Disorders of pigmentation

2010 ◽  
pp. 4656-4664
Author(s):  
Eugene Healy
Keyword(s):  
Human Skin ◽  
Systemic Disease ◽  
Skin Pigmentation ◽  
Skin Colour ◽  
Normal Human Skin ◽  
Melanin Pigmentation ◽  
Normal Human ◽  
Reflection Of Light

Normal human skin colour results from the reflection of light from haemoglobin in blood, and carotenoids and melanin pigmentation in skin. The melanin pigmentation is the major component determining differences in skin colour between races. Increases and decreases in skin pigmentation (hyperpigmentation and hypopigmentation, respectively) may be localized or generalized, can result from a wide variety of physiological or pathological processes, including both genetic and acquired factors, and may reflect underlying systemic disease....

Disorders of pigmentation

2020 ◽  
pp. 5677-5687
Author(s):  
Eugene Healy
Keyword(s):  
Human Skin ◽  
Systemic Disease ◽  
Skin Pigmentation ◽  
Skin Colour ◽  
Normal Human Skin ◽  
Melanin Pigmentation ◽  
Normal Human ◽  
Reflection Of Light

Normal human skin colour results from the reflection of light from haemoglobin in blood, and carotenoids and melanin pigmentation in the skin. Melanin pigmentation is the major component for determining differences in skin colour between races. Increases and decreases in skin pigmentation (hyperpigmentation and hypopigmentation, respectively) can be localized or generalized, can result from a wide variety of physiological or pathological processes, including both genetic and acquired factors, and may reflect underlying systemic disease. Irrespective of cause and associations with underlying systemic disease, disorders of pigmentation can cause considerable distress to sufferers due to the visible nature of this condition.

The Effect of Practolol, In Vitro Generated Metabolites of Practolol and Chemical Analogues on the Rate of Growth of Human Skin Fibroblasts

1984 ◽  
Vol 12 (2) ◽  
pp. 89-97
Author(s):  
Graham R. Elliott ◽  
H.E. Amos ◽  
James W. Bridges
Keyword(s):  
Human Skin ◽  
Psoriasis Patient ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Cell Type ◽  
Normal Human Skin ◽  
Rate Of Growth ◽  
Structural Analogues ◽  
Normal Human

The rate of growth of normal human skin fibroblasts was inhibited in a dose related, reversible, fashion by practolol (N-4-(2-hydroxy)-3 (1-methyl)-aminopropoxyphenylacetamine) (ID50 1.35 ± 0.14 x 10-3M), propranolol (1-(isopropylamino)-3(1-naphthyl-oxy)-2-propranolol) (ID50 0.145 ± 0.02 x 10-3M) and paracetamol (N-(4-hydroxyphenyl) acetamide) (ID50 0.85 ± 0.2 x 10-3M). Skin fibroblasts isolated from a psoriasis patient were more sensitive towards practolol (ID50 0.48 ± 0.14 x 10-3M) and propranolol (ID50 0.032 ± 0.002 x 10-3M), but less sensitive towards paracetamol (ID50 1.3 ± 0.07 x 10-3M). In vitro generated metabolites of practolol, using normal or Arochlor 1254-pretreated hamster liver preparations, and structural analogues of practolol had no effect upon the growth of either cell type.

Type I and III collagen content and fibre distribution in normal human skin during ageing

1987 ◽  
Vol 117 (4) ◽  
pp. 419-428 ◽  
Author(s):  
C.R. LOVELL ◽  
K.A. SMOLENSKI ◽  
V.C. DUANCE ◽  
N.D. LIGHT ◽  
S. YOUNG ◽  
...  
Keyword(s):  
Human Skin ◽  
Collagen Content ◽  
Type I ◽  
Normal Human Skin ◽  
Fibre Distribution ◽  
Normal Human

scholarly journals C3b Receptor in Normal Human Skin

1981 ◽  
Vol 77 (4) ◽  
pp. 353-357 ◽  
Author(s):  
Hakan N. Thyresson ◽  
Frederic C. McDuffie ◽  
Arnold L. Schroeter
Keyword(s):  
Human Skin ◽  
Normal Human Skin ◽  
C3b Receptor ◽  
Normal Human
Sign in / Sign up

Export Citation Format

Share Document