FP426LOW SERUM ADIPONECTIN IS ASSOCIATED WITH BETTER PHYSICAL HEALTH-RELATED QUALITY OF LIFE IN CHRONIC KIDNEY DISEASE: FROM THE KNOW-CKD STUDY

2019 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Jimin Han ◽  
Hyun Young Youl ◽  
Kim Hyang ◽  
Oh Kook-Hwan ◽  
Ahn Curie ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Physical Health ◽  
Serum Adiponectin ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals Assessment of Health Related Quality of Life among Chronic Kidney Disease Patients: Challenges for Nephrologists in Pakistan

2020 ◽  
pp. 42-48
Author(s):  
Madeeha Malik ◽  
Iter Un Nisha ◽  
Azhar Hussain
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Physical Health ◽  
Daily Activities ◽  
Health Related Quality ◽  
Significant Difference ◽  
Related Quality ◽  
Health Related

Introduction: During the past few decades, health related quality of life has been considered as an important predictor for positive health outcomes. Health-related quality of life assessment helps in determining the impact of disease on the everyday life of patients. Chronic kidney disease severely affects health related quality of life of patient. Objective: The objective of this study was to assess health related quality of life among patients with chronic kidney diseases in Pakistan. Methodology: A descriptive cross-sectional study design was used. Study respondents included CKD pre-dialysis and dialysis patients with or without comorbidities visiting tertiary care facilities located in twin cities of Pakistan. Sample size was calculated to be 386 pharmacists to achieve 95% confidence level with 5% margin of error. Convenient sampling technique was used to select respondents. A pre- validated questionnaire Kidney Disease Quality of Life questionnaire (KDQoL-36) was used. Data was coded and analyzed using SPSS 21 after collection. Mann-Whitney and Kruskal-Wallis (p ≥ 0.05) tests were according to different demographic variables. Results: The results of the current study showed lowest scores for HRQoL in domain of physical health composite (30.77±11.16) followed by domain of symptoms and problems associated with CKD whereas daily life had the highest scores. The results highlighted that females had better HRQoL in all domains mental health (46.30, ± 8.73), burden of kidney disease (69.47, ± 32.35), symptoms (29.79, ± 31.22) and effect of disease on daily activities (40.96, ± 32.11) while lowest score for physical health (30.90, ± 10.34). Married respondents had better HRQoL among all domains than unmarried patients except for physical health (32.26, ± 10.7). A significant difference (p ≥ 0.05) was observed among different domains of HRQoL of CKD patients with respect to different genders, marital status, age groups and qualification levels. Males had relatively better physical health scores but their daily activities were also affected more by their disease. Married respondents had relatively better HRQoL among all domains than unmarried patients except for physical health. No significant difference (p ≥ 0.05) was observed for different stages of disease. Conclusion: The present study concluded that patients with CKD had poor HRQoL regardless of novel treatments availability. A negative impact was observed across all domains of health related quality of life among chronic kidney disease patients. Necessary programs focusing on health education for patients with low literacy levels should be initiated to increase health awareness and improve mental health among CKD patients.

scholarly journals Low serum adiponectin level is associated with better physical health-related quality of life in chronic kidney disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ji Hye Kim ◽  
◽  
Ji Min Han ◽  
Hyang Kim ◽  
Kyu-Beck Lee ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Adiponectin Level ◽  
Serum Adiponectin ◽  
Health Related Quality ◽  
Serum Adiponectin Level ◽  
Related Quality ◽  
Health Related

AbstractHyperadiponectemia is paradoxically associated with renal disease progression and mortality in chronic kidney disease (CKD). Its association with health-related quality of life (HR-QOL) is unknown. This study aimed to verify the association between adiponectin and HR-QOL in Korean pre-dialysis CKD cohort. This cross-sectional study analyzed 1551 pre-dialysis CKD patients from KNOW-CKD (KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease). Participants were categorized into three tertiles (T1–T3) according to adiponectin levels. HR-QOL was assessed using SF-36. High physical component summary (PCS) and mental component summary (MCS) were defined as highest quartile of each score. Multivariate logistic regression was used to analyze odds ratio (OR) and 95% confidence interval (CI) for high PCS and MCS. Prevalence of high PCS were 33.3%, 27.5%, and 17.0% and that of high MCS were 31.7%, 24.8%, and 21.3% for T1, T2, and T3 (both p for trend < 0.001). The adjusted OR [95% CI] of T1 and T2 in reference to T3 were 1.56 [1.09–2.23] and 1.19 [0.85–1.68] for high PCS and 1.19 [0.85–1.68] and 0.94 [0.68–1.29] for high MCS. Serum adiponectin level was inversely associated with physical HR-QOL in Korean pre-dialysis CKD patients. This relationship was independent of various cardiovascular risk factors.

scholarly journals Better health-related quality of life in kidney transplant patients compared to chronic kidney disease patients with similar renal function

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0257981
Author(s):  
Jung-Hwa Ryu ◽  
Tai Yeon Koo ◽  
Han Ro ◽  
Jang-Hee Cho ◽  
Myung-Gyu Kim ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Health Related Quality ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related ◽  
Over Time

Renal functional deterioration is associated with physical and mental burdens for kidney transplant (KT) and chronic kidney disease (CKD) patients. However, the change in health-related quality of life (HRQOL) over time in KT patients compared to that of native CKD patients has not been evaluated. We addressed this issue using KT patients registered in the KNOW-KT cohort study and patients at CKD stage 1–3 registered in the KNOW-CKD cohort study. HRQOL scores were assessed using the Kidney Disease Quality of Life Short Form at baseline, 2-, and 4-years follow-up in 842 KT patients and at baseline and 5-year follow-up in 1,355 CKD patients. SF-36 scores declined at the 4-year follow-up, whereas CKD-targeted scores showed no change in the KT group. In contrast, CKD-targeted scores as well as SF-36 scores were decreased at the 5-year follow-up in CKD patients. When prognostic factors were analyzed for longitudinal HRQOL data over time, renal functions, diabetes, cardiovascular and cerebrovascular diseases, hemoglobin level, marital status, income, employment, and health care were significant prognostic factors. Furthermore, KT was an independent prognostic factor for better HRQOL. These results highlight that KT can offer a better HRQOL than that of CKD patients, even when renal function is similar.

Health-related Quality of Life among Patients with Chronic Kidney Disease of Unknown Etiology (CKDu) of an agricultural Community in Kebithigollawa, Sri Lanka

2021 ◽  
Author(s):  
Nishantha Kumarasinghe
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Sri Lanka ◽  
Kidney Disease ◽  
Unknown Etiology ◽  
Health Related Quality ◽  
Early Assessment ◽  
Related Quality ◽  
Health Related

Background: The significant increase in the burden of chronic kidney disease of unknown etiology (CKDu) of Sri Lanka has led to evaluate the factors related to physical, social and mental aspects of health-related quality of life (HRQOL) in CKDu patients. Methods: The quality of life of 84 CKDu patients (stages 1-5) were assessed by means of the Kidney Disease Quality of Life Short-Form survey (KDQOL™-36) Version 1.3 along with biomarkers and patient demographics. The estimated glomerular filtration rate (eGFR) was calculated using the Modification of Diet in Renal Disease (MDRD) formula. Results: KDQOL™-36 scores impaired substantially across all stages of CKDu and comparatively lower scores were present in later stages of the disease than the initial stages. The mental composite summary (MCS) scores were more impaired when compared to physical composite summary (PCS) scores during the early stage of the disease. Poor KDQOL™-36 scores were present in males than in females with a significant difference in MCS and social support scales. Biochemical parameters showed a significant correlation with the majority of KDQOL™-36 dimensions while urine albumin to creatinine ratio did not. Conclusion: CKDu patients in any stage of the disease despite their age and gender have a significant physical and mental health burden. Thereby, early assessment of health-related quality of life will help to identify high-risk patients, and modifying these factors may provide a better active and healthy lifestyle.

Assessment of Acute complications and Quality of Life in Hemodialysis patients with Chronic Kidney Disease

2021 ◽  
pp. 2671-2675
Author(s):  
Achsa Thomas ◽  
Julia S. Jacob ◽  
Merin Abraham ◽  
Blessy M. Thomas ◽  
Purnima Ashok
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Hemodialysis Patients ◽  
Health Related Quality ◽  
Muscle Cramps ◽  
Acute Complications ◽  
Related Quality ◽  
Health Related

Introduction: End Stage Renal Disease (ESRD) is the last stage of Chronic Kidney Disease (CKD), where kidneys solely functions at 10 to 15 percent of their normal capacity. Efficacious treatment for ESRD is renal replacement therapies like dialysis and renal transplantation. Health related quality of life (HRQoL) is a neglected aspect of CKD care. Objective: To assess the acute complications and quality of life in hemodialysis patients. Methods: This prospective observational study was conducted for 6 months, 90 patients undergoing hemodialysis were enrolled in the study. Acute complications were assessed during and post dialysis and Health Related Quality of Life were analysed using KDQoL-36TM questionnaire. Result: Among patients assessed; majority of the patients belonged to the age group 30 to 60 years. Acute complications were evaluated and oedema was found in maximum patients followed by muscle cramps, loss of appetite, itching etc. Based on KDQoL-36TM questionnaire, physical functions was mainly affected due to the disease. Oedema and muscle cramps had an impact on the patients physical and mental functioning whereas educational status and addictions showed significance in all domains of KDQOL-36TM. Conclusion: CKD patients undergoing hemodialysis has an intense effect on HRQoL. A better understanding on QOL issues will enable providers to deliver better patient centred care and enhance the overall well-being of the patients.

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