scholarly journals Growing Trends in the Efficient and Selective Extraction of Compounds in Complex Matrices Using Molecularly Imprinted Polymers and Their Relevance to Toxicological Analysis

2020 ◽  
Author(s):  
Haley A Mulder ◽  
Matthew S Halquist
Keyword(s):  
Sample Preparation ◽  
Molecularly Imprinted Polymers ◽  
Drugs Of Abuse ◽  
Matrix Effects ◽  
Solid Phase ◽  
Selective Extraction ◽  
Extraction Methods ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Key Steps

Abstract In the world of forensic and clinical toxicology, proper sample preparation is one of the key steps in identification and quantification of drugs of abuse. Traditional extraction methods such as solid-phase extraction and liquid−liquid extraction are often laborious and nonselective for the target analytes being measured. Molecularly imprinted polymers (MIPs) can be synthesized for sample extraction and their versatility allows the polymer to be employed in off-line, benchtop extractions or on/in-line instrument extractions, offering a faster and more selective sample preparation without the risk of interfering matrix effects. This review details the synthesis and applications of MIP materials for the extraction of drug compounds from biological matrices in publications from 1994 to today.

Synthesis and characterization of molecularly imprinted polymers with modified rosin as a cross-linker and selective SPE-HPLC detection of basic orange II in foods

2014 ◽  
Vol 6 (16) ◽  
pp. 6397-6406 ◽  
Author(s):  
Xiaoyan Li ◽  
Mei Li ◽  
Junjie Li ◽  
Fuhou Lei ◽  
Xiaomeng Su ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Selective Extraction ◽  
Synthesis And Characterization ◽  
Orange Ii ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Cross Linker

A novel sample clean-up technique, i.e., molecularly imprinted solid-phase extraction (MISPE) combined with HPLC, was developed and validated for the selective extraction and determination of basic orange II in foods.

scholarly journals Exploring Matrix Effects on Binding Properties and Characterization of Cotinine Molecularly Imprinted Polymer on Paper-Based Scaffold

Polymers ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 570 ◽  
Author(s):  
Nutcha Larpant ◽  
Yaneenart Suwanwong ◽  
Somchai Boonpangrak ◽  
Wanida Laiwattanapaisal
Keyword(s):  
Adsorption Isotherm ◽  
Molecularly Imprinted Polymers ◽  
Matrix Effects ◽  
Dissociation Constants ◽  
Solid Phase ◽  
Tobacco Smoke Exposure ◽  
Scatchard Analysis ◽  
Water Medium ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Commercially available sorbent materials for solid-phase extraction are widely used in analytical laboratories. However, non-selective binding is a major obstacle for sample analysis. To overcome this problem, molecularly imprinted polymers (MIPs) were used as selective adsorbent materials prior to determining target analysts. In this study, the use of non-covalent molecularly imprinted polymers (MIPs) for cotinine adsorption on a paper-based scaffold was studied. Fiberglass paper was used as a paper scaffold for cotinine-selective MIP adsorption with the use of 0.5% agarose gel. The effects of salt, pH, sample matrix, and solvent on the cotinine adsorption and extraction process were investigated. Under optimal conditions, the adsorption isotherm of synthesized MIPs increased to 125.41 µg/g, whereas the maximum adsorption isotherm of non-imprinted polymers (NIPs) was stable at 42.86 µg/g. The ability of the MIP paper scaffold to absorb cotinine in water medium was approximately 1.8–2.8-fold higher than that of the NIP scaffold. From Scatchard analysis, two dissociation constants of MIPs were calculated to be 2.56 and 27.03 µM. Nicotine, myosmine, and N-nitrosonornicotine were used for selectivity testing, and the calculated selectivity factor of cotinine to nicotine, myosmine, and N-nitrosonornicotine was 1.56, 2.69, and 2.05, respectively. Overall, the MIP paper scaffold is promising for simple onsite sampling of cotinine and can be used to assess tobacco smoke exposure.

Solid-phase extraction using molecularly imprinted polymers for selective extraction of a mycotoxin in cereals

2010 ◽  
Vol 1217 (43) ◽  
pp. 6668-6673 ◽  
Author(s):  
Wassim Hadj Ali ◽  
Delphine Derrien ◽  
Florent Alix ◽  
Céline Pérollier ◽  
Olivier Lépine ◽  
...  
Keyword(s):  
Solid Phase Extraction ◽  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Selective Extraction ◽  
Phase Extraction ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

A new restricted access molecularly imprinted fiber for direct solid phase microextraction of benzodiazepines from plasma samples

The Analyst ◽  
2019 ◽  
Vol 144 (14) ◽  
pp. 4320-4330 ◽  
Author(s):  
Lailah Cristina de Carvalho Abrão ◽  
Eduardo Costa Figueiredo
Keyword(s):  
Sample Preparation ◽  
Molecularly Imprinted Polymers ◽  
Binding Sites ◽  
Solid Phase Microextraction ◽  
Solid Phase ◽  
Plasma Samples ◽  
Molecularly Imprinted ◽  
Restricted Access ◽  
Imprinted Polymers ◽  
Direct Solid

Restricted access molecularly imprinted polymers (RAMIPs) are hybrid materials that present selective binding sites for a template (or similar molecules), and an external hydrophilic layer that avoids the binding of proteins to the material, making them appropriate for the sample preparation of protein fluids.

scholarly journals Recent Advances in Solid-Phase Extraction (SPE) Based on Molecularly Imprinted Polymers (MIPs) for Analysis of Hormones

Chemosensors ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 151
Author(s):  
Anele Mpupa ◽  
Shirley Kholofelo Selahle ◽  
Boris Mizaikoff ◽  
Philiswa Nosizo Nomngongo
Keyword(s):  
Sample Preparation ◽  
Steroid Hormones ◽  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
The Body ◽  
Growth Promoters ◽  
Complex Matrices ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Analytical Instruments

Steroid hormones are active substances that are necessary in the normal functioning of all physiological activities in the body, such as sexual characteristics, metabolism, and mood control. They are also widely used as exogenous chemicals in medical and pharmaceutical applications as treatments and at times growth promoters in animal farming. The vast application of steroid hormones has resulted in them being found in different matrices, such as food, environmental, and biological samples. The presence of hormones in such matrices means that they can easily come into contact with humans and animals as exogenous compounds, resulting in abnormal concentrations that can lead to endocrine disruption. This makes their determination in different matrices a vital part of pollutant management and control. Although advances in analytical instruments are constant, it has been determined that these instruments still require some sample preparation steps to be able to determine the occurrence of pollutants in the complex matrices in which they occur. Advances are still being made in sample preparation to ensure easier, selective, and sensitive analysis of complex matrices. Molecularly imprinted polymers (MIPs) have been termed as advanced solid-phase (SPE) materials for the selective extraction and preconcentration of hormones in complex matrices. This review explores the preparation and application of MIPs for the determination of steroid hormones in different sample types.

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