Primary mesenchymal chondrosarcoma of the orbit in a young female: imaging and histopathological features

Abstract Mesenchymal chondrosarcoma (MCS) is a rare high-grade sarcoma of bone and soft tissue with highly aggressive behavior and a peak incidence in the second and third decades. We report a case of primary orbital MCS in a 30 year-old female, with radiological and clinicopathological features. Orbital MCS is an entity that should be considered in the differential diagnosis of calcified orbital lesions.

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Injection-Site Sarcoma in a Dog: Clinical and Pathological Findings

Case Reports in Veterinary Medicine ◽

10.1155/2017/6952634 ◽

2017 ◽

Vol 2017 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Terry M. Jacobs ◽

Cathy E. Poehlmann ◽

Matti Kiupel

Keyword(s):

Case Report ◽

Soft Tissue ◽

Soft Tissue Sarcoma ◽

Injection Site ◽

Labrador Retriever ◽

High Grade ◽

Pathological Findings ◽

Adjunct Treatment ◽

Positive Expression ◽

High Grade Sarcoma

This case report documents the clinical and pathological findings in a dog that rapidly developed a high-grade sarcoma at the site of multiple vaccinations and follows the response to surgery and adjunct treatment with toceranib. An 11-year-old female spayed Labrador Retriever presented with dorsocervical subcutaneous masses at the injection site three weeks after receiving DA2PP-Lepto, Rabies, and Bordetella vaccinations. A high-grade soft tissue sarcoma was diagnosed microscopically and immunohistochemistry revealed positive expression of VEGFr, PDGFr, SCF, and EGFR. Repeat surgical resections and targeted treatment with toceranib resulted in a stable remission for nearly two years.

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Low-Grade Uterine Epithelioid Hemangioendothelioma Presented as a Submucosal Leiomyoma during Labor

Case Reports in Pathology ◽

10.1155/2013/423584 ◽

2013 ◽

Vol 2013 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Anastasios V. Koutsopoulos ◽

Efthimios Sivridis ◽

Panagiotis Tsikouras ◽

Vasileios Liberis ◽

Georgia Karpathiou ◽

...

Keyword(s):

Differential Diagnosis ◽

Pregnant Woman ◽

Soft Tissue ◽

Soft Tissue Tumors ◽

Epithelioid Hemangioendothelioma ◽

Low Grade ◽

High Grade ◽

Unique Case ◽

Uterine Corpus ◽

Vascular Neoplasms

With the exception of leiomyomas, soft tissue tumors of the uterine corpus are not common. This is particularly true for vascular neoplasms, with the epithelioid hemangioendothelioma being a curiosity; not more than twenty-two cases of malignant hemangioendotheliomas have been reported in the literature so far, all of which were high-grade hemangioendotheliomas (hemangiosarcomas). We present herewith a unique case of low-grade epithelioid hemangioendothelioma of the uterus in a pregnant woman aged 29 years. The clinical, histological, and immunohistochemical characteristics of this entity, together with its differential diagnosis, are discussed.

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Atypical Cardiac Location of Melanoma of Unknown Origin

Medicina ◽

10.3390/medicina57020107 ◽

2021 ◽

Vol 57 (2) ◽

pp. 107

Author(s):

Agnieszka Styczeń ◽

Mariusz Kozak ◽

Marta Karaś-Głodek ◽

Elżbieta Czekajska-Chehab ◽

Andrzej Tomaszewski ◽

...

Keyword(s):

Physical Activity ◽

Differential Diagnosis ◽

Clinical Stage ◽

Unknown Origin ◽

High Grade ◽

Tumor Removal ◽

Abnormal Structure ◽

High Grade Sarcoma ◽

The Subject ◽

Complete Tumor

The subject was a 66-year-old woman, suffering from the chest pain evoked by physical activity. Transthoracic echocardiography (TTE) revealed an abnormal structure, 41 × 29 mm. In MSCT, a hypodensic mobile tissue lesion that was infiltrating the whole thickness of left ventricle was confirmed. PET excluded the existence of other remote lesions. After surgical tumor removal, histopathological differential diagnosis revealed melanoma, myoepithelial cancer, and MPNST “high–grade” sarcoma. A control TTE detected a tumor that was 14 × 10 mm. After immunohistochemical results, immunotherapy with pembrolizumab was used, which resulted in complete tumor resolution. Presently, surgical resection and neoadjuvant targeted immunochemotherapy remain the treatment of choice for clinical stage III/IV melanoma.

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Dedifferentiated Liposarcoma Mimicking a Primary Colon Mass

International Journal of Surgical Pathology ◽

10.1177/1066896917731517 ◽

2017 ◽

Vol 26 (2) ◽

pp. 174-179 ◽

Cited By ~ 3

Author(s):

Blake Hollowoa ◽

Laura W. Lamps ◽

Jason S. Mizell ◽

George W. English ◽

Julia A. Bridge ◽

...

Keyword(s):

Differential Diagnosis ◽

Adipose Tissue ◽

Large Mass ◽

Dedifferentiated Liposarcoma ◽

Radiographic Examination ◽

High Grade ◽

High Grade Sarcoma ◽

Primary Colon ◽

Histopathologic Analysis ◽

Well Differentiated

Dedifferentiated liposarcoma is typically a nonlipogenic high-grade sarcoma that arises from well-differentiated liposarcoma. It most commonly presents as a large mass in the retroperitoneum. Significant involvement of the gastrointestinal tract by dedifferentiated liposarcoma is uncommon. We present a unique case of dedifferentiated liposarcoma radiographically mimicking a primary colon mass with resulting intussusception; stranding of the adjacent adipose tissue was presumed to be a secondary reactive change. On histopathologic analysis of the hemicolectomy specimen, a high-grade sarcoma was seen growing through the colonic wall, and the majority of the surrounding pericolonic adipose tissue was actually composed of well-differentiated liposarcoma with characteristic fibrous bands rather than benign fat with reactive fibrosis. This case raises awareness that well-differentiated liposarcoma and dedifferentiated liposarcoma can rarely present as a primary intestinal mass mimicking colon cancer or other more common entities. When radiographic examination shows a perigastrointestinal or retroperitoneal fatty mass and/or stranding of the fat adjacent to a solid gastrointestinal mass, this unusual scenario should be considered in the radiologic differential diagnosis. Pathologists should keep dedifferentiated liposarcoma in the initial histologic differential diagnosis for any high-grade spindle cell tumor of the retroperitoneum or intra-abdominal visceral organs.

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Primary Orbital Mesenchymal Chondrosarcoma: Case Report and Review of the Literature

Case Reports in Medicine ◽

10.1155/2012/292147 ◽

2012 ◽

Vol 2012 ◽

pp. 1-4 ◽

Cited By ~ 8

Author(s):

Angel Herrera ◽

Cesar Ortega ◽

Gervith Reyes ◽

Miguel Angel Alvarez ◽

Daniela Tellez

Keyword(s):

Differential Diagnosis ◽

Complete Removal ◽

Mesenchymal Chondrosarcoma ◽

Adjuvant Radiation ◽

Rare Entity ◽

Review Of The Literature ◽

Adjuvant Radiation Therapy ◽

History Of ◽

The Right ◽

Orbital Lesions

Orbital mesenchymal chondrosarcoma is a very uncommon lesion of the bone and extraskeletal tissue. To our knowledge, approximately 30 cases have been described. We present the case of a 52-year-old male who presented with a history of progressive proptosis and chemosis of the right eye caused by an orbital tumor. He underwent exenteration of the right orbit, and the histological examination revealed a mesenchymal orbital chondrosarcoma. This paper attempts to describe a rare entity that should be considered in the differential diagnosis of calcified orbital lesions, especially in young adults. Complete removal of the tumor is the mainstay of treatment, but adjuvant radiation therapy and chemotherapy should be considered.

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Malignant Rhabdoid Tumor of Soft Tissue

Pediatric and Developmental Pathology ◽

10.1177/1093526617706814 ◽

2017 ◽

Vol 20 (3) ◽

pp. 262-266 ◽

Cited By ~ 1

Author(s):

Julie Guilmette ◽

Caroline Laverdière ◽

Denis Soulières ◽

Natasha Patey ◽

Geneviève Soucy ◽

...

Keyword(s):

Soft Tissue ◽

Multimodal Treatment ◽

Poor Prognosis ◽

Rhabdoid Tumor ◽

Malignant Rhabdoid Tumor ◽

High Grade ◽

Cell Of Origin ◽

Unique Case ◽

High Grade Sarcoma ◽

Multiple Liver Metastases

Introduction Malignant rhabdoid tumor (MRT) is defined as a high-grade sarcoma derived from an uncertain cell of origin. Its diagnosis is associated with poor prognosis and patient’s life expectancy is greatly reduced. Material and method Here, we describe a unique case of 9-month-old boy who presented with a large MRT arising from the soft tissue of the neck. Following intensive multimodal treatment, the patient benefited from a 25 years’ remission until the discovery of multiple liver metastases. Conclusion MRT of soft tissue needs to be distinguished from other soft tissue neoplasms, as MRT is highly aggressive and is usually associated with a poor outcome. In addition, this is the longest remission time reported in a patient with soft tissue MRT and this might be related to the use of early intensive multimodal treatments.

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