Interaction of Dietary Vitamin C and Vitamin E on Guinea Pig Immune Responses to Mitogens

ABSTRACT Background Previous studies have found that meat-derived mutagens increase, and vitamin C or E decrease, the risk of pancreatic cancer. Objective The aim of this study was to determine whether intake of vitamin C or E modulates the association between meat-derived mutagen exposure and risk of pancreatic cancer. Design We conducted a case-control study in 1321 patients with pathologically confirmed pancreatic ductal adenocarcinoma (PDAC) and 1061 healthy controls (aged 28–88 y). Cases and controls were frequency-matched by age, sex, and race/ethnicity. Mutagen intake was assessed using a meat preparation questionnaire. Intakes of vitamin C, E, and other dietary components were assessed via a food-frequency questionnaire in a subset of 811 cases and 818 controls. ORs and 95% CIs were estimated in multivariable-adjusted logistic regression models. Results The risk of PDAC was not associated with meat intake but was associated with consumption of well-done grilled or barbecued chicken (OR: 1.57; 95% CI: 1.18, 2.09; P = 0.001). Intake of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline was associated with increased PDAC risk (Ptrend = 0.047). Participants in the highest, as compared with the lowest, quintile of 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (PhIP) intake experienced a 38% increased risk of PDAC (95% CI: 1.00, 1.90; P = 0.048). Intakes of total vitamin C or E from food and supplements or from supplements alone were each inversely associated with PDAC risk. Stratified analyses showed differential associations for PhIP intake and PDAC risk, such that risk increased among individuals with lower intake of vitamin C or E and decreased among those with higher vitamin intake. Significant interactions of dietary vitamin C, dietary vitamin E, and total vitamin E with PhIP intake were detected (Pinteraction = 0.023, <0.001, and 0.013, respectively). Conclusions Consistent with experimental evidence, this study of 811 cases and 818 controls has shown that high intake of dietary vitamin C or E mitigates the risk of PhIP-related PDAC.

Download Full-text

Effects of Dietary Vitamin E Level and Unsaturation of Fatty Acids on Chick Immune Responses

Journal of Nutritional Immunology ◽

10.1300/j053v01n04_05 ◽

1993 ◽

Vol 1 (4) ◽

pp. 83-102

Author(s):

C. F. Nockels ◽

S. J. Slota ◽

M. M. Mathias

Keyword(s):

Fatty Acids ◽

Vitamin E ◽

Immune Responses ◽

Dietary Vitamin

Download Full-text

Dietary vitamin C and its derivatives affect immune responses in grass shrimp, Penaeus monodon

Fish & Shellfish Immunology ◽

10.1006/fsim.2001.0357 ◽

2002 ◽

Vol 12 (2) ◽

pp. 119-129 ◽

Cited By ~ 49

Author(s):

Min-Hsien Lee ◽

Shi-Yen Shiau

Keyword(s):

Vitamin C ◽

Immune Responses ◽

Penaeus Monodon ◽

Grass Shrimp ◽

Dietary Vitamin

Download Full-text

Effects of Vitamin C and Vitamin E on Lipid Peroxidation Status, Serum Hormone, Metabolite, and Mineral Concentrations of Japanese Quails Reared under Heat Stress (34º C)

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.72.2.91 ◽

2002 ◽

Vol 72 (2) ◽

pp. 91-100 ◽

Cited By ~ 66

Author(s):

Kazim Sahin ◽

Osman Kucuk ◽

Nurhan Sahin ◽

Mustafa Sari

Keyword(s):

Lipid Peroxidation ◽

Heat Stress ◽

Vitamin E ◽

Vitamin C ◽

Management Practice ◽

Thyroid Stimulating Hormone ◽

Dietary Vitamin ◽

Serum Concentrations ◽

Japanese Quails ◽

Mineral Concentrations

This study was conducted to determine the effects of dietary vitamin C (L-ascorbic acid) and vitamin E (a-tocopherol acetate) on lipid peroxidation status measured as MDA and serum triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), as well as some other serum metabolite and mineral concentrations of Japanese quails reared under heat stress (34º C). One hundred-eighty 10-day-old Japanese quails were randomly assigned to six treatment groups, three replicates of 10 birds each. Using a 2 × 3 factorial design, the birds received two levels of vitamin C (100 and 200 mg/kg of diet) or three levels of vitamin E (125, 250, or 500 mg/kg of diet). Greater dietary vitamin E and vitamin C resulted in a greater serum T3, T4, and TSH (p=0.001), but lower ACTH (p=0.001) concentrations. Serum concentrations of T4 and TSH increased to a greater extent by increasing dietary vitamin C when greater vitamin E levels were fed (interaction, p=0.001). Serum glucose, urea, triglycerides, and cholesterol concentrations decreased (p=0.001), while protein and albumin concentrations increased (p =0.001) when both dietary vitamin C and vitamin E were increased. Serum activities of SGOT and SGPT were not influenced by dietary vitamin C or vitamin E (p>0.43). However, serum activity of AP increased (p=0.001) by increasing both dietary vitamin C and vitamin E. Increasing both dietary vitamin C and vitamin E caused an increase in serum concentrations of Ca, P, K (p=0.001), Fe, and Zn (p=0.01) but a decrease in serum concentrations of Na (p=0.001) and Cu (p=0.01). Interactions between vitamin C and vitamin E were detected for Ca, P, Na, and K (p =0.001). Greater dietary vitamin C and vitamin E resulted in a greater serum and liver vitamin E, C, and A (p_0.05), but lower MDA (p=0.001) concentrations. Results of the present study conclude that supplementing a combination of dietary vitamin C (200 mg) and vitamin E (250–500 mg) offers a good management practice to reduce heat stress-related decreases in performance of Japanese quails.

Download Full-text