Neuroprogression and accelerated ageing in severe psychiatric disorders

A convergent body of evidence suggests an overlap between neural, molecular, and functional findings in patients with severe mental illnesses and normative ageing. Patients in late stages of mood disorders and psychosis present brain changes and cognitive decline consistent with a pattern of accelerated ageing. In addition, replicated but heterogeneous findings support the notion that individuals with major depressive disorder, bipolar disorder, and schizophrenia have shorter telomeres compared to age-matched healthy controls. The recognition that severe mental illnesses are associated with premature or accelerated ageing offers new avenues of investigation for really novel therapeutic approaches. The hope is that these interventions will not only treat symptoms but be able to modify the course of these psychiatric conditions.

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5.21 RATES OF DISRUPTIVE MOOD DYSREGULATION DISORDER AMONG ADOLESCENT OFFSPRING OF PARENTS WITH RECURRENT MAJOR DEPRESSIVE DISORDER VERSUS THOSE WITH BIPOLAR DISORDER AND MATCHED HEALTHY CONTROLS

Journal of the American Academy of Child & Adolescent Psychiatry ◽

10.1016/j.jaac.2016.09.280 ◽

2016 ◽

Vol 55 (10) ◽

pp. S190 ◽

Cited By ~ 1

Author(s):

Zehra Topal ◽

Nuran Demir ◽

Taha Can Tuman ◽

Osman Yildirim ◽

Evren Tufan ◽

...

Keyword(s):

Bipolar Disorder ◽

Major Depressive Disorder ◽

Depressive Disorder ◽

Healthy Controls ◽

Major Depressive ◽

Disruptive Mood Dysregulation Disorder ◽

Adolescent Offspring ◽

Recurrent Major Depressive Disorder ◽

Mood Dysregulation

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Significantly Higher Peripheral Insulin-Like Growth Factor-1 Levels in Patients With Major Depressive Disorder or Bipolar Disorder Than in Healthy Controls

Medicine ◽

10.1097/md.0000000000002411 ◽

2016 ◽

Vol 95 (4) ◽

pp. e2411 ◽

Cited By ~ 17

Author(s):

Kun-Yu Tu ◽

Ming-Kung Wu ◽

Yen-Wen Chen ◽

Pao-Yen Lin ◽

Hung-Yu Wang ◽

...

Keyword(s):

Bipolar Disorder ◽

Major Depressive Disorder ◽

Growth Factor ◽

Depressive Disorder ◽

Healthy Controls ◽

Insulin Like Growth Factor ◽

Major Depressive

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P.2.e.021 Vitamin D deficiency in schizophrenia, bipolar disorder and major depressive disorder compared to healthy controls

European Neuropsychopharmacology ◽

10.1016/s0924-977x(11)70694-0 ◽

2011 ◽

Vol 21 ◽

pp. S429-S430 ◽

Cited By ~ 1

Author(s):

B. Cha ◽

Y.M. Shin ◽

Y.S. Kim ◽

B.J. Kim ◽

C.S. Lee ◽

...

Keyword(s):

Bipolar Disorder ◽

Vitamin D ◽

Major Depressive Disorder ◽

Depressive Disorder ◽

Vitamin D Deficiency ◽

Healthy Controls ◽

Major Depressive

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The loudness dependence of the auditory evoked potential (LDAEP) in schizophrenia, bipolar disorder, major depressive disorder, anxiety disorder, and healthy controls

Progress in Neuro-Psychopharmacology and Biological Psychiatry ◽

10.1016/j.pnpbp.2009.12.004 ◽

2010 ◽

Vol 34 (2) ◽

pp. 313-316 ◽

Cited By ~ 52

Author(s):

Young-Min Park ◽

Seung-Hwan Lee ◽

Sangrae Kim ◽

Sung-Man Bae

Keyword(s):

Bipolar Disorder ◽

Major Depressive Disorder ◽

Anxiety Disorder ◽

Depressive Disorder ◽

Evoked Potential ◽

Auditory Evoked Potential ◽

Healthy Controls ◽

Major Depressive ◽

Loudness Dependence

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A population-based morphometric MRI study in patients with first-episode psychotic bipolar disorder: comparison with geographically matched healthy controls and major depressive disorder subjects

Bipolar Disorders ◽

10.1111/j.1399-5618.2011.00896.x ◽

2011 ◽

Vol 13 (1) ◽

pp. 28-40 ◽

Cited By ~ 31

Author(s):

Cintia de Azevedo-Marques Périco ◽

Fabio L S Duran ◽

Marcus V Zanetti ◽

Luciana C Santos ◽

Robin M Murray ◽

...

Keyword(s):

Bipolar Disorder ◽

Major Depressive Disorder ◽

Depressive Disorder ◽

Population Based ◽

First Episode ◽

Healthy Controls ◽

Major Depressive ◽

Mri Study ◽

Psychotic Bipolar Disorder

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DNA Methylation as a Biomarker of Treatment Response Variability in Serious Mental Illnesses: A Systematic Review Focused on Bipolar Disorder, Schizophrenia, and Major Depressive Disorder

International Journal of Molecular Sciences ◽

10.3390/ijms19103026 ◽

2018 ◽

Vol 19 (10) ◽

pp. 3026 ◽

Cited By ~ 14

Author(s):

Charanraj Goud Alladi ◽

Bruno Etain ◽

Frank Bellivier ◽

Cynthia Marie-Claire

Keyword(s):

Dna Methylation ◽

Bipolar Disorder ◽

Major Depressive Disorder ◽

Depressive Disorder ◽

Treatment Response ◽

Bipolar Disorders ◽

Mental Illnesses ◽

Mood Stabilizers ◽

Major Depressive ◽

Meta Analyses

So far, genetic studies of treatment response in schizophrenia, bipolar disorder, and major depression have returned results with limited clinical utility. A gene × environment interplay has been proposed as a factor influencing not only pathophysiology but also the treatment response. Therefore, epigenetics has emerged as a major field of research to study the treatment of these three disorders. Among the epigenetic marks that can modify gene expression, DNA methylation is the best studied. We performed a systematic search (PubMed) following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA guidelines for preclinical and clinical studies focused on genome-wide and gene-specific DNA methylation in the context of schizophrenia, bipolar disorders, and major depressive disorder. Out of the 112 studies initially identified, we selected 31 studies among them, with an emphasis on responses to the gold standard treatments in each disorder. Modulations of DNA methylation levels at specific CpG sites have been documented for all classes of treatments (antipsychotics, mood stabilizers, and antidepressants). The heterogeneity of the models and methodologies used complicate the interpretation of results. Although few studies in each disorder have assessed the potential of DNA methylation as biomarkers of treatment response, data support this hypothesis for antipsychotics, mood stabilizers and antidepressants.

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Lifestyle and neuroprogression: Diet, sleep, and exercise

Neuroprogression in Psychiatry ◽

10.1093/med/9780198787143.003.0013 ◽

2019 ◽

pp. 207-222

Author(s):

Adrian L. Lopresti ◽

Peter D. Drummond

Keyword(s):

Bipolar Disorder ◽

Major Depressive Disorder ◽

Depressive Disorder ◽

Psychiatric Disorders ◽

Lifestyle Factors ◽

Therapeutic Effects ◽

Physiological Mechanisms ◽

Prevention And Treatment ◽

Psychiatric Conditions

Diet, sleep, and exercise are lifestyle factors important for the prevention and treatment of psychiatric disorders, including major depressive disorder, anxiety disorders, bipolar disorder, and schizophrenia. These lifestyle factors can contribute to dysregulation in important physiological mechanisms associated with psychiatric disorders and influence neuroprogression. We review research highlighting the important role of these lifestyle factors for different psychiatric conditions, and examine the potential mechanisms behind their therapeutic effects, with a particular emphasis on how they may each influence neuroprogression.

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