scholarly journals A Novel Method for Determining the Blood/Gas Partition Coefficients of Inhalation Anesthetics to Calculate the Percentage of Loss at Different Temperatures

2004 ◽  
Vol 28 (2) ◽  
pp. 122-127 ◽  
Author(s):  
N. C. Yang ◽  
H. F. Wang ◽  
K. L. Hwang ◽  
W. M. HO
Keyword(s):  
Partition Coefficients ◽  
Blood Gas ◽  
Inhalation Anesthetics ◽  
Different Temperatures ◽  
Novel Method

Scientific Accuracy Matters

2021 ◽  
Vol 135 (4) ◽  
pp. 724-727
Author(s):  
C. Philip Larson
Keyword(s):  
Partition Coefficients ◽  
Bovine Liver ◽  
Human Muscle ◽  
Human Hemoglobin ◽  
Blood Gas ◽  
Whole Brain ◽  
A Value ◽  
Tissue Homogenates ◽  
Scientific Accuracy ◽  
Tissue Contents

The Solubility of Halothane in Blood and Tissue Homogenates. By Larson CP, Eger EI, Severinghaus JW. Anesthesiology 1962; 23:349–55. Measured samples of human and bovine blood, human hemoglobin, and tissue homogenates from human fat and both human and bovine liver, kidney, muscle, whole brain, and separated gray and white cortex were added to stoppered 2,000-ml Erlenmeyer flasks. To each flask, 0.1 ml of liquid halothane was added under negative pressure using a calibrated micropipette. After the flask was agitated for 2 to 4 h to achieve equilibrium between the gas and blood or tissue contents, a calibrated infrared halothane analyzer was used to measure the concentration of halothane vapor. Calculated partition coefficients ranged from 0.7 for water to 2.3 for blood and from 3.5 for human or bovine kidney to 6 for human whole brain or liver and 8 for human muscle. Human peritoneal fat had a value of 138. The human blood–gas partition coefficient of 2.3 as determined by this equilibration method was well below the previously published value of 3.6.

scholarly journals Blood/gas partition coefficients of halothane, isoflurane and sevoflurane in horse blood

2003 ◽  
Vol 91 (2) ◽  
pp. 276-278 ◽  
Author(s):  
A. Bergadano ◽  
R. Lauber ◽  
A. Zbinden ◽  
U. Schatzmann ◽  
Y. Moens
Keyword(s):  
Partition Coefficients ◽  
Blood Gas ◽  
Horse Blood

Partitioning Behavior of Lysozyme and α-lactalbumin in Aqueous Two-Phase System Formed by Ionic Liquids and Potassium Phosphate

2017 ◽  
Vol 13 (10) ◽  
Author(s):  
Vanessa S. Sampaio ◽  
Renata C. F. Bonomo ◽  
Cristiane M. Veloso ◽  
Rita C. S. Sousa ◽  
Evaldo C. S. Júnior ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Partition Coefficients ◽  
Potassium Phosphate ◽  
Inorganic Salts ◽  
Phase System ◽  
Two Phase ◽  
Separation Processes ◽  
Different Temperatures ◽  
Aqueous Two Phase Systems ◽  
Increasing Temperature

AbstractNowadays ionic liquids (ILs), because of their “green” characteristics, have been used for analytical and separation processes. Therefore the partitioning of lysozyme and α-lactalbumin using aqueous two-phase systems (ATPSs) composed of an ionic liquid (chloride 1-ethyl-3-methylimidazolium) and inorganic salts (K2HPO4, KH2PO4) was studied. Phase equilibrium diagrams were obtained to explore the effect of the different temperatures (293.15, 303.15, 313.15, and 323.15) K and pH (7.5, 8.0, and 8.5) used for the partitioning studies. For both proteins, partition coefficients decreased with increasing temperature. The pH influenced the partition coefficients of lysozyme and α-lactalbumin. The thermodynamic parameters (ΔH◦, ΔS◦, ΔG◦) indicate thermodynamic differences between the partitioning of lysozyme and α-lactalbumin in this system. The ΔH◦, ΔS◦, and ΔG◦values of the process studied showed that this process is spontaneous. This work demonstrates the possible use of ATPSs with ILs and inorganic salts as a methodology for the partitioning of lysozyme and α-lactalbumin.

Right-to-left shunt in normal man determined by the use of tritium and krypton 85

1962 ◽  
Vol 17 (5) ◽  
pp. 778-782 ◽  
Author(s):  
K. Mellemgaard ◽  
N. A. Lassen ◽  
J. Georg
Keyword(s):  
Cardiac Output ◽  
Partition Coefficients ◽  
Normal Subjects ◽  
Back Pressure ◽  
Blue Dye ◽  
Blood Gas ◽  
Quiet Breathing ◽  
Voluntary Hyperventilation ◽  
Arterial Blood ◽  
Normal Man

An aqueous solution of tritium and krypton 85 together with Evans blue dye was injected intravenously in twelve normal subjects during quiet breathing, during apnea, and during voluntary hyperventilation. Arterial blood was sampled within the first 30 sec after the injection to measure the recovery of the two gases. Blood-gas partition coefficients of the two gases at 37 C were determined experimentally and the ratio between them was found to be 3.8 in normal blood. Knowing this ratio it is possible to calculate the fraction of the arterial recovery due to a right-to-left shunt, and that due to alveolar back pressure. The shunt calculated from findings during quiet breathing is 0.26% of the cardiac output. Recoveries during apnea lead to a calculated shunt of identical size, whereas the shunt calculated from the experiments during hyperventilation amounts to only 0.11% of the cardiac output. Submitted on March 8, 1962

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