Risks of acute renal failure after cardiopulmonary bypass surgery in children: a retrospective 10-year case-control study

1995 ◽  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Cardiopulmonary Bypass ◽  
Bypass Surgery ◽  
Case Control Study ◽  
Case Control ◽  
Cardiopulmonary Bypass Surgery ◽  
Control Study

scholarly journals Case-control study of acute renal failure in patients with cystic fibrosis in the UK

Thorax ◽  
2008 ◽  
Vol 63 (6) ◽  
pp. 532-535 ◽  
Author(s):  
A Smyth ◽  
S Lewis ◽  
C Bertenshaw ◽  
I Choonara ◽  
J McGaw ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Risk Factor ◽  
Case Control Study ◽  
Case Control ◽  
Increased Risk ◽  
Long Term Treatment ◽  
The Uk ◽  
Control Study

Background:There has been a recent increase in the number of reported cases of acute renal failure (ARF) in cystic fibrosis (CF). A case-control study was conducted to determine the factors which are associated with an increased risk of ARF.Methods:24 cases of confirmed ARF were identified in patients with CF from 20 UK CF centres presenting between 1997 and 2004. Using the UK CF database, sex- and age-matched controls were identified. Risk factors were analysed by conditional logistic regression and Mantel-Haenszel analysis.Results:21 of the 24 patients with ARF had received an aminoglycoside at the time of their episode of ARF or in the preceding week compared with only 3 of 42 controls during the same time period (OR 81.8, 95% CI 4.7 to 1427, p<0.001). In the year before the episode of ARF, significantly more cases than controls had received gentamicin (19/24 cases vs 1/42 controls, p<0.001). The numbers receiving tobramycin were similar (9/24 cases vs 16/42 controls, p = 0.9). A known risk factor for renal impairment (prior renal disease, acute dehydration or long-term treatment with a nephrotoxic drug) was present in 18/24 cases and 7/42 controls (OR 24.0, 95% CI 3.1 to 186.6, p = 0.002).Conclusions:In patients with CF the use of an intravenous aminoglycoside is a risk factor for ARF; gentamicin is more nephrotoxic than tobramycin. Most patients who develop ARF have a risk factor which necessitates withholding aminoglycosides or more closely monitoring their use.

scholarly journals Acute renal failure complicating cardiopulmonary bypass surgery.

1982 ◽  
Vol 57 (6) ◽  
pp. 425-430 ◽  
Author(s):  
S P Rigden ◽  
T M Barratt ◽  
M J Dillon ◽  
M De Leval ◽  
J Stark
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Cardiopulmonary Bypass ◽  
Bypass Surgery ◽  
Cardiopulmonary Bypass Surgery
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