Collaborative Study of an Ion Exchange Method for Ephedrine in Ephedrine Sulfate Sirup NF

1969 ◽  
Vol 52 (4) ◽  
pp. 854-857
Author(s):  
Donald J Smith
Keyword(s):  
Hydrochloric Acid ◽  
Ion Exchange ◽  
Positive Charge ◽  
Exchange Resin ◽  
Collaborative Study ◽  
Cation Exchange Resin ◽  
Polystyrene Sulfonate ◽  
Resin Column ◽  
Exchange Method ◽  
Ion Exchange Method

Abstract An ion exchange procedure for Ephedrine Sulfate Sirup NF, based on the ability of ephedrine to be retained on a polystyrene sulfonate cation exchange resin column, was studied collaboratively by eight laboratories. The compound is held on the column by a positive charge located in the cationic center of the molecule, it is then eluted with hydrochloric acid, and its ultraviolet absorption is measured. The addition of 57.88 mg ephedrine sulfate to Ephedrine Sulfate Sirup NF resulted in recoveries of 58.39 and 57.72 mg, or 101 and 100%, respectively. Recoveries for collaborative samples, each containing 19.22 and 19.33 mg/5 ml, were 99.8 ± 1.83 and 101 ± 4.09%, respectively.

Ion Exchange Method for Phenylpropanolamine Hydrochloride in an Elixir

1970 ◽  
Vol 53 (1) ◽  
pp. 116-117
Author(s):  
Donald J Smith
Keyword(s):  
Ion Exchange ◽  
Cation Exchange ◽  
Positive Charge ◽  
Exchange Resin ◽  
Collaborative Study ◽  
Cation Exchange Resin ◽  
Sulfonated Polystyrene ◽  
Exchange Method ◽  
Phenylpropanolamine Hydrochloride ◽  
Ion Exchange Method

Abstract Phenylpropanolamine is retained on a sulfonated polystyrene cation exchange resin by the positive charge located in the cationic center of the molecule. Phenylpropanolamine hydrochloride is eluted from the column with 0.27N HCl and determined by UV absorption. Duplicate recoveries were 101 and 101%. The method is recommended for collaborative study.

Collaborative Study and Ion Exchange Method for the Determination of Methyldopa, Chlorothiazide, and Hydrochlorothiazide in Drug Mixtures

1971 ◽  
Vol 54 (3) ◽  
pp. 603-608
Author(s):  
Rod Chu
Keyword(s):  
Standard Deviation ◽  
Ion Exchange ◽  
Exchange Resin ◽  
Collaborative Study ◽  
Cation Exchange Resin ◽  
Resin Column ◽  
Exchange Method ◽  
Average Recovery ◽  
Ion Exchange Method

Abstract A method for the assay of methyldopa with either chlorothiazide or hydrochlorothiazide was studied collaboratively by 8 laboratories. The method involves the use of AG50-4X, 100-200 mesh H+ cation exchange resin to resolve the compounds. The thiazides pass freely through the resin column, while methyldopa is retained and subsequently eluted with 1N methanolic HCl. The components are quantitatively measured by spectrophotometry at 280 (methyldopa), 277 (chlorothiazide), and 270 nm (hydrochlorothiazide). For the methyldopa-chlorothiazide combination, the overall average recovery for methyldopa was 98.5% with a standard deviation of 2.50; and for the methyldopa-hydrochlorothiazide combination, 96.4% with a standard deviation of 2.30. The average recoveries for chlorothiazide and hydrochlorothiazide were 99.6 (standard deviation of 1.14) and 98.8% (standard deviation of 2.92), respectively. The method has been adopted as official first action for the determination of methyldopa and chlorothiazide in combination.

Ion Exchange Method for Rapid Determination of Alkalinity of Water-Soluble Tea Ash Containing High Levels of Manganese

1980 ◽  
Vol 63 (3) ◽  
pp. 460-461
Author(s):  
Saidul Z Qureshi ◽  
Fadhil M Najib ◽  
Fahmi A Mohammed
Keyword(s):  
Ion Exchange ◽  
Cation Exchange ◽  
Exchange Resin ◽  
Rapid Determination ◽  
Cation Exchange Resin ◽  
Water Soluble ◽  
Exchange Method ◽  
Strong Cation Exchange ◽  
Ion Exchange Method

Abstract An ion exchange method to determine the alkalinity of water-soluble tea ash containing high levels of manganese is described. A chromatographic column containing a strong cation exchange resin (20–50 mesh) in Na+ form, with a bed volume of 5 mL is used. The present ion exchange method is compared to pH titrations and also to the official AOAC methods (31.012, 31.015, 31.016). Results with the new method are accurate and precise.

Collaborative Study of a Zincon Ion Exchange Method for the Quantitative Determination of Zinc in Fertilizers

1971 ◽  
Vol 54 (4) ◽  
pp. 790-795
Author(s):  
C E Jones ◽  
L E Pracht
Keyword(s):  
Ion Exchange ◽  
Quantitative Determination ◽  
Atomic Absorption ◽  
Reference Data ◽  
Collaborative Study ◽  
Present Form ◽  
Exchange Method ◽  
Ion Exchange Method ◽  
Absorption Measurements

Abstract This collaborative study represents an attempt to validate the ion exchange zincon method for the quantitative determination of zinc in fertilizers. The values of the standard deviations Sd, Sr, and Sb and the results of the F- and t-tests are presented as an estimate of the precision, accuracy, and dependability. Atomic absorption measurements were also made and provided reference data for evaluation purposes. In its present form, the method falls short of expectations as an alternative wet approach to the dithizone method. It is recommended that the methods for determining zinc in fertilizers be studied further.

A Technique Method of Recycling Cyanide Zinc Plating Waste Liquid in the Laboratory

2013 ◽  
Vol 706-708 ◽  
pp. 496-499
Author(s):  
Shi Lei
Keyword(s):  
Hydrochloric Acid ◽  
Ion Exchange ◽  
Sodium Hydroxide ◽  
Ph Value ◽  
Sodium Hydroxide Solution ◽  
Exchange Method ◽  
Comprehensive Utilization ◽  
Zinc Plating ◽  
Ion Exchange Method ◽  
Plating Solution

It introduces a kind of technique method that recycling cyanide zinc plating waste liquid in the laboratory, involving the fields in electroplating and comprehensive utilization of waste liquid. The process includes the following steps: first remove impurities in the waste liquid, and then add hydrochloric acid to adjust PH value. Using cation-anion and resin, through ion exchange method, remove disturbing ion Cu2+, Cr2O72- in the cyanide zinc plating waste liquid, thus cyanide zinc plating solution can be recycled. Using sodium hydroxide solution to make resin reproduced, and then add NaHSO3, NaOH solid to precipitate Cu2+ and Cr6+ in it, and do incineration treatment. This invention provides an easy and effective method of recycling cyanide zinc plating waste liquid in the laboratory, which improves the utilization of resources, and reduces pollution.

Methods for Some Alkaloids, Barbiturates, and Combinations. II. Collaborative Study of an Ion Exchange Method for Ephedrine Sulfate or Amphetamine Sulfate Alone or Combined with Barbiturates and Antihistamines

1970 ◽  
Vol 53 (4) ◽  
pp. 847-855
Author(s):  
Donald J Smith
Keyword(s):  
Positive Charge ◽  
Collaborative Study ◽  
Cation Exchange Resin ◽  
Uv Absorption ◽  
Sulfonated Polystyrene ◽  
Exchange Method ◽  
Anion Exchange Column ◽  
Pass Through ◽  
Amphetamine Sulfate ◽  
Colored Matter

Abstract Sympathomimetic amines and antihistamines are retained on a column of sulfonated polystyrene cation exchange resin by the positive charge located in the cationic center of the molecule. These basic compounds are eluted from the column with appropriate concentrations of HCl and determined by UV absorption. An anion exchange column assists in removing interfering colored matter. The barbiturates pass through both columns with the original solvent and are measured by UV absorption in a buffered solution. Recoveries for the 8 drug ingredients in 3 combinations range from 98.9±1.7% for ephedrine sulfate to 95.4±3.8% for amphetamine sulfate on 3 practice samples per collaborator, and 99.5±2.0% for ephedrine sulfate to 96.7 ±3.3% for amphetamine sulfate on 6 unknown samples per collaborator. The method is recommended for adoption as official first action.

Ion Exchange Method for Determining Mephentermine Sulfate in Drug Formulations: Collaborative Study

1978 ◽  
Vol 61 (1) ◽  
pp. 60-64
Author(s):  
Rod Chu ◽  
Elaine J Friedman
Keyword(s):  
Ion Exchange ◽  
Collaborative Study ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Drug Formulations ◽  
Ultraviolet Spectrophotometry ◽  
Exchange Method ◽  
Coefficients Of Variation ◽  
Ion Exchange Method

Abstract Ion exchange chromatography is used to separate mephentermine sulfate from drug formulations. The drug is subsequently measured by ultraviolet spectrophotometry. Assays on 4 commercial samples of tablets and injectables gave recoveries from 97.6 to 104% of declared. A collaborative study involving 2 tablet and 2 liquid formulations gave mean recoveries ranging from 94.7 to 99.3% and coefficients of variation from 1.39 to 2.00%.

THE PARTIAL SEPARATION OF Na22 FROM Na24 BY ION EXCHANGE CHROMATOGRAPHY

1956 ◽  
Vol 34 (1) ◽  
pp. 65-74 ◽  
Author(s):  
R. H. Betts ◽  
W. E. Harris ◽  
Margaret D. Stevenson
Keyword(s):  
Hydrochloric Acid ◽  
Ion Exchange ◽  
Cation Exchange ◽  
Exchange Resin ◽  
Isotope Effects ◽  
Cation Exchange Resin ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Partial Separation ◽  
Chloride Salts

Mixtures of the radionuclides Na22 and Na24, as the chloride salts, have been partially separated by chromatographic methods. A column 102 cm. in length containing the cation exchange resin Dowex 50 was used. The eluant was 0.7 M hydrochloric acid. Na22 is held more strongly by the resin than is Na24. The most effective separations were obtained at 25 °C and 5.5 °C.; experiments at 48 °C and 68 °C showed much smaller isotope effects.

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