scholarly journals SO028LONG-TERM OUTCOMES IN LIVE KIDNEY DONORS: PREVALENCE OF ISCHEMIC HEART DISEASE, DIABETES, CANCER AND CEREBROVASCULAR DISEASE AFTER DONATION COMPARED TO HEALTHY CONTROLS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Anders Haugen ◽  
Dag Olav Dahle ◽  
Stein I Hallan ◽  
Karsten Midtvedt ◽  
Anna Varberg Reisater ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Cerebrovascular Disease ◽  
Ischemic Heart ◽  
Healthy Controls ◽  
Kidney Donors ◽  
Increased Risk ◽  
Long Term Follow Up

Abstract Background and Aims During long-term follow-up kidney donors are at increased risk of hypertension and end-stage renal disease after donation. Hypertension is a known risk factor for development of cardiovascular disease, but it is unknown whether kidney donors are at increased risk of cardiovascular disease. We evaluated a large Norwegian kidney donor cohort and assessed prevalence of ischemic heart disease after donation compared to healthy controls. Prevalence of cancer, diabetes and cerebrovascular disease was also calculated. Method Follow-up data were retrospectively retrieved from past kidney donors. Healthy non-donor controls from a general population screening study were selected. Controls were selected according to standard donation criteria, assessed in similar time periods as the living donors. Stratified logistic regression was used to estimate associations with various disease outcomes. The diagnoses at follow-up were self-reported for the controls and registered by a physician for the donors. A total of 1029 donors and 16084 controls were included. Results Mean observation time was eleven years after donation. Forty-four per cent of donors were male and mean age at follow-up was 56 years. Among the controls, 39 % were male and mean age at follow-up was 53 years. At the time of follow up, 3.5 % of donors vs 1.7 % of controls had been diagnosed with ischemic heart disease, 3.7 % vs 4.4 % cancer, 1.8 % vs 1.4 % cerebrovascular disease and 4.1 % vs 1.9 % diabetes. After adjusting for gender, age at follow up, smoking at baseline, BMI at baseline, systolic blood pressure at baseline and time since donation (time since participation in general population survey for controls), odds ratio for ischemic heart disease was 1.64 (CI 1.10-2.43; P=0.01) in previous kidney donors compared with healthy controls. Other outcomes did not differ significantly between donors and controls. Conclusion During long-term follow-up of kidney donors we find an increased risk of ischemic heart disease compared to healthy controls. This information may be important in the follow-up and selection process of living kidney donors.

scholarly journals Increased risk of ischemic heart disease after kidney donation

2021 ◽  
Author(s):  
Anders J Haugen ◽  
Stein Hallan ◽  
Nina E Langberg ◽  
Dag Olav Dahle ◽  
Hege Pihlstrøm ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Cerebrovascular Disease ◽  
Ischemic Heart ◽  
Kidney Donation ◽  
Baseline Body Mass Index ◽  
Healthy Controls ◽  
Kidney Donors ◽  
Increased Risk

Abstract Background Previous reports suggest increased risk of hypertension and cardiovascular mortality after kidney donation. In this study we investigate occurrence of ischemic heart disease and cerebrovascular disease, diabetes and cancer in live kidney donors compared with healthy controls eligible for donation. Methods Different diagnoses were assessed in 1029 kidney donors and 16084 controls. The diagnoses at follow-up were self-reported for the controls and registered by a physician for the donors. Stratified logistic regression was used to estimate associations with various disease outcomes, adjusted for gender, age at follow up, smoking at baseline, body mass index at baseline, systolic blood pressure at baseline and time since donation. Results The mean (standard deviation) observation time was 11.3 (8.1) years for donors versus 16.4 (5.7) years for controls. Age at follow-up was 56.1 (12.4) years in donors vs 53.5 (11.1) years in controls and 44% of donors were males vs 39.3% in the controls. At follow up 35 (3.5%) of the donors had been diagnosed with ischemic heart disease versus 267 (1.7%) of the controls. Adjusted odds ratio for ischemic heart disease was 1.64 (confidence interval 1.10-2.43, P = 0.01) in donors compared with controls. There were no significant differences for the risks of cerebrovascular disease, diabetes or cancer. Conclusions During long-term follow-up of kidney donors we find an increased risk of ischemic heart disease compared to healthy controls. This information may be important in the follow-up and selection process of living kidney donors.

Ischemic heart disease after mantlefield irradiation for Hodgkin's disease in long-term follow-up

1999 ◽  
Vol 51 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Janny G. Reinders ◽  
Ben J.M. Heijmen ◽  
Manouk J.J. Olofsen-van Acht ◽  
Wim L.J. van Putten ◽  
Peter C. Levendag
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Ischemic Heart ◽  
Long Term Follow Up

Lactoferrin is a novel predictor of fatal ischemic heart disease in diabetes mellitus type 2: Long-term follow-up of the HUNT 1 study

2010 ◽  
Vol 212 (2) ◽  
pp. 614-620 ◽  
Author(s):  
Inga Thorsen Vengen ◽  
Ane Cecilie Dale ◽  
Rune Wiseth ◽  
Kristian Midthjell ◽  
Vibeke Videm
Keyword(s):  
Diabetes Mellitus ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type ◽  
Ischemic Heart ◽  
Long Term Follow Up

393Ischemic burden by vasodilator stress CMR predicts long-term all-cause death and the effect of revascularization in patients with known or suspected stable ischemic heart disease

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
V Marcos Garces ◽  
J Gavara ◽  
C Rios-Navarro ◽  
P Racugno ◽  
A Bellver Navarro ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
Vasodilator Stress ◽  
Clinical Event ◽  
Stable Ischemic Heart Disease ◽  
Late Enhancement Imaging ◽  
Increased Risk ◽  
Stress Cmr

Abstract Background In patients with stable ischemic heart disease (SIHD) the effect of revascularization on all-cause death (the most verifiable clinical event) is unknown. Objectives We explored the potential of the ischemic burden as derived from vasodilator stress cardiovascular magnetic resonance (CMR) to guide decision-making in this scenario. Methods In a large prospective multicenter registry, we recruited 6389 patients (mean age 65±11 years, 38% female) submitted to undergo vasodilator stress CMR for known or suspected SIHD. Baseline and CMR characteristics were prospectively recorded. The ischemic burden (at vasodilator stress first-pass perfusion imaging) and necrosis extent (at late enhancement imaging) were computed (17-segment model). The effect of CMR-related revascularization (within the following three months) on all-cause death (revised using the unified regional electronic health system registry) was explored. Results During a 5.75-year median follow-up, 717 (11.2%) all-cause deaths were documented. In multivariable analyses, more extensive ischemic burden (per 1-segment increase) independently related to all-cause death (1.05 [1.03–1.07], p<0.001). In 1034 patients (517 revascularized, 517 non-revascularized) strictly 1:1 matched for the independent predictors of outcome and of undergoing CMR-related revascularization (age, diabetes mellitus, male sex, LVEF, ischemic burden and necrosis extent), CMR-related revascularization did not significantly alter all-cause death rate (13.3% vs. 13.3%, p=0.54). Nevertheless, a potent interaction existed with the ischemic burden (p<0.001). CMR-related revascularization independently reduced the risk of all-cause death in 430 patients with ischemic burden >5 segments (9.3% vs. 16.3%, HR 0.56 [0.32–0.98], p=0.02) but it independently increased risk in 604 patients with ischemic burden ≤5 segments (16.2% vs. 11.3%, HR 1.59 [1.03–2.45], p=0.037). Figure 1. CMR-related revascularization Conclusions In patients with known or suspected stable ischemic heart disease the ischemic burden as derived from vasodilator stress CMR can be helpful to predict the effect of revascularization on long-term all-cause death. Acknowledgement/Funding Funded by “Instituto de Salud Carlos III”/FEDER (PIE15/00013, PI17/01836, and CIBERCV16/11/00486 grants) and Generalitat Valenciana (GV/2018/116).

Abstract 208: Follow-up Study in Kawasaki Disease By Treadmill Exercise Test And Echocardiography

Circulation ◽  
2015 ◽  
Vol 131 (suppl_2) ◽  
Author(s):  
Sin-Ae Park ◽  
Kichul Park ◽  
Jee Won Park
Keyword(s):  
Heart Disease ◽  
Coronary Artery ◽  
Kawasaki Disease ◽  
Ischemic Heart Disease ◽  
Exercise Test ◽  
Treadmill Exercise ◽  
Treadmill Exercise Test ◽  
Long Term Follow Up

Kawasaki disease (KD) may result in coronary aneurysm formation and increased risk of cardiovascular complications such as ischemic heart disease. Therefore, the early detection, non-invasive monitoring and long-term follow-up of myocardial ischemia are essential. This study sought to determine the ischemic heart disease by treadmill exercise test and two-dimensional echocardiography. Three hundred and four patients with a history of KD from 1995 to 2005 were retrospectively analyzed. Among them fifty patients who agree with the study underwent exercise test and 2D-echocardiography. The patients were followed for 11.6 years(8 to 17) from disease onset. The coronary artery ectasia regressed in 21 patients. No stenotic lesion could be found in the coronary artery in follow-up echocardiography. And no significant ischemic changes were detected. There is no evidence of persisting coronary ectasia and dysfunction of cardiac perfusion in patients with previous KD in this study. However, these patients should be counselled to avoid potential risk factors for other complication such as atherosclerosis and long term follow up is needed into adult life.

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