pp. 159-163 ◽  
Author(s):  
C. Edlund ◽  
C. E. Nord
Keyword(s):  
Anaerobic Bacteria ◽  
In Vitro Susceptibility

In Vitro Activity of New Quinolones against Anaerobic Bacteria

Drugs ◽  
1995 ◽  
Vol 49 (Supplement 2) ◽  
pp. 233-234
Author(s):  
Carl Erik Nord ◽  
Ann Lindmark ◽  
Ingela Persson
Keyword(s):  
Anaerobic Bacteria ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
New Quinolones

scholarly journals In Vitro Sensitivity to Antibiotics of Swedish Strains of Mycoplasma Gallisepticum

1965 ◽  
Vol 6 (1) ◽  
pp. 234-238
Author(s):  
Lena Silvén
Keyword(s):  
Mycoplasma Gallisepticum ◽  
In Vitro Sensitivity

scholarly journals Development of Cephradine-Loaded Gelatin/Polyvinyl Alcohol Electrospun Nanofibers for Effective Diabetic Wound Healing: In-Vitro and In-Vivo Assessments

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 349
Author(s):  
Anam Razzaq ◽  
Zaheer Ullah Khan ◽  
Aasim Saeed ◽  
Kiramat Ali Shah ◽  
Naveed Ullah Khan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Polyvinyl Alcohol ◽  
Mtt Assay ◽  
Chronic Wound ◽  
Drug Loading ◽  
Group Identification ◽  
Wound Infections ◽  
Diabetic Wound

Diabetic wound infections caused by conventional antibiotic-resistant Staphylococcus aureus strains are fast emerging, leading to life-threatening situations (e.g., high costs, morbidity, and mortality) associated with delayed healing and chronic inflammation. Electrospinning is one of the most widely used techniques for the fabrication of nanofibers (NFs), induced by a high voltage applied to a drug-loaded polymer solution. Particular attention is given to electrospun NFs for pharmaceutical applications (e.g., original drug delivery systems) and tissue regeneration (e.g., as tissue scaffolds). However, there is a paucity of reports related to their application in diabetic wound infections. Therefore, we prepared eco-friendly, biodegradable, low-immunogenic, and biocompatible gelatin (GEL)/polyvinyl alcohol (PVA) electrospun NFs (BNFs), in which we loaded the broad-spectrum antibiotic cephradine (Ceph). The resulting drug-loaded NFs (LNFs) were characterized physically using ultraviolet-visible (UV-Vis) spectrophotometry (for drug loading capacity (LC), drug encapsulation efficiency (EE), and drug release kinetics determination), thermogravimetric analysis (TGA) (for thermostability evaluation), scanning electron microscopy (SEM) (for surface morphology analysis), and Fourier-transform infrared spectroscopy (FTIR) (for functional group identification). LNFs were further characterized biologically by in-vitro assessment of their potency against S. aureus clinical strains (N = 16) using the Kirby–Bauer test and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, by ex-vivo assessment to evaluate their cytotoxicity against primary human epidermal keratinocytes using MTT assay, and by in-vivo assessment to estimate their diabetic chronic wound-healing efficiency using NcZ10 diabetic/obese mice (N = 18). Thin and uniform NFs with a smooth surface and standard size (<400 nm) were observed by SEM at the optimized 5:5 (GEL:PVA) volumetric ratio. FTIR analyses confirmed the drug loading into BNFs. Compared to free Ceph, LNFs were significantly more thermostable and exhibited sustained/controlled Ceph release. LNFs also exerted a significantly stronger antibacterial activity both in-vitro and in-vivo. LNFs were significantly safer and more efficient for bacterial clearance-induced faster chronic wound healing. LNF-based therapy could be employed as a valuable dressing material to heal S. aureus-induced chronic wounds in diabetic subjects.

In Vitro Sensitivity Analysis of the Gastrointestinal Dissolution Profile of Weakly Basic Drugs in the Stomach-to-Intestine Fluid Changing System: Explanation for Variable Plasma Exposure after Oral Administration

2021 ◽  
Vol 18 (4) ◽  
pp. 1711-1719
Author(s):  
Toshihide Takagi ◽  
Takato Masada ◽  
Keiko Minami ◽  
Makoto Kataoka ◽  
Ken-ichi Izutsu ◽  
...  
Keyword(s):  
Sensitivity Analysis ◽  
Oral Administration ◽  
Dissolution Profile ◽  
Basic Drugs ◽  
Plasma Exposure ◽  
In Vitro Sensitivity

scholarly journals The in-vitro activity of trovafloxacin and nine other antimicrobials against 413 anaerobic bacteria

1996 ◽  
Vol 38 (2) ◽  
pp. 271-281 ◽  
Author(s):  
K. E. Bowker ◽  
M. Wootton ◽  
H. A. Holt ◽  
D. S. Reeves ◽  
A. P. MacGowan
Keyword(s):  
Anaerobic Bacteria ◽  
Vitro Activity ◽  
In Vitro Activity
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