Gastric cancer

2018 ◽  
pp. 279-294
Author(s):  
Abdullah Jibawi ◽  
Mohamed Baguneid ◽  
Arnab Bhowmick
Keyword(s):  
Gastric Cancer ◽  
Endoscopic Resection ◽  
Patient Selection ◽  
Locally Advanced ◽  
Prognostic Features ◽  
Early Lesions ◽  
Oncological Therapy ◽  
Multiple Biopsies ◽  
The World ◽  
Selection For

Gastric cancer presents in the majority of cases at a locally advanced/metastatic stage. Initial investigations should be on the dyspepsia pathway. Multiple biopsies are necessary from any suspicious endoscopic lesions. Accurate staging and MDT assessment is essential for optimum patient selection for surgery. Endoscopic resection can now be recommended for very early lesions with good prognostic features. In gastrectomy, controversy exists across the world as to the extent of lymphadenectomy. This is discussed, as well as neoadjuvant and adjuvant oncological therapy.

scholarly journals Optimal Patient Selection for Trastuzumab Treatment in HER2-Positive Advanced Gastric Cancer

2015 ◽  
Vol 21 (11) ◽  
pp. 2520-2529 ◽  
Author(s):  
Chan-Young Ock ◽  
Keun-Wook Lee ◽  
Jin Won Kim ◽  
Jin-Soo Kim ◽  
Tae-Yong Kim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Advanced Gastric Cancer ◽  
Patient Selection ◽  
Her2 Positive ◽  
Trastuzumab Treatment ◽  
Selection For

scholarly journals Optimizing Patient Selection for Irreversible Electroporation of Locally Advanced Pancreatic Cancer: Analyses of Survival

2022 ◽  
Vol 11 ◽  
Author(s):  
Matthew R. Woeste ◽  
Khaleel D. Wilson ◽  
Edward J. Kruse ◽  
Matthew J. Weiss ◽  
John D. Christein ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Overall Survival ◽  
Induction Chemotherapy ◽  
Patient Selection ◽  
Locally Advanced ◽  
Irreversible Electroporation ◽  
Multivariable Analysis ◽  
Advanced Pancreatic Cancer ◽  
Locally Advanced Pancreatic Cancer ◽  
Selection For

BackgroundIrreversible electroporation (IRE) has emerged as a viable consolidative therapy after induction chemotherapy, in which this combination has improved overall survival of locally advanced pancreatic cancer (LAPC). Optimal timing and patient selection for irreversible electroporation remains a clinically unmet need. The aim of this study was to investigate preoperative factors that may assist in predicting progression-free and overall survival following IRE.MethodsA multi-institutional, prospectively maintained database was reviewed for patients with LAPC treated with induction chemotherapy followed by open-technique irreversible electroporation from 7/2015-5/2019. RECIST 1.1 criteria were used to assess tumor response and radiological progression. Overall survival (OS) and progression-free survival (PFS) were recorded. Survival analyses were performed using Kaplan Meier and Cox multivariable regression analyses.Results187 LAPC patients (median age 62 years range, 21 – 91, 65% men, 35% women) were treated with IRE. Median PFS was 21.7 months and median OS from diagnosis was 25.5 months. On multivariable analysis, age ≤ 61 (HR 0.41, 95%CI 0.21-0.78, p<0.008) and no prior radiation (HR 0.49, 95%CI 0.26-0.94, p=0.03) were positive predictors of OS after IRE. Age ≤ 61(HR 0.53, 95%CI, 0.28-.99, p=0.046) and FOLFIRINOX followed by gemcitabine/abraxane induction chemotherapy (HR 0.37,95%CI 0.15-0.89, p=0.027) predicted prolonged PFS after IRE. Abnormal CA19-9 values at the time of surgery negatively impacted both OS (HR 2.46, 95%CI 1.28-4.72, p<0.007) and PFS (HR 2.192, 95%CI 1.143-4.201, p=0.018) following IRE.ConclusionsAge, CA 19-9 response, avoidance of pre-IRE radiation, and FOLFIRINOX plus gemcitabine/abraxane induction chemotherapy are prominent factors to consider when referring or selecting LAPC patients to undergo IRE.

scholarly journals Bariatric surgery in the treatment of morbid obesity in adolescents (literature review)

2016 ◽  
Vol 62 (3) ◽  
pp. 25-32 ◽  
Author(s):  
Pavel L. Okorokov ◽  
Olga V. Vasyukova ◽  
Ivan I. Dedov
Keyword(s):  
Bariatric Surgery ◽  
Morbid Obesity ◽  
Conservative Treatment ◽  
Literature Review ◽  
Patient Selection ◽  
Metabolic Surgery ◽  
Metabolic Complications ◽  
The World ◽  
Different Types ◽  
Selection For

Morbid obesity in children is associated with various metabolic complications, often persisting into adulthood and leading to reduced quality and duration of life. Conservative treatment of morbid obesity, often ineffective, and therefore, bariatric surgery in adolescents is becoming more common throughout the world. This review presents an analysis of international clinical guidelines for patient selection for bariatric surgery, assessed the efficiency and safety of different types of bariatric operations and identified the main problems of the widespread use of metabolic surgery as a method of treatment of morbid obesity in adolescents.

scholarly journals Preoperative accuracy of gastric cancer staging in patient selection for preoperative therapy: race may affect accuracy of endoscopic ultrasonography

2017 ◽  
Vol 8 (6) ◽  
pp. 1009-1017 ◽  
Author(s):  
Naruhiko Ikoma ◽  
Jeffrey H. Lee ◽  
Manoop S. Bhutani ◽  
William A. Ross ◽  
Brian Weston ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Endoscopic Ultrasonography ◽  
Patient Selection ◽  
Cancer Staging ◽  
Preoperative Therapy ◽  
Selection For

scholarly journals Improving Patient Selection for 18F-FDG PET Scanning in the Staging of Gastric Cancer

2015 ◽  
Vol 56 (4) ◽  
pp. 523-529 ◽  
Author(s):  
Y. Kaneko ◽  
W. K. Murray ◽  
E. Link ◽  
R. J. Hicks ◽  
C. Duong
Keyword(s):  
Gastric Cancer ◽  
Patient Selection ◽  
Fdg Pet ◽  
Pet Scanning ◽  
18F Fdg ◽  
Selection For ◽  
Staging Of Gastric Cancer
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