Long-term epigenetic effects of exposure to low doses of 56Fe in the mouse lung

The present study was conducted to examine the chronic effects of potassium octatitanate fibers (trade name TISMO; chemical formula K2O·6TiO2) on the mouse lung and thoracic cavity. This method of infusion was employed to examine the direct effects of the fibers to the pleura. In the present study, 52- and 65-week experiments were employed to examine the long-term chronic effects after infusion of fiber-shaped TISMO into the thoracic cavities of A/J mice. Following this infusion, TISMO fibers were observed in the alveoli, indicating penetration through the visceral pleura. The additional histopathological detection of TISMO fibers in the liver, spleen, kidneys, ovary, heart, bone marrow, and brain of TISMO-infused mice indicated migration of the fibers out from the thoracic cavity. Atypical mesothelial cells with severe pleural proliferation were observed, but malignant mesotheliomas were not detected. This study demonstrated that intrathoracic infusion of TISMO fiber did not cause malignant mesothelioma but did cause severe chronic inflammation and proliferation of pleural mesothelial cells.

Download Full-text

Long-term 238Pu and 239Pu Retention and Organ Distribution in Mice at Low Doses

Health Physics ◽

10.1097/00004032-198301001-00051 ◽

1983 ◽

Vol 44 ◽

pp. 505-511

Author(s):

U. Andreozzi ◽

G. F. Clemente ◽

G. Ingrao ◽

G. Santori

Keyword(s):

Organ Distribution ◽

Low Doses

Download Full-text

Long-Term Administration of Low Doses of Mycotoxins in Poultry

Poultry Science ◽

10.3382/ps.0660047 ◽

1987 ◽

Vol 66 (1) ◽

pp. 47-50 ◽

Cited By ~ 16

Author(s):

C. MICCO ◽

M. MIRAGLIA ◽

R. ONORI ◽

A. IOPPOLO ◽

A. MANTOVANI

Keyword(s):

Low Doses ◽

Term Administration

Download Full-text

Sialidosis type 1: Long-term care of two unrelated patients and effectiveness of low doses of Perampanel

Journal of the Neurological Sciences ◽

10.1016/j.jns.2021.117685 ◽

2021 ◽

Vol 429 ◽

pp. 117685

Author(s):

Claudia Cuccurullo ◽

Lia Santulli ◽

Serena Troisi ◽

Paola Russo ◽

Anna Catone ◽

...

Keyword(s):

Long Term Care ◽

Low Doses ◽

Term Care

Download Full-text

Long-term treatment of onchocerciasis in children with low doses of diethylcarbamazine

Annals of Tropical Medicine and Parasitology ◽

10.1080/00034983.1978.11719282 ◽

1978 ◽

Vol 72 (1) ◽

pp. 79-85 ◽

Cited By ~ 8

Author(s):

J. Sowa ◽

Shiona C. I. Sowa

Keyword(s):

Term Treatment ◽

Low Doses ◽

Long Term Treatment

Download Full-text

Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

eLife ◽

10.7554/elife.26575 ◽

2017 ◽

Vol 6 ◽

Cited By ~ 84

Author(s):

Marko Z Nikolić ◽

Oriol Caritg ◽

Quitz Jeng ◽

Jo-Anne Johnson ◽

Dawei Sun ◽

...

Keyword(s):

Lung Development ◽

Mouse Lung ◽

Lung Epithelium ◽

Human Embryonic Lung ◽

Self Renewal ◽

Embryonic Mouse ◽

Multipotent Progenitors ◽

Lung Epithelial

The embryonic mouse lung is a widely used substitute for human lung development. For example, attempts to differentiate human pluripotent stem cells to lung epithelium rely on passing through progenitor states that have only been described in mouse. The tip epithelium of the branching mouse lung is a multipotent progenitor pool that self-renews and produces differentiating descendants. We hypothesized that the human distal tip epithelium is an analogous progenitor population and tested this by examining morphology, gene expression and in vitro self-renewal and differentiation capacity of human tips. These experiments confirm that human and mouse tips are analogous and identify signalling pathways that are sufficient for long-term self-renewal of human tips as differentiation-competent organoids. Moreover, we identify mouse-human differences, including markers that define progenitor states and signalling requirements for long-term self-renewal. Our organoid system provides a genetically-tractable tool that will allow these human-specific features of lung development to be investigated.

Download Full-text

Long-Term Exposure of Early-Transformed Human Mammary Cells to Low Doses of Benzo[a]pyrene and/or Bisphenol A Enhances Their Cancerous Phenotype via an AhR/GPR30 Interplay

Frontiers in Oncology ◽

10.3389/fonc.2020.00712 ◽

2020 ◽

Vol 10 ◽

Cited By ~ 1

Author(s):

Caterina F. Donini ◽

Myriam El Helou ◽

Anne Wierinckx ◽

Balázs Győrffy ◽

Sophie Aires ◽

...

Keyword(s):

Bisphenol A ◽

Low Doses ◽

Mammary Cells

Download Full-text

Immunological and genetic indices in workers under long-term exposure to low-doses of acrylonitrile

Hygiene and Sanitation ◽

10.47470/0016-9900-2021-100-10-1115-1122 ◽

2021 ◽

Vol 100 (10) ◽

pp. 1115-1122

Author(s):

Nina V. Zaitseva ◽

Tatyana S. Ulanova ◽

Oleg V. Dolgikh ◽

Tatyana V. Nurislamova ◽

Olga A. Kazakova ◽

...

Keyword(s):

T Lymphocytes ◽

Malonic Dialdehyde ◽

Test Group ◽

Invasive Procedure ◽

Low Doses ◽

Non Invasive ◽

Exhaled Air ◽

Activated T Lymphocytes ◽

The Impact

Introduction. Nowadays there is very relevant research on the study of the characteristics of the impact on the health of workers of low levels of harmful factors (acrylonitrile) of production during long-term exposure. Aim of the study was to examine peculiarities of immunologic and genetic indices in workers under the long-term exposure to acrylonitrile in low doses. Materials and methods. Our research object was working area air (MPCw.ar.=0.5 mg/m3) and biological media (blood and exhaled air) of workers employed at industrial rubber manufacture. Acrylonitrile was determined via a non-invasive procedure in exhaled air with samples being concentrated on sorption tubes that were then analyzed with capillary gas chromatography. Blood samples were examined to determine contents of malonic dialdehyde, lymphocytes (absolute and relative activated T-lymphocytes CD3+CD25+, absolute and relative activated T-lymphocytes CD3+CD95+), cytokines (VEGF), oncomarkers (PSA), and adrenals hormones; to do that, we applied ELISA tests and flow cytometry. Results. Acrylonitrile was established to occur in working area air in concentrations varying within MPCw.ar. range (0.007-0.015 mg/m3) being 2-3 times higher than in air inside offices at the same enterprise. We obtained statistically significant linear dependence between concentrations of acrylonitrile in the air exhaled by workers (y) and their working experience (x) that was given with the following equation: y=0.00046+0.00027x. According to the results of the laboratory examination of the workers, violations of the antioxidant defense were established. Contents of malonic dialdehyde and steroid hormones including progesterone, estradiol, and hydrocortisone that were pathogenetically linked to each other were authentically up to 3.2 times higher in the test group than in the reference one (p<0.05). Risk for antioxidant protection disorders such as elevated malonic dialdehyde contents in blood plasma might occur in the test group was 1.58 times higher than in the reference one. Conclusion. We revealed certain peculiarities in polymorphism of PPARGC1A Gly482Ser rs8192678 gene, the variability of which contributes to the formation of pathology of the cardiovascular, endocrine systems, oncoproliferative states that increase the likelihood of these undesirable events.

Download Full-text