scholarly journals Factors Associated with Bone Erosion in Patients with Gout: A Dual-Energy Gemstone Spectral Imaging Computed Tomography Study

2021 ◽  
Author(s):  
Xiaofei Liu ◽  
Xiaohuan Zhang ◽  
Shiyan Mo ◽  
Dongfeng Liang ◽  
Baige Li ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Disease Duration ◽  
Bone Erosion ◽  
Spectral Imaging ◽  
Dual Energy ◽  
Bone Interface ◽  
Factors Associated ◽  
Gemstone Spectral Imaging

ABSTRACT Objective This study aimed to assess the factors influencing bone erosion in patients with gout using dual-energy gemstone spectral imaging CT. Methods We compared the clinical data, laboratory indices, and tissue urate levels at the monosodium urate (MSU)-bone interface measured by dual-energy gemstone spectral imaging computed tomography of 87 gout patients with (n=41) and without (n=46) bone erosion. Logistic regression analysis was used to investigate the risk factors associated with bone erosion. Results In total, 47.1% of patients with gout had bone erosion. The disease duration, serum uric acid, tissue urate levels, and the presence of tophi were significantly higher (p<0.05) in gout patients with bone erosion than in those without bone erosion. Longer disease duration (OR=1.11, 95% CI: 1.00–1.24, p<0.05) and increased tissue urate levels (OR=1.01, 95% CI: 1.00–1.02, p<0.05) were independently associated with bone erosion. Tissue urate levels at the MSU-bone interface were correlated with the presence of tophi (r=0.62, p<0.001), bone erosion (r=0.51, p<0.001), renal calculus (r=0.24, p=0.03), and serum uric acid levels (r=0.23, p=0.03). Conclusion This study found that longer disease duration and elevated tissue urate concentrations at the MSU-bone interface were associated with bone erosion in patients with gout.

Dual-Energy Computed Tomography Gemstone Spectral Imaging

2016 ◽  
Vol 40 (2) ◽  
pp. 283-289
Author(s):  
Ching-Li Cheng ◽  
Hsiao-Huang Chang ◽  
Shih-Chi Ko ◽  
Pei-Jung Huang ◽  
Shan-Yang Lin
Keyword(s):  
Computed Tomography ◽  
Spectral Imaging ◽  
Dual Energy ◽  
Dual Energy Computed Tomography ◽  
Gemstone Spectral Imaging

scholarly journals What is the diagnostic value of dual-energy computed tomography in patients with clinical diagnosis of gout?

2021 ◽  
Vol 61 (1) ◽  
Author(s):  
Jung Sun Lee ◽  
Wook Jang Seo
Keyword(s):  
Computed Tomography ◽  
Renal Insufficiency ◽  
Clinical Diagnosis ◽  
Disease Duration ◽  
Serum Urate ◽  
Dual Energy ◽  
Crystal Deposition ◽  
Dual Energy Computed Tomography ◽  
Factors Associated ◽  
Serum Urate Level

Abstract Objectives To investigate the frequency of monosodium urate (MSU) crystal deposits on dual-energy computed tomography (DECT) in patients with clinical diagnosis of gout and the factors associated MSU crystal positivity. Methods This study was conducted in patients with clinical diagnosis of gout who underwent DECT. Clinical features were compared between patients with positive and those with negative DECT results. A logistic regression analysis was performed to determine the factors associated with MSU crystal positivity on DECT. Results A total of 148 patients with clinical diagnosis of gout were included, and MSU crystal deposition on DECT was observed in 64 patients (43.3%). The patients with positive DECT results were more likely to have renal insufficiency, longer disease duration, and higher serum urate level than those with negative. In the multivariable analysis, first gout attack (odds ratio 0.462; 95% confidence interval 0.229–0.931, p = 0.031) was associated with a less likely MSU crystal deposit-positive DECT result. In the subgroup analysis of patients with first attack, serum urate level > 8 mg/dL was associated with DECT positivity. Conclusion Of the patients with clinical diagnosis of gout, those with renal insufficiency, longer disease duration, and high serum urate level were more likely to be positive of gout on DECT. First gout attack was associated with less likely to be positive for MSU crystal on DECT. Thus, performing DECT scan in the selected patients who had characteristics that highly probability of DECT positivity could increase positive predictive value.

scholarly journals Distribution of bony erosions in feet and performance of two bone erosion scores: A dual-energy computed tomography study of 61 patients with gout

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259194
Author(s):  
Amandine Chabernaud Negrier ◽  
Lokmane Taihi ◽  
Eric Vicaut ◽  
Pascal Richette ◽  
Thomas Bardin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Erosion ◽  
Intraclass Correlation ◽  
Metatarsophalangeal Joint ◽  
Dual Energy ◽  
Radiology Department ◽  
Crystal Deposition ◽  
First Metatarsophalangeal Joint ◽  
Dual Energy Computed Tomography ◽  
Bone Erosions

Objectives To assess the distribution of bone erosions and two erosion scores in the feet of patients with gout and analyze the association between erosion scores and monosodium urate (MSU) crystal deposition using dual-energy computed tomography (DECT). Materials and methods We included all patients who underwent DECT of both feet between 2016 and 2019 in our radiology department, with positive detection of MSU deposits. Data on sex, age, treatment, serum urate, and DECT urate volumes were obtained. CT images were analyzed to score bone erosions in 31 sites per foot by using the semi-quantitative method based on the Rheumatoid Arthritis MRI Scoring (RAMRIS) system and the Dalbeth-simplified score. Reproducibility for the two scores was calculated with intraclass correlation coefficients (ICCs). Correlations between clinical features, erosion scores and urate crystal volume were analyzed by the Spearman correlation coefficient (r). Results We studied 61 patients (mean age 62.0 years); 3,751 bones were scored. The first metatarsophalangeal joint and the midfoot were the most involved in terms of frequency and severity of bone erosions. The distribution of bone erosions was not asymmetrical. The intra- and inter-observer reproducibility was similar for the RAMRIS and Dalbeth-simplified scores (ICC 0.93 vs 0.94 and 0.96 vs 0.90). DECT urate volume was significantly correlated with each of the two erosion scores (r = 0.58–0.63, p < 0.001). There was a high correlation between the two scores (r = 0.96, p < 0.001). Conclusions DECT demonstrates that foot erosions are not asymmetric in distribution and predominate at the first ray and midfoot. The two erosion scores are significantly correlated with DECT urate volume. An almost perfect correlation between the RAMRIS and Dalbeth-simplified scores is observed.

Diagnostic accuracy of dual-energy computed tomography (DECT) to differentiate uric acid from non-uric acid calculi: systematic review and meta-analysis

2020 ◽  
Vol 30 (5) ◽  
pp. 2791-2801 ◽  
Author(s):  
Trevor A. McGrath ◽  
Robert A. Frank ◽  
Nicola Schieda ◽  
Brian Blew ◽  
Jean-Paul Salameh ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Systematic Review ◽  
Uric Acid ◽  
Diagnostic Accuracy ◽  
Meta Analysis ◽  
Dual Energy ◽  
Dual Energy Computed Tomography
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