scholarly journals HHP1, a novel signalling component in the cross-talk between the cold and osmotic signalling pathways in Arabidopsis

2010 ◽  
Vol 61 (12) ◽  
pp. 3305-3320 ◽  
Author(s):  
C.-C. Chen ◽  
C.-S. Liang ◽  
A.-L. Kao ◽  
C.-C. Yang
Keyword(s):  
Cross Talk ◽  
Signalling Pathways ◽  
The Cross

Cross-talk between steroid-receptor-mediated and cell-membrane-receptor-mediated signalling pathways results in the in vivo modulation of c-Met and ornithine decarboxylase gene expression in mouse kidney

2001 ◽  
Vol 353 (2) ◽  
pp. 317-323 ◽  
Author(s):  
Magdalena DUDKOWSKA ◽  
Agnieszka STACHURSKA ◽  
Wanda CHMURZYŃSKA ◽  
Barbara GRZELAKOWSKA-SZTABERT ◽  
Małgorzata MANTEUFFEL-CYMBOROWSKA
Keyword(s):  
Gene Expression ◽  
Ornithine Decarboxylase ◽  
Cross Talk ◽  
Mrna Level ◽  
Signalling Pathways ◽  
Renal Tubules ◽  
The Cross ◽  
Transient Elevation ◽  
Hepatocyte Growth

The cross-talk in vivo between two signalling pathways activated by testosterone via intracellular androgen receptor, and induced by damage to renal tubules evoked by anti-folate [N10-propargyl-5,8-dideazafolic acid (CB 3717)] or folate is reported. We show that CB 3717/folate induces the expression of the hepatocyte growth factor (HGF)/c-Met signalling system in injured kidneys in which a significant, but transient, elevation of the HGF mRNA level occurs. It is followed by a severalfold increase in the c-Met transmembrane receptor message that persists for up to 24h. The c-Met expression is also positively controlled by testosterone, which induces a significant increase in its mRNA level that is abolished by an anti-androgen, casodex. However, when testosterone and anti-folate/folate are administered sequentially, a substantial (3.5Ő4.0-fold) decrease in the increase of c-Met expression caused by CB 3717/folate alone occurs. Similarly, testosterone-induced ornithine decarboxylase (ODC) mRNA level and activity are decreased 2.8Ő7.7-fold when the androgen is applied together with CB 3717. Antagonism between these pathways is also visible under physiological conditions in the kidneys of male mice in which, owing to elevated endogenous testosterone levels, neither the ODC activity nor the mRNA level is induced by anti-folate/folate, whereas the c-Met message response to these drugs is significantly decreased. Our results document a substantial negative regulation of c-Met and ODC gene expression as a result of the cross-talk between testosterone-activated and HGF-activated pathways and suggest a sex-differentiated response to injury of mouse kidneys.

scholarly journals The Cross-Talk Between the TNF-α and RASSF-Hippo Signalling Pathways

2019 ◽  
Vol 20 (9) ◽  
pp. 2346 ◽  
Author(s):  
Delvac Oceandy ◽  
Bella Amanda ◽  
Faisal Ashari ◽  
Zakiyatul Faizah ◽  
M Aziz ◽  
...  
Keyword(s):  
Cross Talk ◽  
Hippo Pathway ◽  
Signalling Pathways ◽  
Physiological Processes ◽  
Tnf Α ◽  
The Cross ◽  
Factor Α ◽  
Apoptosis Regulation ◽  
The Hippo Pathway ◽  
Hippo Signalling

The regulation of cell death through apoptosis is essential to a number of physiological processes. Defective apoptosis regulation is associated with many abnormalities including anomalies in organ development, altered immune response and the development of cancer. Several signalling pathways are known to regulate apoptosis including the Tumour Necrosis Factor-α (TNF-α) and Hippo signalling pathways. In this paper we review the cross-talk between the TNF-α pathway and the Hippo signalling pathway. Several molecules that tightly regulate the Hippo pathway, such as members of the Ras-association domain family member (RASSF) family proteins, interact and modulate some key proteins within the TNF-α pathway. Meanwhile, TNF-α stimulation also affects the expression and activation of core components of the Hippo pathway. This implies the crucial role of signal integration between these two major pathways in regulating apoptosis.

The Role of Sensing Peptides in the Cross-talk between Microbiota and Human Cancer Cells

2018 ◽  
Vol 18 (18) ◽  
pp. 1567-1571
Author(s):  
Anna Lucia Tornesello ◽  
Luigi Buonaguro ◽  
Maria Lina Tornesello ◽  
Franco M. Buonaguro
Keyword(s):  
Cancer Cells ◽  
Cross Talk ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
The Cross

Effect of the cross-talk between autophagy and endoplasmic reticulum stress on Mn-induced alpha-synuclein oligomerization

2017 ◽  
Vol 33 (3) ◽  
pp. 315-324 ◽  
Author(s):  
Chang Liu ◽  
Dong-Ying Yan ◽  
Xuan Tan ◽  
Zhuo Ma ◽  
Can Wang ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cross Talk ◽  
Alpha Synuclein ◽  
The Cross

scholarly journals LecRK-Ⅷ.2 mediates the cross-talk between sugar and brassinosteroid during hypocotyl elongation in Arabidopsis

2021 ◽  
Vol 1 (1) ◽  
pp. 55-63
Author(s):  
NingJie Hao ◽  
Xiaoxiao Zou ◽  
Xiaoxia Lin ◽  
Ruqiong Cai ◽  
Wenjun Xiao ◽  
...  
Keyword(s):  
Cross Talk ◽  
Hypocotyl Elongation ◽  
The Cross

Are neutrophil extracellular traps the link for the cross-talk between periodontitis and rheumatoid arthritis physiopathology?

Rheumatology ◽  
2021 ◽  
Author(s):  
Sicília Rezende Oliveira ◽  
José Alcides A de Arruda ◽  
Ayda Henriques Schneider ◽  
Valessa Florindo Carvalho ◽  
Caio Machado ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cross Talk ◽  
Neutrophil Extracellular Traps ◽  
Periodontal Therapy ◽  
Clinical Parameters ◽  
Extracellular Traps ◽  
Early Ra ◽  
The Cross ◽  
High Concentrations ◽  
The Impact

Abstract Objectives Neutrophil extracellular traps (NETs) play a role in the pathogenesis of periodontitis and rheumatoid arthritis (RA). However, it remains poorly understood whether NETs participate in the cross-talk between periodontitis and RA. Herein, we investigated the production of NETs in individuals with periodontitis and RA and its association with clinical parameters. The impact of periodontal therapy on RA and NET release was also assessed. Methods The concentration of NETs and cytokines was determined in the saliva and plasma of individuals with early RA (n = 24), established RA (n = 64), and individuals without RA (n = 76). The influence of periodontitis on the production of NETs and cytokines was also evaluated. Results Individuals with early RA had a higher concentration of NETs in saliva and plasma than individuals with established RA or without RA. Periodontitis resulted in an increase in the concentration of NETs of groups of individuals without RA and with early RA. The proportion of individuals with high concentrations of IL-6, IL-10 and GM-CSF was higher among individuals with periodontitis than among individuals without periodontitis. The concentrations of TNF-α, IL-6, IL-17/IL-25, and IL-28A were particularly high in individuals with early RA. Worse periodontal clinical parameters, RA onset and RA activity were significantly associated with circulating NETs. Periodontal therapy was associated with a reduction in the concentration of NETs and inflammatory cytokines and amelioration in periodontitis and RA. Conclusion This study reveals that NETs are a possible link between periodontitis and RA, with periodontal therapy resulting in a dramatic switch in circulating NET levels.

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