This chapter details the main neurological presentations in adults, both chronic and acute, that a medical student should be familiar with. The common presentations of headache such as migraine, tension, and cluster headaches are covered, as are important less common diagnoses such as tumours, central nervous system infections, and subarachnoid haemorrhage. The chapter considers in detail the management of Parkinson’s disease and attendant movement disorders and includes a summary of drug therapies and multidisciplinary management of this disorder. The chapter discusses the difference between delirium and dementia and continues on to cover the epidemiology and presentations of the main types of dementia, including Alzheimer’s disease, vascular dementia, Lewy body dementia, and frontotemporal dementia. Screening tools for dementia such as the Mini-Mental State Examination are also covered. Acute neurological presentations are also included: status epilepticus, central nervous system infections and their management, acute stroke, and Guillain–Barré syndrome. The management of acute stroke, including thrombolysis, is discussed in detail, including several recent clinical trials. The chapter also devotes space to careful history taking, especially in the diagnosis and management of seizure disorders.