scholarly journals The regulatory role of heat shock protein 70-reactive CD4+ T cells during rat listeriosis.

1998 ◽  
Vol 10 (2) ◽  
pp. 117-130 ◽  
Author(s):  
Y. Kimura ◽  
K. Yamada ◽  
T. Sakai ◽  
K. Mishima ◽  
H. Nishimura ◽  
...  
Keyword(s):  
T Cells ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cd4 T Cells ◽  
Heat Shock Protein 70 ◽  
Regulatory Role

Heat shock protein 70 (Hsp70) interacts with the Notch1 intracellular domain and contributes to the activity of Notch signaling in myelin-reactive CD4 T cells

2015 ◽  
Vol 287 ◽  
pp. 19-26 ◽  
Author(s):  
Maciej Juryńczyk ◽  
Przemysław Lewkowicz ◽  
Małgorzata Domowicz ◽  
Marcin P. Mycko ◽  
Krzysztof W. Selmaj
Keyword(s):  
T Cells ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Notch Signaling ◽  
Cd4 T Cells ◽  
Heat Shock Protein 70 ◽  
Intracellular Domain

scholarly journals Cytoskeletal proteins bound to heat-shock protein 70 may elicit resistance to simian immunodeficiency virus infection of CD4+ T cells

Immunology ◽  
2009 ◽  
Vol 129 (4) ◽  
pp. 506-515 ◽  
Author(s):  
Lesley A. Bergmeier ◽  
Kaboutar Babaahmady ◽  
Jeffrey Pido-Lopez ◽  
Kate J. Heesom ◽  
Charles G. Kelly ◽  
...  
Keyword(s):  
T Cells ◽  
Heat Shock ◽  
Virus Infection ◽  
Heat Shock Protein ◽  
Simian Immunodeficiency Virus ◽  
Cd4 T Cells ◽  
Heat Shock Protein 70 ◽  
Cytoskeletal Proteins ◽  
Simian Immunodeficiency Virus Infection ◽  
Immunodeficiency Virus

scholarly journals Peripheral T-Cell Reactivity to Heat Shock Protein 70 and Its Cofactor GrpE from Tropheryma whipplei Is Reduced in Patients with Classical Whipple's Disease

2017 ◽  
Vol 85 (8) ◽  
Author(s):  
Lucia Trotta ◽  
Kathleen Weigt ◽  
Katina Schinnerling ◽  
Anika Geelhaar-Karsch ◽  
Gerrit Oelkers ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
T Cell Responses ◽  
Tropheryma Whipplei ◽  
Content Type ◽  
Cell Responses ◽  
Ifn Γ

ABSTRACT Classical Whipple's disease (CWD) is characterized by the lack of specific Th1 response toward Tropheryma whipplei in genetically predisposed individuals. The cofactor GrpE of heat shock protein 70 (Hsp70) from T. whipplei was previously identified as a B-cell antigen. We tested the capacity of Hsp70 and GrpE to elicit specific proinflammatory T-cell responses. Peripheral mononuclear cells from CWD patients and healthy donors were stimulated with T. whipplei lysate or recombinant GrpE or Hsp70 before levels of CD40L, CD69, perforin, granzyme B, CD107a, and gamma interferon (IFN-γ) were determined in T cells by flow cytometry. Upon stimulation with total bacterial lysate or recombinant GrpE or Hsp70 of T. whipplei, the proportions of activated effector CD4+ T cells, determined as CD40L+ IFN-γ+, were significantly lower in patients with CWD than in healthy controls; CD8+ T cells of untreated CWD patients revealed an enhanced activation toward unspecific stimulation and T. whipplei-specific degranulation, although CD69+ IFN-γ+ CD8+ T cells were reduced upon stimulation with T. whipplei lysate and recombinant T. whipplei-derived proteins. Hsp70 and its cofactor GrpE are immunogenic in healthy individuals, eliciting effective responses against T. whipplei to control bacterial spreading. The lack of specific T-cell responses against these T. whipplei-derived proteins may contribute to the pathogenesis of CWD.

Protective role of myocardial heat shock protein 70 in burn trauma: Another brick in the wall?

2004 ◽  
Vol 32 (6) ◽  
pp. 1425-1426 ◽  
Author(s):  
Martin Westphal ◽  
Perenlei Enkhbaatar ◽  
Daniel L. Traber
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Protective Role ◽  
Burn Trauma

The Role of Heat Shock Protein 70 in Infection and Immunity

2015 ◽  
pp. 95-117
Author(s):  
Jose Rey-Ladino ◽  
Abiola Senok ◽  
Abdullah Sarkar ◽  
Ahlam Al Shedoukhy
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70

The role of heat shock protein 70 in the thermoresistance of prostate cancer cell line spheroids

FEBS Letters ◽  
2004 ◽  
Vol 561 (1-3) ◽  
pp. 144-148 ◽  
Author(s):  
Samideh Khoei ◽  
Bahram Goliaei ◽  
Ali Neshasteh-Riz ◽  
Abdolkhalegh Deizadji
Keyword(s):  
Prostate Cancer ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cell Line ◽  
Cancer Cell ◽  
Heat Shock Protein 70 ◽  
Prostate Cancer Cell ◽  
Cancer Cell Line ◽  
Prostate Cancer Cell Line
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