Toward Multi-Omic–Informed Psychotropic Prescribing

2021 ◽  
pp. 303-316
Author(s):  
Abdullah Al Maruf ◽  
Chad Bousman
Keyword(s):  
Mental Health ◽  
Psychotropic Drug ◽  
Biological Markers ◽  
Drug Response ◽  
The Past ◽  
Technological Advances ◽  
The Future ◽  
Medication Selection

Matching individuals to tolerable and efficacious pharmacotherapies in mental health has proven challenging. As such, efforts to personalize psychotropic prescribing in mental health has received considerable attention over the past decade. This attention has been fueled by technological advances in genomics, specifically, pharmacogenomics, and, more recently, epigenomics, transcriptomics, proteomics, and metabolomics that have facilitated the identification of clinically useful biological markers to guide medication selection and dosing. The convergence of these omic technologies is arguably the future of personalized psychotropic prescribing. This chapter provides an overview of the current genomic, epigenomic, transcriptomic, proteomic, and metabolomic knowledgebase as it relates to psychotropic drug response in an effort to identify promising linkages between and facilitate convergence across these approaches to guide safe and effective pharmacotherapy relevant to psychiatry.

Catholicism and Cosmopolitanism: the Confluence of Three Catholic Scholars and the Cosmopolitan Democrats on State Sovereignty and the Future of Global Governance

2016 ◽  
Vol 3 (2) ◽  
pp. 37-51
Author(s):  
Matthew Bagot
Keyword(s):  
Global Governance ◽  
State Sovereignty ◽  
Current Debate ◽  
Past Century ◽  
Jacques Maritain ◽  
The Past ◽  
Technological Advances ◽  
The Future ◽  
Cosmopolitan Democracy ◽  
Catholic Tradition

One of the central questions in international relations today is how we should conceive of state sovereignty. The notion of sovereignty—’supreme authority within a territory’, as Daniel Philpott defines it—emerged after the Treaty of Westphalia in 1648 as a result of which the late medieval crisis of pluralism was settled. But recent changes in the international order, such as technological advances that have spurred globalization and the emerging norm of the Responsibility to Protect, have cast the notion of sovereignty into an unclear light. The purpose of this paper is to contribute to the current debate regarding sovereignty by exploring two schools of thought on the matter: first, three Catholic scholars from the past century—Luigi Sturzo, Jacques Maritain, and John Courtney Murray, S.J.—taken as representative of Catholic tradition; second, a number of contemporary political theorists of cosmopolitan democracy. The paper argues that there is a confluence between the Catholic thinkers and the cosmopolitan democrats regarding their understanding of state sovereignty and that, taken together, the two schools have much to contribute not only to our current understanding of sovereignty, but also to the future of global governance.

scholarly journals Single-particle cryo-EM—How did it get here and where will it go

Science ◽  
2018 ◽  
Vol 361 (6405) ◽  
pp. 876-880 ◽  
Author(s):  
Yifan Cheng
Keyword(s):  
Electron Microscopy ◽  
Structural Biology ◽  
Single Particle ◽  
Electron Crystallography ◽  
The Past ◽  
Cryo Electron Microscopy ◽  
Technological Advances ◽  
The Future ◽  
Electron Cryotomography

Cryo–electron microscopy, or simply cryo-EM, refers mainly to three very different yet closely related techniques: electron crystallography, single-particle cryo-EM, and electron cryotomography. In the past few years, single-particle cryo-EM in particular has triggered a revolution in structural biology and has become a newly dominant discipline. This Review examines the fascinating story of its start and evolution over the past 40-plus years, delves into how and why the recent technological advances have been so groundbreaking, and briefly considers where the technique may be headed in the future.

scholarly journals Operating without operations: how is technology changing the role of the firm?

2018 ◽  
Vol 29 (5) ◽  
pp. 809-833 ◽  
Author(s):  
Christoph Breidbach ◽  
Sunmee Choi ◽  
Benjamin Ellway ◽  
Byron W. Keating ◽  
Katerina Kormusheva ◽  
...  
Keyword(s):  
Operations Research ◽  
Design Methodology ◽  
Service Operations ◽  
Science Literature ◽  
Content Type ◽  
The Past ◽  
Technological Advances ◽  
The Future ◽  
Practical Implications

Purpose The purpose of this paper is to analyze the history and future of service operations, with the goal to identify key theoretical and technological advances, as well as fundamental themes that can help to imagine the future of service operations in 2050. Design/methodology/approach A review of the service operations literature was undertaken to inform a discussion regarding the role that technology will play in the future of service operations. Findings The future of service operations is framed in terms of three key themes – complexity, orchestration, and elasticity. The paper makes three contributions to the service science literature by: reviewing key themes underpinning extant service operations research to frame future trajectories of service operations research; elaborating a vision of service operations in 2050 based on history and technology; and outlining a research agenda for future service operations. Practical implications The case of service automation is used to provide an illustration of how the three themes converge to define future service operations, and in particular, to show how technology is recasting the role of the firm. Originality/value Service operations in the next 30 years will be very different from what it was in the past 30 years. This paper differs from other review papers by identifying three key themes that will characterize and instill new insights into the future of service operations research.

scholarly journals The Continuing Evolution of Official Statistics: Some Challenges and Opportunities

2016 ◽  
Vol 32 (4) ◽  
pp. 789-810 ◽  
Author(s):  
Steve MacFeely
Keyword(s):  
Official Statistics ◽  
Cultural Changes ◽  
The Past ◽  
Technological Advances ◽  
Disruptive Innovations ◽  
The Future ◽  
Challenges And Opportunities ◽  
Motivation For Change

Abstract As economies, societies, and environments change, official statistics evolve and develop to reflect those changes. In reaction to disruptive innovations arising from globalisation, technological advances, and cultural changes, the pace of change of official statistics will accelerate in the future. The motivation for change may also be more existential than that of the past as official statisticians consider the survival of their discipline. This article examines some of the emerging developments and questions whether they present threats or offer opportunities.

High variability of the current mental health practices around the globe: Twenty days in the lives of psychiatrists and other mental health care professionals from all over the world

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Reinhard Heun ◽  
Jibril Ibrahim Moussa Handuleh ◽  
Juan Evangelista Tercero Gaitán Buitrago ◽  
Melvin S. Marsh ◽  
Vitalii Klymchuk ◽  
...  
Keyword(s):  
Mental Health ◽  
Health Care ◽  
Mental Health Care ◽  
Health Care Professionals ◽  
Mental Health Problems ◽  
Health Problems ◽  
Health Practices ◽  
The Past ◽  
The Future ◽  
Mental Health Practices

AbstractIntroductionThe present is the future of the past, and the past of the future. This journal as well as this paper endeavour to document the lives and practices of psychiatrists and other mental health care professionals for the future mental health community and to help the clinicians of the future to understand the history and practice of psychiatry and mental health care in 2019/20. We, therefore, report the current days in the lives of psychiatrists and other mental health care professionals.Material and MethodsTo obtain reports of days in the lives of psychiatrists and other mental health professionals, we published the request on eight occasions from May 2019 to May 2020. We invited the prospective respondents/participants to send a relevant report of their psychiatric practice in a day with a maximum word count of 750 words.ResultsWe received 20 reports of variable lengths from 10 countries from six continents, including from psychiatrists, psychiatrists in training, clinical psychologists and from medical students about their psychiatric training. The reports revealed a wide and highly variable range of psychiatric and mental health practices, experiences and expectations. Last but not least, the reports we received were informative and provided much information to reflect on.ConclusionsThere is a common strong commitment to support patients with mental health problems, but the ways this is achieved are so diverse that generalisations about a typical common practice seem impossible. Future studies should focus more systematically on the procedures and practices applied in helping patients with mental health problems in different countries and communities. This knowledge might eventually help identify the procedures and services that are most efficient and helpful in various clinical contexts.

scholarly journals Working with elderly carers of people with learning disabilities and planning for the future

2000 ◽  
Vol 6 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Jane Hubert ◽  
Sheila Hollins
Keyword(s):  
Mental Health ◽  
Learning Disabilities ◽  
Old Age ◽  
Later Life ◽  
Elderly Parents ◽  
The Past ◽  
The Future ◽  
Mental Health Foundation ◽  
The Uk ◽  
Expanding Population

The majority of people with learning disabilities in the UK live at home with their families, usually with their parents (Mental Health Foundation, 1996) or – more commonly in later life – with one parent, usually their mother. Nowadays, people with learning disabilities live much longer than they did in the past, with the result that there is also an expanding population of elderly parents who are continuing to care for a son or daughter well into old age.

scholarly journals Does Psychological Capital Influence Employees’ Burnout? A Review Paper

2018 ◽  
Vol 2 (4) ◽  
pp. 36-42
Author(s):  
Keyword(s):  
Mental Health ◽  
Organizational Performance ◽  
Review Paper ◽  
Psychological Capital ◽  
Negative Emotions ◽  
Poor Mental Health ◽  
Negative Consequences ◽  
The Past ◽  
The Future ◽  
Critical Issues

In this globalization era, burnout has been known as one of the critical issues in organizations. Overlooking the issue of burnout could lead to negative consequences, such as negatively affecting the overall organizational performance, and poor mental health among employees. It is crucial to know the factors that can help to improve burnout. One of the factors that can reduce burnout is psychological capital. Psychological capital is known as one of the elements that could help to reduce negative emotions. However, it was claimed that the influence of psychological capital is remained unexplored. Hence, this article reviewed the past studies that were conducted in the past decade (2008-2018) on the linkage between psychological capital and employees’ burnout. From the findings, it was revealed that there are inconsistency of the findings in the past studies. Hence, this has triggered a need for further exploration on the linkage between psychological capital and employees’ burnout. It is suggested that more empirical researches to be conducted in the future to provide a more concrete evidences on the linkage between psychological capital and employees’ burnout.

scholarly journals Overview of Electrical Energy Planning in West Sumatera

2021 ◽  
Vol 1 (1) ◽  
pp. 41-46
Author(s):  
Rizki Aditio Pribadi ◽  
Syafii Syafii
Keyword(s):  
Electrical Energy ◽  
Energy Planning ◽  
Percentage Increase ◽  
Average Growth ◽  
Average Percentage ◽  
The Past ◽  
Generation Planning ◽  
Technological Advances ◽  
The Future ◽  
West Sumatra

Electrical energy is one of the most important components in the development of an area. The development of sustainable development accompanied by rapid technological advances and an increase in living standards can cause the consumption of electrical energy to continue to increase, including in West Sumatra Province. To meet the needs of electrical energy in the future, it is necessary to build and develop the existing electrical system at PT. PLN (Persero) in order to serve the needs of electrical energy in the future. One of them is by predicting or predicting the demand for electrical energy in the next few years by utilizing historical data on the consumption of electrical energy in the past. In this study, the authors predict the electricity needs of West Sumatra Province from 2019 to 2028. The need for electrical energy tends to increase from year to year. In 2019 the need for electrical energy is 3,705 GWh, while in 2028 it is 6,980 GWh with an average growth in energy sales of 7.29 percent. The household sector has the highest demand for electrical energy in 2028, namely 3,769 GWh with an average percentage increase per year of 6.6 percent. Keywords: Power system planning, Electrical energy consumption, Generation planning and Electrification ratio.

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