Platelet Enhancement of Tumor Cell Adhesion to Subendothelial Matrix: Role of Platelet Cytoskeleton and Platelet Membrane2

1987 ◽  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Platelet Membrane ◽  
Tumor Cell Adhesion ◽  
Subendothelial Matrix

Platelet and Shear Rate Promote Tumor Cell Adhesion to Human Endothelial Extracellular Matrix - Absence of a Role for Platelet Cyclooxygenase

1989 ◽  
Vol 61 (03) ◽  
pp. 485-489 ◽  
Author(s):  
Eva Bastida ◽  
Lourdes Almirall ◽  
Antonio Ordinas
Keyword(s):  
Cell Adhesion ◽  
Shear Rate ◽  
Tumor Cell ◽  
Umbilical Vein ◽  
Blood Platelets ◽  
Flow Conditions ◽  
Tumor Cell Adhesion ◽  
Rate Dependent ◽  
Static Conditions

SummaryBlood platelets are thought to be involved in certain aspects of malignant dissemination. To study the role of platelets in tumor cell adherence to vascular endothelium we performed studies under static and flow conditions, measuring tumor cell adhesion in the absence or presence of platelets. We used highly metastatic human adenocarcinoma cells of the lung, cultured human umbilical vein endothelial cells (ECs) and extracellular matrices (ECM) prepared from confluent EC monolayers. Our results indicated that under static conditions platelets do not significantly increase tumor cell adhesion to either intact ECs or to exposed ECM. Conversely, the studies performed under flow conditions using the flat chamber perfusion system indicated that the presence of 2 × 105 pl/μl in the perfusate significantly increased the number of tumor cells adhered to ECM, and that this effect was shear rate dependent. The maximal values of tumor cell adhesion were obtained, in presence of platelets, at a shear rate of 1,300 sec-1. Furthermore, our results with ASA-treated platelets suggest that the role of platelets in enhancing tumor cell adhesion to ECM is independent of the activation of the platelet cyclooxygenase pathway.

Enhanced tumor cell adhesion to the subendothelial matrix resulting from 12(S)‐HETE‐induced endothelial cell retraction

1989 ◽  
Vol 3 (11) ◽  
pp. 2285-2293 ◽  
Author(s):  
Kenneth V. Honn ◽  
Irma M. Grossi ◽  
Clement A. Diglio ◽  
Marek Wojtukiewicz ◽  
John D. Taylor
Keyword(s):  
Cell Adhesion ◽  
Endothelial Cell ◽  
Tumor Cell ◽  
Tumor Cell Adhesion ◽  
Subendothelial Matrix ◽  
Endothelial Cell Retraction ◽  
Cell Retraction

scholarly journals Transcriptome analysis of human cancer reveals a functional role of Heme Oxygenase-1 in tumor cell adhesion

2010 ◽  
Vol 9 (1) ◽  
pp. 200 ◽  
Author(s):  
Stefanie Tauber ◽  
Alexander Jais ◽  
Markus Jeitler ◽  
Sandra Haider ◽  
Julia Husa ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Heme Oxygenase ◽  
Transcriptome Analysis ◽  
Functional Role ◽  
Human Cancer ◽  
Heme Oxygenase 1 ◽  
Tumor Cell Adhesion
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