scholarly journals A soluble and highly fermentable dietary fiber with carbohydrases improved gut barrier integrity markers and growth performance in F18 ETEC challenged pigs1

2019 ◽  
Vol 97 (5) ◽  
pp. 2139-2153 ◽  
Author(s):  
Qingyun Li ◽  
Eric R Burrough ◽  
Nicholas K Gabler ◽  
Crystal L Loving ◽  
Orhan Sahin ◽  
...  
Keyword(s):  
Growth Performance ◽  
Dietary Fiber ◽  
Gut Barrier ◽  
Barrier Integrity

scholarly journals Xylanase increased the energetic contribution of fiber and improved the oxidative status, gut barrier integrity, and growth performance of growing pigs fed insoluble corn-based fiber

2020 ◽  
Vol 98 (7) ◽  
Author(s):  
Amy L Petry ◽  
Nichole F Huntley ◽  
Michael R Bedford ◽  
John F Patience
Keyword(s):  
Antioxidant Capacity ◽  
Growth Performance ◽  
Treatment Time ◽  
Oxidative Status ◽  
Growing Pigs ◽  
Neutral Detergent Fiber ◽  
Gut Barrier ◽  
Barrier Integrity ◽  
Adaptation Time ◽  
Ad Libitum

Abstract The experimental objective was to investigate the impact of xylanase on the bioavailability of energy, oxidative status, and gut function of growing pigs fed a diet high in insoluble fiber and given a longer adaptation time than typically reported. Three replicates of 20 gilts with an initial body weight (BW) of 25.43 ± 0.88 kg were blocked by BW, individually housed, and randomly assigned to one of four dietary treatments: a low-fiber control (LF) with 7.5% neutral detergent fiber (NDF), a 30% corn bran without solubles high-fiber control (HF; 21.9% NDF), HF + 100 mg/kg xylanase (HF + XY; Econase XT 25P), and HF + 50 mg/kg arabinoxylan-oligosaccharide (HF + AX). Gilts were fed ad libitum for 36 d across two dietary phases. Pigs and feeders were weighed on days 0, 14, 27, and 36. On day 36, pigs were housed in metabolism crates for a 10-d period, limit fed (80% of average ad libitum intake), and feces and urine were collected the last 72 h to determine the digestible energy (DE) and metabolizable energy (ME). On day 46, serum and ileal and colonic tissue were collected. Data were analyzed as a linear mixed model with block and replication as random effects, and treatment, time, and treatment × time as fixed effects. There was a significant treatment × time interaction for BW, average daily gain (ADG), and gain to feed (G:F; P < 0.001). By design, BW at day 0 did not differ; at day 14, pigs fed LF were 3.5% heavier, and pigs fed HF + XY, when compared with HF, were 4% and 4.2% heavier at days 27 and 36, respectively (P < 0.001). From day 14 to 27 and day 27 to 36, when compared with HF, HF + XY improved ADG by 12.4% and 10.7% and G:F by 13.8% and 8.8%, respectively (P < 0.05). Compared with LF, HF decreased DE and ME by 0.51 and 0.42 Mcal/kg, respectively, but xylanase partially mitigated that effect by increasing DE and ME by 0.15 and 0.12 Mcal/kg, over HF, respectively (P < 0.05). Pigs fed HF + XY had increased total antioxidant capacity in the serum and ileum (P < 0.05) and tended to have less circulating malondialdehyde (P = 0.098). Pigs fed LF had increased ileal villus height, and HF + XY and HF + AX had shallower intestinal crypts (P < 0.001). Pigs fed HF + XY had increased ileal messenger ribonucleic acid abundance of claudin 4 and occludin (P < 0.05). Xylanase, but not AX, improved the growth performance of pigs fed insoluble corn-based fiber. This was likely a result of the observed increase in ME, improved antioxidant capacity, and enhanced gut barrier integrity, but it may require increased adaptation time to elicit this response.

scholarly journals Effects of type and particle size of dietary fiber on growth performance and digestive traits of broilers from 1 to 21 days of age

2010 ◽  
Vol 89 (10) ◽  
pp. 2197-2212 ◽  
Author(s):  
E. Jiménez-Moreno ◽  
J.M. González-Alvarado ◽  
D. González-Sánchez ◽  
R. Lázaro ◽  
G.G. Mateos
Keyword(s):  
Particle Size ◽  
Growth Performance ◽  
Dietary Fiber

Plasma Levels of Endocannabinoids and Their Analogues Are Related to Specific Fecal Bacterial Genera in Young Adults: Role on Gut Barrier Integrity

2022 ◽  
Author(s):  
Lourdes Ortiz-Alvarez ◽  
Huiwen Xu ◽  
Xinyu Di ◽  
Isabelle Kohler ◽  
Francisco J. Osuna-Prieto ◽  
...  
Keyword(s):  
Young Adults ◽  
Plasma Levels ◽  
Gut Barrier ◽  
Barrier Integrity

153 Impact of xylanase and an enzyme blend on gut barrier function and growth performance in nursery pigs

2017 ◽  
Vol 95 (suppl_2) ◽  
pp. 72-73
Author(s):  
Q. Y. Li ◽  
N. K. Gabler ◽  
C. Sparks ◽  
J. F. Patience
Keyword(s):  
Growth Performance ◽  
Barrier Function ◽  
Gut Barrier ◽  
Nursery Pigs ◽  
Gut Barrier Function

scholarly journals Effects of Anti-Cytokine Antibodies on Gut Barrier Function

2019 ◽  
Vol 2019 ◽  
pp. 1-15 ◽  
Author(s):  
Fang Liu ◽  
Seul A. Lee ◽  
Stephen M. Riordan ◽  
Li Zhang ◽  
Lixin Zhu
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Barrier Function ◽  
Inflammatory Diseases ◽  
Immunomodulatory Effects ◽  
Gut Barrier ◽  
Barrier Integrity ◽  
Chronic Inflammatory Diseases ◽  
Gut Barrier Function ◽  
Inflammatory Bowel

Anti-cytokine antibodies are used in treating chronic inflammatory diseases and autoimmune diseases such as inflammatory bowel disease and rheumatic diseases. Patients with these diseases often have a compromised gut barrier function, suggesting that anti-cytokine antibodies may contribute to the re-establishment of gut barrier integrity, in addition to their immunomodulatory effects. This paper reviews the effects of anti-cytokine antibodies on gut barrier function and their mechanisms.

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