scholarly journals Atypical Cardiac Location of Melanoma of Unknown Origin

Medicina ◽  
2021 ◽  
Vol 57 (2) ◽  
pp. 107
Author(s):  
Agnieszka Styczeń ◽  
Mariusz Kozak ◽  
Marta Karaś-Głodek ◽  
Elżbieta Czekajska-Chehab ◽  
Andrzej Tomaszewski ◽  
...  
Keyword(s):  
Physical Activity ◽  
Differential Diagnosis ◽  
Clinical Stage ◽  
Unknown Origin ◽  
High Grade ◽  
Tumor Removal ◽  
Abnormal Structure ◽  
High Grade Sarcoma ◽  
The Subject ◽  
Complete Tumor

The subject was a 66-year-old woman, suffering from the chest pain evoked by physical activity. Transthoracic echocardiography (TTE) revealed an abnormal structure, 41 × 29 mm. In MSCT, a hypodensic mobile tissue lesion that was infiltrating the whole thickness of left ventricle was confirmed. PET excluded the existence of other remote lesions. After surgical tumor removal, histopathological differential diagnosis revealed melanoma, myoepithelial cancer, and MPNST “high–grade” sarcoma. A control TTE detected a tumor that was 14 × 10 mm. After immunohistochemical results, immunotherapy with pembrolizumab was used, which resulted in complete tumor resolution. Presently, surgical resection and neoadjuvant targeted immunochemotherapy remain the treatment of choice for clinical stage III/IV melanoma.

Dedifferentiated Liposarcoma Mimicking a Primary Colon Mass

2017 ◽  
Vol 26 (2) ◽  
pp. 174-179 ◽  
Author(s):  
Blake Hollowoa ◽  
Laura W. Lamps ◽  
Jason S. Mizell ◽  
George W. English ◽  
Julia A. Bridge ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Adipose Tissue ◽  
Large Mass ◽  
Dedifferentiated Liposarcoma ◽  
Radiographic Examination ◽  
High Grade ◽  
High Grade Sarcoma ◽  
Primary Colon ◽  
Histopathologic Analysis ◽  
Well Differentiated

Dedifferentiated liposarcoma is typically a nonlipogenic high-grade sarcoma that arises from well-differentiated liposarcoma. It most commonly presents as a large mass in the retroperitoneum. Significant involvement of the gastrointestinal tract by dedifferentiated liposarcoma is uncommon. We present a unique case of dedifferentiated liposarcoma radiographically mimicking a primary colon mass with resulting intussusception; stranding of the adjacent adipose tissue was presumed to be a secondary reactive change. On histopathologic analysis of the hemicolectomy specimen, a high-grade sarcoma was seen growing through the colonic wall, and the majority of the surrounding pericolonic adipose tissue was actually composed of well-differentiated liposarcoma with characteristic fibrous bands rather than benign fat with reactive fibrosis. This case raises awareness that well-differentiated liposarcoma and dedifferentiated liposarcoma can rarely present as a primary intestinal mass mimicking colon cancer or other more common entities. When radiographic examination shows a perigastrointestinal or retroperitoneal fatty mass and/or stranding of the fat adjacent to a solid gastrointestinal mass, this unusual scenario should be considered in the radiologic differential diagnosis. Pathologists should keep dedifferentiated liposarcoma in the initial histologic differential diagnosis for any high-grade spindle cell tumor of the retroperitoneum or intra-abdominal visceral organs.

scholarly journals Primary mesenchymal chondrosarcoma of the orbit in a young female: imaging and histopathological features

2020 ◽  
Vol 2020 (3) ◽  
Author(s):  
Lorenzo D’Alì ◽  
Angelica Tulisso ◽  
Laura Mariuzzi
Keyword(s):  
Differential Diagnosis ◽  
Soft Tissue ◽  
Aggressive Behavior ◽  
Young Female ◽  
Clinicopathological Features ◽  
Mesenchymal Chondrosarcoma ◽  
High Grade ◽  
Peak Incidence ◽  
High Grade Sarcoma ◽  
Orbital Lesions

Abstract Mesenchymal chondrosarcoma (MCS) is a rare high-grade sarcoma of bone and soft tissue with highly aggressive behavior and a peak incidence in the second and third decades. We report a case of primary orbital MCS in a 30 year-old female, with radiological and clinicopathological features. Orbital MCS is an entity that should be considered in the differential diagnosis of calcified orbital lesions.

scholarly journals Tumour Versus Germline BRCA Testing in Ovarian Cancer: A Single-Site Institution Experience in the United Kingdom

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 547
Author(s):  
Iolia Akaev ◽  
Siavash Rahimi ◽  
Olubukola Onifade ◽  
Francis John Edward Gardner ◽  
David Castells-Rufas ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Unknown Origin ◽  
Parp Inhibitors ◽  
Serous Carcinoma ◽  
High Grade ◽  
Brca1 And Brca2 ◽  
Brca Mutations ◽  
Epithelial Cancers ◽  
Pathogenic Variants ◽  
Pathogenic Mutations

The aim of this audit was to evaluate the usefulness and serviceability of testing for pathogenic mutations in BRCA1 or BRCA2 (BRCA1/2) genes in ovarian cancer (OC) patients. One hundred and thirty-five patients with more common histological sub-types of OC were retrospectively identified between 2011 and 2019. The fail rate of the molecular analysis was 7.4% (10/135). One hundred and twenty-five records were evaluated: 99 (79.2%) patients had wild-type BRCA (both somatic and germline); tumour BRCA1/2 (tBRCA1/2) pathogenic mutations were found in 20 (16%) patients with distribution between BRCA1 and BRCA2 being 40% and 60%, respectively; 13 (10.4%) patients with pathogenic variants had germline mutations; and tBRCA1/2 with variant of unknown significance (VUS), in the absence of pathogenic BRCA1 or BRCA2 variants, was detected in 6 (4.8%) patients. Our data show that expanding the molecular service to the routine first-tumour testing for patients with OC will potentially increase the detection rate of BRCA mutations, thereby providing early benefits of PARP inhibitors therapy. The tumour testing service should continue to be offered to newly diagnosed patients with high-grade epithelial cancers, including high-grade serous carcinoma, but also with carcinosarcomas and poorly-differentiated metastatic adenocarcinomas of unknown origin.

Acute Aortic Thromboembolism After Right Middle and Lower Bilobectomy for Metastatic High-Grade Sarcoma

CHEST Journal ◽  
2017 ◽  
Vol 152 (4) ◽  
pp. A37
Author(s):  
Adil Malik ◽  
Andrew Serdiuk ◽  
David Thrush ◽  
Evan Glazer ◽  
Puya Alikhani ◽  
...  
Keyword(s):  
High Grade ◽  
High Grade Sarcoma

Intracanalicular Acoustic Neurinomas

Neurosurgery ◽  
1991 ◽  
Vol 29 (2) ◽  
pp. 189-199 ◽  
Author(s):  
Madjid Samii ◽  
Cordula Matthies ◽  
Marcos Tatagiba
Keyword(s):  
Resonance Imaging ◽  
Tumor Removal ◽  
Diagnostic Reliability ◽  
Computed Tomographic ◽  
Acoustic Neurinomas ◽  
Vestibular Symptoms ◽  
Symptoms And Signs ◽  
Facial Function ◽  
Complete Tumor

Abstract The cases of 16 patients with acoustic neurinomas confined to the intracanalicular area are presented. These represent 2.7% of the 600 patients with acoustic neurinomas consecutively operated upon at the Neurosurgical Clinic at Nordstadt Hospital during the last 8 years. The comparatively earlier onset of vestibular symptoms and signs was characteristic of this group and precipitated diagnosis. The diagnostic reliability of magnetic resonance imaging was at least equivalent to that of air computed tomographic cisternography. Complete tumor removal was accomplished via the suboccipital approach in all patients, with 100% preservation of facial nerve and facial function; the cochlear nerve was preserved anatomically in 100% of the patients and functionally in 57%. No recurrence has occurred during follow-up periods of up to 8 years in all 16 patients. A broad spectrum of the current literature is considered, and purely intracanalicular acoustic neurinomas are discussed with regard to clinical characteristics, diagnostic steps—including neuroradiological and neurophysiological approaches—and surgical treatment and results.

scholarly journals Somatically derived Yolk Sac tumor of the urinary bladder: A case report and differential diagnosis

2020 ◽  
Author(s):  
Nadia Espejo-Herrera ◽  
Enric Condom Mundó
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Final Diagnosis ◽  
Yolk Sac ◽  
Yolk Sac Tumor ◽  
High Grade ◽  
Yolk Sac Tumors ◽  
Urinary Bladder Tumor

Abstract Background: Yolk sac tumor is a germ cell neoplasm that arises predominantly in the gonads, but can also derive from somatic neoplasms in extragonadal locations. These cases have been denominated recently as “somatically derived Yolk sac tumors”, and have been documented in several locations, although reports from the urinary tract are scarce. To our knowledge, this is the first report of a Yolk sac tumor derived from urothelial carcinoma. Case presentation: We present a unique case of a 76-year-old man with a recurrent urinary bladder tumor, initially interpreted as a high grade urothelial carcinoma with glandular differentiation. In the recurrent tumor, diverse histological patterns were identified, including glandular, hepatoid and sarcomatoid. This tumor showed positivity for AFP, GLP3 and SALL4, and negativity for CK7 and EMA. Fluorescent in situ hybridization study showed a polysomic pattern of chromosome 12. All these findings led to the final diagnosis of a Yolk sac tumor derived from urothelial carcinoma. Conclusions: Somatically derived Yolk Sac tumors should be considered in the differential diagnosis of a high grade urothelial carcinoma, particularly when glandular and other unusual patterns are observed. Key words: Yolk sac tumor, somatically derived, urothelial carcinoma, urinary bladder, case report.

scholarly journals Neoadjuvant concurrent chemoradiotherapy with and without hyperthermia in retroperitoneal and intra-abdominal sarcomas: Feasibility, efficacy, toxicity and long-term outcome

2021 ◽  
Author(s):  
Alexander Willner ◽  
Katja Fechner ◽  
Abbas Agaimy ◽  
Florian Haller ◽  
Markus Eckstein ◽  
...  
Keyword(s):  
Neoadjuvant Chemoradiotherapy ◽  
Tumor Control ◽  
High Grade ◽  
Regional Hyperthermia ◽  
Abdominal Tumor ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Free Survival ◽  
High Grade Sarcoma

Abstract Background Retroperitoneal (RPS) and intra-abdominal sarcomas (IAS) are associated with poor local and abdominal tumor control. Yet, the benefit of preoperative radio- or chemotherapy alone for these entities currently is unclear. Moreover, as intermediate- and high-grade sarcomas have a tendency for early metastasis, exploration of neoadjuvant strategies is of high importance. This analysis reports the results of our 20-year single-institution experience with preoperative neoadjuvant concurrent chemoradiation.Methods From 2000-2019, 27 patients with intermediate- or high-grade RPS or IAS (12 dedifferentiated liposarcoma, 10 leiomyosarcoma, 5 others) were treated with radiotherapy (median dose: 50.4 Gy; range 45-75 Gy) and two cycles of chemotherapy (doxorubicin 50mg/m² BSA/d3 q28 and ifosfamide 1.5g/m2 BSA/d1-5 q28) in neoadjuvant intention. Chemotherapy consisted of doxorubicin alone in two cases and ifosfamide alone in one case. Fifteen patients (56%) received deep regional hyperthermia additionally.Results The median follow-up time was 53 months (± 56.7 months). 92% of patients received two cycles of chemotherapy as planned and 92% underwent surgery. At 5 and 10 years, abdominal-recurrence-free-survival was 74.6% (± 10.1%) and 66.3% (± 11.9%), distant-metastasis-free-survival was 67.2% (± 9.7%) and 59.7% (± 11.1%), and overall-survival was 60.3% (± 10.5%) and 60.3% (± 10.5%), respectively. CTC grade III and IV toxicities were leukocytopenia (85%), thrombocytopenia (33%) and anemia (11%). There were no treatment-related deaths.Conclusions Neoadjuvant chemoradiotherapy with and without hyperthermia for retroperitoneal and intra-abdominal sarcoma is feasible and provided high local control of intermediate - and high-grade sarcoma.

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