Head and neck cancer

2016 ◽  
pp. 329-364
Author(s):  
Christine H. Chung ◽  
Andreas Dietz ◽  
Vincent Gregoire ◽  
Marco Guzzo ◽  
Marc Hamoir ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Human Papillomavirus ◽  
High Risk ◽  
Molecular Biology ◽  
Head And Neck ◽  
Neck Cancer ◽  
Hpv Infection ◽  
Head And Neck Cancers ◽  
Patient Treatment ◽  
Genomic Analyses

This chapter discusses head and neck cancers, and covers the epidemiology and molecular biology of head and neck cancer. Head and neck cancer is a heterogeneous disease and most commonly caused by tobacco and alcohol use, as well as high-risk human papillomavirus (HPV) infection. HPV-negative and -positive HNSCC are demographically, biologically and clinically distinct entities with more favourable outcomes associated with HPV-positive tumours of the oropharynx. Comprehensive genomic analyses show that more functional loss of tumour suppressors are present in HPV-negative tumours compared to HPV-positive tumours. Furthermore, HNSCC can be molecularly characterized into five subtypes. The challenges facing future investigations are efficient translation of these biological findings into clinically meaningful advancements in patient treatment.

scholarly journals Alcohol and Tobacco Increases Risk of High Risk HPV Infection in Head and Neck Cancer Patients: Study from North-East Region of India

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0140700 ◽  
Author(s):  
Rupesh Kumar ◽  
Avdhesh Kumar Rai ◽  
Debabrata Das ◽  
Rajjyoti Das ◽  
R. Suresh Kumar ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
High Risk ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Hpv Infection ◽  
North East ◽  
East Region ◽  
High Risk Hpv

EGFR mutations and human papillomavirus in squamous cell carcinoma of tongue and tonsil

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 10027-10027 ◽  
Author(s):  
I. Na ◽  
H. Kang ◽  
Y. Park ◽  
J. Koh ◽  
S. Cho ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Human Papillomavirus ◽  
Head And Neck ◽  
Neck Cancer ◽  
Egfr Mutation ◽  
Tongue Cancer ◽  
Disease Free Survival ◽  
Hpv Infection ◽  
Egfr Mutations ◽  
Tonsil Cancer

10027 Background: Some studies reported the presence of somatic mutation of EGFR in head and neck cancer. Human papillomavirus (HPV) was associated with some types of head and neck cancer. We performed this study to determine clinical significance of EGFR mutation and its association with HPV infection in patients with tongue and tonsil cancer. Methods: We sequenced exons 18–21 of EGFR TK domain and HPV typing was performed using the HPV DNA chip in tissues of patients with tongue and tonsil cancer. Univariate and multivariate analysis was performed. Results: Eighty-one patients were included. We detected EGFR mutation in 10 (12%) patients. Mutation was significantly frequent in never-smoker (21% versus 5%; P = 0.031). The mutation frequency did not differ between tongue and tonsil cancer (12% vs. 13%, respectively; P = 0.978). There was no difference between female and male (12% vs. 14%, respectively; P = 0.754). Eleven of 81 (14%) patients were HPV positive. HPV positivity was more common in young (<60 years) than older (≥60 years) patients (20% vs. 3%, respectively; P = 0.039). Patients with tonsil cancer showed more frequent HPV positivity than tongue cancer (42% vs. 2%, respectively; P < 0.001). There was no association between HPV positivity and EGFR mutation. In terms of disease-free survival, patients with EGFR mutation had better survival independently of stage and primary site (hazard ratio, 0.246; 95% CI, 0.075 to 0.802). Conclusions: We did not find association between EGFR mutation and HPV positivity. Patients with EGFR mutation showed better outcome in tongue and tonsil cancer. These results suggest that EGFR mutation may be a prognostic factor in patients with head and neck cancer. No significant financial relationships to disclose.

scholarly journals Portrait of DNA methylated genes predictive of poor prognosis in head and neck cancer and the implication for targeted therapy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jessica Hier ◽  
Olivia Vachon ◽  
Allison Bernstein ◽  
Iman Ibrahim ◽  
Alex Mlynarek ◽  
...  
Keyword(s):  
Risk Factors ◽  
Head And Neck Cancer ◽  
High Risk ◽  
Head And Neck ◽  
Neck Cancer ◽  
Tongue Cancer ◽  
Hpv Infection ◽  
Environmental Carcinogens ◽  
Dna Hypermethylation ◽  
Regulatory Pathways

AbstractIn addition to chronic infection with human papilloma virus (HPV) and exposure to environmental carcinogens, genetic and epigenetic factors act as major risk factors for head and neck cancer (HNC) development and progression. Here, we conducted a systematic review in order to assess whether DNA hypermethylated genes are predictive of high risk of developing HNC and/or impact on survival and outcomes in non-HPV/non-tobacco/non-alcohol associated HNC. We identified 85 studies covering 32,187 subjects where the relationship between DNA methylation, risk factors and survival outcomes were addressed. Changes in DNA hypermethylation were identified for 120 genes. Interactome analysis revealed enrichment in complex regulatory pathways that coordinate cell cycle progression (CCNA1, SFN, ATM, GADD45A, CDK2NA, TP53, RB1 and RASSF1). However, not all these genes showed significant statistical association with alcohol consumption, tobacco and/or HPV infection in the multivariate analysis. Genes with the most robust HNC risk association included TIMP3, DCC, DAPK, CDH1, CCNA1, MGMT, P16, MINT31, CD44, RARβ. From these candidates, we further validated CD44 at translational level in an independent cohort of 100 patients with tongue cancer followed-up beyond 10 years. CD44 expression was associated with high-risk of tumor recurrence and metastasis (P = 0.01) in HPV-cases. In summary, genes regulated by methylation play a modulatory function in HNC susceptibility and it represent a critical therapeutic target to manage patients with advanced disease.

scholarly journals A Multidisciplinary Approach to Head and Neck Cancer

2021 ◽  
Vol 12 (3) ◽  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Side Effect ◽  
Multidisciplinary Approach ◽  
Hpv Infection ◽  
Head And Neck Cancers

At JADPRO Live Virtual 2020, Casey Fazer-Posorske, PA-C, provided updates in the management of patients with head and neck cancer, including the types of head and neck cancers, their associated treatments and side-effect management, the role of de-escalation treatment, and the prevalence of HPV infection and role of vaccination in the prevention of head and neck cancer.

scholarly journals A Coding Variant in TMC8 (EVER2) Is Associated with High Risk HPV Infection and Head and Neck Cancer Risk

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0123716 ◽  
Author(s):  
Caihua Liang ◽  
Karl T. Kelsey ◽  
Michael D. McClean ◽  
Brock C. Christensen ◽  
Carmen J. Marsit ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
High Risk ◽  
Cancer Risk ◽  
Head And Neck ◽  
Neck Cancer ◽  
Hpv Infection ◽  
High Risk Hpv

scholarly journals Integration of high-risk human papillomavirus into cellular cancer-related genes in head and neck cancer cell lines

Head & Neck ◽  
2017 ◽  
Vol 39 (5) ◽  
pp. 840-852 ◽  
Author(s):  
Heather M. Walline ◽  
Christine M. Goudsmit ◽  
Jonathan B. McHugh ◽  
Alice L. Tang ◽  
John H. Owen ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Human Papillomavirus ◽  
High Risk ◽  
Head And Neck ◽  
Cell Lines ◽  
Cancer Cell ◽  
Neck Cancer ◽  
Cancer Cell Lines

Human papillomavirus in head and neck cancer: Molecular biology and clinicopathological correlations

2005 ◽  
Vol 24 (1) ◽  
pp. 19-34 ◽  
Author(s):  
Zoltán Szentirmay ◽  
Károly Pólus ◽  
László Tamás ◽  
Gabriella Szentkuti ◽  
Judit Kurcsics ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Human Papillomavirus ◽  
Molecular Biology ◽  
Head And Neck ◽  
Neck Cancer ◽  
Clinicopathological Correlations

scholarly journals DETEKSI INFEKSI Human papillomavirus (HPV) 16/18 PADA KARSINOMA SEL SKUAMOSA RONGGA MULUT DENGAN NESTED PCR

2019 ◽  
Author(s):  
Siti Hamidatul Aliyah
Keyword(s):  
Head And Neck Cancer ◽  
Human Papillomavirus ◽  
Head And Neck ◽  
Neck Cancer ◽  
Cancer Incidence ◽  
Nested Pcr ◽  
Hpv Infection ◽  
Hpv 16 ◽  
Hpv E6 ◽  
Hpv 18

Head and neck cancer ranks fourth nationally cancer incidence in Indonesia. Oral SCC isone of Head and neck cancer incidence. Oral SCCrelated to several factors, includingsmoking, alcohol, viral infection human papillomavirus (HPV 16/18) and genetic On theother hand, HPV E6 oncoprotein binds and inactivates TP53, and result in loss of control ofthe cell cycle.This study aimed to detect HPV 16/18 infection in oral SCC. Detection of HPVserotypes 16 and 18 performed on FFPE DNA isolates oral SCC with the method of nestedPolymerase Chain Reaction (PCR). Nested PCR was performed in two stages, namelyamplification with L1 primer, followed by specific PCR E6 HPV-16 and HPV-18. A total of33% (11/33) FFPE samples showed positive for HPV 18 infection (single-sized DNA bands415bp) and not detected the presence of infection with HPV 16. It can be concluded that thetype of FFPE biosampel can be used for studies related to HPV infection. Furthermore, itshould be tested on different types biosampel by a larger amount so as to represent theprevalence of oncogenic HPV infection in Indonesia.

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