Cat Scratch Disease

2019 ◽  
pp. 136-138
Author(s):  
Remide Arkun
Keyword(s):  
Bartonella Henselae ◽  
Systemic Disease ◽  
Granulomatous Inflammation ◽  
Cat Scratch Disease ◽  
Tissue Sampling ◽  
Gram Negative ◽  
Atypical Manifestations ◽  
History Of ◽  
Polymerase Chain ◽  
Severe Systemic Disease

Chapter 94 reviews cat scratch disease, which is an infection caused by Bartonella henselae, a gram-negative intracellular Bacillus, which causes granulomatous inflammation of the tissues. There is usually a history of exposure to cats, and cat scratch, bite or licking. The disease is characterized by chronic lymphadenopathy in children and adolescents. In immunocompromised patients, severe systemic disease or other atypical manifestations may develop, including osteomyelitis together with ipsilateral lymphadenopathy. A history of cat exposure, polymerase chain reaction (PCR), and other serologic tests are helpful in diagnosis and complement imaging findings. Tissue sampling of lymph nodes or bones reveals granulomatous infection.

scholarly journals Atypical presentation of bartonellosis with hepatolienal lesions

2021 ◽  
Vol 20 (1) ◽  
pp. 136-144
Author(s):  
M. A. Lunyakova ◽  
V. G. Demikhov ◽  
N. V. Inyakova ◽  
E. A. Panina
Keyword(s):  
Clinical Course ◽  
Bartonella Henselae ◽  
Human Infection ◽  
Atypical Presentation ◽  
Cat Scratch Disease ◽  
Neurological Manifestations ◽  
Gram Negative ◽  
Duration Of Therapy ◽  
Night Sweats ◽  
History Of

Cat scratch disease is caused by the gram-negative intracellular bacterium Bartonella henselae (B. henselae). Human infection occurs mainly through cat scratches and bites. In typical cases, the clinical course is presented by a primary affect on the skin and regional lymphadenitis. The atypical presentation of infection can occur with fever, abdominal, ocular and neurological manifestations. A special feature of the abdominal form is the presence of solitary or multiple hypo/anechoic foci of different size and shape in the liver and spleen. B. henselae infection is one of the most common mimics of malignant lymphoma, when the spleen is involved in combination with B symptoms (weight loss, night sweats and prolonged fever). A history of recent contact with cats and diagnostic IgG titers to B. henselae indicate infection. There is no consensus on the choice of antimicrobial drug and the duration of therapy for systemic forms. The article presents its own experience in the diagnosis and treatment of such patients. The patient's parents agreed to use the information, including the child's photo, in scientific research and publications. 

scholarly journals An immigrant with acquired immunodeficiency syndrome presenting with a rash: A case report

2019 ◽  
Vol 7 ◽  
pp. 2050313X1982961
Author(s):  
Connie Zhang ◽  
Megan A Sander
Keyword(s):  
Human Immunodeficiency Virus ◽  
Acquired Immunodeficiency Syndrome ◽  
Systemic Disease ◽  
Immunodeficiency Virus ◽  
History Of ◽  
Acquired Immunodeficiency ◽  
Laboratory Investigations ◽  
Polymerase Chain ◽  
Immunodeficiency Syndrome ◽  
Work Up

A 58-year-old woman from Zimbabwe, with a history of untreated human immunodeficiency virus, presented with leonine facies and a diffuse rash. The rash occurred in the context of a 1-year history of constitutional symptoms and cognitive decline. Laboratory investigations confirmed that her human immunodeficiency virus had progressed to acquired immunodeficiency syndrome. Through imaging, tissue biopsies, and polymerase chain reaction, a diagnosis of disseminated histoplasmosis was made. Since there was no history of travel and histoplasmosis is not locally endemic, the patient likely contracted this fungal infection more than 7 years ago, while living in Africa. We speculate that the histoplasmosis remained latent until her immune system began to decline. The work-up and management of this rare cutaneous presentation of a systemic disease, which should be added to the list of “great mimickers” in dermatology, are discussed.

scholarly journals Anaplastic Large Cell Lymphoma Presenting as Haemophagocytic Lymphohistiocytosis with Underlying Coxiella burnetii and Bartonella henselae Seropositivity

2020 ◽  
Author(s):  
Mohammad Ammad Ud Din ◽  
Syed Ather Hussain ◽  
Bassil Said ◽  
Aneeqa Zafar
Keyword(s):  
Coxiella Burnetii ◽  
Cell Lymphoma ◽  
Bartonella Henselae ◽  
Large Cell ◽  
Haemophagocytic Lymphohistiocytosis ◽  
Chain Reaction ◽  
History Of ◽  
Polymerase Chain ◽  
Work Up ◽  
New Onset

A 44-year-old woman with no significant medical history presented with a 3-week history of high-grade fevers, fatigue and shortness of breath. Laboratory investigation was significant for lymphopenia and thrombocytopenia which progressively worsened during her hospital stay, along with new-onset anaemia, and elevated ferritin, transaminase and triglycerides. A computerized tomography (CT) scan of the abdomen revealed retroperitoneal lymphadenopathy. A bone marrow biopsy confirmed the diagnosis of haemophagocytic lymphohistiocytosis (HLH). Extensive infectious work-up revealed high IgG titres for Bartonella henselae and Coxiella burnetii. Interestingly, the left supraclavicular node was negative for both microbes by polymerase chain reaction (PCR), but the biopsy revealed anaplastic large T-cell lymphoma.

Eritema nodoso: gatta ci cova

2021 ◽  
Vol 24 (10) ◽  
pp. 304-308
Author(s):  
Caterina Bacci ◽  
Sara Picariello ◽  
Francesco Vierucci ◽  
Carlo Mazzatenta ◽  
Angelina Vaccaro
Keyword(s):  
Clinical Manifestation ◽  
Erythema Nodosum ◽  
Bartonella Henselae ◽  
Diagnostic Evaluation ◽  
Cat Scratch Disease ◽  
Clinical Presentations ◽  
Atypical Manifestations ◽  
Systemic Symptoms ◽  
Atypical Manifestation ◽  
Subsequent Onset

Erythema nodosum is a panniculitis that can be triggered by many different stimuli. The paper describes the case of a child who presented with erythema nodosum as the unique clinical manifestation of cat scratch disease. Bartonella henselae infection usually presents with non-tender papule in the scratch line followed by subsequent onset of regional lymphadenopathy eventually associated with systemic symptoms. It can also present with atypical manifestation, such as erythema nodosum. The heterogeneity of the clinical presentations makes the disease to be underdiagnosed, whereby it is important to recognize atypical manifestations. Therefore, it is recommended to include Bartonella henselae serology in the diagnostic evaluation of erythema nodosum.

scholarly journals Molecular survey ofBartonella henselaeandBartonella clarridgeiaein pet cats across Japan by species-specific nested-PCR

2017 ◽  
Vol 145 (13) ◽  
pp. 2694-2700 ◽  
Author(s):  
S. SATO ◽  
H. KABEYA ◽  
A. NEGISHI ◽  
H. TSUJIMOTO ◽  
K. NISHIGAKI ◽  
...  
Keyword(s):  
Nested Pcr ◽  
Bartonella Henselae ◽  
23S Rrna ◽  
Cat Scratch Disease ◽  
Internal Transcribed Spacer Region ◽  
Nested Polymerase Chain Reaction ◽  
Polymerase Chain ◽  
Species Specific ◽  
Pcr Targeting ◽  
Eastern Japan

SUMMARYCats are known to be the main reservoir forBartonella henselaeandBartonella clarridgeiae, which are the agents of ‘cat-scratch disease’ in humans. In the present study, we investigated the prevalence of the twoBartonellaspecies on 1754 cat bloods collected from all prefectures in Japan during 2007–2008 by a nested-polymerase chain reaction (PCR) targeting the 16S–23S rRNA internal transcribed spacer region. Overall,BartonellaDNA was detected in 4·6% (80/1754) of the cats examined. The nested-PCR showed that 48·8% (39/80) of the positive cats were infected withB. henselaemono-infection, 33·8% (27/80) withB. clarridgeiaemono-infection and 17·5% (14/80) were infected with both species. The prevalence (5·9%; 65/1103) ofBartonellainfection in the western part of Japan was significantly higher than that (2·3%; 15/651) of eastern Japan (P< 0·001). Statistical analysis of the cats examined suggested a significant association betweenBartonellainfection and FeLV infection (OR = 1·9; 95% CI = 1·1–3·4), but not with FIV infection (OR = 1·6; 95% CI = 1·0–2·6).

scholarly journals Disseminated cat-scratch disease: a case report

2015 ◽  
Vol 22 (2) ◽  
pp. 229-231
Author(s):  
Faizul Islam Chowdhury ◽  
MA Kashem ◽  
Md Anwar Hossain ◽  
Imran Munadil Ahsan ◽  
Avijit Pandit ◽  
...  
Keyword(s):  
Bartonella Henselae ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Cat Scratch Disease ◽  
Gram Negative ◽  
Systemic Involvement ◽  
Medical College ◽  
Negative Bacillus ◽  
Node Biopsy ◽  
Gram Negative Bacillus

Cat-scratch disease is an infectious disease caused by Bartonella henselae, a gram-negative bacillus. The disease is usually transmitted to the human being by cat scratches. Cat-scratch disease typically presents with painful regional lymphadenopathy. Systemic involvement is unusual. A 35 years old lady, came with the complaints of fever, abdominal pain along with nausea, anorexia & difficulties of swallowing for 6 months. She has painful cervical lymphadenopathy. Histopathology of her lymph node biopsy shows features of cat-scratch disease. DOI: http://dx.doi.org/10.3329/jdmc.v22i2.21550 J Dhaka Medical College, Vol. 22, No.2, October, 2013, Page 229-231

scholarly journals Murine Model of Bartonella henselae Infection in the Immunocompetent Host

1998 ◽  
Vol 66 (11) ◽  
pp. 5534-5536 ◽  
Author(s):  
T. Regnath ◽  
M. E. A. Mielke ◽  
M. Arvand ◽  
H. Hahn
Keyword(s):  
Immune Response ◽  
Liver Tissue ◽  
Bartonella Henselae ◽  
Granulomatous Inflammation ◽  
Peliosis Hepatis ◽  
Cat Scratch Disease ◽  
Immunocompetent Host ◽  
Bacillary Angiomatosis ◽  
Model Following ◽  
Intraperitoneal Infection

ABSTRACT Bartonella henselae is an emerging pathogen causing cat scratch disease, bacillary angiomatosis, and peliosis hepatis. Progress in understanding the pathogenesis of and the immune response to these infections has been limited by the lack of an animal model. Following intraperitoneal infection of C57BL/6 mice withB. henselae, organs were cleared of cultivatable bacteria within 6 days. In contrast, B. henselae DNA could be detected in liver tissue for at least 3 months. Liver tissue showed granulomatous inflammation reaching its highest degree of intensity during the fourth week of infection and resolving within 12 weeks postinfection. This mouse model is applicable to the study of the pathogenesis of B. henselae and the immune response to this pathogen in the immunocompetent host.

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