scholarly journals A General Screening Method for Acidic, Neutral, and Basic Drugs in Whole Blood using the Oasis MCX(R) Column

2002 ◽  
Vol 26 (6) ◽  
pp. 325-332 ◽  
Author(s):  
J. Yawney ◽  
S. Treacy ◽  
K. W. Hindmarsh ◽  
F. J. Burczynski
Keyword(s):  
Whole Blood ◽  
Screening Method ◽  
Basic Drugs ◽  
Neutral And Basic Drugs

Profile of Sedatives and Tranquilizers in Serum, as Measured by Gas-Liquid Chromatography

1971 ◽  
Vol 17 (3) ◽  
pp. 222-228 ◽  
Author(s):  
Henning F Proelss ◽  
Herman J Lohmann
Keyword(s):  
Liquid Chromatography ◽  
Solvent Extraction ◽  
Liquid Phase ◽  
Screening Method ◽  
Gas Liquid Chromatography ◽  
Basic Drugs ◽  
Ph Values ◽  
Preliminary Separation ◽  
Glass Columns ◽  
Neutral And Basic Drugs

Abstract We describe here a rapid and comprehensive screening method for 40 commonly used sedatives and tranquilizers with use of gas-liquid chromatography. Barbiturates, nonbarbiturate sedatives, and tranquilizers of the phenothiazine, benzodiazepine, and dibenzazepine type can be both identified and measured in serum. A simple solvent extraction at different pH values, with subsequent solvent partition, effects a preliminary separation into acid, neutral, and basic drugs. The three fractions are separated on two standard 180-cm glass columns: acid and neutral drugs with the liquid phase XE-60 (3.5%) and basic drugs with the liquid phase OV-17(3%). Sera from more than 50 patients have been analyzed by this technique, and the concentrations of several sedatives and tranquilizers are reported.

Non-Aqueous CE Screening Method for 14 Psychotropic Drugs in Whole Blood Samples

2007 ◽  
Vol 65 (5-6) ◽  
pp. 313-317 ◽  
Author(s):  
K. Madej ◽  
A. Marczyk ◽  
M. Woźniakiewicz
Keyword(s):  
Psychotropic Drugs ◽  
Whole Blood ◽  
Screening Method ◽  
Blood Samples ◽  
Whole Blood Samples

Prediction of pKa for Neutral and Basic Drugs Based on Radial Basis Function Neural Networks and the Heuristic Method

2005 ◽  
Vol 22 (9) ◽  
pp. 1454-1460 ◽  
Author(s):  
Feng Luan ◽  
Weiping Ma ◽  
Haixia Zhang ◽  
Xiaoyun Zhang ◽  
Mancang Liu ◽  
...  
Keyword(s):  
Neural Networks ◽  
Radial Basis Function ◽  
Basis Function ◽  
Heuristic Method ◽  
Basic Drugs ◽  
Radial Basis ◽  
Neutral And Basic Drugs

A screening method for biotinidase deficiency in newborns.

1984 ◽  
Vol 30 (1) ◽  
pp. 125-127 ◽  
Author(s):  
G S Heard ◽  
J R Secor McVoy ◽  
B Wolf
Keyword(s):  
Pilot Study ◽  
Whole Blood ◽  
Neonatal Screening ◽  
Screening Method ◽  
Biotinidase Deficiency ◽  
Blood Spots ◽  
Filter Papers ◽  
Biotinidase Activity

Abstract We describe a method for neonatal screening for biotinidase (EC 3.5.1.12) deficiency. Biotinidase activity is assessed colorimetrically from dried samples of whole blood spotted on the same filter papers as used in the neonatal screening for phenylketonuria. After the reaction, samples from normal infants are characteristically purple, whereas those from affected individuals are straw-colored. To confirm the deficiency, the enzyme is quantitatively assayed in additional blood spots or serum. A pilot study has been initiated with samples obtained by the Commonwealth of Virginia for phenylketonuria testing.

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