Colorectal surgery

Chapter 34 provides an overview of the principles of colorectal surgery, and the common pathologies relevant to the speciality including colorectal cancer, inflammatory bowel disease, hernias, and perianal pathology. In addition, the acute abdomen, acute appendicitis, bowel obstruction, and acute diverticulitis are covered. Key investigations, operations, and procedures to see are summarized and include appendicectomy, colectomy, abdominoperineal resection, stoma, hernia repair, and the numerous investigations used in the context of an acute abdomen. Key knowledge and clinical skills relevant to colorectal surgery clinics are summarized with a particular emphasis on colorectal cancer, risk factors, symptoms/presentation, imaging studies, staging, and management. Inflammatory bowel disease may necessitate surgical intervention and the common acute and chronic presentations are summarized. The classification of abdominal wall hernias is outlined and key anatomical landmarks on clinical examination are illustrated. A list of differential diagnoses of groin lumps is presented with key investigations to differentiate them. Diverticular disease, haemorrhoids, anal fissures, rectal prolapse, and pilonidal disease are common and the clinical presentation, investigation, and management of each of these is outlined. Digital rectal examination is a key clinical skill in surgery and the steps involved are summarized. The anatomical approach to colorectal surgery is outlined and common approaches to the surgical management of appendicitis, hernia repair, hemicolectomy, primary anastomosis, and stoma surgery are presented. Mnemonics for recall of key anatomical landmarks are provided. Postoperative complications are outlined together with the approaches to management. An approach to assessment and management of the acute abdomen is outlined. Finally, key OSCE and examination topics relevant to colorectal surgery are outlined including stoma and hernia examination.

2021 ◽  
Vol 30 (6) ◽  
pp. S12-S18
Author(s):  
Jennie Burch

The functions of the lower parts of the bowel, namely the colon and rectum, are predominantly the absorption of fluids and elimination of faeces and flatus. Bowel surgery may be carried out in the treatment of colorectal cancer, inflammatory bowel disease or diverticular disease, and may involve the formation of a permanent or temporary stoma. The type of colorectal surgery carried out depends on the condition and where the problem occurs. Surgery can alter not only the bowel's anatomy but also its functioning. Bowel dysfunction can manifest as constipation, faecal incontinence or diarrhoea. Nurses are well placed to assist patients to resolve many of these problems as well as stoma issues.


2020 ◽  
Vol 8 (Suppl 3) ◽  
pp. A38-A38
Author(s):  
Shilpa Ravindran ◽  
Heba Sidahmed ◽  
Harshitha Manjunath ◽  
Rebecca Mathew ◽  
Tanwir Habib ◽  
...  

BackgroundPatients with inflammatory bowel disease (IBD) have increased risk of developing colorectal cancer (CRC), depending on the duration and severity of the disease. The evolutionary process in IBD is driven by chronic inflammation leading to epithelial-to-mesenchymal transition (EMT) events in colonic fibrotic areas. EMT plays a determinant role in tumor formation and progression, through the acquisition of ‘stemness’ properties and the generation of neoplastic cells. The aim of this study is to monitor EMT/cancer initiating tracts in IBD in association with the deep characterization of inflammation in order to assess the mechanisms of IBD severity and progression towards malignancy.Methods10 pediatric and 20 adult IBD patients, admitted at Sidra Medicine (SM) and Hamad Medical Corporation (HMC) respectively, have been enrolled in this study, from whom gut tissue biopsies (from both left and right side) were collected. Retrospectively collected tissues (N=10) from patients with malignancy and history of IBD were included in the study. DNA and RNA were extracted from fresh small size (2–4 mm in diameter) gut tissues using the BioMasher II (Kimble) and All Prep DNA/RNA kits (Qiagen). MicroRNA (miRNA; N=700) and gene expression (N=800) profiling have been performed (cCounter platform; Nanostring) as well as the methylation profiling microarray (Infinium Methylation Epic Bead Chip kit, Illumina) to interrogate up to 850,000 methylation sites across the genome.ResultsDifferential miRNA profile (N=27 miRNA; p<0.05) was found by the comparison of tissues from pediatric and adult patients. These miRNAs regulate: i. oxidative stress damage (e.g., miR 99b), ii. hypoxia induced autophagy; iii. genes associated with the susceptibility to IBD (ATG16L1, NOD2, IRGM), iv. immune responses, such as TH17 T cell subset (miR 29). N=6 miRNAs (miR135b, 10a196b, 125b, let7c, 375) linked with the regulation of Wnt/b-catenin, EM-transaction, autophagy, oxidative stress and play role also in cell proliferation and mobilization and colorectal cancer development were differentially expressed (p<0.05) in tissues from left and right sides of gut. Gene expression signature, including genes associated with inflammation, stemness and fibrosis, has also been performed for the IBD tissues mentioned above. Methylation sites at single nucleotide resolution have been analyzed.ConclusionsAlthough the results warrant further investigation, differential genomic profiling suggestive of altered pathways involved in oxidative stress, EMT, and of the possible stemness signature was found. The integration of data from multiple platforms will provide insights of the overall molecular determinants in IBD patients along with the evolution of the disease.Ethics ApprovalThis study was approved by Sidra Medicine and Hamad Medical Corporation Ethics Boards; approval number 180402817 and MRC-02-18-096, respectively.


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