Fifty years ago: ‘A poisons information service’

2020 ◽  
pp. 103-104
Author(s):  
Roy Goulding
Keyword(s):  
Information Service ◽  
The Past ◽  
Set Up ◽  
The 1960S ◽  
Poisons Information ◽  
Selection Of

This series provides a selection of articles from the past. In Fifty years ago: ‘A poisons information service’ the author briefly explores a service set up in the 1960s to offer advice on medicinal, veterinary, agricultural, horticultural, and household poisoning, and after some debate, industrial poisoning.

scholarly journals Models of Modernization and geopolitical changes in Latin America

2016 ◽  
pp. 68-76
Author(s):  
István Szilágy
Keyword(s):  
Armed Forces ◽  
Military Dictatorship ◽  
The Past ◽  
State Apparatus ◽  
Political Forces ◽  
1960S And 1970S ◽  
Set Up ◽  
The 1960S ◽  
The Military ◽  
Radical Transformation

In South America in the 1960s and 1970s the contradictions of economic, social and political structures were deepening. In order to surmount the structural crisis the different political forces, tendencies and governments elaborated various strategies. These attempts aiming at reorganizing the society led to undermining the hegemony of ruling governing block and radical transformation of state apparatus. Progressive and regressi-ve forms of military dictatorship and excepcional states of the new militarism appeared on the continent because of the Brazilian military takeover of April, 1964. Formally these state systems were set up by the institutional takeover of the armed forces. The military governments strove for the total reorganization and modernization of the societies in their all - economic, political and ideological - territories. The study aims at analizing the diffe-rent models of modernization during the past sixty years.

Clinical Toxicology - Past, Present and Future

1988 ◽  
Vol 7 (5) ◽  
pp. 481-487 ◽  
Author(s):  
A.T. Proudfoot
Keyword(s):  
Information Service ◽  
Acute Poisoning ◽  
Clinical Toxicology ◽  
Repeat Dose ◽  
Analytical Toxicology ◽  
Dose Oral ◽  
Life Threatening ◽  
The 1960S ◽  
The Uk ◽  
Poisons Information

1 The alarming increase in the incidence of self-poisoning in Western countries in the 1950s prompted the establishment of the National Poisons Information Service in the UK and the designation of certain Regional Poisoning Treatment Centres. 2 The substances taken in acute poisoning episodes largely reflect the poisons available in the community and, in the UK at least, have changed with fashions in prescribing although psychotropic drugs and analgesics always predominate. 3 Intensive supportive care with repeat-dose oral activated charcoal and even haemoperfusion has been proved effective in acute poisoning with central nervous depressant drugs such as barbiturates even though these latter drugs are now rarely encountered in overdose. 4 Other advances in clinical toxicology include the introduction of the opiate antagonist naloxone, Fab antibody fragments for life-threatening digoxin overdosage and proven treatment for paracetamol poisoning. Analytical toxicology has also made a major contribution. 5 On the debit side, formal psychiatric assessment of patients after acute poisoning remains contentious, tricyclic antidepressants are still a major problem and there is no effective treatment for poisoning with paraquat or for paracetamol when presentation is delayed. 6 As to the future, although the 'epidemic' of serious acute poisoning of the 1960s and 70s appears to be past its peak, there will always be unusual and serious problems and the UK poisons information services must develop to make the best use of computer-based technology.

The History of the Family in Africa: Introduction

1983 ◽  
Vol 24 (2) ◽  
pp. 145-161 ◽  
Author(s):  
Shula Marks ◽  
Richard Rathbone
Keyword(s):  
Social Science Research ◽  
Science Research ◽  
Ordinary People ◽  
The Past ◽  
The Family ◽  
History Of ◽  
African Context ◽  
History Department ◽  
The 1960S ◽  
Selection Of

The papers in this special issue of the Journal were originally presented to a conference held at the School of Oriental and African Studies under the joint auspices of the School and the British Social Science Research Council, in September 1981. The conference, which grew out of an earlier series of seminars run by the S.O.A.S. History Department, arose out of the editors' concern that the history of the family, which had become so lively and important an area of study in Europe and America since the 1960s, was being almost totally neglected in Africa; through the seminars, the conference and now the publication of a selection of the papers in the Journal we hoped to stimulate research on a range of questions which could be fruitfully explored in the African context, and which could possibly also feed into the wider historiography on the family in Britain, America and Europe.For many of its formative years, the study of history was concerned in the main with the history of the dominant, of ‘great men’ and their institutions, states and government, armies, churches and culture. The history of the dominated, of ‘ordinary people’ was thought to be lost, for the majority of our ancestors left no obvious written record from which their lives could be re-created. From 1929, when Marc Bloch and Lucien Febvre founded the journal Annales d'histoire économique et sociale, this view has been increasingly challenged, and it is fair to say that today the past of ordinary people is at least as significant historiographically as that of famous leaders or powerful institutions.

Urban planning in the twentieth century

Urban History ◽  
2000 ◽  
Vol 27 (3) ◽  
pp. 384-396 ◽  
Author(s):  
Kevin Hourihan
Keyword(s):  
Twentieth Century ◽  
Urban Planning ◽  
Development Planning ◽  
Historical Research ◽  
Planning History ◽  
High Rise ◽  
The Past ◽  
History Of ◽  
Set Up ◽  
The 1960S

Over the past thirty years, one of the fastest growing fields of urban history has been the history of planning. In some respects, this is surprising, as urban planning had existed on an institutional basis only since the early twentieth century. In other ways, though, it was a very logical development. Planning reached its high point during the 1960s, and by the 1970s was being condemned in many quarters, being blamed, for example, for disasters like high-rise tower blocks and sacrificing old cities to crude commercial and transport developments. Historical research was necessary to understand how a movement which promised so much at the start of the century had degenerated so badly in sixty years. Criticism became so severe that, in the words of one historian, ‘many planners have certainly thought in more pessimistic moments . . . that the past may be the only thing they have to look forward to’. For whatever reason, the Planning History Group was set up in 1974 and a massive body of historical research on planning has been produced. This paper reviews four recent books on planning, two from North America and two European. They represent different aspects of planning and different time periods and will be treated in chronological order.

scholarly journals Synthesis of a bifunctional cytidine derivative and its conjugation to RNA for in vitro selection of a cytidine deaminase ribozyme

2014 ◽  
Vol 10 ◽  
pp. 1906-1913 ◽  
Author(s):  
Nico Rublack ◽  
Sabine Müller
Keyword(s):  
In Vitro Selection ◽  
Cytidine Deaminase ◽  
Standard Technique ◽  
Selection Scheme ◽  
The Past ◽  
Coated Surface ◽  
Set Up ◽  
Functional Rnas ◽  
Selection Of

Over the past 20 years, the generation of functional RNAs by in vitro selection has become a standard technique. Apart from aptamers for simple binding of defined ligands, also RNAs for catalysis of chemical reactions have been selected. In the latter case, a key step often is the conjugation of one of the two reactants to the library, requiring suitable strategies for terminal or internal RNA functionalization. With the aim of selecting a ribozyme for deamination of cytidine, we have set up a selection scheme involving the attachment of the cytidine acting as deamination substrate to the 3'-terminus of the RNAs in the library, and library immobilization. Here, we report the synthesis of a bifunctional cytidine derivative suitable for conjugation to RNA and linkage of the conjugated library to a streptavidine-coated surface. Successful conjugation of the cytidine derivative to the 3'-terminus of a model RNA is demonstrated.

scholarly journals Laboratory analyses for poisoned patients: joint position paper

2002 ◽  
Vol 39 (4) ◽  
pp. 328-339 ◽  
Keyword(s):  
Clinical Utility ◽  
Best Practice ◽  
Information Service ◽  
Turnaround Time ◽  
Laboratory Investigations ◽  
The Uk ◽  
To Receive ◽  
Poisons Information ◽  
Common Laboratory ◽  
Selection Of

To enable consistency of investigation and the establishment of best practice standards, consensus guidelines have been formulated jointly by the UK National Poisons Information Service (NPIS) and the Association of Clinical Biochemists (ACB). The types of laboratory investigation required for poisoned patients were categorized as either (a) essential common laboratory investigations or (b) specific toxicological assays, and also as either (i) common or (ii) specialist or infrequent. Tests in categories (a) and (bi) are expected to be available 24 h per day, with a maximum turnaround time of 2 h. For the specialist assays, i.e. category (bii), availability and turnaround times have been specified individually. The basis for selection of these times has been clinical utility. The adoption of these guidelines, along with the use of the NPIS online poisons information resource TOXBASE (www.spib.axl.co.uk), will enable the poisoned patient to receive appropriate, 'best practice' investigations according to their clinical needs and will avoid the use of unnecessary investigations.

Platelet Anti-Aggregating Activity and Tolerance of Clopidogrel in Atherosclerotic Patients

1996 ◽  
Vol 76 (06) ◽  
pp. 0939-0943 ◽  
Author(s):  
B Boneu ◽  
G Destelle ◽  
Keyword(s):  
Platelet Aggregation ◽  
Large Scale ◽  
Bleeding Time ◽  
Antithrombotic Activity ◽  
Ambulatory Patients ◽  
Patients At Risk ◽  
Set Up ◽  
Ischemic Events ◽  
Large Scale Clinical Trial ◽  
Selection Of

SummaryThe anti-aggregating activity of five rising doses of clopidogrel has been compared to that of ticlopidine in atherosclerotic patients. The aim of this study was to determine the dose of clopidogrel which should be tested in a large scale clinical trial of secondary prevention of ischemic events in patients suffering from vascular manifestations of atherosclerosis [CAPRIE (Clopidogrel vs Aspirin in Patients at Risk of Ischemic Events) trial]. A multicenter study involving 9 haematological laboratories and 29 clinical centers was set up. One hundred and fifty ambulatory patients were randomized into one of the seven following groups: clopidogrel at doses of 10, 25, 50,75 or 100 mg OD, ticlopidine 250 mg BID or placebo. ADP and collagen-induced platelet aggregation tests were performed before starting treatment and after 7 and 28 days. Bleeding time was performed on days 0 and 28. Patients were seen on days 0, 7 and 28 to check the clinical and biological tolerability of the treatment. Clopidogrel exerted a dose-related inhibition of ADP-induced platelet aggregation and bleeding time prolongation. In the presence of ADP (5 \lM) this inhibition ranged between 29% and 44% in comparison to pretreatment values. The bleeding times were prolonged by 1.5 to 1.7 times. These effects were non significantly different from those produced by ticlopidine. The clinical tolerability was good or fair in 97.5% of the patients. No haematological adverse events were recorded. These results allowed the selection of 75 mg once a day to evaluate and compare the antithrombotic activity of clopidogrel to that of aspirin in the CAPRIE trial.

Integrated FAHP-VIKOR model for green supplier selection in a Nickle coating SME

2020 ◽  
pp. 133-139
Author(s):  
Sanatan Ratna ◽  
B Kumar
Keyword(s):  
Staff Training ◽  
Supplier Selection ◽  
Fuzzy Ahp ◽  
Research Work ◽  
Supplier Evaluation ◽  
Green Supplier Selection ◽  
The Past ◽  
Coating Industry ◽  
Sustainability Issue ◽  
Selection Of

In the past few decades, there has been lot of focus on the issue of sustainability. This has occurred due to the growing concerns related to climate change and the growing awareness about environmental concerns. Also, the competition at global level has led to the search for the most sustainable route in the industries. The current research work deals with the selection of green supplier in a Nickle coating industry based on certain weighted green attributes. For this purpose, a hybrid tool comprising of Fuzzy AHP (Fuzzy Analytical Hierarchy) and VIKOR (VlseKriterijumska Optimizacija I Kompromisno Resenje) is used. The Fuzzy AHP is used for assigning proper weights to the selected criteria for supplier evaluation, while VIKOR is used for final supplier selection based on the weighted criteria. The three criterions for green supplier selection are, Ecological packaging, Corporate socio-environmental responsibility and Staff Training. The outcome of the integrated model may serve as a steppingstone to other SMEs in different sectors for selecting the most suitable supplier for addressing the sustainability issue.

STUDY OF INACCURACY IN THE OPERATION OF THE MAIN CONTROLLER OF STB MACHINE

2019 ◽  
Keyword(s):  
Normal Distribution ◽  
Stable Process ◽  
Random Errors ◽  
Actual Length ◽  
Experimental Data Processing ◽  
Set Up ◽  
Main Regulator ◽  
Transmission Gear ◽  
Selection Of

At production of fabrics, including fabrics for agricultural purpose, an important role is played by the cor-rect adjustment of operation of machine main regulator. The quality of setup of machine main controller is determined by the proper selection of rotation angle of warp beam weaving per one filling thread. In the pro-cess of using the regulator as a result of mistakes in adjustment, wear of transmission gear and backlashes in connections of details there are random changes in threads length. The purpose of the article is the research of property of random errors of basis giving by STB machine regulator. Mistakes can be both negative, and positive. In case of emergence only negative or only positive mistakes operation of the machine becomes im-possible as there will be a consecutive accumulation of mistakes. As a result of experimental data processing for stable process of weaving and the invariable diameter of basis threads winding of threads it is revealed that the random error of giving is set up as linear function of the accidental length having normal distribution. Measurements of accidental deviations in giving of a basis by the main regulator allowed to construct a curve of normal distribution of its actual length for one pass of weft thread. The presented curve of distribution of random errors in giving of a basis is the displaced curve of normal distribution of the accidental sizes. Also we define the density of probability of normal distribution of basis giving errors connected with a margin er-ror operation of the main regulator knowing of which allows to plan ways of their decrease that is important for improvement of quality of the produced fabrics.

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