Spectrophotometric Determination of Maleic Hydrazide in Tobaccos

Abstract Maleic hydrazide (6-hydroxy-3-(2H) pyridazinone) has properties that make it an important regulator for the control of sucker growth in tobacco. The stability and persistence of maleic hydrazide in plants was reviewed by Smith and co-workers (3). Several procedures have been reported for its determination in plant material (1, 2, 4) but these have proved to be unsatisfactory when applied to tobacco. This failure is due primarily to the strong red interfering color which results when tobacco in sodium hydroxide solution is distilled with added zinc. The reported procedures attempt to minimize this interference by the use of empirical constants and absorbance ratio factors. This paper outlines a modified procedure of greatly increased sensitivity which removes the interference entirely, and which is applicable to various types of tobacco tested (flue-cured, cigar, burley, and aromatic)

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Collaborative Study of the Spectrophotometric Determination of Procainamide Hydrochloride

Journal of AOAC INTERNATIONAL ◽

10.1093/jaoac/59.4.807 ◽

1976 ◽

Vol 59 (4) ◽

pp. 807-810

Author(s):

Jeffrey C Hamm

Keyword(s):

Sodium Hydroxide ◽

Acid Medium ◽

Spectrophotometric Determination ◽

Spectrophotometric Method ◽

Collaborative Study ◽

Dosage Forms ◽

Standard Deviations

Abstract The USP analysis for procainamide HCl is titrimetric and relatively nonspecific, capsule and tablet dyes may interfere, and the method is not applicable to coated tablets. In the spectrophotofluorometric method the sample deteriorates when exposed to a xenon source. In the ultraviolet spectrophotometric method reported here, the sample is dispersed in acid medium, possible interferences are extracted in chloroform, base is added, procainamide is extracted in chloroform, the residue is dissolved in sodium hydroxide, and the compound is measured by absorption at 272 nm and comparison with a standard. Recoveries of standards added to capsule, tablet, and injection composites ranged from 99.3 to 102%. Twelve collaborators reported duplicate assay results for all 3 dosage forms with per cent standard deviations for 5 samples ranging from 1.01 to 1.27%. The method has been adopted as official first action.

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Rapid Spectrophotometric Determination of Phenoxazine

Baghdad Science Journal ◽

10.21123/bsj.7.2.1001-1005 ◽

2010 ◽

Vol 7 (2) ◽

pp. 1001-1005

Author(s):

Baghdad Science Journal

Keyword(s):

Detection Limit ◽

Spectrophotometric Determination ◽

Acidic Medium ◽

Absorption Maximum ◽

Aqueous Samples ◽

Economic Method ◽

Beer's Law ◽

Beer’S Law ◽

The Stability

A rapid high sensitive and inexpensive economic method has been developed for the Determination of phenoxazine by using molecular spectrophotometry. The method is based on the oxidation of phenoxazine by potassium (meta)periodate in acidic medium. The oxidation conditions were selected to enhance the sensitivity and the stability of the pink colored species which shows an absorption maximum at 530 nm. The Beer’s law was obeyed for phenoxazine concentration range from 1 to 6 µg mL-1 with 0.003 µg mL-1 detection limit and provided variation coefficients between 0.4 to 1.7 %. This method was successfully applied for the determination of phenoxazine in aqueous samples

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Spectrophotometric Determination of the Stability Constants of Rhodamine B-Metal Complexes

Nippon kagaku zassi ◽

10.1246/nikkashi1948.88.7_730 ◽

1967 ◽

Vol 88 (7) ◽

pp. 730-734

Author(s):

Hiromu IMAI

Keyword(s):

Metal Complexes ◽

Stability Constants ◽

Spectrophotometric Determination ◽

Rhodamine B ◽

The Stability

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Colorimetric Determination of Oxyphenisatin and Oxyphenisatin Diacetate in Pharmaceutical Preparations

Journal of AOAC INTERNATIONAL ◽

10.1093/jaoac/47.4.688 ◽

1964 ◽

Vol 47 (4) ◽

pp. 688-692

Author(s):

Antoine Major

Keyword(s):

Aqueous Solution ◽

Organic Solvent ◽

Silver Nitrate ◽

Sodium Hydroxide ◽

Column Chromatography ◽

Sodium Hydroxide Solution ◽

Pharmaceutical Preparations ◽

Colorimetric Determination ◽

Hydroxide Solution

Abstract A method is described which will quantitatively determine 0.1 mg oxyphenisatin or the diacetate in various pharmaceutical preparations. After removal of interferences by organic solvent extractions from aqueous solution and partition column chromatography, the reaction of oxyphenisatin (diacetate) with silver nitrate in alcoholic sodium hydroxide solution produces a violet solution, which follows Beer’s law (1—15 μg per ml). The method was satisfactorily applied to the assay of commercial tablets, liquids, and powders with recoveries, as per cent found of declared, in the range 95—101%.

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Spectrophotometric determination of the stability constants of HgCl−13 and HgCl2−4 in aqueous ethanol

Talanta ◽

10.1016/0039-9140(73)80190-0 ◽

1973 ◽

Vol 20 (5) ◽

pp. 515 ◽

Cited By ~ 1

Author(s):

R Anantaraman

Keyword(s):

Stability Constants ◽

Spectrophotometric Determination ◽

Aqueous Ethanol ◽

The Stability

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Simple Colorimetric Method for Determination of Acetaminophen

Journal of AOAC INTERNATIONAL ◽

10.1093/jaoac/63.6.1189 ◽

1980 ◽

Vol 63 (6) ◽

pp. 1189-1190

Author(s):

Ramesh T Sane ◽

Sudhir S Kamat

Keyword(s):

Elevated Temperature ◽

Sodium Hydroxide ◽

Sodium Hydroxide Solution ◽

Colorimetric Method ◽

Hydroxide Solution

Abstract A simple colorimetric method for the determination of acetaminophen is described. The method is based on the measurement of a crimson complex formed when acetaminophen is treated with 10% sodium hydroxide solution at elevated temperature. Compounds such as phenacetin, aspirin, caffeine, oxyphenbutazone, barbiturates, hydantoins, and dextropropoxyphen which are present in various formulations containing acetaminophen do not interfere. The method is sensitive to concentrations as low as 25 μg acetaminophen/mL.

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