ACTR-16. PHASE 2 STUDY EVALUATING SAFETY, PHARMACOKINETICS (PK), PHARMACODYNAMICS (PD) AND EFFICACY OF THE ORAL TRANSFORMING GROWTH FACTOR-BETA (TGF-β) RECEPTOR I KINASE INHIBITOR GALUNISERTIB WHEN COMBINED WITH CHEMORADIOTHERAPY IN NEWLY DIAGNOSED MALIGNANT GLIOMA

Kinase Inhibitor ◽

Phase 2 ◽

Newly Diagnosed ◽

Phase 2 Study ◽

Growth Factor Beta ◽

A phase 2 study of galunisertib, a novel transforming growth factor-beta (TGF-β) receptor I kinase inhibitor, in patients with advanced hepatocellular carcinoma (HCC) and low serum alpha fetoprotein (AFP).

Journal of Clinical Oncology ◽

10.1200/jco.2016.34.15_suppl.4070 ◽

2016 ◽

Vol 34 (15_suppl) ◽

pp. 4070-4070 ◽

Cited By ~ 12

Author(s):

Sandrine J. Faivre ◽

Armando Santoro ◽

Edward Gane ◽

Robin Kate Kelley ◽

I Ollivier Hourmand ◽

...

Keyword(s):

Kinase Inhibitor ◽

Advanced Hepatocellular Carcinoma ◽

Phase 2 ◽

Phase 2 Study ◽

Serum Alpha Fetoprotein ◽

Growth Factor Beta ◽

Β Receptor ◽

Low Serum

Abstract C261: Pharmacokinetics (PK) and pharmacodynamics (PD) of the oral transforming growth factor-beta (TGF-β) receptor I kinase inhibitor LY2157299 monohydrate (LY) in hepatocellular carcinoma (HCC) compared to glioma patients.

10.1158/1535-7163.targ-13-c261 ◽

2013 ◽

Author(s):

Eric Raymond ◽

Sandrine Faivre ◽

Armondo Santoro ◽

Robin K. Kelley ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Growth Factor ◽

Kinase Inhibitor ◽

Growth Factor Beta ◽

First human dose (FHD) study of the oral transforming growth factor-beta receptor I kinase inhibitor LY2157299 in patients with treatment-refractory malignant glioma.

Journal of Clinical Oncology ◽

10.1200/jco.2011.29.15_suppl.3011 ◽

2011 ◽

Vol 29 (15_suppl) ◽

pp. 3011-3011 ◽

Cited By ~ 10

Author(s):

J. Rodon Ahnert ◽

J. Baselga ◽

E. Calvo ◽

J. Seoane ◽

I. Brana ◽

...

Keyword(s):

Growth Factor ◽

Malignant Glioma ◽

Kinase Inhibitor ◽

Beta Receptor ◽

Human Dose ◽

Growth Factor Beta ◽

Treatment Refractory

Effect of transforming growth factor beta (TGF-β) receptor I kinase inhibitor on prostate cancer bone growth

Bone ◽

10.1016/j.bone.2011.11.022 ◽

2012 ◽

Vol 50 (3) ◽

pp. 695-703 ◽

Cited By ~ 36

Author(s):

Xinhai Wan ◽

Zhi-Gang Li ◽

Jonathan M. Yingling ◽

Jun Yang ◽

Michael W. Starbuck ◽

...

Keyword(s):

Prostate Cancer ◽

Growth Factor ◽

Bone Growth ◽

Kinase Inhibitor ◽

Growth Factor Beta ◽

P002 Interleukin-8 (IL8) and transforming growth-factor beta (TGF-β) as drugable biomarkers of response, progression-free (PFS) and overall survival (OS) with pazopanib (PZP): A phase 2 study in relapsed urothelial cancer (UC)

European Urology Supplements ◽

10.1016/s1569-9056(13)60383-8 ◽

2012 ◽

Vol 11 (5) ◽

pp. 191-192

Author(s):

A. Necchi ◽

L. Mariani ◽

N. Zaffaroni ◽

P. Giannatempo ◽

N. Nicolai ◽

...

Keyword(s):

Overall Survival ◽

Growth Factor ◽

Urothelial Cancer ◽

Interleukin 8 ◽

Phase 2 ◽

Phase 2 Study ◽

EW-7197, a Transforming Growth Factor-Beta Type I Receptor Kinase Inhibitor, Ameliorates Acquired Lymphedema in a Mouse Tail Model

Lymphatic Research and Biology ◽

10.1089/lrb.2018.0070 ◽

2020 ◽

Vol 18 (5) ◽

pp. 433-438

Author(s):

Sung-Hwan Yoon ◽

Kun Yung Kim ◽

Zhe Wang ◽

Jung-Hoon Park ◽

Sang Mun Bae ◽

...

Keyword(s):

Growth Factor ◽

Kinase Inhibitor ◽

Type I ◽

Receptor Kinase ◽

W1352 Nutritional Supplementation With Transforming Growth Factor-Beta (TGF-β) Affects Enterocyte Turnover in Correlation With TGF-β Receptor Expression After Massive Small Bowel Resection in a Rat

Gastroenterology ◽

10.1016/s0016-5085(10)63243-x ◽

2010 ◽

Vol 138 (5) ◽

pp. S-705

Author(s):

Ron Shaoul ◽

Jorge Mogilner ◽

Arnold G. Coran ◽

Elena Chemodanov ◽

Igor Sukhotnik

Keyword(s):

Growth Factor ◽

Small Bowel ◽

Bowel Resection ◽

Small Bowel Resection ◽

Receptor Expression ◽

Growth Factor Beta ◽

Β Receptor ◽

Massive Small Bowel Resection

Novel transforming growth factor beta receptor I kinase inhibitor galunisertib (LY2157299) in advanced hepatocellular carcinoma

Liver International ◽

10.1111/liv.14113 ◽

2019 ◽

Vol 39 (8) ◽

pp. 1468-1477 ◽

Cited By ~ 23

Author(s):

Sandrine Faivre ◽

Armando Santoro ◽

Robin K. Kelley ◽

Ed Gane ◽

Charlotte E. Costentin ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Growth Factor ◽

Kinase Inhibitor ◽

Advanced Hepatocellular Carcinoma ◽

Beta Receptor ◽

Inhibition of intimal hyperplasia in murine aortic allografts by the oral administration of the transforming growth factor-beta receptor I kinase inhibitor SD-208

The Journal of Heart and Lung Transplantation ◽

10.1016/j.healun.2014.02.020 ◽

2014 ◽

Vol 33 (6) ◽

pp. 654-661 ◽

Cited By ~ 12

Author(s):

Yuan Sun ◽

Ping Ye ◽

Jie Wu ◽

Zheng Liu ◽

Anchen Zhang ◽

...

Keyword(s):

Growth Factor ◽

Oral Administration ◽

Intimal Hyperplasia ◽

Kinase Inhibitor ◽

Beta Receptor ◽

Euphol from Euphorbia tirucalli negatively modulates transforming growth factor‐beta (TGF‐β) responsiveness correlate with TGF‐β receptor segregation inside membrane rafts.

The FASEB Journal ◽

10.1096/fasebj.29.1_supplement.574.8 ◽

2015 ◽

Vol 29 (S1) ◽

Author(s):

Chen Ying‐Pin ◽

Chen Chun‐Lin

Keyword(s):

Growth Factor ◽

Membrane Rafts ◽

Euphorbia Tirucalli ◽

Growth Factor Beta ◽