scholarly journals Histone tales: lysine methylation, a protagonist in Arabidopsis development

2019 ◽  
Author(s):  
Kai Cheng ◽  
Yingchao Xu ◽  
Chao Yang ◽  
Luc Ouellette ◽  
Longjian Niu ◽  
...  
Keyword(s):  
Developmental Programming ◽  
Lysine Methylation ◽  
Histone Lysine Methylation ◽  
Histone Lysine ◽  
Recent Advances

Recent advances in the regulation of histone lysine methylation in plants and the role of this modification in the developmental programming of Arabidopsis are discussed.

scholarly journals Histone Lysine Methylation in TGF-β1 Mediated p21 Gene Expression in Rat Mesangial Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Qiaoyan Guo ◽  
Xiaoxia Li ◽  
Hongbo Han ◽  
Chaoyuan Li ◽  
Shujun Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transforming Growth Factor ◽  
Mesangial Cells ◽  
Gene Promoter ◽  
Renal Diseases ◽  
Lysine Methylation ◽  
Histone Lysine Methylation ◽  
Histone Lysine ◽  
Chronic Renal Diseases

Transforming growth factor beta1- (TGF-β1-) induced p21-dependent mesangial cell (MC) hypertrophy plays a key role in the pathogenesis of chronic renal diseases including diabetic nephropathy (DN). Increasing evidence demonstrated the role of posttranscriptional modifications (PTMs) in the event; however, the precise regulatory mechanism of histone lysine methylation remains largely unknown. Here, we examined the roles of both histone H3 lysine 4 and lysine 9 methylations (H3K4me/H3K9me) in TGF-β1 induced p21 gene expression in rat mesangial cells (RMCs). Our results indicated that TGF-β1 upregulated the expression of p21 gene in RMCs, which was positively correlated with the increased chromatin marks associated with active genes (H3K4me1/H3K4me2/H3K4me3) and negatively correlated with the decreased levels of repressive marks (H3K9me2/H3K9me3) at p21 gene promoter. TGF-β1 also elevated the recruitment of the H3K4 methyltransferase (HMT) SET7/9 to the p21 gene promoter. SET7/9 gene silencing with small interfering RNAs (siRNAs) significantly abolished the TGF-β1 induced p21 gene expression. Taken together, these results reveal the key role of histone H3Kme in TGF-β1 mediated p21 gene expression in RMC, partly through HMT SET7/9 occupancy, suggesting H3Kme and SET7/9 may be potential renoprotective agents in managing chronic renal diseases.

scholarly journals The Role of Histone Lysine Methylation in the Response of Mammalian Cells to Ionizing Radiation

2021 ◽  
Vol 12 ◽  
Author(s):  
Elena Di Nisio ◽  
Giuseppe Lupo ◽  
Valerio Licursi ◽  
Rodolfo Negri
Keyword(s):  
Cell Lines ◽  
Protein Interactions ◽  
Mammalian Cells ◽  
Bioinformatic Analysis ◽  
Mrna Levels ◽  
Lysine Methylation ◽  
Histone Lysine Methylation ◽  
Cellular Processes ◽  
Histone Lysine

Eukaryotic genomes are wrapped around nucleosomes and organized into different levels of chromatin structure. Chromatin organization has a crucial role in regulating all cellular processes involving DNA-protein interactions, such as DNA transcription, replication, recombination and repair. Histone post-translational modifications (HPTMs) have a prominent role in chromatin regulation, acting as a sophisticated molecular code, which is interpreted by HPTM-specific effectors. Here, we review the role of histone lysine methylation changes in regulating the response to radiation-induced genotoxic damage in mammalian cells. We also discuss the role of histone methyltransferases (HMTs) and histone demethylases (HDMs) and the effects of the modulation of their expression and/or the pharmacological inhibition of their activity on the radio-sensitivity of different cell lines. Finally, we provide a bioinformatic analysis of published datasets showing how the mRNA levels of known HMTs and HDMs are modulated in different cell lines by exposure to different irradiation conditions.

scholarly journals Dynamic Patterns of Histone Lysine Methylation in the Developing Retina

2010 ◽  
Vol 51 (12) ◽  
pp. 6784 ◽  
Author(s):  
Rajesh C. Rao ◽  
Kissaou T. Tchedre ◽  
Muhammad Taimur A. Malik ◽  
Natasha Coleman ◽  
Yuan Fang ◽  
...  
Keyword(s):  
Lysine Methylation ◽  
Histone Lysine Methylation ◽  
Histone Lysine ◽  
Dynamic Patterns

The Indexing Potential of Histone Lysine Methylation

2008 ◽  
pp. 22-47 ◽  
Author(s):  
Gunnar Schotta ◽  
Monika Lachner ◽  
Antoine H. F. M. Peters ◽  
Thomas Jenuwein
Keyword(s):  
Lysine Methylation ◽  
Histone Lysine Methylation ◽  
Histone Lysine

scholarly journals Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Liping Dou ◽  
Fei Yan ◽  
Jiuxia Pang ◽  
Dehua Zheng ◽  
Dandan Li ◽  
...  
Keyword(s):  
Dna Sequences ◽  
Transcriptional Repression ◽  
Lysine Methylation ◽  
Post Translational Modification ◽  
Histone Lysine Methylation ◽  
Histone Lysine ◽  
Histone Lysine Methyltransferase ◽  
Lysine Methyltransferase

Abstract The oncogenic fusion protein AML1-ETO retains the ability of AML1 to interact with the enhancer core DNA sequences, but blocks AML1-dependent transcription. Previous studies have shown that post-translational modification of AML1-ETO may play a role in its regulation. Here we report that AML1-ETO-positive patients, with high histone lysine methyltransferase Enhancer of zeste homolog 1 (EZH1) expression, show a worse overall survival than those with lower EZH1 expression. EZH1 knockdown impairs survival and proliferation of AML1-ETO-expressing cells in vitro and in vivo. We find that EZH1 WD domain binds to the AML1-ETO NHR1 domain and methylates AML1-ETO at lysine 43 (Lys43). This requires the EZH1 SET domain, which augments AML1-ETO-dependent repression of tumor suppressor genes. Loss of Lys43 methylation by point mutation or domain deletion impairs AML1-ETO-repressive activity. These findings highlight the role of EZH1 in non-histone lysine methylation, indicating that cooperation between AML1-ETO and EZH1 and AML1-ETO site-specific lysine methylation promote AML1-ETO transcriptional repression in leukemia.

Histone lysine methylation exhibits a distinct distribution during spermatogenesis in pigs

2015 ◽  
Vol 84 (9) ◽  
pp. 1455-1462 ◽  
Author(s):  
Junhui An ◽  
Jinzhou Qin ◽  
Yi Wan ◽  
Yaqing Zhang ◽  
Yuan Hu ◽  
...  
Keyword(s):  
Lysine Methylation ◽  
Histone Lysine Methylation ◽  
Histone Lysine ◽  
Distinct Distribution

Impacts of Histone Lysine Methylation on Chromatin

2016 ◽  
pp. 25-53
Author(s):  
S. Lanouette ◽  
J. Haddad ◽  
P. Zhang ◽  
J.-F. Couture
Keyword(s):  
Lysine Methylation ◽  
Histone Lysine Methylation ◽  
Histone Lysine
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