Gene Flow Accelerates Local Adaptation Among Finite Populations: Simulating the Evolution of Insecticide Resistance

1992 ◽  
Vol 85 (3) ◽  
pp. 611-620 ◽  
Author(s):  
Michael A. Caprio ◽  
Bruce E. Tabashnik
Keyword(s):  
Gene Flow ◽  
Insecticide Resistance ◽  
Local Adaptation ◽  
Finite Populations

scholarly journals Evaluating Gene Flow Using Selected Markers: A Case Study

Genetics ◽  
1998 ◽  
Vol 149 (3) ◽  
pp. 1383-1392 ◽  
Author(s):  
Thomas Lenormand ◽  
Thomas Guillemaud ◽  
Denis Bourguet ◽  
Michel Raymond
Keyword(s):  
Gene Flow ◽  
Insecticide Resistance ◽  
Local Adaptation ◽  
Culex Pipiens ◽  
Selection Pressure ◽  
Fitness Costs ◽  
Southern France ◽  
Culex Pipiens Pipiens ◽  
Selection Intensities

Abstract The extent to which an organism is locally adapted in an environmental pocket depends on the selection intensities inside and outside the pocket, on migration, and on the size of the pocket. When two or more loci are involved in this local adaptation, measuring their frequency gradients and their linkage disequilbria allows one to disentangle the forces—migration and selection—acting on the system. We apply this method to the case of a local adaptation to organophosphate insecticides in the mosquito Culex pipiens pipiens in southern France. The study of two different resistance loci allowed us to estimate with support limits gene flow as well as selection pressure on insecticide resistance and the fitness costs associated with each locus. These estimates permit us to pinpoint the conditions for the maintenance of this pocket of adaptation as well as the effect of the interaction between the two resistance loci.

Gene flow favours local adaptation under habitat choice in ciliate microcosms

2017 ◽  
Vol 1 (9) ◽  
pp. 1407-1410 ◽  
Author(s):  
Staffan Jacob ◽  
Delphine Legrand ◽  
Alexis S. Chaine ◽  
Dries Bonte ◽  
Nicolas Schtickzelle ◽  
...  
Keyword(s):  
Gene Flow ◽  
Local Adaptation ◽  
Habitat Choice

scholarly journals A differential expression of pyrethroid resistance genes in the malaria vector Anopheles funestus across Uganda is associated with patterns of gene flow

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0240743
Author(s):  
Maurice Marcel Sandeu ◽  
Charles Mulamba ◽  
Gareth D. Weedall ◽  
Charles S. Wondji
Keyword(s):  
Population Structure ◽  
Gene Flow ◽  
Genetic Structure ◽  
Genetic Differentiation ◽  
Insecticide Resistance ◽  
Pyrethroid Resistance ◽  
Anopheles Funestus ◽  
Metabolic Resistance ◽  
Transcription Analysis ◽  
Genome Wide

Background Insecticide resistance is challenging the effectiveness of insecticide-based control interventions to reduce malaria burden in Africa. Understanding the molecular basis of insecticides resistance and patterns of gene flow in major malaria vectors such as Anopheles funestus are important steps for designing effective resistance management strategies. Here, we investigated the association between patterns of genetic structure and expression profiles of genes involved in the pyrethroid resistance in An. funestus across Uganda and neighboring Kenya. Methods Blood-fed mosquitoes An. funestus were collected across the four localities in Uganda and neighboring Kenya. A Microarray-based genome-wide transcription analysis was performed to identify the set of genes associated with permethrin resistance. 17 microsatellites markers were genotyped and used to establish patterns of genetic differentiation. Results Microarray-based genome-wide transcription profiling of pyrethroid resistance in four locations across Uganda (Arua, Bulambuli, Lira, and Tororo) and Kenya (Kisumu) revealed that resistance was mainly driven by metabolic resistance. The most commonly up-regulated genes in pyrethroid resistance mosquitoes include cytochrome P450s (CYP9K1, CYP6M7, CYP4H18, CYP4H17, CYP4C36). However, expression levels of key genes vary geographically such as the P450 CYP6M7 [Fold-change (FC) = 115.8 (Arua) vs 24.05 (Tororo) and 16.9 (Kisumu)]. In addition, several genes from other families were also over-expressed including Glutathione S-transferases (GSTs), carboxylesterases, trypsin, glycogenin, and nucleotide binding protein which probably contribute to insecticide resistance across Uganda and Kenya. Genotyping of 17 microsatellite loci in the five locations provided evidence that a geographical shift in the resistance mechanisms could be associated with patterns of population structure throughout East Africa. Genetic and population structure analyses indicated significant genetic differentiation between Arua and other localities (FST>0.03) and revealed a barrier to gene flow between Arua and other areas, possibly associated with Rift Valley. Conclusion The correlation between patterns of genetic structure and variation in gene expression could be used to inform future interventions especially as new insecticides are gradually introduced.

Gene Flow, Spatial Structure, Local Adaptation, and Assisted Migration in Trees

2012 ◽  
pp. 71-116 ◽  
Author(s):  
Konstantin V. Krutovsky ◽  
Jaroslaw Burczyk ◽  
Igor Chybicki ◽  
Reiner Finkeldey ◽  
Tanja Pyhäjärvi ◽  
...  
Keyword(s):  
Gene Flow ◽  
Spatial Structure ◽  
Local Adaptation ◽  
Assisted Migration

Local adaptation along a sharp rainfall gradient occurs in a native Patagonian grass, Festuca pallescens, regardless of extensive gene flow

2020 ◽  
Vol 171 ◽  
pp. 103933
Author(s):  
Aldana S. López ◽  
Dardo R. López ◽  
Gonzalo Caballé ◽  
Guillermo L. Siffredi ◽  
Paula Marchelli
Keyword(s):  
Gene Flow ◽  
Local Adaptation ◽  
Rainfall Gradient ◽  
Festuca Pallescens

scholarly journals The limits to parapatric speciation 3: evolution of strong reproductive isolation in presence of gene flow despite limited ecological differentiation

2020 ◽  
Vol 375 (1806) ◽  
pp. 20190532 ◽  
Author(s):  
Alexandre Blanckaert ◽  
Claudia Bank ◽  
Joachim Hermisson
Keyword(s):  
Gene Flow ◽  
Reproductive Isolation ◽  
Local Adaptation ◽  
Theme Issue ◽  
Genetic Barrier ◽  
Incipient Species ◽  
Postzygotic Reproductive Isolation ◽  
Minimal Configuration ◽  
Parapatric Speciation ◽  
Two Populations

Gene flow tends to impede the accumulation of genetic divergence. Here, we determine the limits for the evolution of postzygotic reproductive isolation in a model of two populations that are connected by gene flow. We consider two selective mechanisms for the creation and maintenance of a genetic barrier: local adaptation leads to divergence among incipient species due to selection against migrants, and Dobzhansky–Muller incompatibilities (DMIs) reinforce the genetic barrier through selection against hybrids. In particular, we are interested in the maximum strength of the barrier under a limited amount of local adaptation, a challenge that many incipient species may initially face. We first confirm that with classical two-locus DMIs, the maximum amount of local adaptation is indeed a limit to the strength of a genetic barrier. However, with three or more loci and cryptic epistasis, this limit holds no longer. In particular, we identify a minimal configuration of three epistatically interacting mutations that is sufficient to confer strong reproductive isolation. This article is part of the theme issue ‘Towards the completion of speciation: the evolution of reproductive isolation beyond the first barriers’.

scholarly journals Genomic Patterns of Local Adaptation under Gene Flow in Arabidopsis lyrata

2019 ◽  
Vol 36 (11) ◽  
pp. 2557-2571 ◽  
Author(s):  
Tuomas Hämälä ◽  
Outi Savolainen
Keyword(s):  
Gene Flow ◽  
Local Adaptation ◽  
Demographic History ◽  
Rate Variation ◽  
Arabidopsis Lyrata ◽  
Trade Offs ◽  
Northern Latitudes ◽  
Local Selection ◽  
Empirical Level ◽  
Selected Traits

AbstractShort-scale local adaptation is a complex process involving selection, migration, and drift. The expected effects on the genome are well grounded in theory but examining these on an empirical level has proven difficult, as it requires information about local selection, demographic history, and recombination rate variation. Here, we use locally adapted and phenotypically differentiated Arabidopsis lyrata populations from two altitudinal gradients in Norway to test these expectations at the whole-genome level. Demography modeling indicates that populations within the gradients diverged <2 kya and that the sites are connected by gene flow. The gene flow estimates are, however, highly asymmetric with migration from high to low altitudes being several times more frequent than vice versa. To detect signatures of selection for local adaptation, we estimate patterns of lineage-specific differentiation among these populations. Theory predicts that gene flow leads to concentration of adaptive loci in areas of low recombination; a pattern we observe in both lowland-alpine comparisons. Although most selected loci display patterns of conditional neutrality, we found indications of genetic trade-offs, with one locus particularly showing high differentiation and signs of selection in both populations. Our results further suggest that resistance to solar radiation is an important adaptation to alpine environments, while vegetative growth and bacterial defense are indicated as selected traits in the lowland habitats. These results provide insights into genetic architectures and evolutionary processes driving local adaptation under gene flow. We also contribute to understanding of traits and biological processes underlying alpine adaptation in northern latitudes.

Divergence with gene flow is driven by local adaptation to temperature and soil phosphorus concentration in teosinte subspecies ( Zea mays parviglumis and Zea mays mexicana )

2019 ◽  
Author(s):  
Jonás A. Aguirre‐Liguori ◽  
Brandon S. Gaut ◽  
Juan Pablo Jaramillo‐Correa ◽  
Maud I. Tenaillon ◽  
Salvador Montes‐Hernández ◽  
...  
Keyword(s):  
Zea Mays ◽  
Gene Flow ◽  
Local Adaptation ◽  
Soil Phosphorus ◽  
Phosphorus Concentration ◽  
Divergence With Gene Flow

scholarly journals The Mobilome of Reptiles: Evolution, Structure, and Function

2019 ◽  
Vol 157 (1-2) ◽  
pp. 21-33 ◽  
Author(s):  
Stéphane Boissinot ◽  
Yann Bourgeois ◽  
Joseph D. Manthey ◽  
Robert P. Ruggiero
Keyword(s):  
Gene Flow ◽  
Transposable Elements ◽  
Genome Size ◽  
Local Adaptation ◽  
Size Structure ◽  
Structure And Function ◽  
Genomic Diversity ◽  
Genomic Features ◽  
And Function

Transposable elements (TE) constitute one of the most variable genomic features among vertebrates, impacting genome size, structure, and composition. Despite their important role in shaping genomic diversity, they have mostly been studied in mammals, which display one of the least diverse genomes in terms of TE diversity. Recent new resources in reptilian genomics have opened a broader perspective about TE evolution in amniotes. We discuss these recent results by showing that TE diversity is high in reptiles, particularly in squamates, with strong heterogeneity in the number of TE classes retained in each lineage, even at short evolutionary scales. More research is needed to uncover the exact mechanisms that regulate TE proliferation in reptiles and to what extent these selfish elements can play a role in local adaptation or in the emergence of barriers to gene flow.

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