scholarly journals Consumption of Galacto-Oligosaccharides Increases Iron Absorption from Ferrous Fumarate: A Stable Iron Isotope Study in Iron-Depleted Young Women

2019 ◽  
Vol 149 (5) ◽  
pp. 738-746 ◽  
Author(s):  
Frederike M D Jeroense ◽  
Ladina Michel ◽  
Christophe Zeder ◽  
Isabelle Herter-Aeberli ◽  
Michael B Zimmermann
Keyword(s):  
Stable Isotopes ◽  
Test Meal ◽  
Animal Studies ◽  
Iron Absorption ◽  
Daily Consumption ◽  
Ferritin Concentration ◽  
Ferrous Fumarate ◽  
Median Serum ◽  
Serum Ferritin Concentration ◽  
Isotope Study

ABSTRACTBackgroundAnimal studies suggest prebiotics can increase iron absorption, but results from human studies are equivocal.ObjectivesIn iron-depleted women, before (baseline) and after daily consumption of galacto-oligosaccharides (GOS) for 4 wk, we sought to assess fractional iron absorption (FIA) from an iron supplement given with and without single doses of GOS in test meals or water.MethodsIn all women (n = 34; median serum ferritin concentration = 16.4 µg/L), FIA from doses of 14 mg iron labeled with stable isotopes was measured in the following conditions at baseline: 1) FIA from ferrous fumarate (FeFum) in water given with and without 15 g GOS; 2) FIA from FeFum in a test meal given with and without 15 g GOS; 3) FIA from ferrous sulfate (FeSO4) in a test meal given without 15 g GOS. All subjects then consumed ∼15 g GOS daily for 4 wk. Then the following conditions were tested: 4) FIA from FeFum in a test meal with and without 15 g GOS; and 5) FIA from FeSO4 in a test meal with 15 g GOS. FIA was measured as erythrocyte incorporation of stable isotopes.ResultsAt baseline, GOS significantly increased FIA from FeFum when given with water (+61%; P < 0.001) and the meal (+28%; P = 0.002). After 4 wk of GOS consumption, GOS again significantly increased FIA from FeFum in the meal (+29%; P = 0.044). However, compared with baseline, consumption of GOS for 4 wk did not significantly enhance absorption from FeFum in the meal given without GOS. FIA from FeSO4 given with GOS in a meal after 4 wk of GOS consumption was not significantly greater than FIA from FeSO4 in a meal without GOS at baseline.ConclusionsIn iron-depleted women, GOS given with FeFum increases FIA, but 4 wk of GOS consumption did not enhance this effect. The study was registered at clinicaltrials.gov as NCT03325270.

scholarly journals Acute Consumption of Prebiotic Galacto-Oligosaccharides Increases Iron Absorption from Ferrous Fumarate, but not from Ferrous Sulfate and Ferric Pyrophosphate: Stable Iron Isotope Studies in Iron-Depleted Young Women

2020 ◽  
Vol 150 (9) ◽  
pp. 2391-2397
Author(s):  
Frederike M D Jeroense ◽  
Christophe Zeder ◽  
Michael B Zimmermann ◽  
Isabelle Herter-Aeberli
Keyword(s):  
Stable Isotopes ◽  
Ferrous Sulfate ◽  
Iron Absorption ◽  
Ferric Pyrophosphate ◽  
Ferrous Fumarate ◽  
Paired Samples ◽  
Wilcoxon Rank Sum Test ◽  
Isotope Studies ◽  
High Doses ◽  
Dose Dependent

ABSTRACT Background Although acute consumption of high doses of prebiotic galacto-oligosaccharides (GOS) increases fractional iron absorption (FIA) from ferrous fumarate (FeFum), it is uncertain if low doses of GOS have this effect. Furthermore, whether GOS improve iron absorption from other commonly used iron compounds and whether ascorbic acid (AA) enhances the effect of GOS on iron absorption from FeFum is unclear. Objectives In iron-depleted women [serum ferritin (SF) &lt;30 μg/L], we assessed: 1) whether the acute enhancing effect of GOS on FeFum is dose dependent; 2) if GOS would affect FIA from ferrous sulfate (FeSO4) or ferric pyrophosphate (FePP); and 3) if AA and GOS given together enhance FIA from FeFum to a greater extent compared with GOS alone. Methods We recruited 46 women (mean age 22.0 y, mean BMI 21.3 kg/m2, median SF 17.1 μg/L), and measured FIA from 14 mg iron labeled with stable isotopes in the following conditions: 1) FIA from FeFum given with 3.5 g, 7 g GOS, and without GOS; 2) FIA from FeSO4 and FePP given with and without 15 g GOS; and 3) FIA from FeFum given with 7 g GOS with and without 93 mg AA. FIA was measured as erythrocyte incorporation of stable isotopes after 14 d. Comparisons were made using paired samples t-test or Wilcoxon rank sum test where appropriate. Results Giving 7 g of GOS significantly increased FIA from FeFum (+26%; P = 0.039), whereas 3.5 g GOS did not (P = 0.130). GOS did not significantly increase FIA from FeSO4 (P = 0.998) or FePP (P = 0.059). FIA from FeFum given with GOS and AA was significantly higher compared with FeFum given with GOS alone (+30%; P &lt;0.001). Conclusions In iron-depleted women, GOS does not increase FIA from FeSO4 or FePP, but it increases FIA from FeFum. Thus, a combination of FeFum and GOS may be a well-absorbed formula for iron supplements. The study was registered at clinicaltrials.gov as NCT03762148.

scholarly journals Low iron status and enhanced insulin sensitivity in lacto-ovo vegetarians

2001 ◽  
Vol 86 (4) ◽  
pp. 515-519 ◽  
Author(s):  
Nancy W. Hua ◽  
Riccardo A. Stoohs ◽  
Francesco S. Facchini
Keyword(s):  
Steady State ◽  
Insulin Sensitivity ◽  
Animal Studies ◽  
Iron Status ◽  
Whole Body ◽  
Glucose Disposal ◽  
Lower Body ◽  
Ferritin Concentration ◽  
Serum Ferritin Concentration ◽  
Glucose Tolerant

The efficacy of insulin in stimulating whole-body glucose disposal (insulin sensitivity) was quantified using direct methodology in thirty lacto-ovo vegetarians and in thirty meat-eaters. All subjects were adult, lean (BMI <23 kg/m2), healthy and glucose tolerant. Lacto-ovo vegetarians were more insulin sensitive than meat-eaters, with a steady-state plasma glucose (mmol/l) of 4·1 (95 % CI 3·5, 5·0)v.6·9 (95 % CI 5·2, 7·5; P=0·0028) respectively. In addition, lacto-ovo vegetarians had lower body Fe stores, as indicated by a serum ferritin concentration (μg/l) of 35 (95 % CI 21, 49) compared with 72 (95 % CI 45, 100) for meat-eaters (P=0·0012). To test whether or not Fe status might modulate insulin sensitivity, body Fe was lowered by phlebotomy in six male meat-eaters to levels similar to that seen in vegetarians, with a resultant approximately 40 % enhancement of insulin-mediated glucose disposal (P=0·0008). Our results demonstrate that lacto-ovo vegetarians are more insulin sensitive and have lower Fe stores than meat-eaters. In addition, it seems that reduced insulin sensitivity in meat-eaters is amenable to improvement by reducing body Fe. The latter finding is in agreement with results from animal studies where, no matter how induced, Fe depletion consistently enhanced glucose disposal.

Relationships among Iron Absorption, Percent Saturation of Plasma Transferrin and Serum Ferritin Concentration in Humans

1988 ◽  
Vol 118 (9) ◽  
pp. 1110-1115 ◽  
Author(s):  
Peter Taylor ◽  
Carlos Martínez-Torres ◽  
Irene Leets ◽  
José Ramírez ◽  
María Nieves García-Casal ◽  
...  
Keyword(s):  
Serum Ferritin ◽  
Iron Absorption ◽  
Ferritin Concentration ◽  
Serum Ferritin Concentration

scholarly journals Effect of calcium intake on iron absorption and hematologic status: A systematic review and dose-response meta-analysis of randomized trials and case-cross-over studies

2020 ◽  
Author(s):  
Ajibola I Abioye ◽  
Taofik A Okuneye ◽  
Abdul Majeed O Odesanya ◽  
Olufunmilola Adisa ◽  
Asanat I Abioye ◽  
...  
Keyword(s):  
Serum Ferritin ◽  
Dose Response ◽  
Calcium Intake ◽  
Iron Absorption ◽  
Iron Status ◽  
Detailed Knowledge ◽  
Clinical Effects ◽  
Ferritin Concentration ◽  
Intermediate Outcomes ◽  
Serum Ferritin Concentration

Background: The interaction between dietary (and supplementary) divalent ions has been a long-standing issue in human nutrition research. Developing optimal calcium and iron supplementation recommendation needs detailed knowledge of the potential trade-offs between: a) the clinical effects of concurrent intake on iron absorption and hematological indices, and b) the potentially negative effects of separated ingestion on adherence to either or both iron and calcium supplements. Human clinical studies have examined the effects of calcium intake on iron status, but there are no meta-analyses or recent reviews summarizing the findings. Objective: We aimed to summarize the literature on the effect of calcium consumption from meals and supplements on iron indices in humans, and quantify the pooled effects. Design: Peer-reviewed randomized and case-cross-over studies were included in this review. Result: The negative effect of calcium intake was statistically significant in short-term iron absorption studies but the effect magnitude was low (weighted mean difference (WMD) = -5.57%, (95% CI: -7.09, -4.04)). The effect of calcium on iron status was mixed. There was a quadratic dose-response relationship between calcium intake and serum ferritin concentration. Higher daily calcium intake was associated with a modest reduction in serum ferritin concentration. There was, however, no reduction in hemoglobin concentration (WMD = 1.22g/L, 95% CI: 0.37, 2.07). Conclusion: The existing body of studies is insufficient to make recommendations with high confidence due to heterogeneity in design, limitations of ferritin as an iron biomarker and lack of intake studies in pregnant women. Prescribing separation of prenatal calcium and iron supplements in free living individuals is unlikely to affect the anemia burden. There is a need for effectiveness trials comparing the effects of prescribing separated intake to concurrent intake, with functional end-points as primary outcomes, and adherence to each supplement as intermediate outcomes.

scholarly journals Serum ferritin concentration in Gaucher's disease.

BMJ ◽  
1983 ◽  
Vol 286 (6381) ◽  
pp. 1864-1864 ◽  
Author(s):  
M A Morgan ◽  
A V Hoffbrand ◽  
M Laulicht ◽  
W Luck ◽  
S Knowles
Keyword(s):  
Serum Ferritin ◽  
Gaucher's Disease ◽  
Gaucher’S Disease ◽  
Ferritin Concentration ◽  
Serum Ferritin Concentration

scholarly journals Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression

Blood ◽  
2011 ◽  
Vol 118 (19) ◽  
pp. 5278-5282 ◽  
Author(s):  
Victor R. Gordeuk ◽  
Galina Y. Miasnikova ◽  
Adelina I. Sergueeva ◽  
Xiaomei Niu ◽  
Mehdi Nouraie ◽  
...  
Keyword(s):  
Geometric Mean ◽  
Cell Mass ◽  
Hypoxia Inducible Factor ◽  
Loss Of Function ◽  
Ferritin Concentration ◽  
Hepcidin Expression ◽  
Serum Ferritin Concentration ◽  
Serum Hepcidin ◽  
Relationship Of ◽  
Serum Erythropoietin

Abstract Hypoxia is known to reduce the expression of hepcidin, the master regulator of iron metabolism. However, it is not clear whether this response is primarily related to increased erythropoiesis driven by hypoxically stimulated erythropoietin or to a more direct effect of hypoxia on hepcidin expression. The germline loss-of-function VHLR200W mutation is common in Chuvashia, Russia, and also occurs elsewhere. VHLR200W homozygotes have elevated hypoxia-inducible factor 1α (HIF-1α) and HIF-2α levels, increased red cell mass, propensity to thrombosis, and early mortality. Ninety VHLR200W homozygotes and 52 controls with normal VHL alleles from Chuvashia, Russia, were studied under basal circumstances. In univariate analyses, serum hepcidin concentration was correlated positively with serum ferritin concentration and negatively with homozygosity for VHLR200W. After adjustment for serum erythropoietin and ferritin concentrations by multiple linear regression, the geometric mean (95% confidence interval of mean) hepcidin concentration was 8.1 (6.3-10.5) ng/mL in VHLR200W homozygotes versus 26.9 (18.6-38.0) ng/mL in controls (P < .001). In contrast, a significant independent relationship of serum erythropoietin, hemoglobin, or RBC count with hepcidin was not observed. In conclusion, up-regulation of the hypoxic response leads to decreased expression of hepcidin that may be independent of increased erythropoietin levels and increased RBC counts.

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